Gene Symbol | Usp46 |
Entrez Gene ID | 289584 |
Full Name | ubiquitin specific peptidase 46 |
Synonyms | RGD1564808 |
General protein information |
|
Gene Type | protein-coding |
Organism | Rattus norvegicus(Norway rat) |
Genome |
ORF » Species Summary » Rattus norvegicus » Usp46 cDNA ORF clone
Gene Symbol | Usp46 |
Entrez Gene ID | 289584 |
Full Name | ubiquitin specific peptidase 46 |
Synonyms | RGD1564808 |
General protein information |
|
Gene Type | protein-coding |
Organism | Rattus norvegicus(Norway rat) |
Genome |
mRNA | Protein | Name |
---|---|---|
NM_001191596.1 | NP_001178525.1 | ubiquitin carboxyl-terminal hydrolase 46 |
XM_006250888.2 | XP_006250950.1 | ubiquitin carboxyl-terminal hydrolase 46 isoform X1 |
XM_008770137.2 | XP_008768359.1 | ubiquitin carboxyl-terminal hydrolase 46 isoform X2 |
XM_006250889.3 | XP_006250951.1 | ubiquitin carboxyl-terminal hydrolase 46 isoform X3 |
XM_017599100.1 | XP_017454589.1 | ubiquitin carboxyl-terminal hydrolase 46 isoform X4 |
Rattus norvegicus (Norway rat) | Usp46 | NP_001178525.1 |
Drosophila melanogaster (fruit fly) | CG7023 | NP_651099.1 |
Saccharomyces cerevisiae (baker's yeast) | UBP13 | NP_009486.3 |
Eremothecium gossypii | AGOS_AGR370W | NP_987036.2 |
Bos taurus (cattle) | USP46 | NP_001179373.2 |
Gallus gallus (chicken) | USP46 | XP_420711.1 |
Danio rerio (zebrafish) | usp46 | NP_001231910.1 |
Anopheles gambiae (African malaria mosquito) | AgaP_AGAP012139 | XP_320388.3 |
Xenopus tropicalis (tropical clawed frog) | usp46 | NP_001106637.1 |
Homo sapiens (human) | USP46 | NP_073743.2 |
USP46 | XP_001092352.1 | |
Mus musculus (house mouse) | Usp46 | NP_808229.1 |
Arabidopsis thaliana (thale cress) | UBP4 | NP_565532.1 |
Oryza sativa (rice) | Os04g0452400 | NP_001052951.1 |
Pan troglodytes (chimpanzee) | USP46 | XP_517296.2 |
Canis lupus familiaris (dog) | USP46 | XP_005628243.1 |
Caenorhabditis elegans (roundworm) | usp-46 | NP_499162.2 |
Saccharomyces cerevisiae (baker's yeast) | UBP9 | NP_011024.1 |
Kluyveromyces lactis | KLLA0E20351g | XP_454871.1 |
Arabidopsis thaliana (thale cress) | UBP3 | NP_568074.1 |
Usp12 stabilizes the T-cell receptor complex at the cell surface during signaling.
Jahan AS, Lestra M, Swee LK, Fan Y, Lamers MM, Tafesse FG, Theile CS, Spooner E, Bruzzone R, Ploegh HL, Sanyal S
Proceedings of the National Academy of Sciences of the United States of America113(6)E705-14(2016 Feb)
The deubiquitinating enzyme USP46 regulates AMPA receptor ubiquitination and trafficking.
Huo Y, Khatri N, Hou Q, Gilbert J, Wang G, Man HY
Journal of neurochemistry134(6)1067-80(2015 Sep)
Behavioral characteristics of ubiquitin-specific peptidase 46-deficient mice.
Imai S, Kano M, Nonoyama K, Ebihara S
PloS one8(3)e58566(2013)
Ubiquitin-specific peptidase 46 (Usp46) regulates mouse immobile behavior in the tail suspension test through the GABAergic system.
Imai S, Mamiya T, Tsukada A, Sakai Y, Mouri A, Nabeshima T, Ebihara S
PloS one7(6)e39084(2012)
Lysine 92 amino acid residue of USP46, a gene associated with 'behavioral despair' in mice, influences the deubiquitinating enzyme activity.
Zhang W, Tian QB, Li QK, Wang JM, Wang CN, Liu T, Liu DW, Wang MW
PloS one6(10)e26297(2011)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
USP46-mediated regulation of Alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor ubiquitination and turnover may play an important role in synaptic plasticity and brain function.
Title: The deubiquitinating enzyme USP46 regulates AMPA receptor ubiquitination and trafficking.
results suggest that the Lys 92 deletion of USP46 could influence enzyme activity and thereby provide a molecular clue how the enzyme regulating the pathogenesis of mental illnesses.
Title: Lysine 92 amino acid residue of USP46, a gene associated with 'behavioral despair' in mice, influences the deubiquitinating enzyme activity.
The following Usp46 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Usp46 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | ORa07097 | |
Clone ID Related Accession (Same CDS sequence) | NM_001191596.1 | |
Accession Version | NM_001191596.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1101bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2018-06-29 | |
Organism | Rattus norvegicus(Norway rat) | |
Product | ubiquitin carboxyl-terminal hydrolase 46 | |
Comment | Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AC114452.5 and AABR07072397.1. On Jul 17, 2010 this sequence version replaced XM_214034.5. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## Transcript exon combination :: FQ211578.1, GU455413.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END## |
1 | ATGACTGTCC GAAACATCGC CTCCATCTGT AATATGGGCA CCAATGCCTC TGCTCTGGAA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001178525.1 |
CDS | 77..1177 |
Translation |
Target ORF information:
Target ORF information:
|
NM_001191596.1 |
1 | ATGACTGTCC GAAACATCGC CTCCATCTGT AATATGGGCA CCAATGCCTC TGCTCTGGAA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | ORa36012 | |
Clone ID Related Accession (Same CDS sequence) | XM_006250888.2 | |
Accession Version | XM_006250888.2 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1221bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-07-25 | |
Organism | Rattus norvegicus(Norway rat) | |
Product | ubiquitin carboxyl-terminal hydrolase 46 isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005113.4) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Aug 7, 2014 this sequence version replaced XM_006250888.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGAGGGCAA ACCGCAGTCC TTGCCACAGG ACTGTTAGTC TTACTTACTG TGCTGCATCA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_006250950.1 |
CDS | 467..1687 |
Translation |
Target ORF information:
Target ORF information:
|
XM_006250888.2 |
1 | ATGAGGGCAA ACCGCAGTCC TTGCCACAGG ACTGTTAGTC TTACTTACTG TGCTGCATCA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | ORa36013 | |
Clone ID Related Accession (Same CDS sequence) | XM_006250889.3 | |
Accession Version | XM_006250889.3 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1080bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-07-25 | |
Organism | Rattus norvegicus(Norway rat) | |
Product | ubiquitin carboxyl-terminal hydrolase 46 isoform X3 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005113.4) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_006250889.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGAACTGTT TCCAGGGCAC CAATGCCTCT GCTCTGGAAA AAGACATTGG ACCAGAGCAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_006250951.1 |
CDS | 660..1739 |
Translation |
Target ORF information:
Target ORF information:
|
XM_006250889.3 |
1 | ATGAACTGTT TCCAGGGCAC CAATGCCTCT GCTCTGGAAA AAGACATTGG ACCAGAGCAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | ORa44803 | |
Clone ID Related Accession (Same CDS sequence) | XM_008770137.2 | |
Accession Version | XM_008770137.2 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1089bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-07-25 | |
Organism | Rattus norvegicus(Norway rat) | |
Product | ubiquitin carboxyl-terminal hydrolase 46 isoform X2 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005113.4) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_008770137.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGGATGGCT TTGTGCAACA TTTGGGCACC AATGCCTCTG CTCTGGAAAA AGACATTGGA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_008768359.1 |
CDS | 680..1768 |
Translation |
Target ORF information:
Target ORF information:
|
XM_008770137.2 |
1 | ATGGATGGCT TTGTGCAACA TTTGGGCACC AATGCCTCTG CTCTGGAAAA AGACATTGGA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | ORa58242 | |
Clone ID Related Accession (Same CDS sequence) | XM_017599100.1 | |
Accession Version | XM_017599100.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 906bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-07-25 | |
Organism | Rattus norvegicus(Norway rat) | |
Product | ubiquitin carboxyl-terminal hydrolase 46 isoform X4 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005113.4) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGAGGGCAA ACCGCAGTCC TTGCCACAGG ACTGTTAGTC TTACTTACTG TGCTGCATCA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_017454589.1 |
CDS | 467..1372 |
Translation |
Target ORF information:
Target ORF information:
|
XM_017599100.1 |
1 | ATGAGGGCAA ACCGCAGTCC TTGCCACAGG ACTGTTAGTC TTACTTACTG TGCTGCATCA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Usp12 stabilizes the T-cell receptor complex at the cell surface during signaling. |
The deubiquitinating enzyme USP46 regulates AMPA receptor ubiquitination and trafficking. |
Behavioral characteristics of ubiquitin-specific peptidase 46-deficient mice. |
Ubiquitin-specific peptidase 46 (Usp46) regulates mouse immobile behavior in the tail suspension test through the GABAergic system. |
Lysine 92 amino acid residue of USP46, a gene associated with 'behavioral despair' in mice, influences the deubiquitinating enzyme activity. |