Ednrb cDNA ORF clone, Rattus norvegicus(Norway rat)
| Gene Symbol | Ednrb |
| Entrez Gene ID | 50672 |
| Full Name | endothelin receptor type B |
| Synonyms | Ednra,Etb |
| General protein information |
|
| Gene Type | protein-coding |
| Organism | Rattus norvegicus(Norway rat) |
| Genome |
mRNA and Protein(s)
| mRNA | Protein | Name |
|---|---|---|
| XM_017599786.1 | XP_017455275.1 | endothelin B receptor isoform X1 |
| NM_017333.1 | NP_059029.1 | endothelin receptor type B precursor |
| XM_006252431.3 | XP_006252493.1 | endothelin B receptor isoform X1 |
| Pan troglodytes (chimpanzee) | EDNRB | XP_509693.1 |
| Canis lupus familiaris (dog) | EDNRB | NP_001010943.2 |
| Rattus norvegicus (Norway rat) | Ednrb | NP_059029.1 |
| Homo sapiens (human) | EDNRB | NP_001188326.1 |
| EDNRB | XP_001089047.2 | |
| Danio rerio (zebrafish) | ednrb1a | NP_571272.1 |
| Bos taurus (cattle) | EDNRB | NP_776734.1 |
| Mus musculus (house mouse) | Ednrb | NP_001129533.1 |
| Gallus gallus (chicken) | EDNRB | NP_001001127.1 |
| Xenopus tropicalis (tropical clawed frog) | ednrb | NP_001072476.1 |
Related articles in PubMed
High glucose upregulates endothelin type B receptors in vascular smooth muscle cells via the downregulation of Sirt1.
Lin Y, Zhao Y, Liu E
International journal of molecular medicine41(1)439-445(2018 Jan)
Diurnal pattern in skin Na
Speed JS, Hyndman KA, Kasztan M, Johnston JG, Roth KJ, Titze JM, Pollock DM
American journal of physiology. Regulatory, integrative and comparative physiology(2017 Dec)
Endothelin receptor mediated Ca
Kristiansen SB, Haanes KA, Sheykhzade M, Edvinsson L
Journal of molecular and cellular cardiology1111-9(2017 Oct)
Renal denervation attenuates hypertension but not salt sensitivity in ET
Becker BK, Feagans AC, Chen D, Kasztan M, Jin C, Speed JS, Pollock JS, Pollock DM
American journal of physiology. Regulatory, integrative and comparative physiology313(4)R425-R437(2017 Oct)
Endothelin-1 Decreases Excitability of the Dorsal Root Ganglion Neurons via ET
Mule NK, Singh JN, Shah KU, Gulati A, Sharma SS
Molecular neurobiology(2017 Jun)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
Denervation reduced mean arterial pressure in ETB-deficient rats compared with sham-operated controls, however denervation did not affect the increase in blood pressure after 2 wk of high-salt diet. Denervation reduced cardiac sympathetic-to-parasympathetic tone [low frequency-high frequency (LF/HF)] during normal salt diet and vasomotor LF/HF tone during high-salt diet in ETB-def rats.
Title: Renal denervation attenuates hypertension but not salt sensitivity in ET
Data analyses strongly suggest that the identified deletion in the intergenic region upstream of Ednrb, which might contain a melanocyte-specific enhancer, is the mutation causative of the head spot phenotype in the KFRS4/Kyo rat strain.
Title: A deletion in the intergenic region upstream of Ednrb causes head spot in the rat strain KFRS4/Kyo.
the mRNA expression of prepro-endothelin-1 (ppET-1), as well as that of the ETA and ETB receptors, were quantified by real-time PCR in these veins... exercise training mobilizes endothelin-1 (ET-1) to reinforce the Ang II-induced responses mainly through ETA activation
Title: Prostanoids counterbalance the synergism between endothelin-1 and angiotensin II in mesenteric veins of trained rats.
These findings demonstrate that diurnal excretion of an acute salt load 1) requires ET-1 and the ETB receptor, 2) is more evident in male vs. female rats, and 3) is opposed by the ETA receptor.
Title: Loss of endothelin B receptor function impairs sodium excretion in a time- and sex-dependent manner.
Expression of smooth muscle proteins and both ETA and ETB by the endovascular trophoblast enable it to contract upon activation of both receptors by ET1.
Title: Vasoactivity of the rat endovascular trophoblast.
The following Ednrb gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Ednrb cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
| CloneID | ORa13159 | |
| Clone ID Related Accession (Same CDS sequence) | XM_017599786.1 , NM_017333.1 , XM_006252431.3 | |
| Accession Version | NM_017333.1 Latest version! | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 1329bp) Protein sequence SNP |
|
| Vector | pcDNA3.1+/C-(K)DYK or customized vector |  User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2019-09-23 | |
| Organism | Rattus norvegicus(Norway rat) | |
| Product | endothelin receptor type B precursor | |
| Comment | Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from S65355.1. On Dec 17, 2003 this sequence version replaced XM_344451.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## CDS exon combination :: X57764.1 [ECO:0000331] RNAseq introns :: mixed/partial sample support SAMD00052296, SAMD00052297 [ECO:0000350] ##Evidence-Data-END## | |
1 | ATGCAATCGT CCGCAAGCCG GTGCGGACGC GCCTTGGTGG CGCTGCTGCT GGCCTGTGGC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | NP_059029.1 |
| CDS | 252..1580 |
| Translation |
Target ORF information:
Target ORF information:
|
 NM_017333.1 |
ORF Insert Sequence:
1 | ATGCAATCGT CCGCAAGCCG GTGCGGACGC GCCTTGGTGG CGCTGCTGCT GGCCTGTGGC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| CloneID | ORa13159 | |
| Clone ID Related Accession (Same CDS sequence) | XM_017599786.1 , NM_017333.1 , XM_006252431.3 | |
| Accession Version | XM_017599786.1 Latest version! | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 1329bp) Protein sequence SNP |
|
| Vector | pcDNA3.1+/C-(K)DYK or customized vector | User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2016-07-25 | |
| Organism | Rattus norvegicus(Norway rat) | |
| Product | endothelin B receptor isoform X1 | |
| Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005114.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## | |
1 | ATGCAATCGT CCGCAAGCCG GTGCGGACGC GCCTTGGTGG CGCTGCTGCT GGCCTGTGGC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | XP_017455275.1 |
| CDS | 592..1920 |
| Translation |
Target ORF information:
Target ORF information:
|
XM_017599786.1 |
ORF Insert Sequence:
1 | ATGCAATCGT CCGCAAGCCG GTGCGGACGC GCCTTGGTGG CGCTGCTGCT GGCCTGTGGC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| CloneID | ORa13159 | |
| Clone ID Related Accession (Same CDS sequence) | XM_017599786.1 , NM_017333.1 , XM_006252431.3 | |
| Accession Version | XM_006252431.3 Latest version! | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 1329bp) Protein sequence SNP |
|
| Vector | pcDNA3.1+/C-(K)DYK or customized vector | User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2016-07-25 | |
| Organism | Rattus norvegicus(Norway rat) | |
| Product | endothelin B receptor isoform X1 | |
| Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005114.4) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_006252431.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## | |
1 | ATGCAATCGT CCGCAAGCCG GTGCGGACGC GCCTTGGTGG CGCTGCTGCT GGCCTGTGGC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | XP_006252493.1 |
| CDS | 520..1848 |
| Translation |
Target ORF information:
Target ORF information:
|
XM_006252431.3 |
ORF Insert Sequence:
1 | ATGCAATCGT CCGCAAGCCG GTGCGGACGC GCCTTGGTGG CGCTGCTGCT GGCCTGTGGC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
 |
High glucose upregulates endothelin type B receptors in vascular smooth muscle cells via the downregulation of Sirt1. |
|
Diurnal pattern in skin Na |
|
Endothelin receptor mediated Ca |
|
Renal denervation attenuates hypertension but not salt sensitivity in ET |
|
Endothelin-1 Decreases Excitability of the Dorsal Root Ganglion Neurons via ET |