Gene Symbol | Syne1 |
Entrez Gene ID | 499010 |
Full Name | spectrin repeat containing nuclear envelope protein 1 |
Synonyms | CPG2,Myne-1 |
General protein information |
|
Gene Type | protein-coding |
Organism | Rattus norvegicus(Norway rat) |
Genome |
ORF » Species Summary » Rattus norvegicus » Syne1 cDNA ORF clone
gRNAs
Gene Symbol | Syne1 |
Entrez Gene ID | 499010 |
Full Name | spectrin repeat containing nuclear envelope protein 1 |
Synonyms | CPG2,Myne-1 |
General protein information |
|
Gene Type | protein-coding |
Organism | Rattus norvegicus(Norway rat) |
Genome |
mRNA | Protein | Name |
---|---|---|
XM_006227851.3 | XP_006227913.1 | nesprin-1 isoform X3 |
XM_006227853.3 | XP_006227915.1 | nesprin-1 isoform X4 |
XM_006227852.3 | XP_006227914.1 | nesprin-1 isoform X5 |
XM_008758713.2 | XP_008756935.1 | nesprin-1 isoform X2 |
XM_017590500.1 | XP_017445989.1 | nesprin-1 isoform X1 |
XM_008774326.2 | XP_008772548.1 | nesprin-1 isoform X6 |
Rattus norvegicus (Norway rat) | Syne1 | XP_006227911.1 |
Danio rerio (zebrafish) | syne1b | XP_005158667.1 |
Pan troglodytes (chimpanzee) | SYNE1 | XP_518815.4 |
Canis lupus familiaris (dog) | SYNE1 | XP_005615580.1 |
SYNE1 | XP_001100631.2 | |
Gallus gallus (chicken) | SYNE1 | XP_419679.4 |
Homo sapiens (human) | SYNE1 | NP_892006.3 |
Mus musculus (house mouse) | Syne1 | NP_001073154.1 |
Nesprins: a novel family of spectrin-repeat-containing proteins that localize to the nuclear membrane in multiple tissues.
Zhang Q, Skepper JN, Yang F, Davies JD, Hegyi L, Roberts RG, Weissberg PL, Ellis JA, Shanahan CM
Journal of cell science114(Pt 24)4485-98(2001 Dec)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
Through direct interactions with F-actin and EndoB2, CPG2 physically bridges the spine cytoskeleton and the endocytic machinery, and this tripartite association is critical specifically for activity-dependent clathrin-mediated endocytosis of synaptic glutamate receptors.
Title: CPG2 Recruits Endophilin B2 to the Cytoskeleton for Activity-Dependent Endocytosis of Synaptic Glutamate Receptors.
the expression of nesprin-1 protein was higher during the differentiation process of MSCs and may have an important role in mediating MSC differentiation.
Title: Nesprin-1 has key roles in the process of mesenchymal stem cell differentiation into cardiomyocyte-like cells in vivo and in vitro.
CPG2 regulates synaptic AMPAR endocytosis through its association with the spine cytoskeleton and functions as a nexus for integrating PKA signaling with this process.
Title: Regulation of glutamate receptor internalization by the spine cytoskeleton is mediated by its PKA-dependent association with CPG2.
In the process of mesenchymal stem cell proliferation and differentiation, the upregulation of the protein expression of nesprin-1 may maintain the stability of the cell nuclear membrane and reduce the apoptosis of the mesenchymal stem cells.
Title: Nesprin-1 plays an important role in the proliferation and apoptosis of mesenchymal stem cells.
Through the direct binding of the nesprin-1alpha amino-terminal dimerization domain to the third mAKAP spectrin repeat, nesprin-1alpha targets mAKAP to the nuclear envelope.
Title: Nesprin-1alpha contributes to the targeting of mAKAP to the cardiac myocyte nuclear envelope.
The following Syne1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Syne1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | ORa14058 | |
Clone ID Related Accession (Same CDS sequence) | XM_006227852.3 | |
Accession Version | XM_006227852.3 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 2850bp) Protein sequence SNP |
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Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-07-25 | |
Organism | Rattus norvegicus(Norway rat) | |
Product | nesprin-1 isoform X5 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005100.4) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_006227852.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGGTGGTGG CAGAGGACTT GCGTGCCCTG AGGATGGCAG AGGACGGCAG TGTGGACGCA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_006227914.1 |
CDS | 1536..4385 |
Translation |
Target ORF information:
Target ORF information:
|
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1 | ATGGTGGTGG CAGAGGACTT GCGTGCCCTG AGGATGGCAG AGGACGGCAG TGTGGACGCA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | ORa14055 | |
Clone ID Related Accession (Same CDS sequence) | XM_006227853.3 | |
Accession Version | XM_006227853.3 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 4296bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-07-25 | |
Organism | Rattus norvegicus(Norway rat) | |
Product | nesprin-1 isoform X4 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005100.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_006227853.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGGCAACCT CCCGGGCATC TTCCAGGTCT CATCGGGACA TCACCAACGT GATGCAGAGG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_006227915.1 |
CDS | 488..4783 |
Translation |
Target ORF information:
Target ORF information:
|
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1 | ATGGCAACCT CCCGGGCATC TTCCAGGTCT CATCGGGACA TCACCAACGT GATGCAGAGG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | ORa22125 | |
Clone ID Related Accession (Same CDS sequence) | XM_006227851.3 | |
Accession Version | XM_006227851.3 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 9051bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-07-25 | |
Organism | Rattus norvegicus(Norway rat) | |
Product | nesprin-1 isoform X3 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005100.4) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_006227851.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGTTTCCTC AGGAGCTGGC GCAGAAAATC AAGGGCTACC AGGAGCAAAT TGCCTCTTTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_006227913.1 |
CDS | 1..9051 |
Translation |
Target ORF information:
Target ORF information:
|
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1 | ATGTTTCCTC AGGAGCTGGC GCAGAAAATC AAGGGCTACC AGGAGCAAAT TGCCTCTTTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | ORa49164 | |
Clone ID Related Accession (Same CDS sequence) | XM_008774326.2 | |
Accession Version | XM_008774326.2 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 26469bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-07-25 | |
Organism | Rattus norvegicus(Norway rat) | |
Product | nesprin-1 isoform X6 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (AC_000069.1) and transcript sequence (AF452647.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_008774326.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## ##RefSeq-Attributes-START## assembly gap :: added 515 transcript bases to patch genome assembly gap ##RefSeq-Attributes-END## |
1 | ATGGCAACCT CCCGGGCATC TTCCAGGTCT CATCGGGACA TCACCAACGT GATGCAGAGG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_008772548.1 |
CDS | 485..26953 |
Translation |
Target ORF information:
Target ORF information:
|
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1 | ATGGCAACCT CCCGGGCATC TTCCAGGTCT CATCGGGACA TCACCAACGT GATGCAGAGG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | ORa49165 | |
Clone ID Related Accession (Same CDS sequence) | XM_008758713.2 | |
Accession Version | XM_008758713.2 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 9135bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-07-25 | |
Organism | Rattus norvegicus(Norway rat) | |
Product | nesprin-1 isoform X2 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005100.4) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_008758713.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGTTTCCTC AGGAGCTGGC GCAGAAAATC AAGGGCTACC AGGAGCAAAT TGCCTCTTTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_008756935.1 |
CDS | 361..9495 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGTTTCCTC AGGAGCTGGC GCAGAAAATC AAGGGCTACC AGGAGCAAAT TGCCTCTTTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | ORa57111 | |
Clone ID Related Accession (Same CDS sequence) | XM_017590500.1 | |
Accession Version | XM_017590500.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 9588bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-07-25 | |
Organism | Rattus norvegicus(Norway rat) | |
Product | nesprin-1 isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005100.4) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGGCAACCT CCCGGGCATC TTCCAGGTCT CATCGGGACA TCACCAACGT GATGCAGAGG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_017445989.1 |
CDS | 493..10080 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGGCAACCT CCCGGGCATC TTCCAGGTCT CATCGGGACA TCACCAACGT GATGCAGAGG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Nesprins: a novel family of spectrin-repeat-containing proteins that localize to the nuclear membrane in multiple tissues. |