Cfb cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Cfb
Entrez Gene ID	294257
Full Name	complement factor B
Synonyms	Bf,Da1-24
General protein information	Preferred Names complement factor B Names complement factor B B-factor, properdin properdin factor B
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 20 Map Location: 20p12
Summary	predicted gene; component of the alternative pathway of complement activation; may be linked to the major histocompatibility complex and thus involved in the immune response [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_212466.3	NP_997631.2	complement factor B precursor

Pathways from BioSystems

Homologies

	CFB	XP_001113553.2
Pan troglodytes (chimpanzee)	CFB	NP_001009169.1
Danio rerio (zebrafish)	zgc:158446	NP_001077327.1
Mus musculus (house mouse)	Cfb	NP_032224.2
Danio rerio (zebrafish)	bfb	NP_571316.1
Bos taurus (cattle)	CFB	NP_001035616.1
Rattus norvegicus (Norway rat)	Cfb	NP_997631.2
Danio rerio (zebrafish)	cfb	NP_571413.1
Xenopus tropicalis (tropical clawed frog)	LOC100491419	XP_002943021.2
Homo sapiens (human)	CFB	NP_001701.2
Canis lupus familiaris (dog)	CFB	XP_003431724.1

Gene Ontology
Bibliography

Related articles in PubMed

A novel antibody against human factor B that blocks formation of the C3bB proconvertase and inhibits complement activation in disease models.
Sub?as M, Tortajada A, Gastoldi S, Galbusera M, L?pez-Perrote A, Lopez Lde J, Gonz?lez-Fern?ndez FA, Villegas-Mart?nez A, Dominguez M, Llorca O, Noris M, Morgan BP, Rodr?guez de C?rdoba S
Journal of immunology (Baltimore, Md. : 1950)193(11)5567-75(2014 Dec)

Excessive activation of the alternative complement pathway in autosomal dominant polycystic kidney disease.
Su Z, Wang X, Gao X, Liu Y, Pan C, Hu H, Beyer RP, Shi M, Zhou J, Zhang J, Serra AL, W?thrich RP, Mei C
Journal of internal medicine276(5)470-85(2014 Nov)

Complement factor B is the downstream effector of TLRs and plays an important role in a mouse model of severe sepsis.
Zou L, Feng Y, Li Y, Zhang M, Chen C, Cai J, Gong Y, Wang L, Thurman JM, Wu X, Atkinson JP, Chao W
Journal of immunology (Baltimore, Md. : 1950)191(11)5625-35(2013 Dec)

Association of CFH and CFB gene polymorphisms with retinopathy in type 2 diabetic patients.
Wang J, Yang MM, Li YB, Liu GD, Teng Y, Liu XM
Mediators of inflammation2013748435(2013)

Association between polymorphisms of complement pathway genes and age-related macular degeneration in a Chinese population.
Wu L, Tao Q, Chen W, Wang Z, Song Y, Sheng S, Li P, Zhou J
Investigative ophthalmology & visual science54(1)170-4(2013 Jan)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Cfb gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Cfb cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa05656	NM_212466.3 Latest version!	Rattus norvegicus complement factor B (Cfb), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	Quote Price

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone	30% OFF
2-4 Clone	40% OFF
5 or more Clone	50% OFF
All Other ORF Clones
30% OFF

*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Cfb ( NM_212466.3 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_997631.2 Rattus norvegicus complement factor B (Cfb), mRNA.

Price & Availability↑

CloneID	ORa05656
Clone ID Related Accession (Same CDS sequence)	NM_212466.3
Accession Version	NM_212466.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2292bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-01
Organism	Rattus norvegicus(Norway rat)
Product	complement factor B precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BC087089.1 and BG380277.1. On Dec 17, 2008 this sequence version replaced NM_212466.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC087089.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01906357, SAMN01906358 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGACAATGG AGGGTCCCCA GCTCTGCTTA GTCCTCTTGG TCTTAGGCCT CTCCTCCGGA 
GGTGTGAGCG CAACTCCAGT GCTTGAGGCC CGGCCCCAGG TCTCTTGCTC TCTGGAGGGA 
GTAGAGATCA AAGGCGGCTC CTTCCAACTT CTCCAAGACG GTCAGGCCCT GGAGTACCTG 
TGTCCCTCTG GCTTCTACCC ATACCCTGTG CAGACTCGAA CCTGCAAATC CACAGGCTCC 
TGGAGTGTCC TCCAGACCCG GGACCAAAAG ATTGTCAAGA AGGCAGAATG CAGAGCAATA 
CGCTGCCCAC GACCACAGGA CTTTGAAAAT GGGGAGTTCT GGCCCCGGTC CCCCTACTAC 
AACCTGAGTG ATCAGATTTC TTTTCAATGC TATGATGGCT ACACTCTCCG GGGCTCTGCT 
AATCGCACCT GCCAAGAGAA TGGCCGGTGG GATGGGCAAA CAGCAATCTG TGATGATGGA 
GCGGGATACT GTCCCAACCC GGGTATTCCT ATTGGGACAA GGAAGGTGGG AAGCCAGTAC 
CGTCTTGAAG ACACTGTCAC TTACCACTGT AGTCGGGGAC TTGTCCTACG TGGCTCCCAG 
CAGCGAAGGT GCCAGGAAGG TGGCTCGTGG AGTGGGACAG AGCCTTCCTG CCAAGATTCC 
TTCATGTACG ACAGCCCTCA AGAGGTGGCC GAAGCATTTC TATCCTCCCT GACAGAGACC 
ATCGAAGGAG CAGATGCGGA GGATGGGCAC AGCCCAGGGG AACAGCAGAA GAGGAAGATT 
ATCCTGGACC CCTCGGGCTC CATGAATATC TACATGGTGC TGGATGGATC CGACAGCATC 
GGGGCCAGCA ACTTCACAGG GGCCAAGCGG TGTCTCGCCA ACTTGATTGA GAAGGTGGCG 
AGTTATGGGG TGAAGCCAAG ATACGGTCTA GTGACATATG CCACAGTCCC CAAAGTCTTG 
GTCAGAGTGT CTGAGGAGAG GAGTAGTGAT GCCGACTGGG TCACAGAGAA GCTCAACCAA 
ATCAGTTATG AAGACCACAA GCTGAAGTCA GGGACCAACA CCAAGAAGGC TCTCCAGGCT 
GTATACAGCA TGATGAGCTG GCCAGGGGAT GCTCCGCCTG AAGGCTGGAA TCGAACCCGC 
CACGTCATCA TCATCATGAC TGATGGCTTG CACAACATGG GTGGAGACCC TGTCACTGTC 
ATTGAGGACA TCCGAGACTT GCTGGATATT GGCAGGGATC GCAAAAATCC CCGGGAGGAT 
TATTTGGATG TGTATGTGTT TGGGGTCGGG CCTCTGGTGG ACCCTGTGAA CATCAATGCC 
TTGGCTTCCA AAAAGAACAA TGAGCAGCAT GTGTTCAAGG TCAAGGACAT GGAGGATCTG 
GAGAACGTCT TCTACAAAAT GATCGATGAA ACCAAATCTC TGGGTCTCTG TGGCATGGTG 
TGGGAGCATC AGAAAGGCGG TGATTATTAC AAGCAACCAT GGCAAGCCAA GATCTCAGTC 
ACTCGTCCTC TGAAAGGACA TGAGAACTGT ATGGGGGCCG TGGTGTCCGA GTACTTCGTG 
CTGACAGCAG CGCATTGCTT CACAGTGGAA GATCAGAAAC ACTCCATCAA GGTCAACGTG 
GAGGGGAAAA GGCGGGACCT GGAGATTGAA GAGGTCCTGT TCCACCCTAA TTACGACATC 
AATGGGAAAA AGGCAGAAGG AATCTCTGAG TTCTATGACT ATGATGTTGC CCTCATCAAG 
CTCAAGACCA AGCTGAAGTA CAGCCAGACT CTCAGGCCCA TCTGTCTCCC CTGCACAGAG 
GGAACCACCC GAGCCTTGCG GCTTCCTCAG ACAGCCACCT GCAAACAGCA CAAGGAAGAG 
TTGCTCCCTA TGAAGGACGT CAAAGCTCTG TTTGTATCCG AGGAAGGGAA GAAGCTGACC 
CGGAAGGAGG TGTACATCAA GAATGGGGAA AAGAAAGCCA GTTGTGAGAG AGATGCTACA 
AAGGCCCAAG GCTATGAGAA GGTCAAAGTT GCCTCTGAGG TGGTCACCCC CAGGTTCCTG 
TGCACCGGAG GGGTAGATCC CTATGCTGAC CCCAACACAT GCAAAGGAGA CTCCGGGGGC 
CCTCTCATTG TTCACAAGAG AAGCCGCTTC ATTCAAGTTG GTGTGATCAG CTGGGGAGTA 
GTGGATGTCT GCAAAGACCC GAGGCGGCAA CAGTTGGTGC CCTCCTATGC CCGGGACTTC 
CACATCAATC TCTTCCAGGT GCTGCCCTGG CTAAAGGAGA AGCTCAAAGA CGAGGACTTG 
GGTTTCTTAT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_997631.2
CDS	212..2503
Translation	MTMEGPQLCLVLLVLGLSSGGVSATPVLEARPQVSCSLEGVEIKGGSFQLLQDGQALEYLCPSGFYPYPVQTRTCKSTGSWSVLQTRDQKIVKKAECRAIRCPRPQDFENGEFWPRSPYYNLSDQISFQCYDGYTLRGSANRTCQENGRWDGQTAICDDGAGYCPNPGIPIGTRKVGSQYRLEDTVTYHCSRGLVLRGSQQRRCQEGGSWSGTEPSCQDSFMYDSPQEVAEAFLSSLTETIEGADAEDGHSPGEQQKRKIILDPSGSMNIYMVLDGSDSIGASNFTGAKRCLANLIEKVASYGVKPRYGLVTYATVPKVLVRVSEERSSDADWVTEKLNQISYEDHKLKSGTNTKKALQAVYSMMSWPGDAPPEGWNRTRHVIIIMTDGLHNMGGDPVTVIEDIRDLLDIGRDRKNPREDYLDVYVFGVGPLVDPVNINALASKKNNEQHVFKVKDMEDLENVFYKMIDETKSLGLCGMVWEHQKGGDYYKQPWQAKISVTRPLKGHENCMGAVVSEYFVLTAAHCFTVEDQKHSIKVNVEGKRRDLEIEEVLFHPNYDINGKKAEGISEFYDYDVALIKLKTKLKYSQTLRPICLPCTEGTTRALRLPQTATCKQHKEELLPMKDVKALFVSEEGKKLTRKEVYIKNGEKKASCERDATKAQGYEKVKVASEVVTPRFLCTGGVDPYADPNTCKGDSGGPLIVHKRSRFIQVGVISWGVVDVCKDPRRQQLVPSYARDFHINLFQVLPWLKEKLKDEDLGFL

Target ORF information:

RefSeq Version	NM_212466.3
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus complement factor B (Cfb), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_212466.3

ORF Insert Sequence:

ATGACAATGG AGGGTCCCCA GCTCTGCTTA GTCCTCTTGG TCTTAGGCCT CTCCTCCGGA 
GGTGTGAGCG CAACTCCAGT GCTTGAGGCC CGGCCCCAGG TCTCTTGCTC TCTGGAGGGA 
GTAGAGATCA AAGGCGGCTC CTTCCAACTT CTCCAAGACG GTCAGGCCCT GGAGTACCTG 
TGTCCCTCTG GCTTCTACCC ATACCCTGTG CAGACTCGAA CCTGCAAATC CACAGGCTCC 
TGGAGTGTCC TCCAGACCCG GGACCAAAAG ATTGTCAAGA AGGCAGAATG CAGAGCAATA 
CGCTGCCCAC GACCACAGGA CTTTGAAAAT GGGGAGTTCT GGCCCCGGTC CCCCTACTAC 
AACCTGAGTG ATCAGATTTC TTTTCAATGC TATGATGGCT ACACTCTCCG GGGCTCTGCT 
AATCGCACCT GCCAAGAGAA TGGCCGGTGG GATGGGCAAA CAGCAATCTG TGATGATGGA 
GCGGGATACT GTCCCAACCC GGGTATTCCT ATTGGGACAA GGAAGGTGGG AAGCCAGTAC 
CGTCTTGAAG ACACTGTCAC TTACCACTGT AGTCGGGGAC TTGTCCTACG TGGCTCCCAG 
CAGCGAAGGT GCCAGGAAGG TGGCTCGTGG AGTGGGACAG AGCCTTCCTG CCAAGATTCC 
TTCATGTACG ACAGCCCTCA AGAGGTGGCC GAAGCATTTC TATCCTCCCT GACAGAGACC 
ATCGAAGGAG CAGATGCGGA GGATGGGCAC AGCCCAGGGG AACAGCAGAA GAGGAAGATT 
ATCCTGGACC CCTCGGGCTC CATGAATATC TACATGGTGC TGGATGGATC CGACAGCATC 
GGGGCCAGCA ACTTCACAGG GGCCAAGCGG TGTCTCGCCA ACTTGATTGA GAAGGTGGCG 
AGTTATGGGG TGAAGCCAAG ATACGGTCTA GTGACATATG CCACAGTCCC CAAAGTCTTG 
GTCAGAGTGT CTGAGGAGAG GAGTAGTGAT GCCGACTGGG TCACAGAGAA GCTCAACCAA 
ATCAGTTATG AAGACCACAA GCTGAAGTCA GGGACCAACA CCAAGAAGGC TCTCCAGGCT 
GTATACAGCA TGATGAGCTG GCCAGGGGAT GCTCCGCCTG AAGGCTGGAA TCGAACCCGC 
CACGTCATCA TCATCATGAC TGATGGCTTG CACAACATGG GTGGAGACCC TGTCACTGTC 
ATTGAGGACA TCCGAGACTT GCTGGATATT GGCAGGGATC GCAAAAATCC CCGGGAGGAT 
TATTTGGATG TGTATGTGTT TGGGGTCGGG CCTCTGGTGG ACCCTGTGAA CATCAATGCC 
TTGGCTTCCA AAAAGAACAA TGAGCAGCAT GTGTTCAAGG TCAAGGACAT GGAGGATCTG 
GAGAACGTCT TCTACAAAAT GATCGATGAA ACCAAATCTC TGGGTCTCTG TGGCATGGTG 
TGGGAGCATC AGAAAGGCGG TGATTATTAC AAGCAACCAT GGCAAGCCAA GATCTCAGTC 
ACTCGTCCTC TGAAAGGACA TGAGAACTGT ATGGGGGCCG TGGTGTCCGA GTACTTCGTG 
CTGACAGCAG CGCATTGCTT CACAGTGGAA GATCAGAAAC ACTCCATCAA GGTCAACGTG 
GAGGGGAAAA GGCGGGACCT GGAGATTGAA GAGGTCCTGT TCCACCCTAA TTACGACATC 
AATGGGAAAA AGGCAGAAGG AATCTCTGAG TTCTATGACT ATGATGTTGC CCTCATCAAG 
CTCAAGACCA AGCTGAAGTA CAGCCAGACT CTCAGGCCCA TCTGTCTCCC CTGCACAGAG 
GGAACCACCC GAGCCTTGCG GCTTCCTCAG ACAGCCACCT GCAAACAGCA CAAGGAAGAG 
TTGCTCCCTA TGAAGGACGT CAAAGCTCTG TTTGTATCCG AGGAAGGGAA GAAGCTGACC 
CGGAAGGAGG TGTACATCAA GAATGGGGAA AAGAAAGCCA GTTGTGAGAG AGATGCTACA 
AAGGCCCAAG GCTATGAGAA GGTCAAAGTT GCCTCTGAGG TGGTCACCCC CAGGTTCCTG 
TGCACCGGAG GGGTAGATCC CTATGCTGAC CCCAACACAT GCAAAGGAGA CTCCGGGGGC 
CCTCTCATTG TTCACAAGAG AAGCCGCTTC ATTCAAGTTG GTGTGATCAG CTGGGGAGTA 
GTGGATGTCT GCAAAGACCC GAGGCGGCAA CAGTTGGTGC CCTCCTATGC CCGGGACTTC 
CACATCAATC TCTTCCAGGT GCTGCCCTGG CTAAAGGAGA AGCTCAAAGA CGAGGACTTG 
GGTTTCTTAT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

A novel antibody against human factor B that blocks formation of the C3bB proconvertase and inhibits complement activation in disease models.
Journal of immunology (Baltimore, Md. : 1950)193(11)5567-75(2014 Dec)
Sub?as M,Tortajada A,Gastoldi S,Galbusera M,L?pez-Perrote A,Lopez Lde J,Gonz?lez-Fern?ndez FA,Villegas-Mart?nez A,Dominguez M,Llorca O,Noris M,Morgan BP,Rodr?guez de C?rdoba S

Excessive activation of the alternative complement pathway in autosomal dominant polycystic kidney disease.
Journal of internal medicine276(5)470-85(2014 Nov)
Su Z,Wang X,Gao X,Liu Y,Pan C,Hu H,Beyer RP,Shi M,Zhou J,Zhang J,Serra AL,W?thrich RP,Mei C

Complement factor B is the downstream effector of TLRs and plays an important role in a mouse model of severe sepsis.
Journal of immunology (Baltimore, Md. : 1950)191(11)5625-35(2013 Dec)
Zou L,Feng Y,Li Y,Zhang M,Chen C,Cai J,Gong Y,Wang L,Thurman JM,Wu X,Atkinson JP,Chao W

Association of CFH and CFB gene polymorphisms with retinopathy in type 2 diabetic patients.
Mediators of inflammation2013748435(2013)
Wang J,Yang MM,Li YB,Liu GD,Teng Y,Liu XM

Association between polymorphisms of complement pathway genes and age-related macular degeneration in a Chinese population.
Investigative ophthalmology & visual science54(1)170-4(2013 Jan)
Wu L,Tao Q,Chen W,Wang Z,Song Y,Sheng S,Li P,Zhou J