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Elmod1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Summary

Gene Symbol Elmod1
Entrez Gene ID 315670
Full Name ELMO domain containing 1
Synonyms RGD1564186
General protein information
Preferred Names

ELMO domain containing 1

Names

ELMO domain-containing protein 1
ELMO/CED-12 domain containing 1
Gene Type protein-coding
Organism Rattus norvegicus(Norway rat)
Genome

8

8q24

Reference Sequences (RefSeq)

mRNA and Protein(s)

mRNA Protein Name
XM_017595642.1 XP_017451131.1 ELMO domain-containing protein 1 isoform X1
XM_006243083.3 XP_006243145.1 ELMO domain-containing protein 1 isoform X2
NM_001191579.1 NP_001178508.1 ELMO domain-containing protein 1

Pathways from BioSystems


Homologies


Homo sapiens (human) ELMOD1 NP_061182.3
Bos taurus (cattle) ELMOD1 NP_001071576.1
Pan troglodytes (chimpanzee) ELMOD1 XP_003313399.2
ELMOD1 XP_001103189.1
Rattus norvegicus (Norway rat) Elmod1 NP_001178508.1
Gallus gallus (chicken) ELMOD1 XP_417165.1
Danio rerio (zebrafish) elmod1 NP_001074150.1
Xenopus tropicalis (tropical clawed frog) elmod1 NP_001072315.1
Canis lupus familiaris (dog) ELMOD1 XP_005619892.1
Mus musculus (house mouse) Elmod1 NP_808437.2

Gene Ontology


Bibliography

Related articles in PubMed

High-content genome-wide RNAi screens identify regulators of parkin upstream of mitophagy.
Hasson SA, Kane LA, Yamano K, Huang CH, Sliter DA, Buehler E, Wang C, Heman-Ackah SM, Hessa T, Guha R, Martin SE, Youle RJ
Nature504(7479)291-5(2013 Dec)

ELMOD2 is an Arl2 GTPase-activating protein that also acts on Arfs.
Bowzard JB, Cheng D, Peng J, Kahn RA
The Journal of biological chemistry282(24)17568-80(2007 Jun)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Elmod1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Elmod1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID Accession No. Definition **Vector *Turnaround time Price (USD) Select
ORa07046 NM_001191579.1
Latest version!		 Rattus norvegicus ELMO domain containing 1 (Elmod1), mRNA. pcDNA3.1+/C-(K)DYK or customized vector 7-9 $223.30
$319.00
ORa31174 XM_006243083.3
Latest version!		 Rattus norvegicus ELMO domain containing 1 (Elmod1), transcript variant X2, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 7-9 $139.30
$199.00
ORa62415 XM_017595642.1
Latest version!		 Rattus norvegicus ELMO domain containing 1 (Elmod1), transcript variant X1, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 9-11 $139.30
$199.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone 30% OFF
2-4 Clone 40% OFF
5 or more Clone 50% OFF
All Other ORF Clones
30% OFF

*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)


CloneID ORa07046
Clone ID Related Accession (Same CDS sequence) NM_001191579.1
Accession Version NM_001191579.1 Latest version! Documents for ORF clone product in default vector
Sequence Information ORF Nucleotide Sequence (Length: 1005bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ™ Seamless cloning technology
Insert Structure linear
Update Date 2017-10-02
Organism Rattus norvegicus(Norway rat)
Product ELMO domain-containing protein 1
Comment Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AABR07070214.1 and AABR07070213.1. On Jul 17, 2010 this sequence version replaced XM_002729923.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## RNAseq introns :: mixed/partial sample support SAMD00052296, SAMD00052297 [ECO:0000350] ##Evidence-Data-END## 

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
ATGAAGCACT TCCTGAGGAT GTTGATCCAG GTGTGCCTCT ATTTCTACTG TAAATTTTTG 
TGGCGCTGCA TGAAGTTTGT GATGCGTAAG CTCACGGGAA GGTGTGAGCT GCAAAGGATT 
TGCTACGGCA CCAAACCCGG AGCTTCCAGA ACCATGAAAA TTGAAACGTC ACTGAGAGAT 
TCAAAAAGCA AGCTGTTGCA GACATCAGTG AGTGTTCATC CTGATGCTAT CGAAAAGACT 
ATTGATGACA TCATGGAATT GAAAAAAATT AACCCTGACA TCAATCCACA GTTGGGAATC 
TCTCTCCAGG CTTGCCTTCT GCAAATTGTG GGTTACAGAA ACCTCATTGC AGATGTGGAA 
AAACTGCGCA GAGAACCCTA CGATTCCGAC AACCCCCAGC ATGAAGAGAT GCTTCTGAAG 
CTATGGGAGT TCCTGAAGCC CAACACTCCA CTGGAGTCTC GGATTTCTAA GCAGTGGTGT 
GAGATTGGCT TCCAAGGTGA TGATCCGAAA ACAGATTTTC GAGGAATGGG TCTTCTGGGA 
CTTTACAATT TGCAATATTT CGCAGAACGG GATGCCACGG TAGCTCAGCA AGTTCTGTGT 
GACTCTGTTC ATCCAAAATG CAGGGATATC ACTAAGGAGG AAATAAGCAA ATTCAGCAAA 
ACAGAATGGG AAAAGAAAAA GATGGATAAA GCAATTGGGT ACTCCTTTGC AATCGTGGGC 
ATCAATATCA CCGACCTGGC ATATAATCTG CTCGTGAGCG GCGCTCTGAA AACACATTTC 
TACAACATCG CTCCCGAAGC TCCAACACTG TCTCACTTCC AGCAAACATT CTGCTATTTG 
ATGCACGAGT TTCACAAGTT TTGGATTGAA GAGGACCCCA TGGACATAAT GGAATTTAAC 
CGCGTGCGGG AGAAATTCCG CAAGAGAATC ATAAAACAGC TGCAGAACCC AGACATGGCG 
CTGTGCCCAC ATTTCGCTGC CTCTGAAGGT TTAATCAACA TGTAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_001178508.1
CDS194..1198
Translation

Target ORF information:

RefSeq Version NM_001191579.1
Organism Rattus norvegicus(Norway rat)
Definition Rattus norvegicus ELMO domain containing 1 (Elmod1), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
 NM_001191579.1

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
ATGAAGCACT TCCTGAGGAT GTTGATCCAG GTGTGCCTCT ATTTCTACTG TAAATTTTTG 
TGGCGCTGCA TGAAGTTTGT GATGCGTAAG CTCACGGGAA GGTGTGAGCT GCAAAGGATT 
TGCTACGGCA CCAAACCCGG AGCTTCCAGA ACCATGAAAA TTGAAACGTC ACTGAGAGAT 
TCAAAAAGCA AGCTGTTGCA GACATCAGTG AGTGTTCATC CTGATGCTAT CGAAAAGACT 
ATTGATGACA TCATGGAATT GAAAAAAATT AACCCTGACA TCAATCCACA GTTGGGAATC 
TCTCTCCAGG CTTGCCTTCT GCAAATTGTG GGTTACAGAA ACCTCATTGC AGATGTGGAA 
AAACTGCGCA GAGAACCCTA CGATTCCGAC AACCCCCAGC ATGAAGAGAT GCTTCTGAAG 
CTATGGGAGT TCCTGAAGCC CAACACTCCA CTGGAGTCTC GGATTTCTAA GCAGTGGTGT 
GAGATTGGCT TCCAAGGTGA TGATCCGAAA ACAGATTTTC GAGGAATGGG TCTTCTGGGA 
CTTTACAATT TGCAATATTT CGCAGAACGG GATGCCACGG TAGCTCAGCA AGTTCTGTGT 
GACTCTGTTC ATCCAAAATG CAGGGATATC ACTAAGGAGG AAATAAGCAA ATTCAGCAAA 
ACAGAATGGG AAAAGAAAAA GATGGATAAA GCAATTGGGT ACTCCTTTGC AATCGTGGGC 
ATCAATATCA CCGACCTGGC ATATAATCTG CTCGTGAGCG GCGCTCTGAA AACACATTTC 
TACAACATCG CTCCCGAAGC TCCAACACTG TCTCACTTCC AGCAAACATT CTGCTATTTG 
ATGCACGAGT TTCACAAGTT TTGGATTGAA GAGGACCCCA TGGACATAAT GGAATTTAAC 
CGCGTGCGGG AGAAATTCCG CAAGAGAATC ATAAAACAGC TGCAGAACCC AGACATGGCG 
CTGTGCCCAC ATTTCGCTGC CTCTGAAGGT TTAATCAACA TGTAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID ORa31174
Clone ID Related Accession (Same CDS sequence) XM_006243083.3
Accession Version XM_006243083.3 Latest version! Documents for ORF clone product in default vector
Sequence Information ORF Nucleotide Sequence (Length: 981bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ™ Seamless cloning technology
Insert Structure linear
Update Date 2016-07-25
Organism Rattus norvegicus(Norway rat)
Product ELMO domain-containing protein 1 isoform X2
Comment Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005107.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_006243083.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## 

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
ATGAAGCACT TCCTGAGGAT GTTGATCCAG GTGTGCCTCT ATTTCTACTG TAAATTTTTG 
TGGCGCTGCA TGAAGTTTGT GATGCGTAAG CTCACGGGAA GGTGTGAGCT GCAAAGGATT 
TGCTACGGCA CCAAACCCGG AGCTTCCAGA ACCATGAAAA TTGAAACGTC ACTGAGAGAT 
TCAAAAAGCA AGCTGTTGCA GACATCAGTG AGTGTTCATC CTGATGCTAT CGAAAAGACT 
ATTGATGACA TCATGGAATT GAAAAAAATT AACCCTGACA TCAATCCACA GTTGGGAATC 
TCTCTCCAGG CTTGCCTTCT GCAAATTGTG GGTTACAGAA ACCTCATTGC AGATGTGGAA 
AAACTGCGCA GAGAACCCTA CGATTCCGAC AACCCCCAGC ATGAAGAGAT GCTTCTGAAG 
CTATGGGAGT TCCTGAAGCC CAACACTCCA CTGGAGTCTC GGATTTCTAA GCAGTGGTGT 
GAGATTGGCT TCCAAGGTGA TGATCCGAAA ACAGATTTTC GAGGAATGGG TCTTCTGGGA 
CTTTACAATT TGCAATATTT CGCAGAACGG GATGCCACGG TAGCTCAGCA AGTTCTGTGT 
GACTCTGTTC ATCCAAAATG CAGCAAATTC AGCAAAACAG AATGGGAAAA GAAAAAGATG 
GATAAAGCAA TTGGGTACTC CTTTGCAATC GTGGGCATCA ATATCACCGA CCTGGCATAT 
AATCTGCTCG TGAGCGGCGC TCTGAAAACA CATTTCTACA ACATCGCTCC CGAAGCTCCA 
ACACTGTCTC ACTTCCAGCA AACATTCTGC TATTTGATGC ACGAGTTTCA CAAGTTTTGG 
ATTGAAGAGG ACCCCATGGA CATAATGGAA TTTAACCGCG TGCGGGAGAA ATTCCGCAAG 
AGAATCATAA AACAGCTGCA GAACCCAGAC ATGGCGCTGT GCCCACATTT CGCTGCCTCT 
GAAGGTTTAA TCAACATGTA G

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq XP_006243145.1
CDS233..1213
Translation

Target ORF information:

RefSeq Version XM_006243083.3
Organism Rattus norvegicus(Norway rat)
Definition Rattus norvegicus ELMO domain containing 1 (Elmod1), transcript variant X2, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
 XM_006243083.3

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
ATGAAGCACT TCCTGAGGAT GTTGATCCAG GTGTGCCTCT ATTTCTACTG TAAATTTTTG 
TGGCGCTGCA TGAAGTTTGT GATGCGTAAG CTCACGGGAA GGTGTGAGCT GCAAAGGATT 
TGCTACGGCA CCAAACCCGG AGCTTCCAGA ACCATGAAAA TTGAAACGTC ACTGAGAGAT 
TCAAAAAGCA AGCTGTTGCA GACATCAGTG AGTGTTCATC CTGATGCTAT CGAAAAGACT 
ATTGATGACA TCATGGAATT GAAAAAAATT AACCCTGACA TCAATCCACA GTTGGGAATC 
TCTCTCCAGG CTTGCCTTCT GCAAATTGTG GGTTACAGAA ACCTCATTGC AGATGTGGAA 
AAACTGCGCA GAGAACCCTA CGATTCCGAC AACCCCCAGC ATGAAGAGAT GCTTCTGAAG 
CTATGGGAGT TCCTGAAGCC CAACACTCCA CTGGAGTCTC GGATTTCTAA GCAGTGGTGT 
GAGATTGGCT TCCAAGGTGA TGATCCGAAA ACAGATTTTC GAGGAATGGG TCTTCTGGGA 
CTTTACAATT TGCAATATTT CGCAGAACGG GATGCCACGG TAGCTCAGCA AGTTCTGTGT 
GACTCTGTTC ATCCAAAATG CAGCAAATTC AGCAAAACAG AATGGGAAAA GAAAAAGATG 
GATAAAGCAA TTGGGTACTC CTTTGCAATC GTGGGCATCA ATATCACCGA CCTGGCATAT 
AATCTGCTCG TGAGCGGCGC TCTGAAAACA CATTTCTACA ACATCGCTCC CGAAGCTCCA 
ACACTGTCTC ACTTCCAGCA AACATTCTGC TATTTGATGC ACGAGTTTCA CAAGTTTTGG 
ATTGAAGAGG ACCCCATGGA CATAATGGAA TTTAACCGCG TGCGGGAGAA ATTCCGCAAG 
AGAATCATAA AACAGCTGCA GAACCCAGAC ATGGCGCTGT GCCCACATTT CGCTGCCTCT 
GAAGGTTTAA TCAACATGTA G

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID ORa62415
Clone ID Related Accession (Same CDS sequence) XM_017595642.1
Accession Version XM_017595642.1 Latest version! Documents for ORF clone product in default vector
Sequence Information ORF Nucleotide Sequence (Length: 987bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ™ Seamless cloning technology
Insert Structure linear
Update Date 2016-07-25
Organism Rattus norvegicus(Norway rat)
Product ELMO domain-containing protein 1 isoform X1
Comment Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005107.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## 

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
ATGTTGATCC AGGTGTGCCT CTATTTCTAC TGTAAATTTT TGTGGCGCTG CATGAAGTTT 
GTGATGCGTA AGCTCACGGG AAGGTGTGAG CTGCAAAGGA TTTGCTACGG CACCAAACCC 
GGAGCTTCCA GAACCATGAA AATTGAAACG TCACTGAGAG ATTCAAAAAG CAAGCTGTTG 
CAGACATCAG TGAGTGTTCA TCCTGATGCT ATCGAAAAGA CTATTGATGA CATCATGGAA 
TTGAAAAAAA TTAACCCTGA CATCAATCCA CAGTTGGGAA TCTCTCTCCA GGCTTGCCTT 
CTGCAAATTG TGGGTTACAG AAACCTCATT GCAGATGTGG AAAAACTGCG CAGAGAACCC 
TACGATTCCG ACAACCCCCA GCATGAAGAG ATGCTTCTGA AGCTATGGGA GTTCCTGAAG 
CCCAACACTC CACTGGAGTC TCGGATTTCT AAGCAGTGGT GTGAGATTGG CTTCCAAGGT 
GATGATCCGA AAACAGATTT TCGAGGAATG GGTCTTCTGG GACTTTACAA TTTGCAATAT 
TTCGCAGAAC GGGATGCCAC GGTAGCTCAG CAAGTTCTGT GTGACTCTGT TCATCCAAAA 
TGCAGGGATA TCACTAAGGA GGAAATAAGC AAATTCAGCA AAACAGAATG GGAAAAGAAA 
AAGATGGATA AAGCAATTGG GTACTCCTTT GCAATCGTGG GCATCAATAT CACCGACCTG 
GCATATAATC TGCTCGTGAG CGGCGCTCTG AAAACACATT TCTACAACAT CGCTCCCGAA 
GCTCCAACAC TGTCTCACTT CCAGCAAACA TTCTGCTATT TGATGCACGA GTTTCACAAG 
TTTTGGATTG AAGAGGACCC CATGGACATA ATGGAATTTA ACCGCGTGCG GGAGAAATTC 
CGCAAGAGAA TCATAAAACA GCTGCAGAAC CCAGACATGG CGCTGTGCCC ACATTTCGCT 
GCCTCTGAAG GTTTAATCAA CATGTAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq XP_017451131.1
CDS290..1276
Translation

Target ORF information:

RefSeq Version XM_017595642.1
Organism Rattus norvegicus(Norway rat)
Definition Rattus norvegicus ELMO domain containing 1 (Elmod1), transcript variant X1, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
 XM_017595642.1

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
ATGTTGATCC AGGTGTGCCT CTATTTCTAC TGTAAATTTT TGTGGCGCTG CATGAAGTTT 
GTGATGCGTA AGCTCACGGG AAGGTGTGAG CTGCAAAGGA TTTGCTACGG CACCAAACCC 
GGAGCTTCCA GAACCATGAA AATTGAAACG TCACTGAGAG ATTCAAAAAG CAAGCTGTTG 
CAGACATCAG TGAGTGTTCA TCCTGATGCT ATCGAAAAGA CTATTGATGA CATCATGGAA 
TTGAAAAAAA TTAACCCTGA CATCAATCCA CAGTTGGGAA TCTCTCTCCA GGCTTGCCTT 
CTGCAAATTG TGGGTTACAG AAACCTCATT GCAGATGTGG AAAAACTGCG CAGAGAACCC 
TACGATTCCG ACAACCCCCA GCATGAAGAG ATGCTTCTGA AGCTATGGGA GTTCCTGAAG 
CCCAACACTC CACTGGAGTC TCGGATTTCT AAGCAGTGGT GTGAGATTGG CTTCCAAGGT 
GATGATCCGA AAACAGATTT TCGAGGAATG GGTCTTCTGG GACTTTACAA TTTGCAATAT 
TTCGCAGAAC GGGATGCCAC GGTAGCTCAG CAAGTTCTGT GTGACTCTGT TCATCCAAAA 
TGCAGGGATA TCACTAAGGA GGAAATAAGC AAATTCAGCA AAACAGAATG GGAAAAGAAA 
AAGATGGATA AAGCAATTGG GTACTCCTTT GCAATCGTGG GCATCAATAT CACCGACCTG 
GCATATAATC TGCTCGTGAG CGGCGCTCTG AAAACACATT TCTACAACAT CGCTCCCGAA 
GCTCCAACAC TGTCTCACTT CCAGCAAACA TTCTGCTATT TGATGCACGA GTTTCACAAG 
TTTTGGATTG AAGAGGACCC CATGGACATA ATGGAATTTA ACCGCGTGCG GGAGAAATTC 
CGCAAGAGAA TCATAAAACA GCTGCAGAAC CCAGACATGG CGCTGTGCCC ACATTTCGCT 
GCCTCTGAAG GTTTAATCAA CATGTAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

PubMed

book

High-content genome-wide RNAi screens identify regulators of parkin upstream of mitophagy.
Nature504(7479)291-5(2013 Dec)
Hasson SA,Kane LA,Yamano K,Huang CH,Sliter DA,Buehler E,Wang C,Heman-Ackah SM,Hessa T,Guha R,Martin SE,Youle RJ


book

ELMOD2 is an Arl2 GTPase-activating protein that also acts on Arfs.
The Journal of biological chemistry282(24)17568-80(2007 Jun)
Bowzard JB,Cheng D,Peng J,Kahn RA