Gene Symbol | Dok1 |
Entrez Gene ID | 312477 |
Full Name | docking protein 1 |
Synonyms | Dok-1 |
General protein information |
|
Gene Type | protein-coding |
Organism | Rattus norvegicus(Norway rat) |
Genome |
ORF » Species Summary » Rattus norvegicus » Dok1 cDNA ORF clone
gRNAs
Gene Symbol | Dok1 |
Entrez Gene ID | 312477 |
Full Name | docking protein 1 |
Synonyms | Dok-1 |
General protein information |
|
Gene Type | protein-coding |
Organism | Rattus norvegicus(Norway rat) |
Genome |
mRNA | Protein | Name |
---|---|---|
XM_008763022.2 | XP_008761244.1 | docking protein 1 isoform X1 |
NM_001025416.1 | NP_001020587.1 | docking protein 1 |
Homo sapiens (human) | DOK1 | NP_001372.1 |
Rattus norvegicus (Norway rat) | Dok1 | NP_001020587.1 |
DOK1 | XP_001111248.2 | |
Danio rerio (zebrafish) | dok1b | NP_998253.1 |
Xenopus tropicalis (tropical clawed frog) | LOC101730410 | XP_004920263.1 |
Canis lupus familiaris (dog) | DOK1 | XP_540216.4 |
Bos taurus (cattle) | DOK1 | NP_001019714.2 |
Pan troglodytes (chimpanzee) | DOK1 | XP_001161802.1 |
Mus musculus (house mouse) | Dok1 | NP_034200.4 |
The unique N-terminal region of SRMS regulates enzymatic activity and phosphorylation of its novel substrate docking protein 1.
Goel RK, Miah S, Black K, Kalra N, Dai C, Lukong KE
The FEBS journal280(18)4539-59(2013 Sep)
Dexamethasone up-regulates the inhibitory adaptor protein Dok-1 and suppresses downstream activation of the mitogen-activated protein kinase pathway in antigen-stimulated RBL-2H3 mast cells.
Hiragun T, Peng Z, Beaven MA
Molecular pharmacology67(3)598-603(2005 Mar)
Dok protein family members are involved in signaling mediated by the type 1 Fcepsilon receptor.
Abramson J, Rozenblum G, Pecht I
European journal of immunology33(1)85-91(2003 Jan)
SHP-1 regulation of p62(DOK) tyrosine phosphorylation in macrophages.
Berg KL, Siminovitch KA, Stanley ER
The Journal of biological chemistry274(50)35855-65(1999 Dec)
Identification of the Abl- and rasGAP-associated 62 kDa protein as a docking protein, Dok.
Yamanashi Y, Baltimore D
Cell88(2)205-11(1997 Jan)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
Dok-1 is the mediator of the antiallergic actions of dexamethasone and as a negative regulator of the MAP kinase pathway and downstream release of inflammatory mediators.
Title: Dexamethasone up-regulates the inhibitory adaptor protein Dok-1 and suppresses downstream activation of the mitogen-activated protein kinase pathway in antigen-stimulated RBL-2H3 mast cells.
The following Dok1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Dok1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | ORa07565 | |
Clone ID Related Accession (Same CDS sequence) | NM_001025416.1 | |
Accession Version | NM_001025416.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1443bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-12-25 | |
Organism | Rattus norvegicus(Norway rat) | |
Product | docking protein 1 | |
Comment | Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC097972.1. On Jul 15, 2005 this sequence version replaced XM_232106.3. ##Evidence-Data-START## Transcript exon combination :: BC097972.1, CV115728.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END## |
1 | ATGGACGGGG CTTTGATGGA GGGTCCGCTT TTTCTGCAGA GTCAGCGCTT CGGGACCAAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001020587.1 |
CDS | 9..1451 |
Translation |
Target ORF information:
Target ORF information:
|
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1 | ATGGACGGGG CTTTGATGGA GGGTCCGCTT TTTCTGCAGA GTCAGCGCTT CGGGACCAAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | ORa47138 | |
Clone ID Related Accession (Same CDS sequence) | XM_008763022.2 | |
Accession Version | XM_008763022.2 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1422bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-07-25 | |
Organism | Rattus norvegicus(Norway rat) | |
Product | docking protein 1 isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005103.4) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_008763022.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGCTGCCGC TCACTCTCGA GTCTTTCGTT CTTTCCCAGA GGTGGAAGAA AACTTGGGCT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_008761244.1 |
CDS | 95..1516 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGCTGCCGC TCACTCTCGA GTCTTTCGTT CTTTCCCAGA GGTGGAAGAA AACTTGGGCT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
The unique N-terminal region of SRMS regulates enzymatic activity and phosphorylation of its novel substrate docking protein 1. |
Dexamethasone up-regulates the inhibitory adaptor protein Dok-1 and suppresses downstream activation of the mitogen-activated protein kinase pathway in antigen-stimulated RBL-2H3 mast cells. |
Dok protein family members are involved in signaling mediated by the type 1 Fcepsilon receptor. |
SHP-1 regulation of p62(DOK) tyrosine phosphorylation in macrophages. |
Identification of the Abl- and rasGAP-associated 62 kDa protein as a docking protein, Dok. |