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Mcfd2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Summary

Gene Symbol Mcfd2
Entrez Gene ID 246117
Full Name multiple coagulation factor deficiency 2
Synonyms Sdnsf
General protein information
Preferred Names

multiple coagulation factor deficiency 2

Names

multiple coagulation factor deficiency protein 2 homolog
neural stem cell-derived neuronal survival protein
stem cell derived neuronal survival protein
Gene Type protein-coding
Organism Rattus norvegicus(Norway rat)
Genome

6

6q12
Summary a survival factor involved in maintaining stem cell potential and lifelong neurogenesis in the adult central nervous system [RGD, Feb 2006].

Reference Sequences (RefSeq)

mRNA and Protein(s)

mRNA Protein Name
XM_006239710.2 XP_006239772.1 multiple coagulation factor deficiency protein 2 homolog isoform X1
XM_006239711.3 XP_006239773.1 multiple coagulation factor deficiency protein 2 homolog isoform X1
NM_139253.1 NP_640346.1 multiple coagulation factor deficiency protein 2 homolog precursor

Pathways from BioSystems


Homologies


Mus musculus (house mouse) Mcfd2 NP_789778.1
Homo sapiens (human) MCFD2 NP_644808.1
Canis lupus familiaris (dog) MCFD2 XP_005626141.1
LOC717900 XP_001109911.2
Bos taurus (cattle) MCFD2 XP_005217264.1
Caenorhabditis elegans (roundworm) F55A11.1 NP_505967.1
Pan troglodytes (chimpanzee) MCFD2 XP_515454.3
Gallus gallus (chicken) MCFD2 NP_001006400.1
Xenopus tropicalis (tropical clawed frog) mcfd2 NP_001011062.1
Rattus norvegicus (Norway rat) Mcfd2 NP_640346.1
Danio rerio (zebrafish) mcfd2 NP_001005939.1

Gene Ontology


Bibliography

Related articles in PubMed

Mutations in the MCFD2 gene are predominant among patients with hereditary combined FV and FVIII deficiency (F5F8D) in India.
Jayandharan G, Spreafico M, Viswabandya A, Chandy M, Srivastava A, Peyvandi F
Haemophilia : the official journal of the World Federation of Hemophilia13(4)413-9(2007 Jul)

Expression change of stem cell-derived neural stem/progenitor cell supporting factor gene in injured spinal cord of rats.
Feng Y, Gao YL, Ding F, Liu Y
Neuroscience bulletin23(3)165-9(2007 May)

Stem cell-derived neural stem/progenitor cell supporting factor is an autocrine/paracrine survival factor for adult neural stem/progenitor cells.
Toda H, Tsuji M, Nakano I, Kobuke K, Hayashi T, Kasahara H, Takahashi J, Mizoguchi A, Houtani T, Sugimoto T, Hashimoto N, Palmer TD, Honjo T, Tashiro K
The Journal of biological chemistry278(37)35491-500(2003 Sep)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

SDNSF is expressed in the gray matter of spinal cord. The expression of SDNSF mRNA in the spinal cord varies with injured time. (2) The nestin-positive cells proliferate accompanied with spinal cord injury repair, but do not secrete SDNSF.
Title: Expression change of stem cell-derived neural stem/progenitor cell supporting factor gene in injured spinal cord of rats.

role as an autocrine/paracrine factor in maintaining stem cell potential and lifelong neurogenesis in adult central nervous system
Title: Stem cell-derived neural stem/progenitor cell supporting factor is an autocrine/paracrine survival factor for adult neural stem/progenitor cells.

The following Mcfd2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Mcfd2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID Accession No. Definition **Vector *Turnaround time Price (USD) Select
ORa42371 NM_139253.1
Latest version!		 Rattus norvegicus multiple coagulation factor deficiency 2, ER cargo receptor complex subunit (Mcfd2), mRNA. pcDNA3.1+/C-(K)DYK or customized vector 7-9 $69.30
$99.00
ORa29105 XM_006239710.2
Latest version!		 Rattus norvegicus multiple coagulation factor deficiency 2 (Mcfd2), transcript variant X1, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 7-9 $69.30
$99.00
ORa29105 XM_006239711.3
Latest version!		 Rattus norvegicus multiple coagulation factor deficiency 2 (Mcfd2), transcript variant X2, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 7-9 $69.30
$99.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone 30% OFF
2-4 Clone 40% OFF
5 or more Clone 50% OFF
All Other ORF Clones
30% OFF

*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)


CloneID ORa42371
Clone ID Related Accession (Same CDS sequence) NM_139253.1
Accession Version NM_139253.1 Latest version! Documents for ORF clone product in default vector
Sequence Information ORF Nucleotide Sequence (Length: 438bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ™ Seamless cloning technology
Insert Structure linear
Update Date 2019-11-19
Organism Rattus norvegicus(Norway rat)
Product multiple coagulation factor deficiency protein 2 homolog precursor
Comment Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AF475282.1. ##Evidence-Data-START## Transcript exon combination :: AF475282.1, BC071179.1 [ECO:0000332] ##Evidence-Data-END## 

1
61
121
181
241
301
361
421
ATGGCATCCC TGCAGCTGCT CAGAGGTCCC TTCCTGTGTG TTCTGCTCTG GGCCTTTTGT 
GTTCCTGGTG CCAGGGCCCA GGAGCATGGG GCTGGTGTCC ACCATGGCAG CGTGGGCCTG 
GACAAGAGCA CAGTGCACGA CCAAGAGCAC ATTATGGAAC ATCTGGAAGG TGTCATCAAC 
CAGCCAGAGG CGGAGATGTC CCCACAGGAA CTACAGCTCC ATTATTTCAA AATGCATGAT 
TACGATGGCA ACAGTTTGCT TGATGGCTTA GAGCTCTCGA CGGCCATCAC TCACGTGCAC 
AAGGAGGAGG GGAGTGAGCA GGTCCCACCC ATGAGCGAGG ACGAGCTCAT CAGCATCATA 
GACGGTGTCC TGAGAGACGA CGACAAGAAC AATGACGGCT ACATCGACTA TGCAGAGTTT 
GCCAAGTCGC TGCAGTAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_640346.1
CDS80..517
Translation

Target ORF information:

RefSeq Version NM_139253.1
Organism Rattus norvegicus(Norway rat)
Definition Rattus norvegicus multiple coagulation factor deficiency 2, ER cargo receptor complex subunit (Mcfd2), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
 NM_139253.1

ORF Insert Sequence:

1
61
121
181
241
301
361
421
ATGGCATCCC TGCAGCTGCT CAGAGGTCCC TTCCTGTGTG TTCTGCTCTG GGCCTTTTGT 
GTTCCTGGTG CCAGGGCCCA GGAGCATGGG GCTGGTGTCC ACCATGGCAG CGTGGGCCTG 
GACAAGAGCA CAGTGCACGA CCAAGAGCAC ATTATGGAAC ATCTGGAAGG TGTCATCAAC 
CAGCCAGAGG CGGAGATGTC CCCACAGGAA CTACAGCTCC ATTATTTCAA AATGCATGAT 
TACGATGGCA ACAGTTTGCT TGATGGCTTA GAGCTCTCGA CGGCCATCAC TCACGTGCAC 
AAGGAGGAGG GGAGTGAGCA GGTCCCACCC ATGAGCGAGG ACGAGCTCAT CAGCATCATA 
GACGGTGTCC TGAGAGACGA CGACAAGAAC AATGACGGCT ACATCGACTA TGCAGAGTTT 
GCCAAGTCGC TGCAGTAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID ORa29105
Clone ID Related Accession (Same CDS sequence) XM_006239710.2 , XM_006239711.3
Accession Version XM_006239710.2 Latest version! Documents for ORF clone product in default vector
Sequence Information ORF Nucleotide Sequence (Length: 438bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ™ Seamless cloning technology
Insert Structure linear
Update Date 2016-07-25
Organism Rattus norvegicus(Norway rat)
Product multiple coagulation factor deficiency protein 2 homolog isoform X1
Comment Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005105.4) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Aug 7, 2014 this sequence version replaced XM_006239710.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## 

1
61
121
181
241
301
361
421
ATGGCATCCC TGCAGCTGCT CAGAGGTCCC TTCCTGTGTG TTCTGCTCTG GGCCTTTTGT 
GTTCCTGGTG CCAGGGCCCA GGAGCATGGG GCTGGTGTCC ACTATGGCAG CGTGGGCCTG 
GACAAGAGCA CAGTGCACGA CCAAGAGCAC ATTATGGAAC ATCTGGAAGG TGTCATCAAC 
CAGCCAGAGG CGGAGATGTC CCCACAGGAA CTACAGCTCC ATTATTTCAA AATGCATGAT 
TACGATGGCA ACAGTTTGCT TGATGGCTTA GAGCTCTCGA CGGCCATCAC TCACGTGCAC 
AAGGAGGAGG GGAGTGAGCA GGTCCCACCC ATGAGCGAGG ACGAGCTCAT CAGCATCATA 
GACGGTGTCC TGAGAGACGA CGACAAGAAC AATGACGGCT ACATCGACTA TGCAGAGTTT 
GCCAAGTCGC TGCAGTAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq XP_006239772.1
CDS119..556
Translation

Target ORF information:

RefSeq Version XM_006239710.2
Organism Rattus norvegicus(Norway rat)
Definition Rattus norvegicus multiple coagulation factor deficiency 2 (Mcfd2), transcript variant X1, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
 XM_006239710.2

ORF Insert Sequence:

1
61
121
181
241
301
361
421
ATGGCATCCC TGCAGCTGCT CAGAGGTCCC TTCCTGTGTG TTCTGCTCTG GGCCTTTTGT 
GTTCCTGGTG CCAGGGCCCA GGAGCATGGG GCTGGTGTCC ACTATGGCAG CGTGGGCCTG 
GACAAGAGCA CAGTGCACGA CCAAGAGCAC ATTATGGAAC ATCTGGAAGG TGTCATCAAC 
CAGCCAGAGG CGGAGATGTC CCCACAGGAA CTACAGCTCC ATTATTTCAA AATGCATGAT 
TACGATGGCA ACAGTTTGCT TGATGGCTTA GAGCTCTCGA CGGCCATCAC TCACGTGCAC 
AAGGAGGAGG GGAGTGAGCA GGTCCCACCC ATGAGCGAGG ACGAGCTCAT CAGCATCATA 
GACGGTGTCC TGAGAGACGA CGACAAGAAC AATGACGGCT ACATCGACTA TGCAGAGTTT 
GCCAAGTCGC TGCAGTAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID ORa29105
Clone ID Related Accession (Same CDS sequence) XM_006239710.2 , XM_006239711.3
Accession Version XM_006239711.3 Latest version! Documents for ORF clone product in default vector
Sequence Information ORF Nucleotide Sequence (Length: 438bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ™ Seamless cloning technology
Insert Structure linear
Update Date 2016-07-25
Organism Rattus norvegicus(Norway rat)
Product multiple coagulation factor deficiency protein 2 homolog isoform X1
Comment Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005105.4) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_006239711.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## 

1
61
121
181
241
301
361
421
ATGGCATCCC TGCAGCTGCT CAGAGGTCCC TTCCTGTGTG TTCTGCTCTG GGCCTTTTGT 
GTTCCTGGTG CCAGGGCCCA GGAGCATGGG GCTGGTGTCC ACTATGGCAG CGTGGGCCTG 
GACAAGAGCA CAGTGCACGA CCAAGAGCAC ATTATGGAAC ATCTGGAAGG TGTCATCAAC 
CAGCCAGAGG CGGAGATGTC CCCACAGGAA CTACAGCTCC ATTATTTCAA AATGCATGAT 
TACGATGGCA ACAGTTTGCT TGATGGCTTA GAGCTCTCGA CGGCCATCAC TCACGTGCAC 
AAGGAGGAGG GGAGTGAGCA GGTCCCACCC ATGAGCGAGG ACGAGCTCAT CAGCATCATA 
GACGGTGTCC TGAGAGACGA CGACAAGAAC AATGACGGCT ACATCGACTA TGCAGAGTTT 
GCCAAGTCGC TGCAGTAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq XP_006239773.1
CDS143..580
Translation

Target ORF information:

RefSeq Version XM_006239711.3
Organism Rattus norvegicus(Norway rat)
Definition Rattus norvegicus multiple coagulation factor deficiency 2 (Mcfd2), transcript variant X2, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
 XM_006239711.3

ORF Insert Sequence:

1
61
121
181
241
301
361
421
ATGGCATCCC TGCAGCTGCT CAGAGGTCCC TTCCTGTGTG TTCTGCTCTG GGCCTTTTGT 
GTTCCTGGTG CCAGGGCCCA GGAGCATGGG GCTGGTGTCC ACTATGGCAG CGTGGGCCTG 
GACAAGAGCA CAGTGCACGA CCAAGAGCAC ATTATGGAAC ATCTGGAAGG TGTCATCAAC 
CAGCCAGAGG CGGAGATGTC CCCACAGGAA CTACAGCTCC ATTATTTCAA AATGCATGAT 
TACGATGGCA ACAGTTTGCT TGATGGCTTA GAGCTCTCGA CGGCCATCAC TCACGTGCAC 
AAGGAGGAGG GGAGTGAGCA GGTCCCACCC ATGAGCGAGG ACGAGCTCAT CAGCATCATA 
GACGGTGTCC TGAGAGACGA CGACAAGAAC AATGACGGCT ACATCGACTA TGCAGAGTTT 
GCCAAGTCGC TGCAGTAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

PubMed

book

Mutations in the MCFD2 gene are predominant among patients with hereditary combined FV and FVIII deficiency (F5F8D) in India.
Haemophilia : the official journal of the World Federation of Hemophilia13(4)413-9(2007 Jul)
Jayandharan G,Spreafico M,Viswabandya A,Chandy M,Srivastava A,Peyvandi F


book

Expression change of stem cell-derived neural stem/progenitor cell supporting factor gene in injured spinal cord of rats.
Neuroscience bulletin23(3)165-9(2007 May)
Feng Y,Gao YL,Ding F,Liu Y


book

Stem cell-derived neural stem/progenitor cell supporting factor is an autocrine/paracrine survival factor for adult neural stem/progenitor cells.
The Journal of biological chemistry278(37)35491-500(2003 Sep)
Toda H,Tsuji M,Nakano I,Kobuke K,Hayashi T,Kasahara H,Takahashi J,Mizoguchi A,Houtani T,Sugimoto T,Hashimoto N,Palmer TD,Honjo T,Tashiro K