Ywhah cDNA ORF clone, Mus musculus(house mouse)
| Gene Symbol | Ywhah |
| Entrez Gene ID | 22629 |
| Full Name | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide |
| General protein information |
|
| Gene Type | protein-coding |
| Organism | Mus musculus(house mouse) |
| Genome |
mRNA and Protein(s)
| mRNA | Protein | Name |
|---|---|---|
| NM_011738.2 | NP_035868.1 | 14-3-3 protein eta |
| Homo sapiens (human) | YWHAH | NP_003396.1 |
| Pan troglodytes (chimpanzee) | YWHAH | XP_001151423.1 |
| Bos taurus (cattle) | YWHAH | NP_776917.2 |
| Mus musculus (house mouse) | Ywhah | NP_035868.1 |
| Danio rerio (zebrafish) | ywhah | NP_998329.1 |
| Rattus norvegicus (Norway rat) | Ywhah | NP_037184.1 |
| YWHAH | XP_001111998.1 | |
| Gallus gallus (chicken) | YWHAH | NP_001007840.1 |
| Canis lupus familiaris (dog) | YWHAH | XP_003433473.2 |
| Xenopus tropicalis (tropical clawed frog) | ywhah | NP_001016868.1 |
Related articles in PubMed
Myocardial 14-3-3? protein protects against mitochondria mediated apoptosis.
Sreedhar R, Arumugam S, Thandavarayan RA, Giridharan VV, Karuppagounder V, Pitchaimani V, Afrin R, Miyashita S, Nomoto M, Harima M, Gurusamy N, Suzuki K, Watanabe K
Cellular signalling27(4)770-6(2015 Apr)
Evidence for the requirement of 14-3-3eta (YWHAH) in meiotic spindle assembly during mouse oocyte maturation.
De S, Kline D
BMC developmental biology1310(2013 Apr)
14-3-3? plays a role in cardiac ventricular compaction by regulating the cardiomyocyte cell cycle.
Kosaka Y, Cieslik KA, Li L, Lezin G, Maguire CT, Saijoh Y, Toyo-oka K, Gambello MJ, Vatta M, Wynshaw-Boris A, Baldini A, Yost HJ, Brunelli L
Molecular and cellular biology32(24)5089-102(2012 Dec)
Phosphorylation-dependent 14-3-3 binding to LRRK2 is impaired by common mutations of familial Parkinson's disease.
Li X, Wang QJ, Pan N, Lee S, Zhao Y, Chait BT, Yue Z
PloS one6(3)e17153(2011 Mar)
Depletion of 14-3-3 protein exacerbates cardiac oxidative stress, inflammation and remodeling process via modulation of MAPK/NF-?B signaling pathways after streptozotocin-induced diabetes mellitus.
Thandavarayan RA, Giridharan VV, Sari FR, Arumugam S, Veeraveedu PT, Pandian GN, Palaniyandi SS, Ma M, Suzuki K, Gurusamy N, Watanabe K
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology28(5)911-22(2011)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
These results suggest that 14-3-3 eta has a protective role against mitochondria mediated cardiomyocyte apoptosis with the involvement of Ask-1/JNK signaling during high fat diet induced type 2 diabetes mellitus.
Title: Myocardial 14-3-3? protein protects against mitochondria mediated apoptosis.
14-3-3 eta plays a regulatory role in chondrogenic differentiation.
Title: 14-3-3 ? inhibits chondrogenic differentiation of ATDC5 cell.
The myocardial NF-kappaB activation, inhibitor of kappa B-alpha degradation and mRNA expression of proinflammatory cytokines were significantly increased in DN 14-3-3 mice compared to WT mice.(14-3-3 protein eta)
Title: Depletion of 14-3-3 protein exacerbates cardiac oxidative stress, inflammation and remodeling process via modulation of MAPK/NF-?B signaling pathways after streptozotocin-induced diabetes mellitus.
Inhibition of a single protective isoform, 14-3-3theta;, by shRNA did not increase vulnerability to neurotoxic injury, but toxicity was enhanced by broad-based inhibition of 14-3-3 action with the peptide inhibitor difopein.
Title: Differential neuroprotective effects of 14-3-3 proteins in models of Parkinson's disease.
Targeting of dominant-negative 14-3-3eta (DN-14-3-3) to murine postnatal cardiac tissue potentiates Ask1, c-jun N-terminal kinase (JNK), and p38 mitogen-activated protein kinase (MAPK) activation
Title: Role of 14-3-3-mediated p38 mitogen-activated protein kinase inhibition in cardiac myocyte survival.
The following Ywhah gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Ywhah cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
| CloneID | OMu08718 |
|
| Clone ID Related Accession (Same CDS sequence) | NM_011738.2 | |
| Accession Version | NM_011738.2 Latest version! | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 741bp) Protein sequence SNP |
|
| Vector | pcDNA3.1+/C-(K)DYK or customized vector |  User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2019-06-07 | |
| Organism | Mus musculus(house mouse) | |
| Product | 14-3-3 protein eta | |
| Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from CB183421.1, AK149224.1 and CD770463.1. On Dec 18, 2007 this sequence version replaced NM_011738.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC061497.1, AK149224.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. | |
1 | ATGGGGGATC GAGAGCAGCT GCTGCAGCGG GCGCGACTGG CGGAGCAGGC GGAGCGCTAC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | NP_035868.1 |
| CDS | 253..993 |
| Translation |
Target ORF information:
Target ORF information:
|
 NM_011738.2 |
ORF Insert Sequence:
1 | ATGGGGGATC GAGAGCAGCT GCTGCAGCGG GCGCGACTGG CGGAGCAGGC GGAGCGCTAC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
 |
Myocardial 14-3-3? protein protects against mitochondria mediated apoptosis. |
|
Evidence for the requirement of 14-3-3eta (YWHAH) in meiotic spindle assembly during mouse oocyte maturation. |
|
14-3-3? plays a role in cardiac ventricular compaction by regulating the cardiomyocyte cell cycle. |
|
Phosphorylation-dependent 14-3-3 binding to LRRK2 is impaired by common mutations of familial Parkinson's disease. |
|
Depletion of 14-3-3 protein exacerbates cardiac oxidative stress, inflammation and remodeling process via modulation of MAPK/NF-?B signaling pathways after streptozotocin-induced diabetes mellitus. |