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Cyp1b1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Summary

Gene Symbol Cyp1b1
Entrez Gene ID 25426
Full Name cytochrome P450, family 1, subfamily b, polypeptide 1
General protein information
Preferred Names

cytochrome P450, family 1, subfamily b, polypeptide 1

Names

cytochrome P450 1B1
CYPIB1
P450RAP
cytochrome P450, subfamily 1B, polypeptide 1
cytochrome P450RAP
Gene Type protein-coding
Organism Rattus norvegicus(Norway rat)
Genome

6

6q11
Summary plays a role in polycyclic aromatic hydrocarbon metabolism in adrenal microsomes [RGD, Feb 2006].

Reference Sequences (RefSeq)

mRNA and Protein(s)

mRNA Protein Name
XM_017594045.1 XP_017449534.1 cytochrome P450 1B1 isoform X1
XM_017594046.1 XP_017449535.1 cytochrome P450 1B1 isoform X1
NM_012940.2 NP_037072.1 cytochrome P450 1B1

Pathways from BioSystems


Homologies


Pan troglodytes (chimpanzee) CYP1B1 XP_001167556.1
Canis lupus familiaris (dog) CYP1B1 NP_001153156.1
Bos taurus (cattle) CYP1B1 NP_001179223.1
Xenopus tropicalis (tropical clawed frog) LOC100490477 XP_002933924.1
Mus musculus (house mouse) Cyp1b1 NP_034124.1
Oryza sativa (rice) Os10g0320100 NP_001064338.1
Gallus gallus (chicken) CYP1B1 XP_419515.4
Homo sapiens (human) CYP1B1 NP_000095.2
CYP1B1 XP_001109361.1
Oryza sativa (rice) Os10g0317900 NP_001064333.1
Rattus norvegicus (Norway rat) Cyp1b1 NP_037072.1
Danio rerio (zebrafish) cyp1b1 NP_001139180.1
Arabidopsis thaliana (thale cress) TT7 NP_196416.1

Gene Ontology


Bibliography

Related articles in PubMed

Cytochrome P450 1A1 and 1B1 promoter CpG island methylation regulates rat liver injury induced by isoniazid.
Li Y, Li Y, Zheng G, Zhu L, Wang J, Mu S, Ren Q, Feng F
Molecular medicine reports17(1)753-762(2018 Jan)

Ontogeny of the major xenobiotic-metabolizing enzymes expression and the dietary lipids modulatory effect in the rat dimethylbenz(a)anthracene-induced breast cancer model.
Manzanares M?, Solanas M, Moral R, Escrich R, Vela E, Escrich E
Journal of biochemical and molecular toxicology28(12)539-48(2014 Dec)

Induction of CYP1A1, CYP1A2, CYP1B1, increased oxidative stress and inflammation in the lung and liver tissues of rats exposed to incense smoke.
Hussain T, Al-Attas OS, Al-Daghri NM, Mohammed AA, De Rosas E, Ibrahim S, Vinodson B, Ansari MG, El-Din KI
Molecular and cellular biochemistry391(1-2)127-36(2014 Jun)

Cytochrome P450 1B1 contributes to increased blood pressure and cardiovascular and renal dysfunction in spontaneously hypertensive rats.
Jennings BL, Montanez DE, May ME Jr, Estes AM, Fang XR, Yaghini FA, Kanu A, Malik KU
Cardiovascular drugs and therapy28(2)145-61(2014 Apr)

Inflammatory mediators accelerate metabolism of benzo[a]pyrene in rat alveolar type II cells: the role of enhanced cytochrome P450 1B1 expression.
Smerdov? L, Ne?a J, Svobodov? J, Topinka J, Schmuczerov? J, Kozub?k A, Machala M, Vondr??ek J
Toxicology314(1)30-8(2013 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The influence of dietary lipids on the ontogeny of XMEs was also evaluated. mRNA and protein levels of phase I (CYP1A1, CYP1A2, and CYP1B1) and phase II (NAD(P)H:quinone acceptor oxidoreductase 1 and GSTP1) enzymes were analyzed.
Title: Ontogeny of the major xenobiotic-metabolizing enzymes expression and the dietary lipids modulatory effect in the rat dimethylbenz(a)anthracene-induced breast cancer model.

Incense smoke exposure significantly induced the expression of CYP1A1, CYP1A2, and CYP1B1 mRNAs in both lung and liver tissues.
Title: Induction of CYP1A1, CYP1A2, CYP1B1, increased oxidative stress and inflammation in the lung and liver tissues of rats exposed to incense smoke.

Increased oxidative stress generated by CYP1B1 contributes to hypertension.
Title: Cytochrome P450 1B1 contributes to increased blood pressure and cardiovascular and renal dysfunction in spontaneously hypertensive rats.

Diphenylarsinic acid induced the expression of CYP1B1 in the liver and caused oxidative DNA damage.
Title: Diphenylarsinic acid, a chemical warfare-related neurotoxicant, promotes liver carcinogenesis via activation of aryl hydrocarbon receptor signaling and consequent induction of oxidative DNA damage in rats.

Luteinizing hormone upregulates CYP1B1 protein expression in rat R2C leydig cells.
Title: Regulation of cytochrome P450 1B1 expression by luteinizing hormone in mouse MA-10 and rat R2C Leydig cells: role of protein kinase A.

The following Cyp1b1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Cyp1b1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID Accession No. Definition **Vector *Turnaround time Price (USD) Select
ORa42737 NM_012940.2
Latest version!		 Rattus norvegicus cytochrome P450, family 1, subfamily b, polypeptide 1 (Cyp1b1), mRNA. pcDNA3.1+/C-(K)DYK or customized vector 7-9 $321.30
$459.00
ORa61560 XM_017594045.1
Latest version!		 Rattus norvegicus cytochrome P450, family 1, subfamily b, polypeptide 1 (Cyp1b1), transcript variant X1, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 9-11 $223.30
$319.00
ORa61560 XM_017594046.1
Latest version!		 Rattus norvegicus cytochrome P450, family 1, subfamily b, polypeptide 1 (Cyp1b1), transcript variant X2, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 9-11 $223.30
$319.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)


CloneID ORa42737
Clone ID Related Accession (Same CDS sequence) NM_012940.2
Accession Version NM_012940.2 Latest version! Documents for ORF clone product in default vector
Sequence Information ORF Nucleotide Sequence (Length: 1632bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ™ Seamless cloning technology
Insert Structure linear
Update Date 2019-09-28
Organism Rattus norvegicus(Norway rat)
Product cytochrome P450 1B1
Comment Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from U09540.1. On Apr 12, 2007 this sequence version replaced NM_012940.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: U09540.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END## 

1
61
121
181
241
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361
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481
541
601
661
721
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841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
ATGGCCACCA GCCTTAGTGC AGACAGTCCA CAGCAGCTGA GCTCGCTGTC TACCCAACAG 
ACCATTCTTC TGCTACTCGT TTCGGTCCTG GCCATCGTGC ACTTAGGCCA GTGGCTGCTG 
CGCCAGTGGC GACGGAAACC GTGGTCCTCG CCCCCGGGTC CCTTTCCTTG GCCATTGATC 
GGAAACGCGG CGTCTGTTGG CCGGGCATCG CACTTGTACT TCGCTCGCCT TGCGAGGCGC 
TATGGCGACG TTTTTCAGAT CCGTCTGGGC AGCTGTCCCG TGGTGGTGCT GAATGGCGAG 
AGTGCCATCC ATCAGGCTCT GGTGCAGCAG GGCGGCGTCT TTGCGGACCG GCCTCCCTTC 
GCCTCTTTCC GTGTGGTGTC TGGTGGCCGC AGCCTGGCGT TCGGCCACTA CTCAGAGCGC 
TGGAAGGAGC GGCGACGTGC AGCCTATGGC ACGATGCGTG CCTTCTCCAC CCGCCACCCG 
CGCAGCCGCG GTCTCCTCGA GGGCCACGCG CTGGGAGAGG CTCGAGAGTT GGTGGCAGTG 
TTGGTGCGGC GCTGCGCCGG TGGCGCCTGC CTCGATCCGA CGCAGCCGAT CATAGTGGCG 
GTGGCTAATG TCATGAGCGC TGTATGCTTC GGCTGTCGGT ACAACCACGA CGATGCCGAG 
TTCCTGGAGC TGCTCAGCCA CAACGAGGAG TTCGGGCGCA CCGTGGGCGC GGGCAGCCTG 
GTGGACGTGA TGCCCTGGCT GCAGCTTTTT CCCAACCCGG TGCGCACCAT CTTCCGCGAG 
TTCGAGCAGA TCAACCGCAA CTTCAGCAAC TTCGTCCTGG ACAAGTTCCT GAGGCACCGA 
GAAAGCCTCG TGCCCGGGGC TGCTCCTCGA GACATGATGG ACGCCTTCAT CCTCTCCGCC 
GAAAAGAAGG CGACTGGGGA CCCTGGTGAC AGTCCCTCCG GGCTGGATTT GGAGGATGTG 
CCTGCCACTA TTACAGACAT CTTTGGAGCC AGCCAGGACA CCCTTTCCAC CGCGCTGCTG 
TGGCTGCTCA TCCTCTTTAC CAGATACCCG GATGTGCAGG CCCGCGTGCA GGCCGAGTTG 
GACCAGGTTG TGGGGAGGGA CCGCCTGCCC TGCATGAGTG ACCAACCCAA CTTACCATAC 
GTCATGGCTT TTCTTTATGA ATCCATGCGA TTCACCAGCT TTTTGCCTGT CACCCTTCCA 
CATGCCACCA CTGCCAACAC CTTTGTTTTA GGCTACTACA TCCCCAAAAA CACGGTAGTT 
TTTGTTAACC AGTGGTCTGT GAATCATGAC CCAGCAAAGT GGTCTAACCC AGAGGACTTT 
GATCCGGCCC GCTTCCTGGA CAAGGACGGC TTCATTAACA AGGCACTAGC CAGCAGCGTG 
ATGATATTTT CAGTGGGCAA ACGACGGTGC ATCGGCGAGG AGTTGTCTAA GACGCTTCTG 
TTTCTCTTCA TCTCCATCCT CGCTCATCAG TGCAATTTCA AGGCTAACCA AAACGAGCCC 
TCAAACATGA GTTTCAGTTA CGGCCTGAGC ATTAAGCCCA AGTCGTTTAA AATCCATGTG 
TCTCTCAGAG AGTCCATGAA GCTCCTTGAT AGTGCTGTCG AGAAGCTGCA AGCTGAGGAA 
GCTTGCCAGT GA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_037072.1
CDS372..2003
Translation

Target ORF information:

RefSeq Version NM_012940.2
Organism Rattus norvegicus(Norway rat)
Definition Rattus norvegicus cytochrome P450, family 1, subfamily b, polypeptide 1 (Cyp1b1), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
 NM_012940.2

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
ATGGCCACCA GCCTTAGTGC AGACAGTCCA CAGCAGCTGA GCTCGCTGTC TACCCAACAG 
ACCATTCTTC TGCTACTCGT TTCGGTCCTG GCCATCGTGC ACTTAGGCCA GTGGCTGCTG 
CGCCAGTGGC GACGGAAACC GTGGTCCTCG CCCCCGGGTC CCTTTCCTTG GCCATTGATC 
GGAAACGCGG CGTCTGTTGG CCGGGCATCG CACTTGTACT TCGCTCGCCT TGCGAGGCGC 
TATGGCGACG TTTTTCAGAT CCGTCTGGGC AGCTGTCCCG TGGTGGTGCT GAATGGCGAG 
AGTGCCATCC ATCAGGCTCT GGTGCAGCAG GGCGGCGTCT TTGCGGACCG GCCTCCCTTC 
GCCTCTTTCC GTGTGGTGTC TGGTGGCCGC AGCCTGGCGT TCGGCCACTA CTCAGAGCGC 
TGGAAGGAGC GGCGACGTGC AGCCTATGGC ACGATGCGTG CCTTCTCCAC CCGCCACCCG 
CGCAGCCGCG GTCTCCTCGA GGGCCACGCG CTGGGAGAGG CTCGAGAGTT GGTGGCAGTG 
TTGGTGCGGC GCTGCGCCGG TGGCGCCTGC CTCGATCCGA CGCAGCCGAT CATAGTGGCG 
GTGGCTAATG TCATGAGCGC TGTATGCTTC GGCTGTCGGT ACAACCACGA CGATGCCGAG 
TTCCTGGAGC TGCTCAGCCA CAACGAGGAG TTCGGGCGCA CCGTGGGCGC GGGCAGCCTG 
GTGGACGTGA TGCCCTGGCT GCAGCTTTTT CCCAACCCGG TGCGCACCAT CTTCCGCGAG 
TTCGAGCAGA TCAACCGCAA CTTCAGCAAC TTCGTCCTGG ACAAGTTCCT GAGGCACCGA 
GAAAGCCTCG TGCCCGGGGC TGCTCCTCGA GACATGATGG ACGCCTTCAT CCTCTCCGCC 
GAAAAGAAGG CGACTGGGGA CCCTGGTGAC AGTCCCTCCG GGCTGGATTT GGAGGATGTG 
CCTGCCACTA TTACAGACAT CTTTGGAGCC AGCCAGGACA CCCTTTCCAC CGCGCTGCTG 
TGGCTGCTCA TCCTCTTTAC CAGATACCCG GATGTGCAGG CCCGCGTGCA GGCCGAGTTG 
GACCAGGTTG TGGGGAGGGA CCGCCTGCCC TGCATGAGTG ACCAACCCAA CTTACCATAC 
GTCATGGCTT TTCTTTATGA ATCCATGCGA TTCACCAGCT TTTTGCCTGT CACCCTTCCA 
CATGCCACCA CTGCCAACAC CTTTGTTTTA GGCTACTACA TCCCCAAAAA CACGGTAGTT 
TTTGTTAACC AGTGGTCTGT GAATCATGAC CCAGCAAAGT GGTCTAACCC AGAGGACTTT 
GATCCGGCCC GCTTCCTGGA CAAGGACGGC TTCATTAACA AGGCACTAGC CAGCAGCGTG 
ATGATATTTT CAGTGGGCAA ACGACGGTGC ATCGGCGAGG AGTTGTCTAA GACGCTTCTG 
TTTCTCTTCA TCTCCATCCT CGCTCATCAG TGCAATTTCA AGGCTAACCA AAACGAGCCC 
TCAAACATGA GTTTCAGTTA CGGCCTGAGC ATTAAGCCCA AGTCGTTTAA AATCCATGTG 
TCTCTCAGAG AGTCCATGAA GCTCCTTGAT AGTGCTGTCG AGAAGCTGCA AGCTGAGGAA 
GCTTGCCAGT GA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID ORa61560
Clone ID Related Accession (Same CDS sequence) XM_017594045.1 , XM_017594046.1
Accession Version XM_017594045.1 Latest version! Documents for ORF clone product in default vector
Sequence Information ORF Nucleotide Sequence (Length: 1122bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ™ Seamless cloning technology
Insert Structure linear
Update Date 2016-07-25
Organism Rattus norvegicus(Norway rat)
Product cytochrome P450 1B1 isoform X1
Comment Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005105.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## 

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
ATGGCCACCA GCCTTAGTGC AGACAGTCCA CAGCAGCTGA GCTCGCTGTC TACCCAACAG 
ACCATTCTTC TGCTACTCGT TTCGGTCCTG GCCATCGTGC ACTTAGGCCA GTGGCTGCTG 
CGCCAGTGGC GACGGAAACC GTGGTCCTCG CCCCCGGGTC CCTTTCCTTG GCCATTGATC 
GGAAACGCGG CGTCTGTTGG CCGGGCATCG CACTTGTACT TCGCTCGCCT TGCGAGGCGC 
TATGGCGACG TTTTTCAGAT CCGTCTGGGC AGCTGTCCCG TGGTGGTGCT GAATGGCGAG 
AGTGCCATCC ATCAGGCTCT GGTGCAGCAG GGCGGCGTCT TTGCGGACCG GCCTCCCTTC 
GCCTCTTTCC GTGTGGTGTC TGGTGGCCGC AGCCTGGCGT TCGGCCACTA CTCAGAGCGC 
TGGAAGGAGC GGCGACGTGC AGCCTATGGC ACGATGCGTG CCTTCTCCAC CCGCCACCCG 
CGCAGCCGCG GTCTCCTCGA GGGCCACGCG CTGGGAGAGG CTCGAGAGTT GGTGGCAGTG 
TTGGTGCGGC GCTGCGCCGG TGGCGCCTGC CTCGATCCGA CGCAGCCGAT CATAGTGGCG 
GTGGCTAATG TCATGAGCGC TGTATGCTTC GGCTGTCGGT ACAACCACGA CGATGCCGAG 
TTCCTGGAGC TGCTCAGCCA CAACGAGGAG TTCGGGCGCA CCGTGGGCGC GGGCAGCCTG 
GTGGACGTGA TGCCCTGGCT GCAGCTTTTT CCCAACCCGG TGCGCACCAT CTTCCGCGAG 
TTCGAGCAGA TCAACCGCAA CTTCAGCAAC TTCGTCCTGG ACAAGTTCCT GAGGCACCGA 
GAAAGCCTCG TGCCCGGGGC TGCTCCTCGA GACATGATGG ACGCCTTCAT CCTCTCCGCC 
GAAAAGAAGG CGACTGGGGA CCCTGGTGAC AGTCCCTCCG GGCTGGATTT GGAGGATGTG 
CCTGCCACTA TTACAGACAT CTTTGGAGCC AGCCAGGACA CCCTTTCCAC CGCGCTGCTG 
TGGCTGCTCA TCCTCTTTAC CAGATACCGG ATGTGCAGGC CCCGCGTGCA GGCCGCGAGT 
TGGACCAGGT TGTGGGAGGG ACCGCCTGGC CTGCATGAGT GA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq XP_017449534.1
CDS389..1510
Translation

Target ORF information:

RefSeq Version XM_017594045.1
Organism Rattus norvegicus(Norway rat)
Definition Rattus norvegicus cytochrome P450, family 1, subfamily b, polypeptide 1 (Cyp1b1), transcript variant X1, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
 XM_017594045.1

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
ATGGCCACCA GCCTTAGTGC AGACAGTCCA CAGCAGCTGA GCTCGCTGTC TACCCAACAG 
ACCATTCTTC TGCTACTCGT TTCGGTCCTG GCCATCGTGC ACTTAGGCCA GTGGCTGCTG 
CGCCAGTGGC GACGGAAACC GTGGTCCTCG CCCCCGGGTC CCTTTCCTTG GCCATTGATC 
GGAAACGCGG CGTCTGTTGG CCGGGCATCG CACTTGTACT TCGCTCGCCT TGCGAGGCGC 
TATGGCGACG TTTTTCAGAT CCGTCTGGGC AGCTGTCCCG TGGTGGTGCT GAATGGCGAG 
AGTGCCATCC ATCAGGCTCT GGTGCAGCAG GGCGGCGTCT TTGCGGACCG GCCTCCCTTC 
GCCTCTTTCC GTGTGGTGTC TGGTGGCCGC AGCCTGGCGT TCGGCCACTA CTCAGAGCGC 
TGGAAGGAGC GGCGACGTGC AGCCTATGGC ACGATGCGTG CCTTCTCCAC CCGCCACCCG 
CGCAGCCGCG GTCTCCTCGA GGGCCACGCG CTGGGAGAGG CTCGAGAGTT GGTGGCAGTG 
TTGGTGCGGC GCTGCGCCGG TGGCGCCTGC CTCGATCCGA CGCAGCCGAT CATAGTGGCG 
GTGGCTAATG TCATGAGCGC TGTATGCTTC GGCTGTCGGT ACAACCACGA CGATGCCGAG 
TTCCTGGAGC TGCTCAGCCA CAACGAGGAG TTCGGGCGCA CCGTGGGCGC GGGCAGCCTG 
GTGGACGTGA TGCCCTGGCT GCAGCTTTTT CCCAACCCGG TGCGCACCAT CTTCCGCGAG 
TTCGAGCAGA TCAACCGCAA CTTCAGCAAC TTCGTCCTGG ACAAGTTCCT GAGGCACCGA 
GAAAGCCTCG TGCCCGGGGC TGCTCCTCGA GACATGATGG ACGCCTTCAT CCTCTCCGCC 
GAAAAGAAGG CGACTGGGGA CCCTGGTGAC AGTCCCTCCG GGCTGGATTT GGAGGATGTG 
CCTGCCACTA TTACAGACAT CTTTGGAGCC AGCCAGGACA CCCTTTCCAC CGCGCTGCTG 
TGGCTGCTCA TCCTCTTTAC CAGATACCGG ATGTGCAGGC CCCGCGTGCA GGCCGCGAGT 
TGGACCAGGT TGTGGGAGGG ACCGCCTGGC CTGCATGAGT GA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID ORa61560
Clone ID Related Accession (Same CDS sequence) XM_017594045.1 , XM_017594046.1
Accession Version XM_017594046.1 Latest version! Documents for ORF clone product in default vector
Sequence Information ORF Nucleotide Sequence (Length: 1122bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ™ Seamless cloning technology
Insert Structure linear
Update Date 2016-07-25
Organism Rattus norvegicus(Norway rat)
Product cytochrome P450 1B1 isoform X1
Comment Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005105.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## 

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
ATGGCCACCA GCCTTAGTGC AGACAGTCCA CAGCAGCTGA GCTCGCTGTC TACCCAACAG 
ACCATTCTTC TGCTACTCGT TTCGGTCCTG GCCATCGTGC ACTTAGGCCA GTGGCTGCTG 
CGCCAGTGGC GACGGAAACC GTGGTCCTCG CCCCCGGGTC CCTTTCCTTG GCCATTGATC 
GGAAACGCGG CGTCTGTTGG CCGGGCATCG CACTTGTACT TCGCTCGCCT TGCGAGGCGC 
TATGGCGACG TTTTTCAGAT CCGTCTGGGC AGCTGTCCCG TGGTGGTGCT GAATGGCGAG 
AGTGCCATCC ATCAGGCTCT GGTGCAGCAG GGCGGCGTCT TTGCGGACCG GCCTCCCTTC 
GCCTCTTTCC GTGTGGTGTC TGGTGGCCGC AGCCTGGCGT TCGGCCACTA CTCAGAGCGC 
TGGAAGGAGC GGCGACGTGC AGCCTATGGC ACGATGCGTG CCTTCTCCAC CCGCCACCCG 
CGCAGCCGCG GTCTCCTCGA GGGCCACGCG CTGGGAGAGG CTCGAGAGTT GGTGGCAGTG 
TTGGTGCGGC GCTGCGCCGG TGGCGCCTGC CTCGATCCGA CGCAGCCGAT CATAGTGGCG 
GTGGCTAATG TCATGAGCGC TGTATGCTTC GGCTGTCGGT ACAACCACGA CGATGCCGAG 
TTCCTGGAGC TGCTCAGCCA CAACGAGGAG TTCGGGCGCA CCGTGGGCGC GGGCAGCCTG 
GTGGACGTGA TGCCCTGGCT GCAGCTTTTT CCCAACCCGG TGCGCACCAT CTTCCGCGAG 
TTCGAGCAGA TCAACCGCAA CTTCAGCAAC TTCGTCCTGG ACAAGTTCCT GAGGCACCGA 
GAAAGCCTCG TGCCCGGGGC TGCTCCTCGA GACATGATGG ACGCCTTCAT CCTCTCCGCC 
GAAAAGAAGG CGACTGGGGA CCCTGGTGAC AGTCCCTCCG GGCTGGATTT GGAGGATGTG 
CCTGCCACTA TTACAGACAT CTTTGGAGCC AGCCAGGACA CCCTTTCCAC CGCGCTGCTG 
TGGCTGCTCA TCCTCTTTAC CAGATACCGG ATGTGCAGGC CCCGCGTGCA GGCCGCGAGT 
TGGACCAGGT TGTGGGAGGG ACCGCCTGGC CTGCATGAGT GA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq XP_017449535.1
CDS99..1220
Translation

Target ORF information:

RefSeq Version XM_017594046.1
Organism Rattus norvegicus(Norway rat)
Definition Rattus norvegicus cytochrome P450, family 1, subfamily b, polypeptide 1 (Cyp1b1), transcript variant X2, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
 XM_017594046.1

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
ATGGCCACCA GCCTTAGTGC AGACAGTCCA CAGCAGCTGA GCTCGCTGTC TACCCAACAG 
ACCATTCTTC TGCTACTCGT TTCGGTCCTG GCCATCGTGC ACTTAGGCCA GTGGCTGCTG 
CGCCAGTGGC GACGGAAACC GTGGTCCTCG CCCCCGGGTC CCTTTCCTTG GCCATTGATC 
GGAAACGCGG CGTCTGTTGG CCGGGCATCG CACTTGTACT TCGCTCGCCT TGCGAGGCGC 
TATGGCGACG TTTTTCAGAT CCGTCTGGGC AGCTGTCCCG TGGTGGTGCT GAATGGCGAG 
AGTGCCATCC ATCAGGCTCT GGTGCAGCAG GGCGGCGTCT TTGCGGACCG GCCTCCCTTC 
GCCTCTTTCC GTGTGGTGTC TGGTGGCCGC AGCCTGGCGT TCGGCCACTA CTCAGAGCGC 
TGGAAGGAGC GGCGACGTGC AGCCTATGGC ACGATGCGTG CCTTCTCCAC CCGCCACCCG 
CGCAGCCGCG GTCTCCTCGA GGGCCACGCG CTGGGAGAGG CTCGAGAGTT GGTGGCAGTG 
TTGGTGCGGC GCTGCGCCGG TGGCGCCTGC CTCGATCCGA CGCAGCCGAT CATAGTGGCG 
GTGGCTAATG TCATGAGCGC TGTATGCTTC GGCTGTCGGT ACAACCACGA CGATGCCGAG 
TTCCTGGAGC TGCTCAGCCA CAACGAGGAG TTCGGGCGCA CCGTGGGCGC GGGCAGCCTG 
GTGGACGTGA TGCCCTGGCT GCAGCTTTTT CCCAACCCGG TGCGCACCAT CTTCCGCGAG 
TTCGAGCAGA TCAACCGCAA CTTCAGCAAC TTCGTCCTGG ACAAGTTCCT GAGGCACCGA 
GAAAGCCTCG TGCCCGGGGC TGCTCCTCGA GACATGATGG ACGCCTTCAT CCTCTCCGCC 
GAAAAGAAGG CGACTGGGGA CCCTGGTGAC AGTCCCTCCG GGCTGGATTT GGAGGATGTG 
CCTGCCACTA TTACAGACAT CTTTGGAGCC AGCCAGGACA CCCTTTCCAC CGCGCTGCTG 
TGGCTGCTCA TCCTCTTTAC CAGATACCGG ATGTGCAGGC CCCGCGTGCA GGCCGCGAGT 
TGGACCAGGT TGTGGGAGGG ACCGCCTGGC CTGCATGAGT GA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

PubMed

book

Cytochrome P450 1A1 and 1B1 promoter CpG island methylation regulates rat liver injury induced by isoniazid.
Molecular medicine reports17(1)753-762(2018 Jan)
Li Y,Li Y,Zheng G,Zhu L,Wang J,Mu S,Ren Q,Feng F


book

Ontogeny of the major xenobiotic-metabolizing enzymes expression and the dietary lipids modulatory effect in the rat dimethylbenz(a)anthracene-induced breast cancer model.
Journal of biochemical and molecular toxicology28(12)539-48(2014 Dec)
Manzanares M?,Solanas M,Moral R,Escrich R,Vela E,Escrich E


book

Induction of CYP1A1, CYP1A2, CYP1B1, increased oxidative stress and inflammation in the lung and liver tissues of rats exposed to incense smoke.
Molecular and cellular biochemistry391(1-2)127-36(2014 Jun)
Hussain T,Al-Attas OS,Al-Daghri NM,Mohammed AA,De Rosas E,Ibrahim S,Vinodson B,Ansari MG,El-Din KI


book

Cytochrome P450 1B1 contributes to increased blood pressure and cardiovascular and renal dysfunction in spontaneously hypertensive rats.
Cardiovascular drugs and therapy28(2)145-61(2014 Apr)
Jennings BL,Montanez DE,May ME Jr,Estes AM,Fang XR,Yaghini FA,Kanu A,Malik KU


book

Inflammatory mediators accelerate metabolism of benzo[a]pyrene in rat alveolar type II cells: the role of enhanced cytochrome P450 1B1 expression.
Toxicology314(1)30-8(2013 Dec)
Smerdov? L,Ne?a J,Svobodov? J,Topinka J,Schmuczerov? J,Kozub?k A,Machala M,Vondr??ek J