Gene Symbol | Ehd4 |
Entrez Gene ID | 192204 |
Full Name | EH-domain containing 4 |
Synonyms | Past2 |
General protein information |
|
Gene Type | protein-coding |
Organism | Rattus norvegicus(Norway rat) |
Genome |
ORF » Species Summary » Rattus norvegicus » Ehd4 cDNA ORF clone
Gene Symbol | Ehd4 |
Entrez Gene ID | 192204 |
Full Name | EH-domain containing 4 |
Synonyms | Past2 |
General protein information |
|
Gene Type | protein-coding |
Organism | Rattus norvegicus(Norway rat) |
Genome |
mRNA | Protein | Name |
---|---|---|
NM_139324.1 | NP_647540.1 | EH domain-containing protein 4 |
EHD4 | XP_001102348.1 | |
Rattus norvegicus (Norway rat) | Ehd4 | NP_647540.1 |
Bos taurus (cattle) | EHD4 | NP_001178982.1 |
Mus musculus (house mouse) | Ehd4 | NP_598599.2 |
Gallus gallus (chicken) | LOC100859860 | XP_003641397.2 |
Danio rerio (zebrafish) | im:7147183 | XP_698033.4 |
Homo sapiens (human) | EHD4 | NP_644670.1 |
Pan troglodytes (chimpanzee) | EHD4 | XP_510639.2 |
Canis lupus familiaris (dog) | EHD4 | XP_851017.1 |
Xenopus tropicalis (tropical clawed frog) | ehd4 | NP_001096442.2 |
E-cadherin interactome complexity and robustness resolved by quantitative proteomics.
Guo Z, Neilson LJ, Zhong H, Murray PS, Zanivan S, Zaidel-Bar R
Science signaling7(354)rs7(2014 Dec)
Trk retrograde signaling requires persistent, Pincher-directed endosomes.
Philippidou P, Valdez G, Akmentin W, Bowers WJ, Federoff HJ, Halegoua S
Proceedings of the National Academy of Sciences of the United States of America108(2)852-7(2011 Jan)
MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis.
Buschow SI, van Balkom BW, Aalberts M, Heck AJ, Wauben M, Stoorvogel W
Immunology and cell biology88(8)851-6(2010 Nov-Dec)
EH domain proteins regulate cardiac membrane protein targeting.
Gudmundsson H, Hund TJ, Wright PJ, Kline CF, Snyder JS, Qian L, Koval OM, Cunha SR, George M, Rainey MA, Kashef FE, Dun W, Boyden PA, Anderson ME, Band H, Mohler PJ
Circulation research107(1)84-95(2010 Jul)
Alterations of EHD1/EHD4 protein levels interfere with L1/NgCAM endocytosis in neurons and disrupt axonal targeting.
Yap CC, Lasiecka ZM, Caplan S, Winckler B
The Journal of neuroscience : the official journal of the Society for Neuroscience30(19)6646-57(2010 May)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
Retrograde signaling through Pincher-generated Trk-multivesicular bodies is distinctively refractory to signal termination by lysosomal processing
Title: Trk retrograde signaling requires persistent, Pincher-directed endosomes.
balanced levels of EHD1 and EHD4 are important for NgCAM endocytosis in neurons; suggest that EHD1 plays roles in both endosomal recycling and a specialized endocytosis pathway in neurons used by NgCAM
Title: Alterations of EHD1/EHD4 protein levels interfere with L1/NgCAM endocytosis in neurons and disrupt axonal targeting.
Pincher-dependent macroendocytosis leads to the formation of Nogo-A signaling endosomes, which act both within growth cones and after retrograde transport in the cell body to negatively regulate the neuronal growth program.
Title: Pincher-generated Nogo-A endosomes mediate growth cone collapse and retrograde signaling.
The following Ehd4 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Ehd4 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | ORa01742 | |
Clone ID Related Accession (Same CDS sequence) | NM_139324.1 | |
Accession Version | NM_139324.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1626bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2017-09-30 | |
Organism | Rattus norvegicus(Norway rat) | |
Product | EH domain-containing protein 4 | |
Comment | Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AY094093.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AY094093.1, BC083175.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END## |
1 | ATGTTCAGCT GGATGGGGCG GCAGGCGGGC GGGCGCGAGC GCTCGGGCGG TATGGACGCG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_647540.1 |
CDS | 22..1647 |
Translation |
Target ORF information:
Target ORF information:
|
NM_139324.1 |
1 | ATGTTCAGCT GGATGGGGCG GCAGGCGGGC GGGCGCGAGC GCTCGGGCGG TATGGACGCG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
E-cadherin interactome complexity and robustness resolved by quantitative proteomics. |
Trk retrograde signaling requires persistent, Pincher-directed endosomes. |
MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis. |
EH domain proteins regulate cardiac membrane protein targeting. |
Alterations of EHD1/EHD4 protein levels interfere with L1/NgCAM endocytosis in neurons and disrupt axonal targeting. |