Neu4 cDNA ORF clone, Mus musculus(house mouse)
| Gene Symbol | Neu4 |
| Entrez Gene ID | 241159 |
| Full Name | sialidase 4 |
| Synonyms | 9330166I04 |
| General protein information |
|
| Gene Type | protein-coding |
| Organism | Mus musculus(house mouse) |
| Genome |
mRNA and Protein(s)
| mRNA | Protein | Name |
|---|---|---|
| NM_001310769.1 | NP_001297698.1 | sialidase-4 isoform 1 |
| NM_173772.3 | NP_776133.1 | sialidase-4 isoform 2 |
| Bos taurus (cattle) | NEU4 | XP_002686672.1 |
| Rattus norvegicus (Norway rat) | Neu4 | NP_001101704.1 |
| Xenopus tropicalis (tropical clawed frog) | LOC100486976 | XP_002943103.2 |
| NEU4 | XP_001095081.2 | |
| Mus musculus (house mouse) | Neu4 | NP_776133.1 |
| Danio rerio (zebrafish) | neu4 | NP_001018384.1 |
| Homo sapiens (human) | NEU4 | NP_001161071.1 |
| Gallus gallus (chicken) | NEU4 | XP_004937059.1 |
Related articles in PubMed
Neuraminidases 3 and 4 regulate neuronal function by catabolizing brain gangliosides.
Pan X, De Arag?o CBP, Velasco-Martin JP, Priestman DA, Wu HY, Takahashi K, Yamaguchi K, Sturiale L, Garozzo D, Platt FM, Lamarche-Vane N, Morales CR, Miyagi T, Pshezhetsky AV
FASEB journal : official publication of the Federation of American Societies for Experimental Biology31(8)3467-3483(2017 Aug)
Sialidase NEU4 hydrolyzes polysialic acids of neural cell adhesion molecules and negatively regulates neurite formation by hippocampal neurons.
Takahashi K, Mitoma J, Hosono M, Shiozaki K, Sato C, Yamaguchi K, Kitajima K, Higashi H, Nitta K, Shima H, Miyagi T
The Journal of biological chemistry287(18)14816-26(2012 Apr)
Mice doubly-deficient in lysosomal hexosaminidase A and neuraminidase 4 show epileptic crises and rapid neuronal loss.
Seyrantepe V, Lema P, Caqueret A, Dridi L, Bel Hadj S, Carpentier S, Boucher F, Levade T, Carmant L, Gravel RA, Hamel E, Vachon P, Di Cristo G, Michaud JL, Morales CR, Pshezhetsky AV
PLoS genetics6(9)e1001118(2010 Sep)
Developmental change of sialidase neu4 expression in murine brain and its involvement in the regulation of neuronal cell differentiation.
Shiozaki K, Koseki K, Yamaguchi K, Shiozaki M, Narimatsu H, Miyagi T
The Journal of biological chemistry284(32)21157-64(2009 Aug)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
These results provide the first in vivo evidence that neuraminidases 3 and 4 have important roles in CNS function by catabolizing gangliosides and preventing their storage in lipofuscin bodies.
Title: Neuraminidases 3 and 4 regulate neuronal function by catabolizing brain gangliosides.
NEU4 is involved in regulation of neuronal function by polySia degradation in mammals.
Title: Sialidase NEU4 hydrolyzes polysialic acids of neural cell adhesion molecules and negatively regulates neurite formation by hippocampal neurons.
Neu4 is not the only sialidase contributing to the metabolic bypass in Hexa(-/-) mice.
Title: Mice doubly-deficient in lysosomal hexosaminidase A and neuraminidase 4 show epileptic crises and rapid neuronal loss.
mouse Neu4 plays an important regulatory role in neurite formation, possibly through desialylation of glycoproteins
Title: Developmental change of sialidase neu4 expression in murine brain and its involvement in the regulation of neuronal cell differentiation.
Neu4 is a functional component of the ganglioside-metabolizing system, contributing to the postnatal development of the brain and other vital organs.
Title: Mice deficient in Neu4 sialidase exhibit abnormal ganglioside catabolism and lysosomal storage.
The following Neu4 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Neu4 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
| CloneID | OMu04156 | |
| Clone ID Related Accession (Same CDS sequence) | NM_173772.3 | |
| Accession Version | NM_173772.3 Latest version! | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 1437bp) Protein sequence SNP |
|
| Vector | pcDNA3.1+/C-(K)DYK or customized vector |  User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2019-12-24 | |
| Organism | Mus musculus(house mouse) | |
| Product | sialidase-4 isoform 2 | |
| Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BC070438.1. On May 16, 2004 this sequence version replaced NM_173772.2. Transcript Variant: This variant (2) lacks an alternate exon compared to variant 1, which causes translation initiation at a downstream AUG. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1. ##Evidence-Data-START## Transcript exon combination :: BC070438.1, AK034236.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164131, SAMN01164132 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. | |
1 | ATGGGGCCCA CGCGTGTTCC CAGGAGAACG GTGCTCTTCC AGAGGGAAAG GACGGGCCTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | NP_776133.1 |
| CDS | 157..1593 |
| Translation |
Target ORF information:
Target ORF information:
|
 NM_173772.3 |
ORF Insert Sequence:
1 | ATGGGGCCCA CGCGTGTTCC CAGGAGAACG GTGCTCTTCC AGAGGGAAAG GACGGGCCTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| CloneID | OMu74048 | |
| Clone ID Related Accession (Same CDS sequence) | NM_001310769.1 | |
| Accession Version | NM_001310769.1 Latest version! | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 1506bp) Protein sequence SNP |
|
| Vector | pcDNA3.1+/C-(K)DYK or customized vector | User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2019-12-29 | |
| Organism | Mus musculus(house mouse) | |
| Product | sialidase-4 isoform 1 | |
| Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from CB521925.1, AB510404.1 and BC070438.1. On Jul 18, 2015 this sequence version replaced XM_006529593.1. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). ##Evidence-Data-START## Transcript exon combination :: AB510404.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164131, SAMN01164132 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. | |
1 | ATGGAGACTG CTGGAGCTCC CTTCTGCTTC CATGTGGACT CCCTGGTACC TTGCTCCTAC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | NP_001297698.1 |
| CDS | 172..1677 |
| Translation |
Target ORF information:
Target ORF information:
|
NM_001310769.1 |
ORF Insert Sequence:
1 | ATGGAGACTG CTGGAGCTCC CTTCTGCTTC CATGTGGACT CCCTGGTACC TTGCTCCTAC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
 |
Neuraminidases 3 and 4 regulate neuronal function by catabolizing brain gangliosides. |
|
Sialidase NEU4 hydrolyzes polysialic acids of neural cell adhesion molecules and negatively regulates neurite formation by hippocampal neurons. |
|
Mice doubly-deficient in lysosomal hexosaminidase A and neuraminidase 4 show epileptic crises and rapid neuronal loss. |
|
Developmental change of sialidase neu4 expression in murine brain and its involvement in the regulation of neuronal cell differentiation. |