Gene Symbol | Cfb |
Entrez Gene ID | 14962 |
Full Name | complement factor B |
Synonyms | AI195813,AI255840,B,Bf,C2,Fb,H2-Bf |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
ORF » Species Summary » Mus musculus » Cfb cDNA ORF clone
Gene Symbol | Cfb |
Entrez Gene ID | 14962 |
Full Name | complement factor B |
Synonyms | AI195813,AI255840,B,Bf,C2,Fb,H2-Bf |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
mRNA | Protein | Name |
---|---|---|
XM_006523672.2 | XP_006523735.1 | complement factor B isoform X2 |
XM_006523671.2 | XP_006523734.1 | complement factor B isoform X1 |
XM_006523671.1 | XP_006523734.1 | complement factor B isoform X1 |
NM_001142706.1 | NP_001136178.1 | complement factor B isoform 2 precursor |
NM_008198.2 | NP_032224.2 | complement factor B isoform 1 precursor |
CFB | XP_001113553.2 | |
Pan troglodytes (chimpanzee) | CFB | NP_001009169.1 |
Danio rerio (zebrafish) | zgc:158446 | NP_001077327.1 |
Mus musculus (house mouse) | Cfb | NP_032224.2 |
Danio rerio (zebrafish) | bfb | NP_571316.1 |
Bos taurus (cattle) | CFB | NP_001035616.1 |
Rattus norvegicus (Norway rat) | Cfb | NP_997631.2 |
Danio rerio (zebrafish) | cfb | NP_571413.1 |
Xenopus tropicalis (tropical clawed frog) | LOC100491419 | XP_002943021.2 |
Homo sapiens (human) | CFB | NP_001701.2 |
Canis lupus familiaris (dog) | CFB | XP_003431724.1 |
Adipose tissue complement factor B promotes adipocyte maturation.
Matsunaga H, Iwashita M, Shinjo T, Yamashita A, Tsuruta M, Nagasaka S, Taniguchi A, Fukushima M, Watanabe N, Nishimura F
Biochemical and biophysical research communications495(1)740-748(2018 01)
Angiogenic factor imbalance precedes complement deposition in placentae of the BPH/5 model of preeclampsia.
Sones JL, Merriam AA, Seffens A, Brown-Grant DA, Butler SD, Zhao AM, Xu X, Shawber CJ, Grenier JK, Douglas NC
FASEB journal : official publication of the Federation of American Societies for Experimental Biology(2017 Dec)
Activation of complement factor B contributes to murine and human myocardial ischemia/reperfusion injury.
Chun N, Haddadin AS, Liu J, Hou Y, Wong KA, Lee D, Rushbrook JI, Gulaya K, Hines R, Hollis T, Nistal Nuno B, Mangi AA, Hashim S, Pekna M, Catalfamo A, Chin HY, Patel F, Rayala S, Shevde K, Heeger PS, Zhang M
PloS one12(6)e0179450(2017)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
CfB plays a crucial role in late-phase of adipocyte differentiation and subsequent lipid droplet formation.
Title: Adipose tissue complement factor B promotes adipocyte maturation.
AP inhibitors not only prevent, but have the potential to accelerate the clearance of complement-mediated ocular injury. Improving our understanding of the regulation of the AP is paramount to developing novel treatment approaches for AMD.
Title: A Targeted Inhibitor of the Alternative Complement Pathway Accelerates Recovery From Smoke-Induced Ocular Injury.
The roles of C3, CfB, and C3a receptor in the severity of S. aureus induced septic arthritis are reported.
Title: Deficiency of the Complement Component 3 but Not Factor B Aggravates Staphylococcus aureus Septic Arthritis in Mice.
Study shows that Factor B regulates UVA and UVB induced immunosuppression, UV induced edema and mast cell infiltration into the skin
Title: The alternative complement component factor B regulates UV-induced oedema, systemic suppression of contact and delayed hypersensitivity, and mast cell infiltration into the skin.
Properdin provides protection from Citrobacter rodentium-induced intestinal inflammation in a C5a/IL-6-dependent manner.
Title: Properdin provides protection from Citrobacter rodentium-induced intestinal inflammation in a C5a/IL-6-dependent manner.
The following Cfb gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Cfb cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OMu22490 | |
Clone ID Related Accession (Same CDS sequence) | NM_008198.2 | |
Accession Version | NM_008198.2 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 2292bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-12-24 | |
Organism | Mus musculus(house mouse) | |
Product | complement factor B isoform 1 precursor | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from CA492475.1, AK149531.1 and BP766400.1. On Dec 17, 2008 this sequence version replaced NM_008198.1. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC005451.1, M57890.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849386, SAMN01164135 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGACAATGG AGAGCCCCCA GCTCTGCCTC GTCCTCTTGG TCTTAGGCTT CTCCTCTGGA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_032224.2 |
CDS | 403..2694 |
Translation |
Target ORF information:
Target ORF information:
|
NM_008198.2 |
1 | ATGACAATGG AGAGCCCCCA GCTCTGCCTC GTCCTCTTGG TCTTAGGCTT CTCCTCTGGA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu22492 | |
Clone ID Related Accession (Same CDS sequence) | NM_001142706.1 | |
Accession Version | NM_001142706.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 2142bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-12-24 | |
Organism | Mus musculus(house mouse) | |
Product | complement factor B isoform 2 precursor | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from CA492475.1, AK149573.1 and BP766400.1. Transcript Variant: This variant (2) uses an alternate splice site in the 3' coding region that results in a frameshift, compared to variant 1. The encoded isoform (2) is shorter and has a distinct C-terminus, compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK149573.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164135 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGACAATGG AGAGCCCCCA GCTCTGCCTC GTCCTCTTGG TCTTAGGCTT CTCCTCTGGA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001136178.1 |
CDS | 403..2544 |
Translation |
Target ORF information:
Target ORF information:
|
NM_001142706.1 |
1 | ATGACAATGG AGAGCCCCCA GCTCTGCCTC GTCCTCTTGG TCTTAGGCTT CTCCTCTGGA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu53145 | |
Clone ID Related Accession (Same CDS sequence) | XM_006523671.2 , XM_006523671.1 | |
Accession Version | XM_006523671.1 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 2166bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-06-21 | |
Organism | Mus musculus(house mouse) | |
Product | complement factor B isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000083.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Mus musculus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGACAATGG AGAGCCCCCA GCTCTGCCTC GTCCTCTTGG TCTTAGGCTT CTCCTCTGGA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_006523734.1 |
CDS | 402..2567 |
Translation |
Target ORF information:
Target ORF information:
|
XM_006523671.1 |
1 | ATGACAATGG AGAGCCCCCA GCTCTGCCTC GTCCTCTTGG TCTTAGGCTT CTCCTCTGGA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu53146 | |
Clone ID Related Accession (Same CDS sequence) | XM_006523672.2 | |
Accession Version | XM_006523672.2 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 2136bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-08-07 | |
Organism | Mus musculus(house mouse) | |
Product | complement factor B isoform X2 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000083.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Feb 9, 2015 this sequence version replaced XM_006523672.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGACAATGG AGAGCCCCCA GCTCTGCCTC GTCCTCTTGG TCTTAGGCTT CTCCTCTGGA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_006523735.1 |
CDS | 402..2537 |
Translation |
Target ORF information:
Target ORF information:
|
XM_006523672.2 |
1 | ATGACAATGG AGAGCCCCCA GCTCTGCCTC GTCCTCTTGG TCTTAGGCTT CTCCTCTGGA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu53145 | |
Clone ID Related Accession (Same CDS sequence) | XM_006523671.2 , XM_006523671.1 | |
Accession Version | XM_006523671.2 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 2166bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-08-07 | |
Organism | Mus musculus(house mouse) | |
Product | complement factor B isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000083.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Aug 8, 2019 this sequence version replaced XM_006523671.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGACAATGG AGAGCCCCCA GCTCTGCCTC GTCCTCTTGG TCTTAGGCTT CTCCTCTGGA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_006523734.1 |
CDS | 209..2374 |
Translation |
Target ORF information:
Target ORF information:
|
XM_006523671.2 |
1 | ATGACAATGG AGAGCCCCCA GCTCTGCCTC GTCCTCTTGG TCTTAGGCTT CTCCTCTGGA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Adipose tissue complement factor B promotes adipocyte maturation. |
Angiogenic factor imbalance precedes complement deposition in placentae of the BPH/5 model of preeclampsia. |
Activation of complement factor B contributes to murine and human myocardial ischemia/reperfusion injury. |