Gene Symbol | Arl3 |
Entrez Gene ID | 56350 |
Full Name | ADP-ribosylation factor-like 3 |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
ORF » Species Summary » Mus musculus » Arl3 cDNA ORF clone
gRNAs
Gene Symbol | Arl3 |
Entrez Gene ID | 56350 |
Full Name | ADP-ribosylation factor-like 3 |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
mRNA | Protein | Name |
---|---|---|
NM_019718.2 | NP_062692.1 | ADP-ribosylation factor-like protein 3 |
XM_006527223.2 | XP_006527286.1 | ADP-ribosylation factor-like protein 3 isoform X1 |
NM_001355233.1 | NP_001342162.1 | ADP-ribosylation factor-like protein 3 isoform 2 |
NM_019718.3 | NP_062692.1 | ADP-ribosylation factor-like protein 3 isoform 1 |
Pan troglodytes (chimpanzee) | ARL3 | XP_508005.1 |
Danio rerio (zebrafish) | arl3 | NP_001038373.1 |
Caenorhabditis elegans (roundworm) | arl-3 | NP_497037.1 |
Canis lupus familiaris (dog) | ARL3 | XP_003640041.1 |
Rattus norvegicus (Norway rat) | Arl3 | NP_073191.1 |
Gallus gallus (chicken) | ARL3 | XP_421730.1 |
Drosophila melanogaster (fruit fly) | dnd | NP_650995.1 |
Anopheles gambiae (African malaria mosquito) | AgaP_AGAP004496 | XP_313793.5 |
Bos taurus (cattle) | ARL3 | NP_001033656.1 |
Xenopus tropicalis (tropical clawed frog) | arl3 | XP_002938771.2 |
Homo sapiens (human) | ARL3 | NP_004302.1 |
Mus musculus (house mouse) | Arl3 | NP_062692.1 |
Biochemical characterization of purified mammalian ARL13B protein indicates that it is an atypical GTPase and ARL3 guanine nucleotide exchange factor (GEF).
Ivanova AA, Caspary T, Seyfried NT, Duong DM, West AB, Liu Z, Kahn RA
The Journal of biological chemistry292(26)11091-11108(2017 06)
ARL3 regulates trafficking of prenylated phototransduction proteins to the rod outer segment.
Wright ZC, Singh RK, Alpino R, Goldberg AF, Sokolov M, Ramamurthy V
Human molecular genetics25(10)2031-2044(2016 05)
PDE6?-mediated sorting of INPP5E into the cilium is determined by cargo-carrier affinity.
Fansa EK, K?sling SK, Zent E, Wittinghofer A, Ismail S
Nature communications711366(2016 Apr)
Arf-like Protein 3 (ARL3) Regulates Protein Trafficking and Ciliogenesis in Mouse Photoreceptors.
Hanke-Gogokhia C, Wu Z, Gerstner CD, Frederick JM, Zhang H, Baehr W
The Journal of biological chemistry291(13)7142-55(2016 Mar)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
Biochemical characterization of purified mammalian ARL13B protein indicates that it is an atypical GTPase and ARL3 guanine nucleotide exchange factor (GEF).(
Title: Biochemical characterization of purified mammalian ARL13B protein indicates that it is an atypical GTPase and ARL3 guanine nucleotide exchange factor (GEF).
this study identifies ARL3 as a key player in prenylated protein trafficking in rod photoreceptor cells and establishes the potential role for ARL3 dysregulation in the pathogenesis of RP2-related forms of X-linked retinitis pigmentosa
Title: ARL3 regulates trafficking of prenylated phototransduction proteins to the rod outer segment.
ARL3 regulates protein trafficking and ciliogenesis in mouse photoreceptors.
Title: Arf-like Protein 3 (ARL3) Regulates Protein Trafficking and Ciliogenesis in Mouse Photoreceptors.
Studies indicate that Arf-like proteins ARL2 and ARL3 are not substrates for N-myristoyl transferase.
Title: The Function of Arf-like Proteins ARL2 and ARL3 in Photoreceptors.
The authors show that the ciliary G-protein Arl13B, mutated in Joubert syndrome, is the guanine nucleotide exchange factor for Arl3, and its function is conserved in evolution
Title: A G-protein activation cascade from Arl13B to Arl3 and implications for ciliary targeting of lipidated proteins.
The following Arl3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Arl3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OMu55657 | |
Clone ID Related Accession (Same CDS sequence) | XM_006527223.2 , NM_001355233.1 | |
Accession Version | NM_001355233.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 543bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-10-24 | |
Organism | Mus musculus(house mouse) | |
Product | ADP-ribosylation factor-like protein 3 isoform 2 | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC156982.8. On Sep 13, 2017 this sequence version replaced XM_006527223.2. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660817.386348.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849383, SAMN00849390 [ECO:0000348] ##Evidence-Data-END## |
1 | ATGGGCTTGC TCTCTATTTT GCGCAAATTG AAAAGTGCAC CAGACCAGGA GGTGCGAATC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001342162.1 |
CDS | 141..683 |
Translation |
Target ORF information:
Target ORF information:
|
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1 | ATGGGCTTGC TCTCTATTTT GCGCAAATTG AAAAGTGCAC CAGACCAGGA GGTGCGAATC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu55657 | |
Clone ID Related Accession (Same CDS sequence) | XM_006527223.2 , NM_001355233.1 | |
Accession Version | XM_006527223.2 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 543bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-06-21 | |
Organism | Mus musculus(House mouse) | |
Product | ADP-ribosylation factor-like protein 3 isoform X1 | |
Comment | MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000085.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Feb 9, 2015 this sequence version replaced XM_006527223.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Mus musculus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGGGCTTGC TCTCTATTTT GCGCAAATTG AAAAGTGCAC CAGACCAGGA GGTGCGAATC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_006527286.1 |
CDS | 140..682 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGGGCTTGC TCTCTATTTT GCGCAAATTG AAAAGTGCAC CAGACCAGGA GGTGCGAATC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu21716 | |
Clone ID Related Accession (Same CDS sequence) | NM_019718.2 , NM_019718.3 | |
Accession Version | NM_019718.2 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 549bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2017-04-25 | |
Organism | Mus musculus(House mouse) | |
Product | ADP-ribosylation factor-like protein 3 | |
Comment | PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC042941.1. On Dec 20, 2003 this sequence version replaced NM_019718.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC042941.1, BU520638.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849381, SAMN00849383 [ECO:0000348] ##Evidence-Data-END## |
1 | ATGGGCTTGC TCTCTATTTT GCGCAAATTG AAAAGTGCAC CAGACCAGGA GGTGCGAATC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_062692.1 |
CDS | 44..592 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGGGCTTGC TCTCTATTTT GCGCAAATTG AAAAGTGCAC CAGACCAGGA GGTGCGAATC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu21716 | |
Clone ID Related Accession (Same CDS sequence) | NM_019718.2 , NM_019718.3 | |
Accession Version | NM_019718.3 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 549bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-09-25 | |
Organism | Mus musculus(house mouse) | |
Product | ADP-ribosylation factor-like protein 3 isoform 1 | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC156982.8. On Sep 13, 2017 this sequence version replaced NM_019718.2. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC042941.1, BU520638.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849381, SAMN00849383 [ECO:0000348] ##Evidence-Data-END## |
1 | ATGGGCTTGC TCTCTATTTT GCGCAAATTG AAAAGTGCAC CAGACCAGGA GGTGCGAATC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_062692.1 |
CDS | 141..689 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGGGCTTGC TCTCTATTTT GCGCAAATTG AAAAGTGCAC CAGACCAGGA GGTGCGAATC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Biochemical characterization of purified mammalian ARL13B protein indicates that it is an atypical GTPase and ARL3 guanine nucleotide exchange factor (GEF). |
ARL3 regulates trafficking of prenylated phototransduction proteins to the rod outer segment. |
PDE6?-mediated sorting of INPP5E into the cilium is determined by cargo-carrier affinity. |
Arf-like Protein 3 (ARL3) Regulates Protein Trafficking and Ciliogenesis in Mouse Photoreceptors. |