Endog cDNA ORF clone, Rattus norvegicus(Norway rat)

Ovariectomy and 17?-estradiol replacement play a role on the expression of Endonuclease-G and phosphorylated cyclic AMP response element-binding (CREB) protein in hippocampus.
Pereira RT, Porto CS, Abdalla FM
Molecular and cellular endocrinology382(1)227-33(2014 Jan)

Naringenin prevents high glucose-induced mitochondria-mediated apoptosis involving AIF, Endo-G and caspases.
Kapoor R, Rizvi F, Kakkar P
Apoptosis : an international journal on programmed cell death18(1)9-27(2013 Jan)

Intranuclear localization of apoptosis-inducing factor and endonuclease G involves in peroxynitrite-induced apoptosis of spiral ganglion neurons.
Liu W, Fan Z, Han Y, Zhang D, Li J, Wang H
Neurological research34(10)915-22(2012 Dec)

Natural terpenes prevent mitochondrial dysfunction, oxidative stress and release of apoptotic proteins during nimesulide-hepatotoxicity in rats.
Singh BK, Tripathi M, Chaudhari BP, Pandey PK, Kakkar P
PloS one7(4)e34200(2012)

Endonuclease G is a novel determinant of cardiac hypertrophy and mitochondrial function.
McDermott-Roe C, Ye J, Ahmed R, Sun XM, Seraf?n A, Ware J, Bottolo L, Muckett P, Ca?as X, Zhang J, Rowe GC, Buchan R, Lu H, Braithwaite A, Mancini M, Hauton D, Mart? R, Garc?a-Arum? E, Hubner N, Jacob H, Serikawa T, Zidek V, Papousek F, Kolar F, Cardona M, Ruiz-Meana M, Garc?a-Dorado D, Comella JX, Felkin LE, Barton PJ, Arany Z, Pravenec M, Petretto E, Sanchis D, Cook SA
Nature478(7367)114-8(2011 Oct)

The aim of the present study was to investigate the effects of ovariectomy and 17beta-estradiol (E2) replacement on the expression of Cytochrome C, apoptosis inducing factor (AIF) and Endonuclease-G (Endo-G) and CREB in hippocampus of the adult female rats.
Title: Ovariectomy and 17?-estradiol replacement play a role on the expression of Endonuclease-G and phosphorylated cyclic AMP response element-binding (CREB) protein in hippocampus.

Peroxynitrite can trigger apoptosis in spiral ganglion neurons associated with mitochondrial AIF and endonuclease G intranuclear localization.
Title: Intranuclear localization of apoptosis-inducing factor and endonuclease G involves in peroxynitrite-induced apoptosis of spiral ganglion neurons.

present study has further established the link between mitochondrial dysfunction, reactive oxygen species and heart disease and has uncovered a role for Endog in maladaptive cardiac hypertrophy
Title: Endonuclease G is a novel determinant of cardiac hypertrophy and mitochondrial function.

These data establish a link between Bnip3 and EndoG-dependent, TUNEL-positive, DNA fragmentation in ischemic cardiomyocytes in the absence of caspases, defining an alternative cell death pathway in postmitotic cells.
Title: EndoG links Bnip3-induced mitochondrial damage and caspase-independent DNA fragmentation in ischemic cardiomyocytes.

EndoG upregulates and translocates from mitochondria to nucleus in cultured hippocampal neurons following oxygen-glucose deprivation, before observable pyknosis. When EndoG translocation is increased, neuronal death increases and vice versa.
Title: Mitochondrial BNIP3 upregulation precedes endonuclease G translocation in hippocampal neuronal death following oxygen-glucose deprivation.