Ostn cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Gene Symbol	Ostn
Entrez Gene ID	239790
Full Name	osteocrin
Synonyms	Ostc
General protein information	Preferred Names osteocrin Names osteocrin musclin
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 16 Map Location: 16\|16 B2

mRNA and Protein(s)

mRNA Protein Name

XM_006522114.1 XP_006522177.1 osteocrin isoform X1

NM_198112.2 NP_932780.1 osteocrin precursor
Pathways from BioSystems

mRNA	Protein	Name
XM_006522114.1	XP_006522177.1	osteocrin isoform X1
NM_198112.2	NP_932780.1	osteocrin precursor

Homologies

	OSTN	XP_001094278.1
Pan troglodytes (chimpanzee)	OSTN	XP_001144666.2
Bos taurus (cattle)	OSTN	NP_001092405.1
Homo sapiens (human)	OSTN	NP_937827.1
Mus musculus (house mouse)	Ostn	NP_932780.1
Gallus gallus (chicken)	OSTN	NP_001092078.1
Canis lupus familiaris (dog)	OSTN	XP_850347.2
Danio rerio (zebrafish)	LOC100333936	XP_002664707.1
Xenopus tropicalis (tropical clawed frog)	ostn	XP_002934095.2
Rattus norvegicus (Norway rat)	Ostn	NP_997495.1

Gene Ontology
Bibliography

Related articles in PubMed

Circulating osteocrin stimulates bone growth by limiting C-type natriuretic peptide clearance.
Kanai Y, Yasoda A, Mori KP, Watanabe-Takano H, Nagai-Okatani C, Yamashita Y, Hirota K, Ueda Y, Yamauchi I, Kondo E, Yamanaka S, Sakane Y, Nakao K, Fujii T, Yokoi H, Minamino N, Mukoyama M, Mochizuki N, Inagaki N
The Journal of clinical investigation127(11)4136-4147(2017 Nov)

Musclin is an activity-stimulated myokine that enhances physical endurance.
Subbotina E, Sierra A, Zhu Z, Gao Z, Koganti SR, Reyes S, Stepniak E, Walsh SA, Acevedo MR, Perez-Terzic CM, Hodgson-Zingman DM, Zingman LV
Proceedings of the National Academy of Sciences of the United States of America112(52)16042-7(2015 Dec)

Palmitate increases musclin gene expression through activation of PERK signaling pathway in C2C12 myotubes.
Gu N, Guo Q, Mao K, Hu H, Jin S, Zhou Y, He H, Oh Y, Liu C, Wu Q
Biochemical and biophysical research communications467(3)521-6(2015 Nov)

Transcriptional profiling of the megabladder mouse: a unique model of bladder dysmorphogenesis.
Singh S, Robinson M, Ismail I, Saha M, Auer H, Kornacker K, Robinson ML, Bates CM, McHugh KM
Developmental dynamics : an official publication of the American Association of Anatomists237(1)170-86(2008 Jan)

Osteocrin is a specific ligand of the natriuretic Peptide clearance receptor that modulates bone growth.
Moffatt P, Thomas G, Sellin K, Bessette MC, Lafreni?re F, Akhouayri O, St-Arnaud R, Lanct?t C
The Journal of biological chemistry282(50)36454-62(2007 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The mechanism underlying the effect of OSTN on skeletal growth relevant to C-type natriuretic peptide /Natriuretic peptide receptor B signaling.
Title: Circulating osteocrin stimulates bone growth by limiting C-type natriuretic peptide clearance.

Data show that musclin (Ostn) production is stimulated by Ca2+-dependent proto-oncogene protein c-Akt (Akt) phosphorylation.
Title: Musclin is an activity-stimulated myokine that enhances physical endurance.

findings suggest that palmitate increases musclin gene expression via the activation of the PERK signaling pathway in C2C12 myotubes
Title: Palmitate increases musclin gene expression through activation of PERK signaling pathway in C2C12 myotubes.

Foxo1 downregulates musclin mRNA expression both in vitro and in vivo, which should explain insulin-mediated upregulation of this gene in muscle cells.
Title: Foxo1 represses expression of musclin, a skeletal muscle-derived secretory factor.

Ostn is a naturally occurring ligand of the NPR-C clearance receptor and may act to locally modulate the actions of the natriuretic system in bone by blocking the clearance action of NPR-C, thus locally elevating levels of C-type natriuretic peptide.
Title: Osteocrin is a specific ligand of the natriuretic Peptide clearance receptor that modulates bone growth.

The following Ostn gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Ostn cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu08875	NM_198112.2 Latest version!	Mus musculus osteocrin (Ostn), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00
OMu08875	XM_006522114.1 Latest version!	Mus musculus osteocrin (Ostn), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone	30% OFF
2-4 Clone	40% OFF
5 or more Clone	50% OFF
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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Ostn ( NM_198112.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_932780.1 Mus musculus osteocrin (Ostn), mRNA.

Price & Availability↑

CloneID	OMu08875
Clone ID Related Accession (Same CDS sequence)	XM_006522114.1 , NM_198112.2
Accession Version	NM_198112.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 393bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-22
Organism	Mus musculus(house mouse)
Product	osteocrin precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AC154512.2. On Mar 21, 2007 this sequence version replaced NM_198112.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## Transcript exon combination :: AY395730.1, AY573932.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164131, SAMN01164136 [ECO:0000348] ##Evidence-Data-END##

ATGCTGGACT GGAGATTGGC AAGTACACAC TTCATCCTGG CTATGATTGT GATGCTGTGG 
GGCTCAGGAA AGGCATTCTC TGTGGACTTA GCATCACAGG AGTTTGGAAC AGCAAGCTTG 
CAGTCTCCAC CCACAGCCAG AGAAGAGAAG TCAGCCACTG AGCTTTCGGC TAAGCTCCTG 
CGTCTTGATG ATCTGGTGTC CTTAGAGAAT GACGTATTTG AGACCAAGAA AAAGAGAAGC 
TTCTCTGGCT TTGGGTCTCC CCTTGACAGA CTCTCAGCTG GGTCTGTAGA GCATAGAGGG 
AAACAAAGGA AAGCAGTAGA TCATTCAAAA AAGCGGTTTG GTATTCCCAT GGATCGGATT 
GGTAGAAACC GGCTCTCCAG TTCCAGAGGC TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_932780.1
CDS	62..454
Translation	MLDWRLASTHFILAMIVMLWGSGKAFSVDLASQEFGTASLQSPPTAREEKSATELSAKLLRLDDLVSLENDVFETKKKRSFSGFGSPLDRLSAGSVEHRGKQRKAVDHSKKRFGIPMDRIGRNRLSSSRG

Target ORF information:

RefSeq Version	NM_198112.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus osteocrin (Ostn), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_198112.2

ORF Insert Sequence:

ATGCTGGACT GGAGATTGGC AAGTACACAC TTCATCCTGG CTATGATTGT GATGCTGTGG 
GGCTCAGGAA AGGCATTCTC TGTGGACTTA GCATCACAGG AGTTTGGAAC AGCAAGCTTG 
CAGTCTCCAC CCACAGCCAG AGAAGAGAAG TCAGCCACTG AGCTTTCGGC TAAGCTCCTG 
CGTCTTGATG ATCTGGTGTC CTTAGAGAAT GACGTATTTG AGACCAAGAA AAAGAGAAGC 
TTCTCTGGCT TTGGGTCTCC CCTTGACAGA CTCTCAGCTG GGTCTGTAGA GCATAGAGGG 
AAACAAAGGA AAGCAGTAGA TCATTCAAAA AAGCGGTTTG GTATTCCCAT GGATCGGATT 
GGTAGAAACC GGCTCTCCAG TTCCAGAGGC TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Ostn ( XM_006522114.1 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_006522177.1 Mus musculus osteocrin (Ostn), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OMu08875
Clone ID Related Accession (Same CDS sequence)	XM_006522114.1 , NM_198112.2
Accession Version	XM_006522114.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 393bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2015-02-08
Organism	Mus musculus(House mouse)
Product	osteocrin isoform X1
Comment

ATGCTGGACT GGAGATTGGC AAGTACACAC TTCATCCTGG CTATGATTGT GATGCTGTGG 
GGCTCAGGAA AGGCATTCTC TGTGGACTTA GCATCACAGG AGTTTGGAAC AGCAAGCTTG 
CAGTCTCCAC CCACAGCCAG AGAAGAGAAG TCAGCCACTG AGCTTTCGGC TAAGCTCCTG 
CGTCTTGATG ATCTGGTGTC CTTAGAGAAT GACGTATTTG AGACCAAGAA AAAGAGAAGC 
TTCTCTGGCT TTGGGTCTCC CCTTGACAGA CTCTCAGCTG GGTCTGTAGA GCATAGAGGG 
AAACAAAGGA AAGCAGTAGA TCATTCAAAA AAGCGGTTTG GTATTCCCAT GGATCGGATT 
GGTAGAAACC GGCTCTCCAG TTCCAGAGGC TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006522177.1
Translation	MLDWRLASTHFILAMIVMLWGSGKAFSVDLASQEFGTASLQSPPTAREEKSATELSAKLLRLDDLVSLENDVFETKKKRSFSGFGSPLDRLSAGSVEHRGKQRKAVDHSKKRFGIPMDRIGRNRLSSSRG

Target ORF information:

RefSeq Version	XM_006522114.1
Organism	Mus musculus(House mouse)
Definition	Mus musculus osteocrin (Ostn), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006522114.1

ORF Insert Sequence:

ATGCTGGACT GGAGATTGGC AAGTACACAC TTCATCCTGG CTATGATTGT GATGCTGTGG 
GGCTCAGGAA AGGCATTCTC TGTGGACTTA GCATCACAGG AGTTTGGAAC AGCAAGCTTG 
CAGTCTCCAC CCACAGCCAG AGAAGAGAAG TCAGCCACTG AGCTTTCGGC TAAGCTCCTG 
CGTCTTGATG ATCTGGTGTC CTTAGAGAAT GACGTATTTG AGACCAAGAA AAAGAGAAGC 
TTCTCTGGCT TTGGGTCTCC CCTTGACAGA CTCTCAGCTG GGTCTGTAGA GCATAGAGGG 
AAACAAAGGA AAGCAGTAGA TCATTCAAAA AAGCGGTTTG GTATTCCCAT GGATCGGATT 
GGTAGAAACC GGCTCTCCAG TTCCAGAGGC TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Circulating osteocrin stimulates bone growth by limiting C-type natriuretic peptide clearance.
The Journal of clinical investigation127(11)4136-4147(2017 Nov)
Kanai Y,Yasoda A,Mori KP,Watanabe-Takano H,Nagai-Okatani C,Yamashita Y,Hirota K,Ueda Y,Yamauchi I,Kondo E,Yamanaka S,Sakane Y,Nakao K,Fujii T,Yokoi H,Minamino N,Mukoyama M,Mochizuki N,Inagaki N

Musclin is an activity-stimulated myokine that enhances physical endurance.
Proceedings of the National Academy of Sciences of the United States of America112(52)16042-7(2015 Dec)
Subbotina E,Sierra A,Zhu Z,Gao Z,Koganti SR,Reyes S,Stepniak E,Walsh SA,Acevedo MR,Perez-Terzic CM,Hodgson-Zingman DM,Zingman LV

Palmitate increases musclin gene expression through activation of PERK signaling pathway in C2C12 myotubes.
Biochemical and biophysical research communications467(3)521-6(2015 Nov)
Gu N,Guo Q,Mao K,Hu H,Jin S,Zhou Y,He H,Oh Y,Liu C,Wu Q

Transcriptional profiling of the megabladder mouse: a unique model of bladder dysmorphogenesis.
Developmental dynamics : an official publication of the American Association of Anatomists237(1)170-86(2008 Jan)
Singh S,Robinson M,Ismail I,Saha M,Auer H,Kornacker K,Robinson ML,Bates CM,McHugh KM

Osteocrin is a specific ligand of the natriuretic Peptide clearance receptor that modulates bone growth.
The Journal of biological chemistry282(50)36454-62(2007 Dec)
Moffatt P,Thomas G,Sellin K,Bessette MC,Lafreni?re F,Akhouayri O,St-Arnaud R,Lanct?t C

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Ostn cDNA ORF clone, Mus musculus(house mouse)

Gene

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Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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