Gene Symbol | Dok3 |
Entrez Gene ID | 27261 |
Full Name | docking protein 3 |
Synonyms | AI450713,Dokl |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
ORF » Species Summary » Mus musculus » Dok3 cDNA ORF clone
gRNAs
Gene Symbol | Dok3 |
Entrez Gene ID | 27261 |
Full Name | docking protein 3 |
Synonyms | AI450713,Dokl |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
mRNA | Protein | Name |
---|---|---|
NM_013739.2 | NP_038767.1 | docking protein 3 |
XM_017315524.1 | XP_017171013.1 | docking protein 3 isoform X1 |
DOK3 Modulates Bone Remodeling by Negatively Regulating Osteoclastogenesis and Positively Regulating Osteoblastogenesis.
Cai X, Xing J, Long CL, Peng Q, Humphrey MB
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research32(11)2207-2218(2017 Nov)
A functional genomics predictive network model identifies regulators of inflammatory bowel disease.
Peters LA, Perrigoue J, Mortha A, Iuga A, Song WM, Neiman EM, Llewellyn SR, Di Narzo A, Kidd BA, Telesco SE, Zhao Y, Stojmirovic A, Sendecki J, Shameer K, Miotto R, Losic B, Shah H, Lee E, Wang M, Faith JJ, Kasarskis A, Brodmerkel C, Curran M, Das A, Friedman JR, Fukui Y, Humphrey MB, Iritani BM, Sibinga N, Tarrant TK, Argmann C, Hao K, Roussos P, Zhu J, Zhang B, Dobrin R, Mayer LF, Schadt EE
Nature genetics49(10)1437-1449(2017 Oct)
DOK3 Degradation is Required for the Development of LPS-induced ARDS in Mice.
Liu N, Liu X, Li X, Duan K, Deng Y, Yu X, Peng Q
Current gene therapy16(4)256-262(2016)
TRAF6-mediated degradation of DOK3 is required for production of IL-6 and TNF? in TLR9 signaling.
Liu N, Tang B, Wei P, Sun W, Wang S, Peng Q
Molecular immunology68(2 Pt C)699-705(2015 Dec)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
DOK3 lung expression negatively regulates the development of lipopolysaccharide-induced acute respiratory distress syndrome in mice.
Title: DOK3 Degradation is Required for the Development of LPS-induced ARDS in Mice.
we demonstrate that CpG treatment leads to ubiquitin-mediated degradation of DOK3 via interaction with an E3 ligase TNFR-associated factor 6 (TRAF6).
Title: TRAF6-mediated degradation of DOK3 is required for production of IL-6 and TNF? in TLR9 signaling.
This study reveals DOK3 as a nonredundant regulator of plasma cell differentiation by up-regulating PD-1 ligand expression through the attenuation of calcium signaling.
Title: Adaptor protein DOK3 promotes plasma cell differentiation by regulating the expression of programmed cell death 1 ligands.
Data show that docking protein 3 (DOK3) plays a role in TLR3 signaling by enabling TNFR-associated factor (TRAF) 3/TANK-binding kinase (TBK) 1 binding and facilitating TBK1 and IFN regulatory factor 3 activation and the induction of IFN-beta production.
Title: DOK3 is required for IFN-? production by enabling TRAF3/TBK1 complex formation and IRF3 activation.
DOK3 physically associated with the ITAM of DAP12 through its phosphotyrosine-binding domain. In response to LPS, DOK3 was phosphorylated in a DAP12- and Src-dependent manner, which led to translocation of phosphorylated DOK3 to the plasma membrane.
Title: A physical interaction between the adaptor proteins DOK3 and DAP12 is required to inhibit lipopolysaccharide signaling in macrophages.
The following Dok3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Dok3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OMu15979 | |
Clone ID Related Accession (Same CDS sequence) | NM_013739.2 , XM_017315524.1 | |
Accession Version | NM_013739.2 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1335bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-12-27 | |
Organism | Mus musculus(house mouse) | |
Product | docking protein 3 | |
Comment | Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from CT009762.8. On Nov 17, 2006 this sequence version replaced NM_013739.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF179242.1, AF237580.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164135, SAMN01164138 [ECO:0000348] ##Evidence-Data-END## |
1 | ATGGAGTCTG TGGAGCCCCC GGTCAAAGAC GGCATCCTCT ACCAGCAGCA CGTAAAGTTT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_038767.1 |
CDS | 25..1359 |
Translation |
Target ORF information:
Target ORF information:
|
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1 | ATGGAGTCTG TGGAGCCCCC GGTCAAAGAC GGCATCCTCT ACCAGCAGCA CGTAAAGTTT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu15979 | |
Clone ID Related Accession (Same CDS sequence) | NM_013739.2 , XM_017315524.1 | |
Accession Version | XM_017315524.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1335bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-08-07 | |
Organism | Mus musculus(house mouse) | |
Product | docking protein 3 isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000079.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGGAGTCTG TGGAGCCCCC GGTCAAAGAC GGCATCCTCT ACCAGCAGCA CGTAAAGTTT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_017171013.1 |
CDS | 1668..3002 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGGAGTCTG TGGAGCCCCC GGTCAAAGAC GGCATCCTCT ACCAGCAGCA CGTAAAGTTT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
DOK3 Modulates Bone Remodeling by Negatively Regulating Osteoclastogenesis and Positively Regulating Osteoblastogenesis. |
A functional genomics predictive network model identifies regulators of inflammatory bowel disease. |
DOK3 Degradation is Required for the Development of LPS-induced ARDS in Mice. |
TRAF6-mediated degradation of DOK3 is required for production of IL-6 and TNF? in TLR9 signaling. |