Tnfaip8l2 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Tnfaip8l2
Entrez Gene ID	69769
Full Name	tumor necrosis factor, alpha-induced protein 8-like 2
Synonyms	1810019A08Rik,AW610835,TIPE2
General protein information	Preferred Names tumor necrosis factor, alpha-induced protein 8-like 2 Names tumor necrosis factor alpha-induced protein 8-like protein 2 TNF alpha-induced protein 8-like protein 2 TNFAIP8-like protein 2 tumor necrosis factor, alpha-induced protein 8-like protein 2
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 3 Map Location: 3\|3 F2.1

mRNA and Protein(s)

mRNA	Protein	Name
XM_006502040.3	XP_006502103.1	tumor necrosis factor alpha-induced protein 8-like protein 2 isoform X1
XM_006502040.2	XP_006502103.1	tumor necrosis factor alpha-induced protein 8-like protein 2 isoform X1
NM_027206.2	NP_081482.1	tumor necrosis factor alpha-induced protein 8-like protein 2
NM_027206.3	NP_081482.1	tumor necrosis factor alpha-induced protein 8-like protein 2
XM_006502040.4	XP_006502103.1	tumor necrosis factor alpha-induced protein 8-like protein 2 isoform X1

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	TNFAIP8L2	XP_003308421.1
Rattus norvegicus (Norway rat)	Tnfaip8l2	NP_001014061.1
Homo sapiens (human)	TNFAIP8L2	NP_078851.2
Canis lupus familiaris (dog)	TNFAIP8L2	XP_005630850.1
Mus musculus (house mouse)	Tnfaip8l2	NP_081482.1
	TNFAIP8L2	XP_002801815.1
Danio rerio (zebrafish)	tnfaip8l2b	NP_956668.1
Xenopus tropicalis (tropical clawed frog)	tnfaip8l2	NP_001025614.1
Bos taurus (cattle)	TNFAIP8L2	NP_001029561.1

Gene Ontology
Bibliography

Related articles in PubMed

TIPE2 governs macrophage polarization via negative regulation of mTORC1.
Jiang Y, Li Q, Zhang Y, Gao Y, Jiang L, Chen Z
Molecular medicine reports17(1)952-960(2018 Jan)

Direction of leukocyte polarization and migration by the phosphoinositide-transfer protein TIPE2.
Fayngerts SA, Wang Z, Zamani A, Sun H, Boggs AE, Porturas TP, Xie W, Lin M, Cathopoulis T, Goldsmith JR, Vourekas A, Chen YH
Nature immunology18(12)1353-1360(2017 Dec)

TIPE2 attenuates liver fibrosis by reversing the activated hepatic stellate cells.
Xu DD, Li XF, Li YH, Liu YH, Huang C, Meng XM, Li J
Biochemical and biophysical research communications(2017 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The results reported here indicated a crucial role for TIPE2 in the infiltration of leukocytes into neural tissue in Experimental Autoimmune Encephalomyelitis.
Title: Direction of leukocyte polarization and migration by the phosphoinositide-transfer protein TIPE2.

TIPE2 inhibited breast cancer development and metastasis possibly via promoting CD8(+) T and NK cell-mediated antitumor immune responses
Title: Gene delivery of TIPE2 inhibits breast cancer development and metastasis via CD8

Our current study shows that TIPE2-deficient bone-marrow cells are defective in IL-4 induced M2 macrophage differentiation in vitro. TIPE2 promotes phosphoinositide metabolism and the activation of the down-stream AKT signaling pathway, which in turn leads to the expression of markers specific for M2 macrophages.
Title: Negative Immune Regulator TIPE2 Promotes M2 Macrophage Differentiation through the Activation of PI3K-AKT Signaling Pathway.

The present study demonstrates that TIPE2 acts as a novel negative regulator of inflammatory and immune responses through TAK1 signaling.
Title: TIPE2 (Tumor Necrosis Factor ?-induced Protein 8-like 2) Is a Novel Negative Regulator of TAK1 Signal.

Data show that after tumor necrosis factor alpha-induced protein 8 like-2 (TIPE2) gene was down-regulated, the expression of the CD69 antigen was increased, and the proliferation of T lymphocytes and the secretion of cytokines IL-2 and IFN-gamma were enhanced.
Title: [Down-regulation of TIPE2 promotes the proliferation and immune activity of T lymphocytes].

The following Tnfaip8l2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Tnfaip8l2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OMu03860	NM_027206.3 Latest version!	Mus musculus tumor necrosis factor, alpha-induced protein 8-like 2 (Tnfaip8l2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00
OMu03860	XM_006502040.4 Latest version!	Mus musculus tumor necrosis factor, alpha-induced protein 8-like 2 (Tnfaip8l2), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$69.30 $99.00
View Old Accession Versions >>
OMu03860	XM_006502040.2	Mus musculus tumor necrosis factor, alpha-induced protein 8-like 2 (Tnfaip8l2), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00
OMu03860	NM_027206.2	Mus musculus tumor necrosis factor, alpha-induced protein 8-like 2 (Tnfaip8l2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00
OMu03860	XM_006502040.3	Mus musculus tumor necrosis factor, alpha-induced protein 8-like 2 (Tnfaip8l2), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Tnfaip8l2 ( NM_027206.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_081482.1 Mus musculus tumor necrosis factor, alpha-induced protein 8-like 2 (Tnfaip8l2), mRNA.

Price & Availability↑

CloneID	OMu03860
Clone ID Related Accession (Same CDS sequence)	XM_006502040.3 , XM_006502040.2 , NM_027206.2 , NM_027206.3 , XM_006502040.4
Accession Version	NM_027206.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 555bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-09-22
Organism	Mus musculus(house mouse)
Product	tumor necrosis factor alpha-induced protein 8-like protein 2
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AK007540.1. On Apr 5, 2007 this sequence version replaced NM_027206.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK007540.1, BY707597.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END##

ATGGAGTCCT TCAGCTCAAA GAGTCTGGCA CTACAAGCGG AGAAGAAGCT GCTGAGTAAA 
ATGGCTGGTC GGTCCGTGGC GCATCTCTTT ATCGACGAGA CCAGCAGCGA GGTGCTAGAC 
GAGCTTTACC GCGTGTCCAA AGAATACACG CACAGCCGGC CCAAGGCACA GCGGGTGATC 
AAAGACCTCA TCAAGGTAGC GGTTAAAGTG GCTGTGCTGC ACCGCAGTGG CTGCTTTGGC 
CCTGGGGAGC TGGCTCTGGC TACACGATTT CGTCAGAAGC TACGGCAGGG CGCCATGACC 
GCACTTAGCT TCGGTGAGGT GGACTTCACC TTTGAGGCTG CCGTGCTAGC AGGTCTGCTC 
GTCGAGTGCC GGGACATTCT GCTGGAGCTG GTGGAGCACC ACCTCACACC CAAGTCACAT 
GACCGCATCA GGCACGTGTT TGATCACTAC TCTGACCCCG ACCTGCTGGC TGCCCTCTAT 
GGGCCTGACT TCACTCAGCA CCTTGGCAAG ATCTGTGATG GGCTCCGGAA GCTGCTGGAC 
GAGGGCAAGC TCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_081482.1
CDS	93..647
Translation	MESFSSKSLALQAEKKLLSKMAGRSVAHLFIDETSSEVLDELYRVSKEYTHSRPKAQRVIKDLIKVAVKVAVLHRSGCFGPGELALATRFRQKLRQGAMTALSFGEVDFTFEAAVLAGLLVECRDILLELVEHHLTPKSHDRIRHVFDHYSDPDLLAALYGPDFTQHLGKICDGLRKLLDEGKL

Target ORF information:

RefSeq Version	NM_027206.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus tumor necrosis factor, alpha-induced protein 8-like 2 (Tnfaip8l2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_027206.2

ORF Insert Sequence:

ATGGAGTCCT TCAGCTCAAA GAGTCTGGCA CTACAAGCGG AGAAGAAGCT GCTGAGTAAA 
ATGGCTGGTC GGTCCGTGGC GCATCTCTTT ATCGACGAGA CCAGCAGCGA GGTGCTAGAC 
GAGCTTTACC GCGTGTCCAA AGAATACACG CACAGCCGGC CCAAGGCACA GCGGGTGATC 
AAAGACCTCA TCAAGGTAGC GGTTAAAGTG GCTGTGCTGC ACCGCAGTGG CTGCTTTGGC 
CCTGGGGAGC TGGCTCTGGC TACACGATTT CGTCAGAAGC TACGGCAGGG CGCCATGACC 
GCACTTAGCT TCGGTGAGGT GGACTTCACC TTTGAGGCTG CCGTGCTAGC AGGTCTGCTC 
GTCGAGTGCC GGGACATTCT GCTGGAGCTG GTGGAGCACC ACCTCACACC CAAGTCACAT 
GACCGCATCA GGCACGTGTT TGATCACTAC TCTGACCCCG ACCTGCTGGC TGCCCTCTAT 
GGGCCTGACT TCACTCAGCA CCTTGGCAAG ATCTGTGATG GGCTCCGGAA GCTGCTGGAC 
GAGGGCAAGC TCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Tnfaip8l2 ( NM_027206.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_081482.1 Mus musculus tumor necrosis factor, alpha-induced protein 8-like 2 (Tnfaip8l2), mRNA.

Price & Availability↑

CloneID	OMu03860
Clone ID Related Accession (Same CDS sequence)	XM_006502040.3 , XM_006502040.2 , NM_027206.2 , NM_027206.3 , XM_006502040.4
Accession Version	NM_027206.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 555bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-01-28
Organism	Mus musculus(house mouse)
Product	tumor necrosis factor alpha-induced protein 8-like protein 2
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC131769.3. On Jan 29, 2019 this sequence version replaced NM_027206.2. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC094616.1, AK007540.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END##

ATGGAGTCCT TCAGCTCAAA GAGTCTGGCA CTACAAGCGG AGAAGAAGCT GCTGAGTAAA 
ATGGCTGGTC GGTCCGTGGC GCATCTCTTT ATCGACGAGA CCAGCAGCGA GGTGCTAGAC 
GAGCTTTACC GCGTGTCCAA AGAATACACG CACAGCCGGC CCAAGGCACA GCGGGTGATC 
AAAGACCTCA TCAAGGTAGC GGTTAAAGTG GCTGTGCTGC ACCGCAGTGG CTGCTTTGGC 
CCTGGGGAGC TGGCTCTGGC TACACGATTT CGTCAGAAGC TACGGCAGGG CGCCATGACC 
GCACTTAGCT TCGGTGAGGT GGACTTCACC TTTGAGGCTG CCGTGCTAGC AGGTCTGCTC 
GTCGAGTGCC GGGACATTCT GCTGGAGCTG GTGGAGCACC ACCTCACACC CAAGTCACAT 
GACCGCATCA GGCACGTGTT TGATCACTAC TCTGACCCCG ACCTGCTGGC TGCCCTCTAT 
GGGCCTGACT TCACTCAGCA CCTTGGCAAG ATCTGTGATG GGCTCCGGAA GCTGCTGGAC 
GAGGGCAAGC TCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_081482.1
CDS	87..641
Translation	MESFSSKSLALQAEKKLLSKMAGRSVAHLFIDETSSEVLDELYRVSKEYTHSRPKAQRVIKDLIKVAVKVAVLHRSGCFGPGELALATRFRQKLRQGAMTALSFGEVDFTFEAAVLAGLLVECRDILLELVEHHLTPKSHDRIRHVFDHYSDPDLLAALYGPDFTQHLGKICDGLRKLLDEGKL

Target ORF information:

RefSeq Version	NM_027206.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus tumor necrosis factor, alpha-induced protein 8-like 2 (Tnfaip8l2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_027206.3

ORF Insert Sequence:

ATGGAGTCCT TCAGCTCAAA GAGTCTGGCA CTACAAGCGG AGAAGAAGCT GCTGAGTAAA 
ATGGCTGGTC GGTCCGTGGC GCATCTCTTT ATCGACGAGA CCAGCAGCGA GGTGCTAGAC 
GAGCTTTACC GCGTGTCCAA AGAATACACG CACAGCCGGC CCAAGGCACA GCGGGTGATC 
AAAGACCTCA TCAAGGTAGC GGTTAAAGTG GCTGTGCTGC ACCGCAGTGG CTGCTTTGGC 
CCTGGGGAGC TGGCTCTGGC TACACGATTT CGTCAGAAGC TACGGCAGGG CGCCATGACC 
GCACTTAGCT TCGGTGAGGT GGACTTCACC TTTGAGGCTG CCGTGCTAGC AGGTCTGCTC 
GTCGAGTGCC GGGACATTCT GCTGGAGCTG GTGGAGCACC ACCTCACACC CAAGTCACAT 
GACCGCATCA GGCACGTGTT TGATCACTAC TCTGACCCCG ACCTGCTGGC TGCCCTCTAT 
GGGCCTGACT TCACTCAGCA CCTTGGCAAG ATCTGTGATG GGCTCCGGAA GCTGCTGGAC 
GAGGGCAAGC TCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Tnfaip8l2 ( XM_006502040.3 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_006502103.1 Mus musculus tumor necrosis factor, alpha-induced protein 8-like 2 (Tnfaip8l2), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OMu03860
Clone ID Related Accession (Same CDS sequence)	XM_006502040.3 , XM_006502040.2 , NM_027206.2 , NM_027206.3 , XM_006502040.4
Accession Version	XM_006502040.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 555bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-21
Organism	Mus musculus(house mouse)
Product	tumor necrosis factor alpha-induced protein 8-like protein 2 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000069.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 22, 2016 this sequence version replaced XM_006502040.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Mus musculus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGAGTCCT TCAGCTCAAA GAGTCTGGCA CTACAAGCGG AGAAGAAGCT GCTGAGTAAA 
ATGGCTGGTC GGTCCGTGGC GCATCTCTTT ATCGACGAGA CCAGCAGCGA GGTGCTAGAC 
GAGCTTTACC GCGTGTCCAA AGAATACACG CACAGCCGGC CCAAGGCACA GCGGGTGATC 
AAAGACCTCA TCAAGGTAGC GGTTAAAGTG GCTGTGCTGC ACCGCAGTGG CTGCTTTGGC 
CCTGGGGAGC TGGCTCTGGC TACACGATTT CGTCAGAAGC TACGGCAGGG CGCCATGACC 
GCACTTAGCT TCGGTGAGGT GGACTTCACC TTTGAGGCTG CCGTGCTAGC AGGTCTGCTC 
GTCGAGTGCC GGGACATTCT GCTGGAGCTG GTGGAGCACC ACCTCACACC CAAGTCACAT 
GACCGCATCA GGCACGTGTT TGATCACTAC TCTGACCCCG ACCTGCTGGC TGCCCTCTAT 
GGGCCTGACT TCACTCAGCA CCTTGGCAAG ATCTGTGATG GGCTCCGGAA GCTGCTGGAC 
GAGGGCAAGC TCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006502103.1
CDS	166..720
Translation	MESFSSKSLALQAEKKLLSKMAGRSVAHLFIDETSSEVLDELYRVSKEYTHSRPKAQRVIKDLIKVAVKVAVLHRSGCFGPGELALATRFRQKLRQGAMTALSFGEVDFTFEAAVLAGLLVECRDILLELVEHHLTPKSHDRIRHVFDHYSDPDLLAALYGPDFTQHLGKICDGLRKLLDEGKL

Target ORF information:

RefSeq Version	XM_006502040.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus tumor necrosis factor, alpha-induced protein 8-like 2 (Tnfaip8l2), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006502040.3

ORF Insert Sequence:

ATGGAGTCCT TCAGCTCAAA GAGTCTGGCA CTACAAGCGG AGAAGAAGCT GCTGAGTAAA 
ATGGCTGGTC GGTCCGTGGC GCATCTCTTT ATCGACGAGA CCAGCAGCGA GGTGCTAGAC 
GAGCTTTACC GCGTGTCCAA AGAATACACG CACAGCCGGC CCAAGGCACA GCGGGTGATC 
AAAGACCTCA TCAAGGTAGC GGTTAAAGTG GCTGTGCTGC ACCGCAGTGG CTGCTTTGGC 
CCTGGGGAGC TGGCTCTGGC TACACGATTT CGTCAGAAGC TACGGCAGGG CGCCATGACC 
GCACTTAGCT TCGGTGAGGT GGACTTCACC TTTGAGGCTG CCGTGCTAGC AGGTCTGCTC 
GTCGAGTGCC GGGACATTCT GCTGGAGCTG GTGGAGCACC ACCTCACACC CAAGTCACAT 
GACCGCATCA GGCACGTGTT TGATCACTAC TCTGACCCCG ACCTGCTGGC TGCCCTCTAT 
GGGCCTGACT TCACTCAGCA CCTTGGCAAG ATCTGTGATG GGCTCCGGAA GCTGCTGGAC 
GAGGGCAAGC TCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Tnfaip8l2 ( XM_006502040.2 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_006502103.1 Mus musculus tumor necrosis factor, alpha-induced protein 8-like 2 (Tnfaip8l2), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OMu03860
Clone ID Related Accession (Same CDS sequence)	XM_006502040.3 , XM_006502040.2 , NM_027206.2 , NM_027206.3 , XM_006502040.4
Accession Version	XM_006502040.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 555bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2015-02-08
Organism	Mus musculus(House mouse)
Product	tumor necrosis factor alpha-induced protein 8-like protein 2 isoform X1
Comment

ATGGAGTCCT TCAGCTCAAA GAGTCTGGCA CTACAAGCGG AGAAGAAGCT GCTGAGTAAA 
ATGGCTGGTC GGTCCGTGGC GCATCTCTTT ATCGACGAGA CCAGCAGCGA GGTGCTAGAC 
GAGCTTTACC GCGTGTCCAA AGAATACACG CACAGCCGGC CCAAGGCACA GCGGGTGATC 
AAAGACCTCA TCAAGGTAGC GGTTAAAGTG GCTGTGCTGC ACCGCAGTGG CTGCTTTGGC 
CCTGGGGAGC TGGCTCTGGC TACACGATTT CGTCAGAAGC TACGGCAGGG CGCCATGACC 
GCACTTAGCT TCGGTGAGGT GGACTTCACC TTTGAGGCTG CCGTGCTAGC AGGTCTGCTC 
GTCGAGTGCC GGGACATTCT GCTGGAGCTG GTGGAGCACC ACCTCACACC CAAGTCACAT 
GACCGCATCA GGCACGTGTT TGATCACTAC TCTGACCCCG ACCTGCTGGC TGCCCTCTAT 
GGGCCTGACT TCACTCAGCA CCTTGGCAAG ATCTGTGATG GGCTCCGGAA GCTGCTGGAC 
GAGGGCAAGC TCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006502103.1
Translation	MESFSSKSLALQAEKKLLSKMAGRSVAHLFIDETSSEVLDELYRVSKEYTHSRPKAQRVIKDLIKVAVKVAVLHRSGCFGPGELALATRFRQKLRQGAMTALSFGEVDFTFEAAVLAGLLVECRDILLELVEHHLTPKSHDRIRHVFDHYSDPDLLAALYGPDFTQHLGKICDGLRKLLDEGKL

Target ORF information:

RefSeq Version	XM_006502040.2
Organism	Mus musculus(House mouse)
Definition	Mus musculus tumor necrosis factor, alpha-induced protein 8-like 2 (Tnfaip8l2), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006502040.2

ORF Insert Sequence:

ATGGAGTCCT TCAGCTCAAA GAGTCTGGCA CTACAAGCGG AGAAGAAGCT GCTGAGTAAA 
ATGGCTGGTC GGTCCGTGGC GCATCTCTTT ATCGACGAGA CCAGCAGCGA GGTGCTAGAC 
GAGCTTTACC GCGTGTCCAA AGAATACACG CACAGCCGGC CCAAGGCACA GCGGGTGATC 
AAAGACCTCA TCAAGGTAGC GGTTAAAGTG GCTGTGCTGC ACCGCAGTGG CTGCTTTGGC 
CCTGGGGAGC TGGCTCTGGC TACACGATTT CGTCAGAAGC TACGGCAGGG CGCCATGACC 
GCACTTAGCT TCGGTGAGGT GGACTTCACC TTTGAGGCTG CCGTGCTAGC AGGTCTGCTC 
GTCGAGTGCC GGGACATTCT GCTGGAGCTG GTGGAGCACC ACCTCACACC CAAGTCACAT 
GACCGCATCA GGCACGTGTT TGATCACTAC TCTGACCCCG ACCTGCTGGC TGCCCTCTAT 
GGGCCTGACT TCACTCAGCA CCTTGGCAAG ATCTGTGATG GGCTCCGGAA GCTGCTGGAC 
GAGGGCAAGC TCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Tnfaip8l2 ( XM_006502040.4 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_006502103.1 Mus musculus tumor necrosis factor, alpha-induced protein 8-like 2 (Tnfaip8l2), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OMu03860
Clone ID Related Accession (Same CDS sequence)	XM_006502040.3 , XM_006502040.2 , NM_027206.2 , NM_027206.3 , XM_006502040.4
Accession Version	XM_006502040.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 555bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-07
Organism	Mus musculus(house mouse)
Product	tumor necrosis factor alpha-induced protein 8-like protein 2 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000069.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Aug 8, 2019 this sequence version replaced XM_006502040.3. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGAGTCCT TCAGCTCAAA GAGTCTGGCA CTACAAGCGG AGAAGAAGCT GCTGAGTAAA 
ATGGCTGGTC GGTCCGTGGC GCATCTCTTT ATCGACGAGA CCAGCAGCGA GGTGCTAGAC 
GAGCTTTACC GCGTGTCCAA AGAATACACG CACAGCCGGC CCAAGGCACA GCGGGTGATC 
AAAGACCTCA TCAAGGTAGC GGTTAAAGTG GCTGTGCTGC ACCGCAGTGG CTGCTTTGGC 
CCTGGGGAGC TGGCTCTGGC TACACGATTT CGTCAGAAGC TACGGCAGGG CGCCATGACC 
GCACTTAGCT TCGGTGAGGT GGACTTCACC TTTGAGGCTG CCGTGCTAGC AGGTCTGCTC 
GTCGAGTGCC GGGACATTCT GCTGGAGCTG GTGGAGCACC ACCTCACACC CAAGTCACAT 
GACCGCATCA GGCACGTGTT TGATCACTAC TCTGACCCCG ACCTGCTGGC TGCCCTCTAT 
GGGCCTGACT TCACTCAGCA CCTTGGCAAG ATCTGTGATG GGCTCCGGAA GCTGCTGGAC 
GAGGGCAAGC TCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006502103.1
CDS	132..686
Translation	MESFSSKSLALQAEKKLLSKMAGRSVAHLFIDETSSEVLDELYRVSKEYTHSRPKAQRVIKDLIKVAVKVAVLHRSGCFGPGELALATRFRQKLRQGAMTALSFGEVDFTFEAAVLAGLLVECRDILLELVEHHLTPKSHDRIRHVFDHYSDPDLLAALYGPDFTQHLGKICDGLRKLLDEGKL

Target ORF information:

RefSeq Version	XM_006502040.4
Organism	Mus musculus(house mouse)
Definition	Mus musculus tumor necrosis factor, alpha-induced protein 8-like 2 (Tnfaip8l2), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006502040.4

ORF Insert Sequence:

ATGGAGTCCT TCAGCTCAAA GAGTCTGGCA CTACAAGCGG AGAAGAAGCT GCTGAGTAAA 
ATGGCTGGTC GGTCCGTGGC GCATCTCTTT ATCGACGAGA CCAGCAGCGA GGTGCTAGAC 
GAGCTTTACC GCGTGTCCAA AGAATACACG CACAGCCGGC CCAAGGCACA GCGGGTGATC 
AAAGACCTCA TCAAGGTAGC GGTTAAAGTG GCTGTGCTGC ACCGCAGTGG CTGCTTTGGC 
CCTGGGGAGC TGGCTCTGGC TACACGATTT CGTCAGAAGC TACGGCAGGG CGCCATGACC 
GCACTTAGCT TCGGTGAGGT GGACTTCACC TTTGAGGCTG CCGTGCTAGC AGGTCTGCTC 
GTCGAGTGCC GGGACATTCT GCTGGAGCTG GTGGAGCACC ACCTCACACC CAAGTCACAT 
GACCGCATCA GGCACGTGTT TGATCACTAC TCTGACCCCG ACCTGCTGGC TGCCCTCTAT 
GGGCCTGACT TCACTCAGCA CCTTGGCAAG ATCTGTGATG GGCTCCGGAA GCTGCTGGAC 
GAGGGCAAGC TCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

TIPE2 governs macrophage polarization via negative regulation of mTORC1.
Molecular medicine reports17(1)952-960(2018 Jan)
Jiang Y,Li Q,Zhang Y,Gao Y,Jiang L,Chen Z

Direction of leukocyte polarization and migration by the phosphoinositide-transfer protein TIPE2.
Nature immunology18(12)1353-1360(2017 Dec)
Fayngerts SA,Wang Z,Zamani A,Sun H,Boggs AE,Porturas TP,Xie W,Lin M,Cathopoulis T,Goldsmith JR,Vourekas A,Chen YH

TIPE2 attenuates liver fibrosis by reversing the activated hepatic stellate cells.
Biochemical and biophysical research communications(2017 Nov)
Xu DD,Li XF,Li YH,Liu YH,Huang C,Meng XM,Li J

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Tnfaip8l2 cDNA ORF clone, Mus musculus(house mouse)

Gene

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gRNAs

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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