Gene Symbol | Htra1 |
Entrez Gene ID | 56213 |
Full Name | HtrA serine peptidase 1 |
Synonyms | AI429470,HTRA,L56,Prss11,RSPP11 |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
ORF » Species Summary » Mus musculus » Htra1 cDNA ORF clone
Gene Symbol | Htra1 |
Entrez Gene ID | 56213 |
Full Name | HtrA serine peptidase 1 |
Synonyms | AI429470,HTRA,L56,Prss11,RSPP11 |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
mRNA | Protein | Name |
---|---|---|
NM_019564.3 | NP_062510.2 | serine protease HTRA1 precursor |
Homo sapiens (human) | HTRA1 | NP_002766.1 |
Rattus norvegicus (Norway rat) | Htra1 | NP_113909.1 |
Xenopus tropicalis (tropical clawed frog) | htra1 | NP_001072730.2 |
HTRA1 | XP_001103628.1 | |
Bos taurus (cattle) | HTRA1 | NP_001231162.1 |
Danio rerio (zebrafish) | htra1a | NP_001002219.1 |
Danio rerio (zebrafish) | htra1b | NP_001104652.1 |
Mus musculus (house mouse) | Htra1 | NP_062510.2 |
Role of HTRA1 in bone formation and regeneration: In vitro and in vivo evaluation.
Filliat G, Mirsaidi A, Tiaden AN, Kuhn GA, Weber FE, Oka C, Richards PJ
PloS one12(7)e0181600(2017)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
transfection of cells with a constitutively active rapamycin-resistant p70S6K mutant could restore the mineralizing capacity of HtrA1-deficient mouse adipose-derived stromal cells.
Title: Loss-of-Function of HtrA1 Abrogates All-Trans Retinoic Acid-Induced Osteogenic Differentiation of Mouse Adipose-Derived Stromal Cells Through Deficiencies in p70S6K Activation.
HtrA1 plays important roles in the differentiation of trophoblasts from Tpbpa-positive precursors in the ectoplacental cone
Title: Abnormal development of placenta in HtrA1-deficient mice.
In mouse brain tissue and embryonic fibroblasts there is a facilitating role of HtrA1 in TGF-beta pathway activation.
Title: Cerebral small vessel disease-related protease HtrA1 processes latent TGF-? binding protein 1 and facilitates TGF-? signaling.
The HtrA1 overexpression and mainstream cigarette smoke can independently lead to CNV. The HtrA1 gene is a strong risk factor for wet AMD
Title: Overexpression of HtrA1 and exposure to mainstream cigarette smoke leads to choroidal neovascularization and subretinal deposits in aged mice.
the inhibitory effect of IFN-gamma on HTRA1 expression was evidenced in collagen-induced arthritis (CIA) mouse models and in human RA synovial cells.
Title: The inhibitory effect of IFN-? on protease HTRA1 expression in rheumatoid arthritis.
The following Htra1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Htra1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OMu19003 | |
Clone ID Related Accession (Same CDS sequence) | NM_019564.3 | |
Accession Version | NM_019564.3 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1443bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-10-07 | |
Organism | Mus musculus(house mouse) | |
Product | serine protease HTRA1 precursor | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from CB193609.1, AF179369.1 and AI429470.1. On May 1, 2009 this sequence version replaced NM_019564.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC013516.1, AK132270.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGCAGTCCC TGCGTACCAC GCTCCTGTCT TTGCTACTGC TGCTGCTAGC GGCTCCTTCC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_062510.2 |
CDS | 70..1512 |
Translation |
Target ORF information:
Target ORF information:
|
NM_019564.3 |
1 | ATGCAGTCCC TGCGTACCAC GCTCCTGTCT TTGCTACTGC TGCTGCTAGC GGCTCCTTCC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Role of HTRA1 in bone formation and regeneration: In vitro and in vivo evaluation. |