Gene Symbol | Gpt2 |
Entrez Gene ID | 307759 |
Full Name | glutamic--pyruvic transaminase 2 |
Synonyms | ALT2,Cc2-5 |
General protein information |
|
Gene Type | protein-coding |
Organism | Rattus norvegicus(Norway rat) |
Genome |
ORF » Species Summary » Rattus norvegicus » Gpt2 cDNA ORF clone
gRNAs
Gene Symbol | Gpt2 |
Entrez Gene ID | 307759 |
Full Name | glutamic--pyruvic transaminase 2 |
Synonyms | ALT2,Cc2-5 |
General protein information |
|
Gene Type | protein-coding |
Organism | Rattus norvegicus(Norway rat) |
Genome |
mRNA | Protein | Name |
---|---|---|
XM_008772406.2 | XP_008770628.1 | alanine aminotransferase 2 isoform X1 |
NM_001012057.2 | NP_001012057.1 | alanine aminotransferase 2 |
XM_008772405.2 | XP_008770627.1 | alanine aminotransferase 2 isoform X1 |
LOC716305 | XP_001113757.2 | |
Drosophila melanogaster (fruit fly) | CG1640 | NP_572879.2 |
Anopheles gambiae (African malaria mosquito) | AgaP_AGAP000901 | XP_316880.5 |
Neurospora crassa | NCU03973 | XP_957612.1 |
Arabidopsis thaliana (thale cress) | AlaAT1 | NP_173173.3 |
Oryza sativa (rice) | Os10g0390500 | NP_001064504.1 |
Bos taurus (cattle) | GPT2 | NP_001180116.1 |
Magnaporthe oryzae (rice blast fungus) | MGG_06503 | XP_003717056.1 |
Mus musculus (house mouse) | Gpt2 | NP_776291.1 |
Caenorhabditis elegans (roundworm) | CELE_C32F10.8 | NP_001021021.1 |
Saccharomyces cerevisiae (baker's yeast) | ALT1 | NP_013190.1 |
Schizosaccharomyces pombe (fission yeast) | SPBC582.08 | NP_595176.1 |
Xenopus tropicalis (tropical clawed frog) | LOC100494152 | XP_002931716.1 |
Homo sapiens (human) | GPT2 | NP_597700.1 |
Rattus norvegicus (Norway rat) | Gpt2 | NP_001012057.1 |
Arabidopsis thaliana (thale cress) | ALAAT2 | NP_001185380.1 |
Pan troglodytes (chimpanzee) | GPT2 | XP_003952890.1 |
Gallus gallus (chicken) | GPT2 | XP_414111.3 |
Danio rerio (zebrafish) | gpt2 | NP_001092227.2 |
Kluyveromyces lactis | KLLA0F19162g | XP_455940.1 |
Hepatic ALT isoenzymes are elevated in gluconeogenic conditions including diabetes and suppressed by insulin at the protein level.
Qian K, Zhong S, Xie K, Yu D, Yang R, Gong DW
Diabetes/metabolism research and reviews31(6)562-71(2015 Sep)
Isoform-specific alanine aminotransferase measurement can distinguish hepatic from extrahepatic injury in humans.
Rafter I, Gr?berg T, Kotronen A, Str?mmer L, Mattson CM, Kim RW, Ehrenborg E, Andersson HB, Yki-J?rvinen H, Schuppe-Koistinen I, Ekblom B, Cotgreave I, Glinghammar B
International journal of molecular medicine30(5)1241-9(2012 Nov)
Alanine aminotransferase regulation by androgens in non-hepatic tissues.
Coss CC, Bauler M, Narayanan R, Miller DD, Dalton JT
Pharmaceutical research29(4)1046-56(2012 Apr)
Increased hepatic expression is a major determinant of serum alanine aminotransferase elevation in mice with nonalcoholic steatohepatitis.
Liu R, Pan X, Whitington PF
Liver international : official journal of the International Association for the Study of the Liver29(3)337-43(2009 Mar)
Alanine aminotransferase isoenzymes: molecular cloning and quantitative analysis of tissue expression in rats and serum elevation in liver toxicity.
Yang RZ, Park S, Reagan WJ, Goldstein R, Zhong S, Lawton M, Rajamohan F, Qian K, Liu L, Gong DW
Hepatology (Baltimore, Md.)49(2)598-607(2009 Feb)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
Data suggest that both Alt1 and Alt2 are induced in liver during gluconeogenesis and in diabetes (Goto-Kakizaki rats); in hepatocytes, both Alt1 and Alt2 are induced by glucocorticoid dexamethasone and are suppressed by insulin.
Title: Hepatic ALT isoenzymes are elevated in gluconeogenic conditions including diabetes and suppressed by insulin at the protein level.
The following Gpt2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Gpt2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | ORa02081 | |
Clone ID Related Accession (Same CDS sequence) | XM_008772406.2 , NM_001012057.2 , XM_008772405.2 | |
Accession Version | NM_001012057.2 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1569bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-10-07 | |
Organism | Rattus norvegicus(Norway rat) | |
Product | alanine aminotransferase 2 | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC131806.6. On Sep 19, 2016 this sequence version replaced NM_001012057.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## RNAseq introns :: mixed/partial sample support SAMD00052296, SAMD00052297 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: inferred from homology inferred exon combination :: based on alignments, homology ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end. |
1 | ATGCAGCGGG CAGCGGTGCT GGTGCGGCGG GGCTCCTGCC CCCGCGCCTC GGGCCCCTGG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001012057.1 |
CDS | 23..1591 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGCAGCGGG CAGCGGTGCT GGTGCGGCGG GGCTCCTGCC CCCGCGCCTC GGGCCCCTGG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | ORa02081 | |
Clone ID Related Accession (Same CDS sequence) | XM_008772406.2 , NM_001012057.2 , XM_008772405.2 | |
Accession Version | XM_008772406.2 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1569bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-07-25 | |
Organism | Rattus norvegicus(Norway rat) | |
Product | alanine aminotransferase 2 isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005118.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_008772406.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGCAGCGGG CAGCGGTGCT GGTGCGGCGG GGCTCCTGCC CCCGCGCCTC GGGCCCCTGG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_008770628.1 |
CDS | 304..1872 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGCAGCGGG CAGCGGTGCT GGTGCGGCGG GGCTCCTGCC CCCGCGCCTC GGGCCCCTGG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | ORa02081 | |
Clone ID Related Accession (Same CDS sequence) | XM_008772406.2 , NM_001012057.2 , XM_008772405.2 | |
Accession Version | XM_008772405.2 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1569bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-07-25 | |
Organism | Rattus norvegicus(Norway rat) | |
Product | alanine aminotransferase 2 isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005118.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_008772405.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGCAGCGGG CAGCGGTGCT GGTGCGGCGG GGCTCCTGCC CCCGCGCCTC GGGCCCCTGG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_008770627.1 |
CDS | 149..1717 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGCAGCGGG CAGCGGTGCT GGTGCGGCGG GGCTCCTGCC CCCGCGCCTC GGGCCCCTGG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Hepatic ALT isoenzymes are elevated in gluconeogenic conditions including diabetes and suppressed by insulin at the protein level. |
Isoform-specific alanine aminotransferase measurement can distinguish hepatic from extrahepatic injury in humans. |
Alanine aminotransferase regulation by androgens in non-hepatic tissues. |
Increased hepatic expression is a major determinant of serum alanine aminotransferase elevation in mice with nonalcoholic steatohepatitis. |
Alanine aminotransferase isoenzymes: molecular cloning and quantitative analysis of tissue expression in rats and serum elevation in liver toxicity. |