Lhfpl5 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Gene Symbol	Lhfpl5
Entrez Gene ID	294303
Full Name	LHFPL tetraspan subfamily member 5
Synonyms	Tmhs
General protein information	Preferred Names LHFPL tetraspan subfamily member 5 Names LHFPL tetraspan subfamily member 5 protein lipoma HMGIC fusion partner-like 5 protein tetraspan membrane protein of hair cell stereocilia tetraspan transmembrane protein, hair cell stereocilia
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 20 Map Location: 20p12

mRNA and Protein(s)

mRNA Protein Name

NM_001013906.1 NP_001013928.1 LHFPL tetraspan subfamily member 5 protein
Pathways from BioSystems

mRNA	Protein	Name
NM_001013906.1	NP_001013928.1	LHFPL tetraspan subfamily member 5 protein

Homologies

	LOC718952	XP_001112357.2
Canis lupus familiaris (dog)	LHFPL5	XP_005627321.1
Rattus norvegicus (Norway rat)	Lhfpl5	NP_001013928.1
Gallus gallus (chicken)	LHFPL5	NP_989729.1
Danio rerio (zebrafish)	lhfpl5a	XP_686620.5
Homo sapiens (human)	LHFPL5	NP_872354.1
Caenorhabditis elegans (roundworm)	F26D10.11	NP_503066.1
Bos taurus (cattle)	LHFPL5	NP_001192875.1
Mus musculus (house mouse)	Lhfpl5	NP_080847.2
Xenopus tropicalis (tropical clawed frog)	lhfpl5	NP_001017269.1

Gene Ontology
Bibliography

Related articles in PubMed

TMHS is an integral component of the mechanotransduction machinery of cochlear hair cells.
Xiong W, Grillet N, Elledge HM, Wagner TF, Zhao B, Johnson KR, Kazmierczak P, M?ller U
Cell151(6)1283-95(2012 Dec)

Targeted knockout and lacZ reporter expression of the mouse Tmhs deafness gene and characterization of the hscy-2J mutation.
Longo-Guess CM, Gagnon LH, Fritzsch B, Johnson KR
Mammalian genome : official journal of the International Mammalian Genome Society18(9)646-56(2007 Sep)

Mutations in the lipoma HMGIC fusion partner-like 5 (LHFPL5) gene cause autosomal recessive nonsyndromic hearing loss.
Kalay E, Li Y, Uzumcu A, Uyguner O, Collin RW, Caylan R, Ulubil-Emiroglu M, Kersten FF, Hafiz G, van Wijk E, Kayserili H, Rohmann E, Wagenstaller J, Hoefsloot LH, Strom TM, N?rnberg G, Baserer N, den Hollander AI, Cremers FP, Cremers CW, Becker C, Brunner HG, N?rnberg P, Karaguzel A, Basaran S, Kubisch C, Kremer H, Wollnik B
Human mutation27(7)633-9(2006 Jul)

A missense mutation in the previously undescribed gene Tmhs underlies deafness in hurry-scurry (hscy) mice.
Longo-Guess CM, Gagnon LH, Cook SA, Wu J, Zheng QY, Johnson KR
Proceedings of the National Academy of Sciences of the United States of America102(22)7894-9(2005 May)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

LHFPL5 is essential for normal function of the human cochlea.
Title: Mutations in the lipoma HMGIC fusion partner-like 5 (LHFPL5) gene cause autosomal recessive nonsyndromic hearing loss.

The following Lhfpl5 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Lhfpl5 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa04198	NM_001013906.1 Latest version!	Rattus norvegicus LHFPL tetraspan subfamily member 5 (Lhfpl5), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Lhfpl5 ( NM_001013906.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001013928.1 Rattus norvegicus LHFPL tetraspan subfamily member 5 (Lhfpl5), mRNA.

Price & Availability↑

CloneID	ORa04198
Clone ID Related Accession (Same CDS sequence)	NM_001013906.1
Accession Version	NM_001013906.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 660bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-09-15
Organism	Rattus norvegicus(Norway rat)
Product	LHFPL tetraspan subfamily member 5 protein
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC087673.1. On Apr 20, 2005 this sequence version replaced XM_228037.3. ##Evidence-Data-START## Transcript exon combination :: BC087673.1, BP483179.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGGTGAAGT TGCTGCCAGC CCAGGAGGCC GCCAAGATCT ACCACACCAA CTATGTGCGA 
AACTCGCGCG CCGTGGGGGT GATGTGGGGC ACACTCACCA TCTGTTTCTC GGTGCTGGTC 
ATGGCCCTCT TTATCCAGCC CTACTGGATA GGCGACAGTG TGAGCACGCC ACAGGCTGGC 
TATTTTGGCT TGTTCTCGTA CTGTGTGGGC AATGTGCTGT CGTCGGAACT CATCTGCAAG 
GGCGGACCTC TGGACTTCTC CTCTATCCCC TCCAGAGCCT TCAAGACCGC CATGTTCTTC 
GTGGCCTTGG CAATGTTCCT CATCATCGGC TCCATTATCT GCTTCAGCCT GTTCTTCGTC 
TGTAACACAG CCACGGTCTA CAAGATTTGC GCCTGGATGC AGCTGGCTGC GGCCACGGGC 
CTGATGATCG GATGTCTGGT CTACCCAGAT GGTTGGGACT CCAGCGAGGT GCGGCGCATG 
TGCGGCGAGC AGACGGGGAA GTATACGCTG GGCCACTGCA CCATCCGCTG GGCCTTCATG 
CTGGCCATCC TCAGTATTGG AGATGCACTC ATCCTCTCCT TCTTGGCTTT CGTGTTGGGC 
TACCGGCAGG ACAAGCTCCT TCCAGATGAC TACAAGGCCG ATGGGAACGA GGAAGTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001013928.1
CDS	247..906
Translation	MVKLLPAQEAAKIYHTNYVRNSRAVGVMWGTLTICFSVLVMALFIQPYWIGDSVSTPQAGYFGLFSYCVGNVLSSELICKGGPLDFSSIPSRAFKTAMFFVALAMFLIIGSIICFSLFFVCNTATVYKICAWMQLAAATGLMIGCLVYPDGWDSSEVRRMCGEQTGKYTLGHCTIRWAFMLAILSIGDALILSFLAFVLGYRQDKLLPDDYKADGNEEV

Target ORF information:

RefSeq Version	NM_001013906.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus LHFPL tetraspan subfamily member 5 (Lhfpl5), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001013906.1

ORF Insert Sequence:

ATGGTGAAGT TGCTGCCAGC CCAGGAGGCC GCCAAGATCT ACCACACCAA CTATGTGCGA 
AACTCGCGCG CCGTGGGGGT GATGTGGGGC ACACTCACCA TCTGTTTCTC GGTGCTGGTC 
ATGGCCCTCT TTATCCAGCC CTACTGGATA GGCGACAGTG TGAGCACGCC ACAGGCTGGC 
TATTTTGGCT TGTTCTCGTA CTGTGTGGGC AATGTGCTGT CGTCGGAACT CATCTGCAAG 
GGCGGACCTC TGGACTTCTC CTCTATCCCC TCCAGAGCCT TCAAGACCGC CATGTTCTTC 
GTGGCCTTGG CAATGTTCCT CATCATCGGC TCCATTATCT GCTTCAGCCT GTTCTTCGTC 
TGTAACACAG CCACGGTCTA CAAGATTTGC GCCTGGATGC AGCTGGCTGC GGCCACGGGC 
CTGATGATCG GATGTCTGGT CTACCCAGAT GGTTGGGACT CCAGCGAGGT GCGGCGCATG 
TGCGGCGAGC AGACGGGGAA GTATACGCTG GGCCACTGCA CCATCCGCTG GGCCTTCATG 
CTGGCCATCC TCAGTATTGG AGATGCACTC ATCCTCTCCT TCTTGGCTTT CGTGTTGGGC 
TACCGGCAGG ACAAGCTCCT TCCAGATGAC TACAAGGCCG ATGGGAACGA GGAAGTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

TMHS is an integral component of the mechanotransduction machinery of cochlear hair cells.
Cell151(6)1283-95(2012 Dec)
Xiong W,Grillet N,Elledge HM,Wagner TF,Zhao B,Johnson KR,Kazmierczak P,M?ller U

Targeted knockout and lacZ reporter expression of the mouse Tmhs deafness gene and characterization of the hscy-2J mutation.
Mammalian genome : official journal of the International Mammalian Genome Society18(9)646-56(2007 Sep)
Longo-Guess CM,Gagnon LH,Fritzsch B,Johnson KR

Mutations in the lipoma HMGIC fusion partner-like 5 (LHFPL5) gene cause autosomal recessive nonsyndromic hearing loss.
Human mutation27(7)633-9(2006 Jul)
Kalay E,Li Y,Uzumcu A,Uyguner O,Collin RW,Caylan R,Ulubil-Emiroglu M,Kersten FF,Hafiz G,van Wijk E,Kayserili H,Rohmann E,Wagenstaller J,Hoefsloot LH,Strom TM,N?rnberg G,Baserer N,den Hollander AI,Cremers FP,Cremers CW,Becker C,Brunner HG,N?rnberg P,Karaguzel A,Basaran S,Kubisch C,Kremer H,Wollnik B

A missense mutation in the previously undescribed gene Tmhs underlies deafness in hurry-scurry (hscy) mice.
Proceedings of the National Academy of Sciences of the United States of America102(22)7894-9(2005 May)
Longo-Guess CM,Gagnon LH,Cook SA,Wu J,Zheng QY,Johnson KR

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Lhfpl5 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

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Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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