Unc5c cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Unc5c
Entrez Gene ID	22253
Full Name	unc-5 netrin receptor C
Synonyms	B130051O18Rik,Unc5h3,rcm
General protein information	Preferred Names unc-5 netrin receptor C Names netrin receptor UNC5C UNC-5 homolog 3 rostral cerebellar malformation protein unc-5 homolog C unc5 homolog 3
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 3 Map Location: 3 H1\|3 65.57 cM

mRNA and Protein(s)

mRNA	Protein	Name
NM_001293561.1	NP_001280490.1	netrin receptor UNC5C isoform 1 precursor
NM_009472.4	NP_033498.1	netrin receptor UNC5C isoform 2 precursor

Pathways from BioSystems

Homologies

Xenopus tropicalis (tropical clawed frog)	unc5c	XP_004911160.1
Pan troglodytes (chimpanzee)	UNC5C	XP_526636.2
	UNC5C	XP_002804202.1
Gallus gallus (chicken)	UNC5C	NP_989782.1
Danio rerio (zebrafish)	unc5c	NP_001093454.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP009061	XP_319812.4
Homo sapiens (human)	UNC5C	NP_003719.3
Canis lupus familiaris (dog)	UNC5C	XP_005639270.1
Bos taurus (cattle)	UNC5C	XP_005207793.1
Rattus norvegicus (Norway rat)	Unc5c	NP_955439.1
Drosophila melanogaster (fruit fly)	unc-5	NP_611033.2
Mus musculus (house mouse)	Unc5c	NP_033498.1

Gene Ontology
Bibliography

Related articles in PubMed

Uncoupling of UNC5C with Polymerized TUBB3 in Microtubules Mediates Netrin-1 Repulsion.
Shao Q, Yang T, Huang H, Alarmanazi F, Liu G
The Journal of neuroscience : the official journal of the Society for Neuroscience37(23)5620-5633(2017 Jun)

Netrin1 Produced by Neural Progenitors, Not Floor Plate Cells, Is Required for Axon Guidance in the Spinal Cord.
Varadarajan SG, Kong JH, Phan KD, Kao TJ, Panaitof SC, Cardin J, Eltzschig H, Kania A, Novitch BG, Butler SJ
Neuron94(4)790-799.e3(2017 May)

ISL1-based LIM complexes control Slit2 transcription in developing cranial motor neurons.
Kim KT, Kim N, Kim HK, Lee H, Gruner HN, Gergics P, Park C, Mastick GS, Park HC, Song MR
Scientific reports636491(2016 Nov)

Netrin1/DCC signaling promotes neuronal migration in the dorsal spinal cord.
Junge HJ, Yung AR, Goodrich LV, Chen Z
Neural development11(1)19(2016 10)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Here, we report that dissociation of UNC5C and polymerized TUBB3, the highly dynamic beta-tubulin isoform in neurons, is essential for netrin-1/UNC5C-promoted axon repulsion. These results not only provide a working model of direct modulation of MTs by guidance cues in growth cone navigation but also help us to understand molecular mechanisms underlying developmental brain disorders associated with TUBB3 mutations.
Title: Uncoupling of UNC5C with Polymerized TUBB3 in Microtubules Mediates Netrin-1 Repulsion.

UNC5C expression levels increased from the 4-cell stage to the blastocyst stage in fertilized murine embryos. Repression of UNC5C in the anterior nucleus stage inhibited development to the blastocyst stage.
Title: Molecular Effects of Polymorphism in the 3'UTR of Unc-5 homolog C Associated with Conception Rate in Holsteins.

UNC5c expression is enriched in CA3 hippocampal neurons, but UNC5c is not expressed in microglia or perpheral blood mononuclear cells.
Title: A rare mutation in UNC5C predisposes to late-onset Alzheimer's disease and increases neuronal cell death.

Unc5C and DCC act downstream of Ctip2 and Satb2 and contribute to corpus callosum formation.
Title: Unc5C and DCC act downstream of Ctip2 and Satb2 and contribute to corpus callosum formation.

unc5c haploinsufficiency results in diminished amphetamine-induced locomotion in male and female mice. This phenotype is identical to that produced by dcc haploinsufficiency and is observed after adolescence.
Title: unc5c haploinsufficient phenotype: striking similarities with the dcc haploinsufficiency model.

The following Unc5c gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Unc5c cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu23417	NM_001293561.1 Latest version!	Mus musculus unc-5 netrin receptor C (Unc5c), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$475.30 $679.00
OMu23418	NM_009472.4 Latest version!	Mus musculus unc-5 netrin receptor C (Unc5c), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$545.30 $779.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Unc5c ( NM_001293561.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001280490.1 Mus musculus unc-5 netrin receptor C (Unc5c), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OMu23417
Clone ID Related Accession (Same CDS sequence)	NM_001293561.1
Accession Version	NM_001293561.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2853bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-28
Organism	Mus musculus(house mouse)
Product	netrin receptor UNC5C isoform 1 precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC170085.2, AK141181.1, AC158552.5 and AC157492.17. On Jun 10, 2014 this sequence version replaced XM_006501311.1. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK141181.1, AK142411.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849385, SAMN00849387 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAGGAAAG GTCTGAGGGC GACAGCGGCC CGCTGCGGAC TGGGACTAGG ATACTTGCTG 
CAGATGCTTG TGTTACCTGC CCTGGCCCTG CTAAGCGCCA GTGGCACCGG CTCCGCCGCT 
CAAGATGATG AATTTTTTCA CGAACTCCCA GAAACCTTTC CATCTGACCC ACCTGAGCCA 
TTGCCACACT TCCTCATTGA GCCCGAGGAA GCTTACATTG TGAAGAACAA GCCTGTGAAC 
CTGTATTGTA AAGCCAGCCC TGCCACCCAG ATCTACTTCA AGTGCAACAG CGAGTGGGTT 
CATCAGAAGG ACCACGTAGT AGACGAGAGA GTAGATGAAA CCTCTGGTCT AATTGTGAGA 
GAAGTGAGCA TTGAGATTTC ACGCCAGCAG GTGGAGGAAC TGTTTGGGCC TGAAGATTAC 
TGGTGCCAGT GTGTGGCCTG GAGCTCAGCA GGCACTACGA AGAGTCGGAA GGCATACGTG 
CGCATTGCGT ATCTGCGGAA GACATTCGAG CAGGAACCCT TGGGAAAGGA AGTGTCCTTG 
GAGCAGGAAG TCTTACTCCA GTGTCGGCCA CCTGAAGGGA TCCCAGTGGC TGAGGTAGAA 
TGGCTAAAGA ATGAAGACAT AATTGATCCT GCTGAAGATC GGAACTTTTA TATTACTATC 
GATCACAACC TGATCATCAA GCAAGCCCGA CTCTCAGATA CAGCAAATTA TACCTGTGTT 
GCCAAAAATA TTGTTGCCAA GAGAAAAAGC ACCACAGCCA CTGTCATCGT GTATGTTAAT 
GGTGGCTGGT CCACCTGGAC AGAGTGGTCT GTGTGTAACA GCCGCTGTGG GCGAGGATAT 
CAGAAACGCA CAAGAACCTG CACCAACCCA GCCCCACTCA ATGGTGGGGC CTTCTGTGAG 
GGGCAGAGTG TGCAGAAAAT AGCATGCACT ACGTTATGTC CAGTGGATGG TAGGTGGACT 
TCATGGAGCA AATGGTCAAC CTGTGGGACT GAATGCACCC ACTGGCGCAG GAGGGAGTGT 
ACAGCACCAG CCCCCAAGAA CGGGGGTAAG GACTGTGATG GCCTGGTCCT CCAATCCAAG 
AACTGCACTG ATGGGCTGTG CATGCAGGGA TTCATTTACC CCATTTCAAC TGAGCACAGA 
CCCCAGAATG AATATGGATT TTCTTCTGCT CCTGACTCAG ATGATGTGGC TCTCTACGTG 
GGGATTGTGA TCGCTGTAAC AGTCTGTCTG GCGATCACTG TTGTGGTGGC CCTGTTTGTG 
TATCGGAAGA ACCACCGTGA CTTTGAGTCT GACATCATTG ACTCCTCAGC ACTCAATGGC 
GGCTTTCAGC CTGTGAACAT CAAGGCTGCC AGACAAGATC TCCTGGCTGT CCCCCCTGAC 
CTCACCTCAG CTGCAGCCAT GTACAGGGGA CCTGTCTATG CTCTGCATGA TGTCTCAGAC 
AAAATCCCAA TGACCAACTC TCCAATTCTG GACCCACTAC CCAACTTGAA AATCAAAGTG 
TACAACAGCT CAGGTGCTGT CACTCCTCAG GATGACCTTG CCGAGTTCTC ATCCAAACTG 
TCACCCCAGA TGACCCAGTC CTTGCTAGAG AATGAGGCCC TTAACCTGAA GAACCAGAGC 
CTCGCAAGAC AGACTGACCC ATCCTGCACA GCATTTGGTA CCTTCAACTC TCTTGGGGGT 
CACCTCATCA TTCCTAATTC AGGAGTAAGC TTGCTGATTC CCGCTGGGGC CATTCCTCAG 
GGGAGAGTCT ATGAAATGTA TGTGACTGTA CACAGGAAAG AAAATATGAG GCCCCCCATG 
GAAGACTCTC AGACCCTACT TACCCCTGTG GTGAGCTGTG GGCCTCCTGG AGCTCTGCTG 
ACCCGCCCTG TCATCCTCAC TCTGCATCAC TGTGCAGACC CCAGCACCGA GGACTGGAAG 
ATCCAGCTCA AAAACCAGGC AGTGCAGGGA CAATGGGAGG ATGTTGTGGT GGTTGGGGAG 
GAGAACTTCA CAACCCCCTG TTACATTCAG CTGGATGCAG AGGCTTGCCA TATCCTCACA 
GAGAACCTCA GTACCTATGC CCTGGTTGGG CAGTCCACCA CCAAAGCAGC TGCCAAGCGT 
CTTAAACTGG CCATCTTTGG GCCCCTCTGC TGCTCTTCCC TGGAGTACAG CATTAGAGTC 
TACTGCCTGG ATGACACACA GGATGCCCTG AAGGAAGTTC TACAACTGGA GAGGCAAATG 
GGAGGACAGC TCCTAGAAGA ACCCAAGGCT CTTCATTTTA AAGGCAGCAT CCACAACCTG 
CGCCTGTCTA TTCATGACAT CGCCCATTCC CTCTGGAAGA GCAAATTGCT GGCTAAGTAT 
CAGGAAATTC CATTTTACCA CATCTGGAGT GGCTCTCAAA GAAACCTCCA CTGCACCTTC 
ACTCTGGAAA GACTCAGCCT AAACACAGTG GAACTGGTTT GCAAACTCTG TGTGCGGCAG 
GTTGAAGGAG AAGGGCAGAT CTTCCAGCTC AACTGTACTG TGTCAGAGGA ACCTACTGGC 
ATCGACTTAC CTCTCCTGGA CCCTGCTAGT ACCATCACCA CTGTCACCGG ACCAAGTGCT 
TTCAGCATTC CTCTCCCTAT CCGGCAGAAG CTATGCAGCA GCCTGGATGC CCCTCAAACA 
AGAGGCCATG ACTGGAGGAT GCTGGCCCAT AAACTCAACC TGGACAGGTA CTTGAATTAC 
TTTGCCACCA AATCGAGCCC AACTGGCGTA ATCCTGGATC TTTGGGAAGC ACAGAACTTC 
CCAGATGGAA ACCTGAGCAT GCTGGCAGCC GTCCTGGAAG AAATGGGAAG ACATGAGACA 
GTGGTGTCCT TGGCAGCAGA AGGACAGTAT TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001280490.1
CDS	151..3003
Translation	MRKGLRATAARCGLGLGYLLQMLVLPALALLSASGTGSAAQDDEFFHELPETFPSDPPEPLPHFLIEPEEAYIVKNKPVNLYCKASPATQIYFKCNSEWVHQKDHVVDERVDETSGLIVREVSIEISRQQVEELFGPEDYWCQCVAWSSAGTTKSRKAYVRIAYLRKTFEQEPLGKEVSLEQEVLLQCRPPEGIPVAEVEWLKNEDIIDPAEDRNFYITIDHNLIIKQARLSDTANYTCVAKNIVAKRKSTTATVIVYVNGGWSTWTEWSVCNSRCGRGYQKRTRTCTNPAPLNGGAFCEGQSVQKIACTTLCPVDGRWTSWSKWSTCGTECTHWRRRECTAPAPKNGGKDCDGLVLQSKNCTDGLCMQGFIYPISTEHRPQNEYGFSSAPDSDDVALYVGIVIAVTVCLAITVVVALFVYRKNHRDFESDIIDSSALNGGFQPVNIKAARQDLLAVPPDLTSAAAMYRGPVYALHDVSDKIPMTNSPILDPLPNLKIKVYNSSGAVTPQDDLAEFSSKLSPQMTQSLLENEALNLKNQSLARQTDPSCTAFGTFNSLGGHLIIPNSGVSLLIPAGAIPQGRVYEMYVTVHRKENMRPPMEDSQTLLTPVVSCGPPGALLTRPVILTLHHCADPSTEDWKIQLKNQAVQGQWEDVVVVGEENFTTPCYIQLDAEACHILTENLSTYALVGQSTTKAAAKRLKLAIFGPLCCSSLEYSIRVYCLDDTQDALKEVLQLERQMGGQLLEEPKALHFKGSIHNLRLSIHDIAHSLWKSKLLAKYQEIPFYHIWSGSQRNLHCTFTLERLSLNTVELVCKLCVRQVEGEGQIFQLNCTVSEEPTGIDLPLLDPASTITTVTGPSAFSIPLPIRQKLCSSLDAPQTRGHDWRMLAHKLNLDRYLNYFATKSSPTGVILDLWEAQNFPDGNLSMLAAVLEEMGRHETVVSLAAEGQY

Target ORF information:

RefSeq Version	NM_001293561.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus unc-5 netrin receptor C (Unc5c), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001293561.1

ORF Insert Sequence:

ATGAGGAAAG GTCTGAGGGC GACAGCGGCC CGCTGCGGAC TGGGACTAGG ATACTTGCTG 
CAGATGCTTG TGTTACCTGC CCTGGCCCTG CTAAGCGCCA GTGGCACCGG CTCCGCCGCT 
CAAGATGATG AATTTTTTCA CGAACTCCCA GAAACCTTTC CATCTGACCC ACCTGAGCCA 
TTGCCACACT TCCTCATTGA GCCCGAGGAA GCTTACATTG TGAAGAACAA GCCTGTGAAC 
CTGTATTGTA AAGCCAGCCC TGCCACCCAG ATCTACTTCA AGTGCAACAG CGAGTGGGTT 
CATCAGAAGG ACCACGTAGT AGACGAGAGA GTAGATGAAA CCTCTGGTCT AATTGTGAGA 
GAAGTGAGCA TTGAGATTTC ACGCCAGCAG GTGGAGGAAC TGTTTGGGCC TGAAGATTAC 
TGGTGCCAGT GTGTGGCCTG GAGCTCAGCA GGCACTACGA AGAGTCGGAA GGCATACGTG 
CGCATTGCGT ATCTGCGGAA GACATTCGAG CAGGAACCCT TGGGAAAGGA AGTGTCCTTG 
GAGCAGGAAG TCTTACTCCA GTGTCGGCCA CCTGAAGGGA TCCCAGTGGC TGAGGTAGAA 
TGGCTAAAGA ATGAAGACAT AATTGATCCT GCTGAAGATC GGAACTTTTA TATTACTATC 
GATCACAACC TGATCATCAA GCAAGCCCGA CTCTCAGATA CAGCAAATTA TACCTGTGTT 
GCCAAAAATA TTGTTGCCAA GAGAAAAAGC ACCACAGCCA CTGTCATCGT GTATGTTAAT 
GGTGGCTGGT CCACCTGGAC AGAGTGGTCT GTGTGTAACA GCCGCTGTGG GCGAGGATAT 
CAGAAACGCA CAAGAACCTG CACCAACCCA GCCCCACTCA ATGGTGGGGC CTTCTGTGAG 
GGGCAGAGTG TGCAGAAAAT AGCATGCACT ACGTTATGTC CAGTGGATGG TAGGTGGACT 
TCATGGAGCA AATGGTCAAC CTGTGGGACT GAATGCACCC ACTGGCGCAG GAGGGAGTGT 
ACAGCACCAG CCCCCAAGAA CGGGGGTAAG GACTGTGATG GCCTGGTCCT CCAATCCAAG 
AACTGCACTG ATGGGCTGTG CATGCAGGGA TTCATTTACC CCATTTCAAC TGAGCACAGA 
CCCCAGAATG AATATGGATT TTCTTCTGCT CCTGACTCAG ATGATGTGGC TCTCTACGTG 
GGGATTGTGA TCGCTGTAAC AGTCTGTCTG GCGATCACTG TTGTGGTGGC CCTGTTTGTG 
TATCGGAAGA ACCACCGTGA CTTTGAGTCT GACATCATTG ACTCCTCAGC ACTCAATGGC 
GGCTTTCAGC CTGTGAACAT CAAGGCTGCC AGACAAGATC TCCTGGCTGT CCCCCCTGAC 
CTCACCTCAG CTGCAGCCAT GTACAGGGGA CCTGTCTATG CTCTGCATGA TGTCTCAGAC 
AAAATCCCAA TGACCAACTC TCCAATTCTG GACCCACTAC CCAACTTGAA AATCAAAGTG 
TACAACAGCT CAGGTGCTGT CACTCCTCAG GATGACCTTG CCGAGTTCTC ATCCAAACTG 
TCACCCCAGA TGACCCAGTC CTTGCTAGAG AATGAGGCCC TTAACCTGAA GAACCAGAGC 
CTCGCAAGAC AGACTGACCC ATCCTGCACA GCATTTGGTA CCTTCAACTC TCTTGGGGGT 
CACCTCATCA TTCCTAATTC AGGAGTAAGC TTGCTGATTC CCGCTGGGGC CATTCCTCAG 
GGGAGAGTCT ATGAAATGTA TGTGACTGTA CACAGGAAAG AAAATATGAG GCCCCCCATG 
GAAGACTCTC AGACCCTACT TACCCCTGTG GTGAGCTGTG GGCCTCCTGG AGCTCTGCTG 
ACCCGCCCTG TCATCCTCAC TCTGCATCAC TGTGCAGACC CCAGCACCGA GGACTGGAAG 
ATCCAGCTCA AAAACCAGGC AGTGCAGGGA CAATGGGAGG ATGTTGTGGT GGTTGGGGAG 
GAGAACTTCA CAACCCCCTG TTACATTCAG CTGGATGCAG AGGCTTGCCA TATCCTCACA 
GAGAACCTCA GTACCTATGC CCTGGTTGGG CAGTCCACCA CCAAAGCAGC TGCCAAGCGT 
CTTAAACTGG CCATCTTTGG GCCCCTCTGC TGCTCTTCCC TGGAGTACAG CATTAGAGTC 
TACTGCCTGG ATGACACACA GGATGCCCTG AAGGAAGTTC TACAACTGGA GAGGCAAATG 
GGAGGACAGC TCCTAGAAGA ACCCAAGGCT CTTCATTTTA AAGGCAGCAT CCACAACCTG 
CGCCTGTCTA TTCATGACAT CGCCCATTCC CTCTGGAAGA GCAAATTGCT GGCTAAGTAT 
CAGGAAATTC CATTTTACCA CATCTGGAGT GGCTCTCAAA GAAACCTCCA CTGCACCTTC 
ACTCTGGAAA GACTCAGCCT AAACACAGTG GAACTGGTTT GCAAACTCTG TGTGCGGCAG 
GTTGAAGGAG AAGGGCAGAT CTTCCAGCTC AACTGTACTG TGTCAGAGGA ACCTACTGGC 
ATCGACTTAC CTCTCCTGGA CCCTGCTAGT ACCATCACCA CTGTCACCGG ACCAAGTGCT 
TTCAGCATTC CTCTCCCTAT CCGGCAGAAG CTATGCAGCA GCCTGGATGC CCCTCAAACA 
AGAGGCCATG ACTGGAGGAT GCTGGCCCAT AAACTCAACC TGGACAGGTA CTTGAATTAC 
TTTGCCACCA AATCGAGCCC AACTGGCGTA ATCCTGGATC TTTGGGAAGC ACAGAACTTC 
CCAGATGGAA ACCTGAGCAT GCTGGCAGCC GTCCTGGAAG AAATGGGAAG ACATGAGACA 
GTGGTGTCCT TGGCAGCAGA AGGACAGTAT TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Unc5c ( NM_009472.4 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_033498.1 Mus musculus unc-5 netrin receptor C (Unc5c), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OMu23418
Clone ID Related Accession (Same CDS sequence)	NM_009472.4
Accession Version	NM_009472.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2796bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-28
Organism	Mus musculus(house mouse)
Product	netrin receptor UNC5C isoform 2 precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC170085.2, AC158552.5 and AC157492.17. On Jun 10, 2014 this sequence version replaced NM_009472.3. Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region compared to variant 1. The encoded isoform (2) is shorter than isoform 1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: U72634.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849385, SAMN00849387 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAGGAAAG GTCTGAGGGC GACAGCGGCC CGCTGCGGAC TGGGACTAGG ATACTTGCTG 
CAGATGCTTG TGTTACCTGC CCTGGCCCTG CTAAGCGCCA GTGGCACCGG CTCCGCCGCT 
CAAGATGATG AATTTTTTCA CGAACTCCCA GAAACCTTTC CATCTGACCC ACCTGAGCCA 
TTGCCACACT TCCTCATTGA GCCCGAGGAA GCTTACATTG TGAAGAACAA GCCTGTGAAC 
CTGTATTGTA AAGCCAGCCC TGCCACCCAG ATCTACTTCA AGTGCAACAG CGAGTGGGTT 
CATCAGAAGG ACCACGTAGT AGACGAGAGA GTAGATGAAA CCTCTGGTCT AATTGTGAGA 
GAAGTGAGCA TTGAGATTTC ACGCCAGCAG GTGGAGGAAC TGTTTGGGCC TGAAGATTAC 
TGGTGCCAGT GTGTGGCCTG GAGCTCAGCA GGCACTACGA AGAGTCGGAA GGCATACGTG 
CGCATTGCGT ATCTGCGGAA GACATTCGAG CAGGAACCCT TGGGAAAGGA AGTGTCCTTG 
GAGCAGGAAG TCTTACTCCA GTGTCGGCCA CCTGAAGGGA TCCCAGTGGC TGAGGTAGAA 
TGGCTAAAGA ATGAAGACAT AATTGATCCT GCTGAAGATC GGAACTTTTA TATTACTATC 
GATCACAACC TGATCATCAA GCAAGCCCGA CTCTCAGATA CAGCAAATTA TACCTGTGTT 
GCCAAAAATA TTGTTGCCAA GAGAAAAAGC ACCACAGCCA CTGTCATCGT GTATGTTAAT 
GGTGGCTGGT CCACCTGGAC AGAGTGGTCT GTGTGTAACA GCCGCTGTGG GCGAGGATAT 
CAGAAACGCA CAAGAACCTG CACCAACCCA GCCCCACTCA ATGGTGGGGC CTTCTGTGAG 
GGGCAGAGTG TGCAGAAAAT AGCATGCACT ACGTTATGTC CAGTGGATGG TAGGTGGACT 
TCATGGAGCA AATGGTCAAC CTGTGGGACT GAATGCACCC ACTGGCGCAG GAGGGAGTGT 
ACAGCACCAG CCCCCAAGAA CGGGGGTAAG GACTGTGATG GCCTGGTCCT CCAATCCAAG 
AACTGCACTG ATGGGCTGTG CATGCAGGCT GCTCCTGACT CAGATGATGT GGCTCTCTAC 
GTGGGGATTG TGATCGCTGT AACAGTCTGT CTGGCGATCA CTGTTGTGGT GGCCCTGTTT 
GTGTATCGGA AGAACCACCG TGACTTTGAG TCTGACATCA TTGACTCCTC AGCACTCAAT 
GGCGGCTTTC AGCCTGTGAA CATCAAGGCT GCCAGACAAG ATCTCCTGGC TGTCCCCCCT 
GACCTCACCT CAGCTGCAGC CATGTACAGG GGACCTGTCT ATGCTCTGCA TGATGTCTCA 
GACAAAATCC CAATGACCAA CTCTCCAATT CTGGACCCAC TACCCAACTT GAAAATCAAA 
GTGTACAACA GCTCAGGTGC TGTCACTCCT CAGGATGACC TTGCCGAGTT CTCATCCAAA 
CTGTCACCCC AGATGACCCA GTCCTTGCTA GAGAATGAGG CCCTTAACCT GAAGAACCAG 
AGCCTCGCAA GACAGACTGA CCCATCCTGC ACAGCATTTG GTACCTTCAA CTCTCTTGGG 
GGTCACCTCA TCATTCCTAA TTCAGGAGTA AGCTTGCTGA TTCCCGCTGG GGCCATTCCT 
CAGGGGAGAG TCTATGAAAT GTATGTGACT GTACACAGGA AAGAAAATAT GAGGCCCCCC 
ATGGAAGACT CTCAGACCCT ACTTACCCCT GTGGTGAGCT GTGGGCCTCC TGGAGCTCTG 
CTGACCCGCC CTGTCATCCT CACTCTGCAT CACTGTGCAG ACCCCAGCAC CGAGGACTGG 
AAGATCCAGC TCAAAAACCA GGCAGTGCAG GGACAATGGG AGGATGTTGT GGTGGTTGGG 
GAGGAGAACT TCACAACCCC CTGTTACATT CAGCTGGATG CAGAGGCTTG CCATATCCTC 
ACAGAGAACC TCAGTACCTA TGCCCTGGTT GGGCAGTCCA CCACCAAAGC AGCTGCCAAG 
CGTCTTAAAC TGGCCATCTT TGGGCCCCTC TGCTGCTCTT CCCTGGAGTA CAGCATTAGA 
GTCTACTGCC TGGATGACAC ACAGGATGCC CTGAAGGAAG TTCTACAACT GGAGAGGCAA 
ATGGGAGGAC AGCTCCTAGA AGAACCCAAG GCTCTTCATT TTAAAGGCAG CATCCACAAC 
CTGCGCCTGT CTATTCATGA CATCGCCCAT TCCCTCTGGA AGAGCAAATT GCTGGCTAAG 
TATCAGGAAA TTCCATTTTA CCACATCTGG AGTGGCTCTC AAAGAAACCT CCACTGCACC 
TTCACTCTGG AAAGACTCAG CCTAAACACA GTGGAACTGG TTTGCAAACT CTGTGTGCGG 
CAGGTTGAAG GAGAAGGGCA GATCTTCCAG CTCAACTGTA CTGTGTCAGA GGAACCTACT 
GGCATCGACT TACCTCTCCT GGACCCTGCT AGTACCATCA CCACTGTCAC CGGACCAAGT 
GCTTTCAGCA TTCCTCTCCC TATCCGGCAG AAGCTATGCA GCAGCCTGGA TGCCCCTCAA 
ACAAGAGGCC ATGACTGGAG GATGCTGGCC CATAAACTCA ACCTGGACAG GTACTTGAAT 
TACTTTGCCA CCAAATCGAG CCCAACTGGC GTAATCCTGG ATCTTTGGGA AGCACAGAAC 
TTCCCAGATG GAAACCTGAG CATGCTGGCA GCCGTCCTGG AAGAAATGGG AAGACATGAG 
ACAGTGGTGT CCTTGGCAGC AGAAGGACAG TATTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_033498.1
CDS	151..2946
Translation	MRKGLRATAARCGLGLGYLLQMLVLPALALLSASGTGSAAQDDEFFHELPETFPSDPPEPLPHFLIEPEEAYIVKNKPVNLYCKASPATQIYFKCNSEWVHQKDHVVDERVDETSGLIVREVSIEISRQQVEELFGPEDYWCQCVAWSSAGTTKSRKAYVRIAYLRKTFEQEPLGKEVSLEQEVLLQCRPPEGIPVAEVEWLKNEDIIDPAEDRNFYITIDHNLIIKQARLSDTANYTCVAKNIVAKRKSTTATVIVYVNGGWSTWTEWSVCNSRCGRGYQKRTRTCTNPAPLNGGAFCEGQSVQKIACTTLCPVDGRWTSWSKWSTCGTECTHWRRRECTAPAPKNGGKDCDGLVLQSKNCTDGLCMQAAPDSDDVALYVGIVIAVTVCLAITVVVALFVYRKNHRDFESDIIDSSALNGGFQPVNIKAARQDLLAVPPDLTSAAAMYRGPVYALHDVSDKIPMTNSPILDPLPNLKIKVYNSSGAVTPQDDLAEFSSKLSPQMTQSLLENEALNLKNQSLARQTDPSCTAFGTFNSLGGHLIIPNSGVSLLIPAGAIPQGRVYEMYVTVHRKENMRPPMEDSQTLLTPVVSCGPPGALLTRPVILTLHHCADPSTEDWKIQLKNQAVQGQWEDVVVVGEENFTTPCYIQLDAEACHILTENLSTYALVGQSTTKAAAKRLKLAIFGPLCCSSLEYSIRVYCLDDTQDALKEVLQLERQMGGQLLEEPKALHFKGSIHNLRLSIHDIAHSLWKSKLLAKYQEIPFYHIWSGSQRNLHCTFTLERLSLNTVELVCKLCVRQVEGEGQIFQLNCTVSEEPTGIDLPLLDPASTITTVTGPSAFSIPLPIRQKLCSSLDAPQTRGHDWRMLAHKLNLDRYLNYFATKSSPTGVILDLWEAQNFPDGNLSMLAAVLEEMGRHETVVSLAAEGQY

Target ORF information:

RefSeq Version	NM_009472.4
Organism	Mus musculus(house mouse)
Definition	Mus musculus unc-5 netrin receptor C (Unc5c), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_009472.4

ORF Insert Sequence:

ATGAGGAAAG GTCTGAGGGC GACAGCGGCC CGCTGCGGAC TGGGACTAGG ATACTTGCTG 
CAGATGCTTG TGTTACCTGC CCTGGCCCTG CTAAGCGCCA GTGGCACCGG CTCCGCCGCT 
CAAGATGATG AATTTTTTCA CGAACTCCCA GAAACCTTTC CATCTGACCC ACCTGAGCCA 
TTGCCACACT TCCTCATTGA GCCCGAGGAA GCTTACATTG TGAAGAACAA GCCTGTGAAC 
CTGTATTGTA AAGCCAGCCC TGCCACCCAG ATCTACTTCA AGTGCAACAG CGAGTGGGTT 
CATCAGAAGG ACCACGTAGT AGACGAGAGA GTAGATGAAA CCTCTGGTCT AATTGTGAGA 
GAAGTGAGCA TTGAGATTTC ACGCCAGCAG GTGGAGGAAC TGTTTGGGCC TGAAGATTAC 
TGGTGCCAGT GTGTGGCCTG GAGCTCAGCA GGCACTACGA AGAGTCGGAA GGCATACGTG 
CGCATTGCGT ATCTGCGGAA GACATTCGAG CAGGAACCCT TGGGAAAGGA AGTGTCCTTG 
GAGCAGGAAG TCTTACTCCA GTGTCGGCCA CCTGAAGGGA TCCCAGTGGC TGAGGTAGAA 
TGGCTAAAGA ATGAAGACAT AATTGATCCT GCTGAAGATC GGAACTTTTA TATTACTATC 
GATCACAACC TGATCATCAA GCAAGCCCGA CTCTCAGATA CAGCAAATTA TACCTGTGTT 
GCCAAAAATA TTGTTGCCAA GAGAAAAAGC ACCACAGCCA CTGTCATCGT GTATGTTAAT 
GGTGGCTGGT CCACCTGGAC AGAGTGGTCT GTGTGTAACA GCCGCTGTGG GCGAGGATAT 
CAGAAACGCA CAAGAACCTG CACCAACCCA GCCCCACTCA ATGGTGGGGC CTTCTGTGAG 
GGGCAGAGTG TGCAGAAAAT AGCATGCACT ACGTTATGTC CAGTGGATGG TAGGTGGACT 
TCATGGAGCA AATGGTCAAC CTGTGGGACT GAATGCACCC ACTGGCGCAG GAGGGAGTGT 
ACAGCACCAG CCCCCAAGAA CGGGGGTAAG GACTGTGATG GCCTGGTCCT CCAATCCAAG 
AACTGCACTG ATGGGCTGTG CATGCAGGCT GCTCCTGACT CAGATGATGT GGCTCTCTAC 
GTGGGGATTG TGATCGCTGT AACAGTCTGT CTGGCGATCA CTGTTGTGGT GGCCCTGTTT 
GTGTATCGGA AGAACCACCG TGACTTTGAG TCTGACATCA TTGACTCCTC AGCACTCAAT 
GGCGGCTTTC AGCCTGTGAA CATCAAGGCT GCCAGACAAG ATCTCCTGGC TGTCCCCCCT 
GACCTCACCT CAGCTGCAGC CATGTACAGG GGACCTGTCT ATGCTCTGCA TGATGTCTCA 
GACAAAATCC CAATGACCAA CTCTCCAATT CTGGACCCAC TACCCAACTT GAAAATCAAA 
GTGTACAACA GCTCAGGTGC TGTCACTCCT CAGGATGACC TTGCCGAGTT CTCATCCAAA 
CTGTCACCCC AGATGACCCA GTCCTTGCTA GAGAATGAGG CCCTTAACCT GAAGAACCAG 
AGCCTCGCAA GACAGACTGA CCCATCCTGC ACAGCATTTG GTACCTTCAA CTCTCTTGGG 
GGTCACCTCA TCATTCCTAA TTCAGGAGTA AGCTTGCTGA TTCCCGCTGG GGCCATTCCT 
CAGGGGAGAG TCTATGAAAT GTATGTGACT GTACACAGGA AAGAAAATAT GAGGCCCCCC 
ATGGAAGACT CTCAGACCCT ACTTACCCCT GTGGTGAGCT GTGGGCCTCC TGGAGCTCTG 
CTGACCCGCC CTGTCATCCT CACTCTGCAT CACTGTGCAG ACCCCAGCAC CGAGGACTGG 
AAGATCCAGC TCAAAAACCA GGCAGTGCAG GGACAATGGG AGGATGTTGT GGTGGTTGGG 
GAGGAGAACT TCACAACCCC CTGTTACATT CAGCTGGATG CAGAGGCTTG CCATATCCTC 
ACAGAGAACC TCAGTACCTA TGCCCTGGTT GGGCAGTCCA CCACCAAAGC AGCTGCCAAG 
CGTCTTAAAC TGGCCATCTT TGGGCCCCTC TGCTGCTCTT CCCTGGAGTA CAGCATTAGA 
GTCTACTGCC TGGATGACAC ACAGGATGCC CTGAAGGAAG TTCTACAACT GGAGAGGCAA 
ATGGGAGGAC AGCTCCTAGA AGAACCCAAG GCTCTTCATT TTAAAGGCAG CATCCACAAC 
CTGCGCCTGT CTATTCATGA CATCGCCCAT TCCCTCTGGA AGAGCAAATT GCTGGCTAAG 
TATCAGGAAA TTCCATTTTA CCACATCTGG AGTGGCTCTC AAAGAAACCT CCACTGCACC 
TTCACTCTGG AAAGACTCAG CCTAAACACA GTGGAACTGG TTTGCAAACT CTGTGTGCGG 
CAGGTTGAAG GAGAAGGGCA GATCTTCCAG CTCAACTGTA CTGTGTCAGA GGAACCTACT 
GGCATCGACT TACCTCTCCT GGACCCTGCT AGTACCATCA CCACTGTCAC CGGACCAAGT 
GCTTTCAGCA TTCCTCTCCC TATCCGGCAG AAGCTATGCA GCAGCCTGGA TGCCCCTCAA 
ACAAGAGGCC ATGACTGGAG GATGCTGGCC CATAAACTCA ACCTGGACAG GTACTTGAAT 
TACTTTGCCA CCAAATCGAG CCCAACTGGC GTAATCCTGG ATCTTTGGGA AGCACAGAAC 
TTCCCAGATG GAAACCTGAG CATGCTGGCA GCCGTCCTGG AAGAAATGGG AAGACATGAG 
ACAGTGGTGT CCTTGGCAGC AGAAGGACAG TATTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Uncoupling of UNC5C with Polymerized TUBB3 in Microtubules Mediates Netrin-1 Repulsion.
The Journal of neuroscience : the official journal of the Society for Neuroscience37(23)5620-5633(2017 Jun)
Shao Q,Yang T,Huang H,Alarmanazi F,Liu G

Netrin1 Produced by Neural Progenitors, Not Floor Plate Cells, Is Required for Axon Guidance in the Spinal Cord.
Neuron94(4)790-799.e3(2017 May)
Varadarajan SG,Kong JH,Phan KD,Kao TJ,Panaitof SC,Cardin J,Eltzschig H,Kania A,Novitch BG,Butler SJ

ISL1-based LIM complexes control Slit2 transcription in developing cranial motor neurons.
Scientific reports636491(2016 Nov)
Kim KT,Kim N,Kim HK,Lee H,Gruner HN,Gergics P,Park C,Mastick GS,Park HC,Song MR

Netrin1/DCC signaling promotes neuronal migration in the dorsal spinal cord.
Neural development11(1)19(2016 10)
Junge HJ,Yung AR,Goodrich LV,Chen Z

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Unc5c cDNA ORF clone, Mus musculus(house mouse)

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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