Ostn cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Ostn
Entrez Gene ID	360730
Full Name	osteocrin
General protein information	Preferred Names osteocrin Names osteocrin musclin
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 11 Map Location: 11q22
Summary	involved in regulation of bone formation and mineralization [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
XM_008768801.2	XP_008767023.1	osteocrin isoform X1
NM_207612.2	NP_997495.1	osteocrin precursor

Pathways from BioSystems

Homologies

	OSTN	XP_001094278.1
Pan troglodytes (chimpanzee)	OSTN	XP_001144666.2
Bos taurus (cattle)	OSTN	NP_001092405.1
Homo sapiens (human)	OSTN	NP_937827.1
Mus musculus (house mouse)	Ostn	NP_932780.1
Gallus gallus (chicken)	OSTN	NP_001092078.1
Canis lupus familiaris (dog)	OSTN	XP_850347.2
Danio rerio (zebrafish)	LOC100333936	XP_002664707.1
Xenopus tropicalis (tropical clawed frog)	ostn	XP_002934095.2
Rattus norvegicus (Norway rat)	Ostn	NP_997495.1

Gene Ontology
Bibliography

Related articles in PubMed

Evolution of Osteocrin as an activity-regulated factor in the primate brain.
Ataman B, Boulting GL, Harmin DA, Yang MG, Baker-Salisbury M, Yap EL, Malik AN, Mei K, Rubin AA, Spiegel I, Durresi E, Sharma N, Hu LS, Pletikos M, Griffith EC, Partlow JN, Stevens CR, Adli M, Chahrour M, Sestan N, Walsh CA, Berezovskii VK, Livingstone MS, Greenberg ME
Nature539(7628)242-247(2016 11)

Role of musclin in the pathogenesis of hypertension in rat.
Li YX, Cheng KC, Asakawa A, Kato I, Sato Y, Amitani H, Kawamura N, Cheng JT, Inui A
PloS one8(8)e72004(2013)

Osteocrin is a specific ligand of the natriuretic Peptide clearance receptor that modulates bone growth.
Moffatt P, Thomas G, Sellin K, Bessette MC, Lafreni?re F, Akhouayri O, St-Arnaud R, Lanct?t C
The Journal of biological chemistry282(50)36454-62(2007 Dec)

Musclin gene expression is strongly related to fast-glycolytic phenotype.
Banzet S, Koulmann N, Sanchez H, Serrurier B, Peinnequin A, Bigard AX
Biochemical and biophysical research communications353(3)713-8(2007 Feb)

Musclin, a novel skeletal muscle-derived secretory factor.
Nishizawa H, Matsuda M, Yamada Y, Kawai K, Suzuki E, Makishima M, Kitamura T, Shimomura I
The Journal of biological chemistry279(19)19391-5(2004 May)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Musclin is involved in blood pressure regulation.
Title: Role of musclin in the pathogenesis of hypertension in rat.

Ostn is a naturally occurring ligand of the NPR-C clearance receptor and may act to locally modulate the actions of the natriuretic system in bone by blocking the clearance action of NPR-C, thus locally elevating levels of C-type natriuretic peptide.
Title: Osteocrin is a specific ligand of the natriuretic Peptide clearance receptor that modulates bone growth.

musclin is produced by myocytes in a highly fiber-type specific manner and that physiological changes in type IIb myosin heavy chain lead to coordinated musclin expression.
Title: Musclin gene expression is strongly related to fast-glycolytic phenotype.

osteocrin represents a novel, unique vitamin D-regulated bone-specific protein that appears to act as a soluble osteoblast regulator.
Title: Osteocrin, a novel bone-specific secreted protein that modulates the osteoblast phenotype.

The following Ostn gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Ostn cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa12937	NM_207612.2 Latest version!	Rattus norvegicus osteocrin (Ostn), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
ORa12937	XM_008768801.2 Latest version!	Rattus norvegicus osteocrin (Ostn), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Ostn ( NM_207612.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_997495.1 Rattus norvegicus osteocrin (Ostn), mRNA.

Price & Availability↑

CloneID	ORa12937
Clone ID Related Accession (Same CDS sequence)	XM_008768801.2 , NM_207612.2
Accession Version	NM_207612.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 399bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-22
Organism	Rattus norvegicus(Norway rat)
Product	osteocrin precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AY573934.1. On Jun 10, 2007 this sequence version replaced NM_207612.1. ##Evidence-Data-START## Transcript exon combination :: AY573934.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2689599, SAMEA2689600 [ECO:0000348] ##Evidence-Data-END##

ATGCTGGACT GGAGATTGGC AAGTGCACAC TTCCTCCTGG CTATGATCCT GATGCTGTGG 
GGCTCAGGAA AGGCATTCTC CGTGGACTTA GCATCAGAGG CCTCCGAGTT TGGAGCAGAA 
AGCTTGCAGT CCCCACCCAC AACCAGAGAA GAGAAGTCAG CCACGGAGCT TGCAGCTAAG 
CTCCTGCTTC TTGATGATCT GGTGTCCTTG GAGAATGATG TGTTTGAGAC CAAGAAGAAG 
AGAAGCTTCT CTGGCTTCGG GTCTCCCCTT GACAGACTCT CGGCTGGGTC TGTAGAGCAT 
AGAGGGAAAC AAAGGAGAGT AGTTGATCAT TCAAAAAAGC GATTTGGTAT TCCCATGGAT 
CGAATTGGTA GAAACCGTCT CTCCAGTTCC AGGGGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_997495.1
CDS	1..399
Translation	MLDWRLASAHFLLAMILMLWGSGKAFSVDLASEASEFGAESLQSPPTTREEKSATELAAKLLLLDDLVSLENDVFETKKKRSFSGFGSPLDRLSAGSVEHRGKQRRVVDHSKKRFGIPMDRIGRNRLSSSRG

Target ORF information:

RefSeq Version	NM_207612.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus osteocrin (Ostn), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_207612.2

ORF Insert Sequence:

ATGCTGGACT GGAGATTGGC AAGTGCACAC TTCCTCCTGG CTATGATCCT GATGCTGTGG 
GGCTCAGGAA AGGCATTCTC CGTGGACTTA GCATCAGAGG CCTCCGAGTT TGGAGCAGAA 
AGCTTGCAGT CCCCACCCAC AACCAGAGAA GAGAAGTCAG CCACGGAGCT TGCAGCTAAG 
CTCCTGCTTC TTGATGATCT GGTGTCCTTG GAGAATGATG TGTTTGAGAC CAAGAAGAAG 
AGAAGCTTCT CTGGCTTCGG GTCTCCCCTT GACAGACTCT CGGCTGGGTC TGTAGAGCAT 
AGAGGGAAAC AAAGGAGAGT AGTTGATCAT TCAAAAAAGC GATTTGGTAT TCCCATGGAT 
CGAATTGGTA GAAACCGTCT CTCCAGTTCC AGGGGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Ostn ( XM_008768801.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_008767023.1 Rattus norvegicus osteocrin (Ostn), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa12937
Clone ID Related Accession (Same CDS sequence)	XM_008768801.2 , NM_207612.2
Accession Version	XM_008768801.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 399bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	osteocrin isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005110.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_008768801.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCTGGACT GGAGATTGGC AAGTGCACAC TTCCTCCTGG CTATGATCCT GATGCTGTGG 
GGCTCAGGAA AGGCATTCTC CGTGGACTTA GCATCAGAGG CCTCCGAGTT TGGAGCAGAA 
AGCTTGCAGT CCCCACCCAC AACCAGAGAA GAGAAGTCAG CCACGGAGCT TGCAGCTAAG 
CTCCTGCTTC TTGATGATCT GGTGTCCTTG GAGAATGATG TGTTTGAGAC CAAGAAGAAG 
AGAAGCTTCT CTGGCTTCGG GTCTCCCCTT GACAGACTCT CGGCTGGGTC TGTAGAGCAT 
AGAGGGAAAC AAAGGAGAGT AGTTGATCAT TCAAAAAAGC GATTTGGTAT TCCCATGGAT 
CGAATTGGTA GAAACCGTCT CTCCAGTTCC AGGGGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_008767023.1
CDS	193..591
Translation	MLDWRLASAHFLLAMILMLWGSGKAFSVDLASEASEFGAESLQSPPTTREEKSATELAAKLLLLDDLVSLENDVFETKKKRSFSGFGSPLDRLSAGSVEHRGKQRRVVDHSKKRFGIPMDRIGRNRLSSSRG

Target ORF information:

RefSeq Version	XM_008768801.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus osteocrin (Ostn), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_008768801.2

ORF Insert Sequence:

ATGCTGGACT GGAGATTGGC AAGTGCACAC TTCCTCCTGG CTATGATCCT GATGCTGTGG 
GGCTCAGGAA AGGCATTCTC CGTGGACTTA GCATCAGAGG CCTCCGAGTT TGGAGCAGAA 
AGCTTGCAGT CCCCACCCAC AACCAGAGAA GAGAAGTCAG CCACGGAGCT TGCAGCTAAG 
CTCCTGCTTC TTGATGATCT GGTGTCCTTG GAGAATGATG TGTTTGAGAC CAAGAAGAAG 
AGAAGCTTCT CTGGCTTCGG GTCTCCCCTT GACAGACTCT CGGCTGGGTC TGTAGAGCAT 
AGAGGGAAAC AAAGGAGAGT AGTTGATCAT TCAAAAAAGC GATTTGGTAT TCCCATGGAT 
CGAATTGGTA GAAACCGTCT CTCCAGTTCC AGGGGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Evolution of Osteocrin as an activity-regulated factor in the primate brain.
Nature539(7628)242-247(2016 11)
Ataman B,Boulting GL,Harmin DA,Yang MG,Baker-Salisbury M,Yap EL,Malik AN,Mei K,Rubin AA,Spiegel I,Durresi E,Sharma N,Hu LS,Pletikos M,Griffith EC,Partlow JN,Stevens CR,Adli M,Chahrour M,Sestan N,Walsh CA,Berezovskii VK,Livingstone MS,Greenberg ME

Role of musclin in the pathogenesis of hypertension in rat.
PloS one8(8)e72004(2013)
Li YX,Cheng KC,Asakawa A,Kato I,Sato Y,Amitani H,Kawamura N,Cheng JT,Inui A

Osteocrin is a specific ligand of the natriuretic Peptide clearance receptor that modulates bone growth.
The Journal of biological chemistry282(50)36454-62(2007 Dec)
Moffatt P,Thomas G,Sellin K,Bessette MC,Lafreni?re F,Akhouayri O,St-Arnaud R,Lanct?t C

Musclin gene expression is strongly related to fast-glycolytic phenotype.
Biochemical and biophysical research communications353(3)713-8(2007 Feb)
Banzet S,Koulmann N,Sanchez H,Serrurier B,Peinnequin A,Bigard AX

Musclin, a novel skeletal muscle-derived secretory factor.
The Journal of biological chemistry279(19)19391-5(2004 May)
Nishizawa H,Matsuda M,Yamada Y,Kawai K,Suzuki E,Makishima M,Kitamura T,Shimomura I

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Ostn cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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