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Mmadhc cDNA ORF clone, Rattus norvegicus(Norway rat)

Summary

Gene Symbol Mmadhc
Entrez Gene ID 362134
Full Name methylmalonic aciduria and homocystinuria, cblD type
Synonyms CblD,RGD1303272
General protein information
Preferred Names

methylmalonic aciduria and homocystinuria, cblD type

Names

methylmalonic aciduria and homocystinuria type D homolog, mitochondrial
methylmalonic aciduria (cobalamin deficiency) cblD type, with homocystinuria
Gene Type protein-coding
Organism Rattus norvegicus(Norway rat)
Genome

3

3q12

Reference Sequences (RefSeq)

mRNA and Protein(s)

mRNA Protein Name
XM_006234158.3 XP_006234220.1 methylmalonic aciduria and homocystinuria type D homolog, mitochondrial isoform X1
NM_001004280.1 NP_001004280.1 methylmalonic aciduria and homocystinuria type D homolog, mitochondrial precursor

Pathways from BioSystems


Homologies


Homo sapiens (human) MMADHC NP_056517.1
Bos taurus (cattle) MMADHC NP_001029713.1
Gallus gallus (chicken) MMADHC NP_001008477.1
Caenorhabditis elegans (roundworm) Y76A2B.5 NP_499801.1
MMADHC XP_001082223.1
Mus musculus (house mouse) Mmadhc NP_598600.1
Rattus norvegicus (Norway rat) Mmadhc NP_001004280.1
Xenopus tropicalis (tropical clawed frog) mmadhc NP_001016731.1
Pan troglodytes (chimpanzee) MMADHC XP_001135306.1
Canis lupus familiaris (dog) MMADHC XP_849074.1
Danio rerio (zebrafish) zgc:92335 NP_001002453.1

Gene Ontology


Bibliography

Related articles in PubMed

Characterization of functional domains of the cblD (MMADHC) gene product.
Jusufi J, Suormala T, Burda P, Fowler B, Froese DS, Baumgartner MR
Journal of inherited metabolic disease37(5)841-9(2014 Sep)

Subcellular location of MMACHC and MMADHC, two human proteins central to intracellular vitamin B(12) metabolism.
Mah W, Deme JC, Watkins D, Fung S, Janer A, Shoubridge EA, Rosenblatt DS, Coulton JW
Molecular genetics and metabolism108(2)112-8(2013 Feb)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Mmadhc gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Mmadhc cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID Accession No. Definition **Vector *Turnaround time Price (USD) Select
ORa13003 NM_001004280.1
Latest version!		 Rattus norvegicus metabolism of cobalamin associated D (Mmadhc), mRNA. pcDNA3.1+/C-(K)DYK or customized vector 5-7 $139.30
$199.00
ORa25843 XM_006234158.3
Latest version!		 Rattus norvegicus methylmalonic aciduria and homocystinuria, cblD type (Mmadhc), transcript variant X1, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 7-9 $223.30
$319.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)


CloneID ORa13003
Clone ID Related Accession (Same CDS sequence) NM_001004280.1
Accession Version NM_001004280.1 Latest version! Documents for ORF clone product in default vector
Sequence Information ORF Nucleotide Sequence (Length: 891bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ™ Seamless cloning technology
Insert Structure linear
Update Date 2019-02-15
Organism Rattus norvegicus(Norway rat)
Product methylmalonic aciduria and homocystinuria type D homolog, mitochondrial precursor
Comment Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC078953.1. On Sep 10, 2004 this sequence version replaced XM_342434.1. ##Evidence-Data-START## Transcript exon combination :: BC078953.1, FQ216405.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01906351 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: inferred from homology ##RefSeq-Attributes-END## 

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
ATGGCCCATG TGCTCTGTAA CAGAGCCAGA CTGGTTTCCT ATCTCCCAGG ATTTTGTTCT 
CTAGTGAAAA GAGTTATCAA TCCAAGAGCC TTTTCAACTG CAGGATCGTC AGGTTCCGAT 
GAGTCTCACG TGGCCACTGC ACCTCCAGAT ATATGCTCTC GGACAGTGTG GCCTGATGAA 
ACCATGGGAC CCTTTGGACC TCAGGACCAG AGATTCCAGC TTCCTGGGAA TATAGGCTTC 
GATTGTCACC TCAATGGGAC AGCCTCACAG AAGAAAAGCC AGGCCCATAA AACCTTGCCT 
GATGTTCTAG CAGAGCCTCT TTCAACCGAA AGGCACGAGT TTGTGATGGC CCAGTATGTG 
AATGAGTTTC AGGATAGCAA TGCACCTGTT GAGCAAGAGA TCAGCAGTGC AGAAACTTAC 
TTTGAAAGTG CCAGAGTTGA GTGTGCCATC CAGACATGTC CCGAACTGCT GCGGAGAGAT 
TTTGAGTCAC TTTTTCCAGA GGTGGCTAAT AGCAAACTGA TGATTCTGAC TGTAACCCAG 
AAAACTGAAC ATGACATGAC TGTCTGGAGT GAAGAGGTAG AAGTTGAGAG AGAGGCGCTC 
TTGGAGAAGT TCATTAATGG TGCTAAGGAA ATTTGCTATG CTCTTCGGGC TGAAGGATAC 
TGGGCTGACT TCATTGACCC GTCGTCTGGT TTGGCATTTT TTGGACCATA TACAAACAAC 
ACACTTTTTG AAACAGATGA ACGGTACCGG CATTTAGGAT TCTCTGTTGA TGACCTTGGC 
TGCTGTAAGG TGATCCGTCA TGGTCTCTGG GGCACTCATG TGGTTGTGGG AAGTATCTTC 
ACTAATGCAA CAGCAGACAG CCATATCATG AGGAAGCTCA GTGGGGACTA G

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_001004280.1
CDS107..997
Translation

Target ORF information:

RefSeq Version NM_001004280.1
Organism Rattus norvegicus(Norway rat)
Definition Rattus norvegicus metabolism of cobalamin associated D (Mmadhc), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
 NM_001004280.1

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
ATGGCCCATG TGCTCTGTAA CAGAGCCAGA CTGGTTTCCT ATCTCCCAGG ATTTTGTTCT 
CTAGTGAAAA GAGTTATCAA TCCAAGAGCC TTTTCAACTG CAGGATCGTC AGGTTCCGAT 
GAGTCTCACG TGGCCACTGC ACCTCCAGAT ATATGCTCTC GGACAGTGTG GCCTGATGAA 
ACCATGGGAC CCTTTGGACC TCAGGACCAG AGATTCCAGC TTCCTGGGAA TATAGGCTTC 
GATTGTCACC TCAATGGGAC AGCCTCACAG AAGAAAAGCC AGGCCCATAA AACCTTGCCT 
GATGTTCTAG CAGAGCCTCT TTCAACCGAA AGGCACGAGT TTGTGATGGC CCAGTATGTG 
AATGAGTTTC AGGATAGCAA TGCACCTGTT GAGCAAGAGA TCAGCAGTGC AGAAACTTAC 
TTTGAAAGTG CCAGAGTTGA GTGTGCCATC CAGACATGTC CCGAACTGCT GCGGAGAGAT 
TTTGAGTCAC TTTTTCCAGA GGTGGCTAAT AGCAAACTGA TGATTCTGAC TGTAACCCAG 
AAAACTGAAC ATGACATGAC TGTCTGGAGT GAAGAGGTAG AAGTTGAGAG AGAGGCGCTC 
TTGGAGAAGT TCATTAATGG TGCTAAGGAA ATTTGCTATG CTCTTCGGGC TGAAGGATAC 
TGGGCTGACT TCATTGACCC GTCGTCTGGT TTGGCATTTT TTGGACCATA TACAAACAAC 
ACACTTTTTG AAACAGATGA ACGGTACCGG CATTTAGGAT TCTCTGTTGA TGACCTTGGC 
TGCTGTAAGG TGATCCGTCA TGGTCTCTGG GGCACTCATG TGGTTGTGGG AAGTATCTTC 
ACTAATGCAA CAGCAGACAG CCATATCATG AGGAAGCTCA GTGGGGACTA G

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID ORa25843
Clone ID Related Accession (Same CDS sequence) XM_006234158.3
Accession Version XM_006234158.3 Latest version! Documents for ORF clone product in default vector
Sequence Information ORF Nucleotide Sequence (Length: 1113bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ™ Seamless cloning technology
Insert Structure linear
Update Date 2016-07-25
Organism Rattus norvegicus(Norway rat)
Product methylmalonic aciduria and homocystinuria type D homolog, mitochondrial isoform X1
Comment Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005102.4) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_006234158.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## 

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
ATGCGCTCGG AGGCAACTAC TCAGGTCTGG GCGTCAACAG CGCCTGCCTG GACCGCCATT 
TTGACAGTGG ACGTGTTGAG GGACTGGATC AGCTGGCCGT GTGGTGACTG GTACGGATGG 
TTCCCACCCG CGGTCTCTTC TGCACTTTCA CGGGTGACCG TGCCCCTGCT GTCGGGATAC 
TTTGCAGAGG GGAAAAGTCT GCGTCCGCCT TCTTCACTAG AAATGGCCCA TGTGCTCTGT 
AACAGAGCCA GACTGGTTTC CTATCTCCCA GGATTTTGTT CTCTAGTGAA AAGAGTTATC 
AATCCAAGAG CCTTTTCAAC TGCAGGATCG TCAGGTTCCG ATGAGTCTCA CGTGGCCACT 
GCACCTCCAG ATATATGCTC TCGGACAGTG TGGCCTGATG AAACCATGGG ACCCTTTGGA 
CCTCAGGACC AGAGATTCCA GCTTCCTGGG AATATAGGCT TCGATTGTCA CCTCAATGGG 
ACAGCCTCAC AGAAGAAAAG CCAGGCCCAT AAAACCTTGC CTGATGTTCT AGCAGAGCCT 
CTTTCAACCG AAAGGCACGA GTTTGTGATG GCCCAGTATG TGAATGAGTT TCAGGATAGC 
AATGCACCTG TTGAGCAAGA GATCAGCAGT GCAGAAACTT ACTTTGAAAG TGCCAGAGTT 
GAGTGTGCCA TCCAGACATG TCCCGAACTG CTGCGGAGAG ATTTTGAGTC ACTTTTTCCA 
GAGGTGGCTA ATAGCAAACT GATGATTCTG ACTGTAACCC AGAAAACTGA ACATGACATG 
ACTGTCTGGA GTGAAGAGGT AGAAGTTGAG AGAGAGGCGC TCTTGGAGAA GTTCATTAAT 
GGTGCTAAGG AAATTTGCTA TGCTCTTCGG GCTGAAGGAT ACTGGGCTGA CTTCATTGAC 
CCGTCGTCTG GTTTGGCATT TTTTGGACCA TATACAAACA ACACACTTTT TGAAACAGAT 
GAACGGTACC GGCATTTAGG ATTCTCTGTT GATGACCTTG GCTGCTGTAA GGTGATCCGT 
CATGGTCTCT GGGGCACTCA TGTGGTTGTG GGAAGTATCT TCACTAATGC AACAGCAGAC 
AGCCATATCA TGAGGAAGCT CAGTGGGGAC TAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq XP_006234220.1
CDS16..1128
Translation

Target ORF information:

RefSeq Version XM_006234158.3
Organism Rattus norvegicus(Norway rat)
Definition Rattus norvegicus methylmalonic aciduria and homocystinuria, cblD type (Mmadhc), transcript variant X1, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
 XM_006234158.3

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
ATGCGCTCGG AGGCAACTAC TCAGGTCTGG GCGTCAACAG CGCCTGCCTG GACCGCCATT 
TTGACAGTGG ACGTGTTGAG GGACTGGATC AGCTGGCCGT GTGGTGACTG GTACGGATGG 
TTCCCACCCG CGGTCTCTTC TGCACTTTCA CGGGTGACCG TGCCCCTGCT GTCGGGATAC 
TTTGCAGAGG GGAAAAGTCT GCGTCCGCCT TCTTCACTAG AAATGGCCCA TGTGCTCTGT 
AACAGAGCCA GACTGGTTTC CTATCTCCCA GGATTTTGTT CTCTAGTGAA AAGAGTTATC 
AATCCAAGAG CCTTTTCAAC TGCAGGATCG TCAGGTTCCG ATGAGTCTCA CGTGGCCACT 
GCACCTCCAG ATATATGCTC TCGGACAGTG TGGCCTGATG AAACCATGGG ACCCTTTGGA 
CCTCAGGACC AGAGATTCCA GCTTCCTGGG AATATAGGCT TCGATTGTCA CCTCAATGGG 
ACAGCCTCAC AGAAGAAAAG CCAGGCCCAT AAAACCTTGC CTGATGTTCT AGCAGAGCCT 
CTTTCAACCG AAAGGCACGA GTTTGTGATG GCCCAGTATG TGAATGAGTT TCAGGATAGC 
AATGCACCTG TTGAGCAAGA GATCAGCAGT GCAGAAACTT ACTTTGAAAG TGCCAGAGTT 
GAGTGTGCCA TCCAGACATG TCCCGAACTG CTGCGGAGAG ATTTTGAGTC ACTTTTTCCA 
GAGGTGGCTA ATAGCAAACT GATGATTCTG ACTGTAACCC AGAAAACTGA ACATGACATG 
ACTGTCTGGA GTGAAGAGGT AGAAGTTGAG AGAGAGGCGC TCTTGGAGAA GTTCATTAAT 
GGTGCTAAGG AAATTTGCTA TGCTCTTCGG GCTGAAGGAT ACTGGGCTGA CTTCATTGAC 
CCGTCGTCTG GTTTGGCATT TTTTGGACCA TATACAAACA ACACACTTTT TGAAACAGAT 
GAACGGTACC GGCATTTAGG ATTCTCTGTT GATGACCTTG GCTGCTGTAA GGTGATCCGT 
CATGGTCTCT GGGGCACTCA TGTGGTTGTG GGAAGTATCT TCACTAATGC AACAGCAGAC 
AGCCATATCA TGAGGAAGCT CAGTGGGGAC TAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

PubMed

book

Characterization of functional domains of the cblD (MMADHC) gene product.
Journal of inherited metabolic disease37(5)841-9(2014 Sep)
Jusufi J,Suormala T,Burda P,Fowler B,Froese DS,Baumgartner MR


book

Subcellular location of MMACHC and MMADHC, two human proteins central to intracellular vitamin B(12) metabolism.
Molecular genetics and metabolism108(2)112-8(2013 Feb)
Mah W,Deme JC,Watkins D,Fung S,Janer A,Shoubridge EA,Rosenblatt DS,Coulton JW