Abcb10 cDNA ORF clone, Mus musculus(house mouse)
| Gene Symbol | Abcb10 |
| Entrez Gene ID | 56199 |
| Full Name | ATP-binding cassette, sub-family B (MDR/TAP), member 10 |
| Synonyms | Abc-me,Abcb12 |
| General protein information |
|
| Gene Type | protein-coding |
| Organism | Mus musculus(house mouse) |
| Genome | |
| Summary | This gene encodes a member of the ATP-binding cassette superfamily of transporters. ATP-binding cassette proteins transport various molecules across extra- and intra-cellular membranes. The encoded protein is localized to the mitochondrial inner membrane where it interacts with and stabilizes mitoferrin-1, and is important for heme biosynthesis. Additional evidence suggests the encoded protein is involved in oxidative stress protection and erythropoisesis. [provided by RefSeq, May 2013]. |
mRNA and Protein(s)
| mRNA | Protein | Name |
|---|---|---|
| XM_006531201.3 | XP_006531264.1 | ATP-binding cassette sub-family B member 10, mitochondrial isoform X1 |
| NM_019552.2 | NP_062425.1 | ATP-binding cassette sub-family B member 10, mitochondrial precursor |
| Homo sapiens (human) | ABCB10 | NP_036221.2 |
| Bos taurus (cattle) | ABCB10 | XP_002698814.2 |
| Rattus norvegicus (Norway rat) | Abcb10 | NP_001012166.1 |
| Caenorhabditis elegans (roundworm) | haf-3 | NP_506927.2 |
| Eremothecium gossypii | AGOS_ACR022W | NP_983425.2 |
| Neurospora crassa | NCU04117 | XP_961273.2 |
| Canis lupus familiaris (dog) | ABCB10 | XP_005618913.1 |
| Kluyveromyces lactis | KLLA0D00748g | XP_453105.1 |
| Schizosaccharomyces pombe (fission yeast) | mdl1 | NP_595751.1 |
| Arabidopsis thaliana (thale cress) | TAP2 | NP_198720.2 |
| Mus musculus (house mouse) | Abcb10 | NP_062425.1 |
| Gallus gallus (chicken) | ABCB10 | XP_419578.3 |
| Anopheles gambiae (African malaria mosquito) | AgaP_AGAP002717 | XP_312209.4 |
| Caenorhabditis elegans (roundworm) | haf-1 | NP_503098.2 |
| Saccharomyces cerevisiae (baker's yeast) | MDL2 | NP_015053.2 |
| Pan troglodytes (chimpanzee) | ABCB10 | XP_003308870.1 |
| ABCB10 | XP_001082734.1 | |
| Danio rerio (zebrafish) | abcb10 | XP_001343218.3 |
| Drosophila melanogaster (fruit fly) | CG3156 | NP_569844.2 |
| Magnaporthe oryzae (rice blast fungus) | MGG_06878 | XP_003709605.1 |
| Oryza sativa (rice) | Os03g0755100 | NP_001051311.1 |
Related articles in PubMed
Blood-brain barrier disruption in diabetic mice is linked to Nrf2 signaling deficits: Role of ABCB10?
Sajja RK, Prasad S, Tang S, Kaisar MA, Cucullo L
Neuroscience letters653152-158(2017 Jul)
Viral Infection-Induced Differential Expression of LncRNAs Associated with Collagen in Mouse Placentas and Amniotic Sacs.
Pan J, Mor G, Ju W, Zhong J, Luo X, Aldo PB, Zhong M, Yu Y, Jenkins EC, Brown WT, Zhong N
American journal of reproductive immunology (New York, N.Y. : 1989)74(3)237-57(2015 Sep)
ATP Binding and Hydrolysis Properties of ABCB10 and Their Regulation by Glutathione.
Qiu W, Liesa M, Carpenter EP, Shirihai OS
PloS one10(6)e0129772(2015)
Abcb10 role in heme biosynthesis in vivo: Abcb10 knockout in mice causes anemia with protoporphyrin IX and iron accumulation.
Yamamoto M, Arimura H, Fukushige T, Minami K, Nishizawa Y, Tanimoto A, Kanekura T, Nakagawa M, Akiyama S, Furukawa T
Molecular and cellular biology34(6)1077-84(2014 Mar)
Snx3 regulates recycling of the transferrin receptor and iron assimilation.
Chen C, Garcia-Santos D, Ishikawa Y, Seguin A, Li L, Fegan KH, Hildick-Smith GJ, Shah DI, Cooney JD, Chen W, King MJ, Yien YY, Schultz IJ, Anderson H, Dalton AJ, Freedman ML, Kingsley PD, Palis J, Hattangadi SM, Lodish HF, Ward DM, Kaplan J, Maeda T, Ponka P, Paw BH
Cell metabolism17(3)343-52(2013 Mar)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
ATP binding and hydrolysis properties of ABCB10 by using the 8-azido-ATP photolabeling technique, was characterized.
Title: ATP Binding and Hydrolysis Properties of ABCB10 and Their Regulation by Glutathione.
A critical role for Abcb10 in heme biosynthesis.
Title: Abcb10 role in heme biosynthesis in vivo: Abcb10 knockout in mice causes anemia with protoporphyrin IX and iron accumulation.
ABC-me deletion causes an increase in mitochondrial superoxide production and protein carbonylation in erythroid precursors.
Title: The mitochondrial transporter ABC-me (ABCB10), a downstream target of GATA-1, is essential for erythropoiesis in vivo.
Ferrochelatase forms an oligomeric complex with Mfrn1 and Abcb10 to synergistically integrate mitochondrial iron importation and use for heme biosynthesis.
Title: Ferrochelatase forms an oligomeric complex with mitoferrin-1 and Abcb10 for erythroid heme biosynthesis.
Data show that the binding domain of Mfrn1-Abcb10 interaction maps to the N terminus of Mfrn1.
Title: Abcb10 physically interacts with mitoferrin-1 (Slc25a37) to enhance its stability and function in the erythroid mitochondria.
The following Abcb10 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Abcb10 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
| CloneID | OMu18731 |
|
| Clone ID Related Accession (Same CDS sequence) | NM_019552.2 | |
| Accession Version | NM_019552.2 Latest version! | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 2148bp) Protein sequence SNP |
|
| Vector | pcDNA3.1+/C-(K)DYK or customized vector |  User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2019-02-16 | |
| Organism | Mus musculus(house mouse) | |
| Product | ATP-binding cassette sub-family B member 10, mitochondrial precursor | |
| Comment | Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC054793.1. On or before Dec 7, 2005 this sequence version replaced XM_925245.1, XM_917783.1, XM_925251.1, XM_925254.1, NM_019552.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC054793.1, AK081782.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164140, SAMN01164143 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: PMID: 15215243; reported by MitoCarta ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end. | |
1 | ATGCGCGCCC CTTCTGCTAG GGCGCTACTG CTGATTCCGC GTCGGGGCCC TGCCGTGCGA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | NP_062425.1 |
| CDS | 310..2457 |
| Translation |
Target ORF information:
Target ORF information:
|
 NM_019552.2 |
ORF Insert Sequence:
1 | ATGCGCGCCC CTTCTGCTAG GGCGCTACTG CTGATTCCGC GTCGGGGCCC TGCCGTGCGA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| CloneID | OMu41620 | |
| Clone ID Related Accession (Same CDS sequence) | XM_006531201.3 | |
| Accession Version | XM_006531201.3 Latest version! | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 1143bp) Protein sequence SNP |
|
| Vector | pcDNA3.1+/C-(K)DYK or customized vector | User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2016-06-21 | |
| Organism | Mus musculus(house mouse) | |
| Product | ATP-binding cassette sub-family B member 10, mitochondrial isoform X1 | |
| Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000074.6) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 22, 2016 this sequence version replaced XM_006531201.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Mus musculus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## | |
1 | ATGACGGAAG TGGAGAAGTA CACCGGCCGA GTGGACCAGT TGCTGCAGCT GGCACAGAAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | XP_006531264.1 |
| CDS | 367..1509 |
| Translation |
Target ORF information:
Target ORF information:
|
XM_006531201.3 |
ORF Insert Sequence:
1 | ATGACGGAAG TGGAGAAGTA CACCGGCCGA GTGGACCAGT TGCTGCAGCT GGCACAGAAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
 |
Blood-brain barrier disruption in diabetic mice is linked to Nrf2 signaling deficits: Role of ABCB10? |
|
Viral Infection-Induced Differential Expression of LncRNAs Associated with Collagen in Mouse Placentas and Amniotic Sacs. |
|
ATP Binding and Hydrolysis Properties of ABCB10 and Their Regulation by Glutathione. |
|
Abcb10 role in heme biosynthesis in vivo: Abcb10 knockout in mice causes anemia with protoporphyrin IX and iron accumulation. |
|
Snx3 regulates recycling of the transferrin receptor and iron assimilation. |