Hnrnpa1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Hnrnpa1
Entrez Gene ID	29578
Full Name	heterogeneous nuclear ribonucleoprotein A1
Synonyms	Hnrpa1,hnRNP A1
General protein information	Preferred Names heterogeneous nuclear ribonucleoprotein A1 Names heterogeneous nuclear ribonucleoprotein A1 HDP helix-destabilizing protein hnRNP core protein A1 single-strand RNA-binding protein
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 7 Map Location: 7q36
Summary	involved in the packaging of pre-mRNA into heterologous nuclear ribonucleoprotein particles and in the transport of poly-A mRNA from the nucleus to the cytoplasm; may modulate splice site selection [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
XM_006242384.1	XP_006242446.1	heterogeneous nuclear ribonucleoprotein A1 isoform X1
NM_017248.1	NP_058944.1	heterogeneous nuclear ribonucleoprotein A1

Pathways from BioSystems

Homologies

Homo sapiens (human)	HNRNPA1	NP_002127.1
Pan troglodytes (chimpanzee)	HNRNPA1	NP_001184040.1
Pan troglodytes (chimpanzee)	LOC100615525	XP_003318234.1
	HNRNPA1	NP_001036248.1
Bos taurus (cattle)	HNRNPA1	NP_001039376.1
Gallus gallus (chicken)	LOC100859627	XP_004942777.1
Pan troglodytes (chimpanzee)	HNRPA1LK1	NP_001091892.1
Rattus norvegicus (Norway rat)	Hnrnpa1	NP_058944.1

Gene Ontology
Bibliography

Related articles in PubMed

A Compendium of RNA-Binding Proteins that Regulate MicroRNA Biogenesis.
Treiber T, Treiber N, Plessmann U, Harlander S, Dai? JL, Eichner N, Lehmann G, Schall K, Urlaub H, Meister G
Molecular cell66(2)270-284.e13(2017 Apr)

Whole-exome sequencing identifies a missense mutation in hnRNPA1 in a family with flail arm ALS.
Liu Q, Shu S, Wang RR, Liu F, Cui B, Guo XN, Lu CX, Li XG, Liu MS, Peng B, Cui LY, Zhang X
Neurology87(17)1763-1769(2016 Oct)

Regulation of RAGE splicing by hnRNP A1 and Tra2?-1 and its potential role in AD pathogenesis.
Liu XY, Li HL, Su JB, Ding FH, Zhao JJ, Chai F, Li YX, Cui SC, Sun FY, Wu ZY, Xu P, Chen XH
Journal of neurochemistry133(2)187-98(2015 Apr)

TERRA-reinforced association of LSD1 with MRE11 promotes processing of uncapped telomeres.
Porro A, Feuerhahn S, Lingner J
Cell reports6(4)765-76(2014 Feb)

Discovery of novel interacting partners of PSMD9, a proteasomal chaperone: Role of an Atypical and versatile PDZ-domain motif interaction and identification of putative functional modules.
Sangith N, Srinivasaraghavan K, Sahu I, Desai A, Medipally S, Somavarappu AK, Verma C, Venkatraman P
FEBS open bio4571-83(2014)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Data indicate that heterogeneous nuclear ribonucleoprotein A1 (hnRNP A1) participates in the IRES (internal ribosome entry site) -dependent translation of sterol-regulatory-element-binding protein 1 (SREBP-1a) mRNA through RNA-protein interaction.
Title: hnRNP A1 mediates the activation of the IRES-dependent SREBP-1a mRNA translation in response to endoplasmic reticulum stress.

data show that hnRNP A1 is an important Quaking target that contributes to its control of myelin gene expression
Title: Quaking regulates Hnrnpa1 expression through its 3' UTR in oligodendrocyte precursor cells.

The following Hnrnpa1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Hnrnpa1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa03389	NM_017248.1 Latest version!	Rattus norvegicus heterogeneous nuclear ribonucleoprotein A1 (Hnrnpa1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$188.30 $269.00
ORa30761	XM_006242384.1 Latest version!	Rattus norvegicus heterogeneous nuclear ribonucleoprotein A1 (Hnrnpa1), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Hnrnpa1 ( NM_017248.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_058944.1 Rattus norvegicus heterogeneous nuclear ribonucleoprotein A1 (Hnrnpa1), mRNA.

Price & Availability↑

CloneID	ORa03389
Clone ID Related Accession (Same CDS sequence)	NM_017248.1
Accession Version	NM_017248.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 963bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-25
Organism	Rattus norvegicus(Norway rat)
Product	heterogeneous nuclear ribonucleoprotein A1
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from M12156.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: M12156.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGTCTAAGT CAGAGTCCCC CAAGGAACCG GAACAGCTGC GGAAGCTCTT CATTGGAGGG 
CTGAGCTTCG AAACAACCGA CGAGAGTCTG AGGAGCCATT TTGAGCAATG GGGAACACTC 
ACCGACTGTG TGGTAATGAG AGATCCAAAC ACCAAAAGAT CCAGAGGCTT TGGGTTTGTC 
ACATATGCCA CTGTGGAGGA AGTGGATGCT GCCATGAATG CAAGACCACA CAAAGTGGAT 
GGAAGAGTTG TGGAACCTAA GAGAGCTGTG TCAAGAGAAG ATTCTCAGAG ACCAGGTGCC 
CACTTAACTG TGAAGAAGAT CTTTGTTGGC GGTATTAAAG AAGACACTGA AGAACATCAC 
CTACGAGATT ATTTTGAGCA GTATGGGAAA ATTGAAGTGA TTGAAATTAT GACTGACAGA 
GGCAGTGGAA AAAAGAGGGG ATTTGCGTTT GTCACCTTTG ATGACCATGA CTCTGTGGAT 
AAGATTGTTA TTCAGAAATA CCATACTGTG AATGGCCACA ACTGTGAAGT AAGAAAGGCT 
CTGTGCAAAC AAGAGATGGC TAGTGCTTCA TCCAGCCAGA GAGGTCGAAG TGGTTCCGGA 
AACTTTGGTG GTGGTCGTGG AGGTGGTTTC GGTGGCAATG ACAATTTTGG TCGAGGAGGG 
AACTTCAGTG GTCGTGGTGG CTTTGGTGGC AGCCGTGGTG GTGGTGGATA TGGTGGCAGT 
GGGGATGGCT ATAATGGATT TGGCAATGAT GGAAGCAATT TTGGAGGTGG TGGAAGCTAC 
AATGATTTTG GCAATTACAA CAACCAGTCA TCAAATTTTG GACCGATGAA AGGAGGAAAC 
TTTGGAGGCA GGAGCTCTGG CCCTTATGGT GGTGGAGGCC AGTACTTTGC TAAACCACGA 
AACCAAGGTG GCTATGGAGG TTCCAGCAGC AGCAGTAGCT ATGGCAGTGG CAGGAGGTTC 
TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_058944.1
CDS	29..991
Translation	MSKSESPKEPEQLRKLFIGGLSFETTDESLRSHFEQWGTLTDCVVMRDPNTKRSRGFGFVTYATVEEVDAAMNARPHKVDGRVVEPKRAVSREDSQRPGAHLTVKKIFVGGIKEDTEEHHLRDYFEQYGKIEVIEIMTDRGSGKKRGFAFVTFDDHDSVDKIVIQKYHTVNGHNCEVRKALCKQEMASASSSQRGRSGSGNFGGGRGGGFGGNDNFGRGGNFSGRGGFGGSRGGGGYGGSGDGYNGFGNDGSNFGGGGSYNDFGNYNNQSSNFGPMKGGNFGGRSSGPYGGGGQYFAKPRNQGGYGGSSSSSSYGSGRRF

Target ORF information:

RefSeq Version	NM_017248.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus heterogeneous nuclear ribonucleoprotein A1 (Hnrnpa1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_017248.1

ORF Insert Sequence:

ATGTCTAAGT CAGAGTCCCC CAAGGAACCG GAACAGCTGC GGAAGCTCTT CATTGGAGGG 
CTGAGCTTCG AAACAACCGA CGAGAGTCTG AGGAGCCATT TTGAGCAATG GGGAACACTC 
ACCGACTGTG TGGTAATGAG AGATCCAAAC ACCAAAAGAT CCAGAGGCTT TGGGTTTGTC 
ACATATGCCA CTGTGGAGGA AGTGGATGCT GCCATGAATG CAAGACCACA CAAAGTGGAT 
GGAAGAGTTG TGGAACCTAA GAGAGCTGTG TCAAGAGAAG ATTCTCAGAG ACCAGGTGCC 
CACTTAACTG TGAAGAAGAT CTTTGTTGGC GGTATTAAAG AAGACACTGA AGAACATCAC 
CTACGAGATT ATTTTGAGCA GTATGGGAAA ATTGAAGTGA TTGAAATTAT GACTGACAGA 
GGCAGTGGAA AAAAGAGGGG ATTTGCGTTT GTCACCTTTG ATGACCATGA CTCTGTGGAT 
AAGATTGTTA TTCAGAAATA CCATACTGTG AATGGCCACA ACTGTGAAGT AAGAAAGGCT 
CTGTGCAAAC AAGAGATGGC TAGTGCTTCA TCCAGCCAGA GAGGTCGAAG TGGTTCCGGA 
AACTTTGGTG GTGGTCGTGG AGGTGGTTTC GGTGGCAATG ACAATTTTGG TCGAGGAGGG 
AACTTCAGTG GTCGTGGTGG CTTTGGTGGC AGCCGTGGTG GTGGTGGATA TGGTGGCAGT 
GGGGATGGCT ATAATGGATT TGGCAATGAT GGAAGCAATT TTGGAGGTGG TGGAAGCTAC 
AATGATTTTG GCAATTACAA CAACCAGTCA TCAAATTTTG GACCGATGAA AGGAGGAAAC 
TTTGGAGGCA GGAGCTCTGG CCCTTATGGT GGTGGAGGCC AGTACTTTGC TAAACCACGA 
AACCAAGGTG GCTATGGAGG TTCCAGCAGC AGCAGTAGCT ATGGCAGTGG CAGGAGGTTC 
TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Hnrnpa1 ( XM_006242384.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_006242446.1 Rattus norvegicus heterogeneous nuclear ribonucleoprotein A1 (Hnrnpa1), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa30761
Clone ID Related Accession (Same CDS sequence)	XM_006242384.1
Accession Version	XM_006242384.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1122bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	heterogeneous nuclear ribonucleoprotein A1 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005106.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGTCTAAGT CAGAGTCCCC CAAGGAACCG GAACAGCTGC GGAAGCTCTT CATTGGAGGG 
CTGAGCTTCG AAACAACCGA CGAGAGTCTG AGGAGCCATT TTGAGCAATG GGGAACACTC 
ACCGACTGTG TGGTAATGAG AGATCCAAAC ACCAAAAGAT CCAGAGGCTT TGGGTTTGTC 
ACATATGCCA CTGTGGAGGA AGTGGATGCT GCCATGAATG CAAGACCACA CAAGGTGGAT 
GGAAGAGTTG TGGAACCTAA GAGAGCTGTG TCAAGAGAAG ATTCTCAGAG ACCAGGTGCC 
CACTTAACTG TGAAGAAGAT CTTTGTTGGC GGTATTAAAG AAGACACTGA AGAACATCAC 
CTACGAGATT ATTTTGAGCA GTATGGGAAA ATTGAAGTGA TTGAAATTAT GACTGACAGA 
GGCAGTGGAA AAAAGAGGGG ATTTGCGTTT GTCACCTTTG ATGACCATGA CTCTGTGGAT 
AAGATTGTTA TTCAGAAATA CCATACTGTG AATGGCCACA ACTGTGAAGT AAGAAAGGCT 
CTGTCGAAAC AAGAGATGGC TAGTGCTTCA TCCAGCCAGA GAGGTCGAAG TGGTTCCGGA 
AACTTTGGTG GTGGTCGTGG AGGTGGTTTC GGTGGCAATG ACAATTTTGG TCGAGGAGGG 
AACTTCAGTG GTCGTGGTGG CTTTGGTGGC AGCCGTGGTG GTGGTGGATA TGGTGGCAGT 
GGGGATGGCT ATAATGGATT TGGCAATGAT GGTGGTTATG GAGGAGGCGG CCCTGGTTAC 
TCTGGAGGAA GCAGAGGCTA TGGAAGTGGT GGACAGGGTT ATGGAAACCA GGGCAGTGGC 
TATGGCGGGA GTGGCAGCTA TGACAGCTAT AACAACGGAG GAGGCGGAGG CGGCTTTGGC 
GGTGGTAGTG GAAGCAATTT TGGAGGTGGT GGAAGCTACA ATGATTTTGG CAATTACAAC 
AACCAGTCAT CAAATTTTGG ACCGATGAAA GGAGGAAACT TTGGAGGCAG GAGCTCTGGC 
CCTTATGGTG GTGGAGGCCA GTACTTTGCT AAACCACGAA ACCAAGGTGG CTATGGAGGT 
TCCAGCAGCA GCAGTAGCTA TGGCAGTGGC AGGAGGTTCT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006242446.1
CDS	367..1488
Translation	MSKSESPKEPEQLRKLFIGGLSFETTDESLRSHFEQWGTLTDCVVMRDPNTKRSRGFGFVTYATVEEVDAAMNARPHKVDGRVVEPKRAVSREDSQRPGAHLTVKKIFVGGIKEDTEEHHLRDYFEQYGKIEVIEIMTDRGSGKKRGFAFVTFDDHDSVDKIVIQKYHTVNGHNCEVRKALSKQEMASASSSQRGRSGSGNFGGGRGGGFGGNDNFGRGGNFSGRGGFGGSRGGGGYGGSGDGYNGFGNDGGYGGGGPGYSGGSRGYGSGGQGYGNQGSGYGGSGSYDSYNNGGGGGGFGGGSGSNFGGGGSYNDFGNYNNQSSNFGPMKGGNFGGRSSGPYGGGGQYFAKPRNQGGYGGSSSSSSYGSGRRF

Target ORF information:

RefSeq Version	XM_006242384.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus heterogeneous nuclear ribonucleoprotein A1 (Hnrnpa1), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006242384.1

ORF Insert Sequence:

ATGTCTAAGT CAGAGTCCCC CAAGGAACCG GAACAGCTGC GGAAGCTCTT CATTGGAGGG 
CTGAGCTTCG AAACAACCGA CGAGAGTCTG AGGAGCCATT TTGAGCAATG GGGAACACTC 
ACCGACTGTG TGGTAATGAG AGATCCAAAC ACCAAAAGAT CCAGAGGCTT TGGGTTTGTC 
ACATATGCCA CTGTGGAGGA AGTGGATGCT GCCATGAATG CAAGACCACA CAAGGTGGAT 
GGAAGAGTTG TGGAACCTAA GAGAGCTGTG TCAAGAGAAG ATTCTCAGAG ACCAGGTGCC 
CACTTAACTG TGAAGAAGAT CTTTGTTGGC GGTATTAAAG AAGACACTGA AGAACATCAC 
CTACGAGATT ATTTTGAGCA GTATGGGAAA ATTGAAGTGA TTGAAATTAT GACTGACAGA 
GGCAGTGGAA AAAAGAGGGG ATTTGCGTTT GTCACCTTTG ATGACCATGA CTCTGTGGAT 
AAGATTGTTA TTCAGAAATA CCATACTGTG AATGGCCACA ACTGTGAAGT AAGAAAGGCT 
CTGTCGAAAC AAGAGATGGC TAGTGCTTCA TCCAGCCAGA GAGGTCGAAG TGGTTCCGGA 
AACTTTGGTG GTGGTCGTGG AGGTGGTTTC GGTGGCAATG ACAATTTTGG TCGAGGAGGG 
AACTTCAGTG GTCGTGGTGG CTTTGGTGGC AGCCGTGGTG GTGGTGGATA TGGTGGCAGT 
GGGGATGGCT ATAATGGATT TGGCAATGAT GGTGGTTATG GAGGAGGCGG CCCTGGTTAC 
TCTGGAGGAA GCAGAGGCTA TGGAAGTGGT GGACAGGGTT ATGGAAACCA GGGCAGTGGC 
TATGGCGGGA GTGGCAGCTA TGACAGCTAT AACAACGGAG GAGGCGGAGG CGGCTTTGGC 
GGTGGTAGTG GAAGCAATTT TGGAGGTGGT GGAAGCTACA ATGATTTTGG CAATTACAAC 
AACCAGTCAT CAAATTTTGG ACCGATGAAA GGAGGAAACT TTGGAGGCAG GAGCTCTGGC 
CCTTATGGTG GTGGAGGCCA GTACTTTGCT AAACCACGAA ACCAAGGTGG CTATGGAGGT 
TCCAGCAGCA GCAGTAGCTA TGGCAGTGGC AGGAGGTTCT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

A Compendium of RNA-Binding Proteins that Regulate MicroRNA Biogenesis.
Molecular cell66(2)270-284.e13(2017 Apr)
Treiber T,Treiber N,Plessmann U,Harlander S,Dai? JL,Eichner N,Lehmann G,Schall K,Urlaub H,Meister G

Whole-exome sequencing identifies a missense mutation in hnRNPA1 in a family with flail arm ALS.
Neurology87(17)1763-1769(2016 Oct)
Liu Q,Shu S,Wang RR,Liu F,Cui B,Guo XN,Lu CX,Li XG,Liu MS,Peng B,Cui LY,Zhang X

Regulation of RAGE splicing by hnRNP A1 and Tra2?-1 and its potential role in AD pathogenesis.
Journal of neurochemistry133(2)187-98(2015 Apr)
Liu XY,Li HL,Su JB,Ding FH,Zhao JJ,Chai F,Li YX,Cui SC,Sun FY,Wu ZY,Xu P,Chen XH

TERRA-reinforced association of LSD1 with MRE11 promotes processing of uncapped telomeres.
Cell reports6(4)765-76(2014 Feb)
Porro A,Feuerhahn S,Lingner J

Discovery of novel interacting partners of PSMD9, a proteasomal chaperone: Role of an Atypical and versatile PDZ-domain motif interaction and identification of putative functional modules.
FEBS open bio4571-83(2014)
Sangith N,Srinivasaraghavan K,Sahu I,Desai A,Medipally S,Somavarappu AK,Verma C,Venkatraman P

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Hnrnpa1 cDNA ORF clone, Rattus norvegicus(Norway rat)

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gRNAs

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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