Vapb cDNA ORF clone, Rattus norvegicus(Norway rat)
| Gene Symbol | Vapb |
| Entrez Gene ID | 60431 |
| Full Name | VAMP associated protein B and C |
| General protein information |
|
| Gene Type | protein-coding |
| Organism | Rattus norvegicus(Norway rat) |
| Genome | |
| Summary | may play a role in exocytosis of neurotransmitters [RGD, Feb 2006]. |
mRNA and Protein(s)
| mRNA | Protein | Name |
|---|---|---|
| NM_021847.3 | NP_068619.1 | vesicle-associated membrane protein-associated protein B |
| XM_006235706.3 | XP_006235768.3 | vesicle-associated membrane protein-associated protein B isoform X1 |
| Xenopus tropicalis (tropical clawed frog) | MGC76271 | NP_988905.1 |
| Homo sapiens (human) | VAPB | NP_004729.1 |
| Mus musculus (house mouse) | Vapb | NP_062780.2 |
| Rattus norvegicus (Norway rat) | Vapb | NP_068619.1 |
| Gallus gallus (chicken) | VAPB | NP_001006296.1 |
| Drosophila melanogaster (fruit fly) | Vap-33-1 | NP_996347.1 |
| Canis lupus familiaris (dog) | VAPB | XP_534466.2 |
| Danio rerio (zebrafish) | vapb | NP_997812.1 |
| Anopheles gambiae (African malaria mosquito) | AgaP_AGAP000626 | XP_310452.5 |
| Pan troglodytes (chimpanzee) | VAPB | XP_001135464.1 |
| Bos taurus (cattle) | VAPB | NP_001075892.1 |
| Caenorhabditis elegans (roundworm) | vpr-1 | NP_491704.1 |
Related articles in PubMed
E-cadherin interactome complexity and robustness resolved by quantitative proteomics.
Guo Z, Neilson LJ, Zhong H, Murray PS, Zanivan S, Zaidel-Bar R
Science signaling7(354)rs7(2014 Dec)
STARD3 or STARD3NL and VAP form a novel molecular tether between late endosomes and the ER.
Alpy F, Rousseau A, Schwab Y, Legueux F, Stoll I, Wendling C, Spiegelhalter C, Kessler P, Mathelin C, Rio MC, Levine TP, Tomasetto C
Journal of cell science126(Pt 23)5500-12(2013 Dec)
The ALS8 protein VAPB interacts with the ER-Golgi recycling protein YIF1A and regulates membrane delivery into dendrites.
Kuijpers M, Yu KL, Teuling E, Akhmanova A, Jaarsma D, Hoogenraad CC
The EMBO journal32(14)2056-72(2013 Jul)
VAPB interacts with the mitochondrial protein PTPIP51 to regulate calcium homeostasis.
De Vos KJ, M?rotz GM, Stoica R, Tudor EL, Lau KF, Ackerley S, Warley A, Shaw CE, Miller CC
Human molecular genetics21(6)1299-311(2012 Mar)
The ALS8-associated mutant VAPB(P56S) is resistant to proteolysis in neurons.
Gkogkas C, Wardrope C, Hannah M, Skehel P
Journal of neurochemistry117(2)286-94(2011 Apr)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
YIF1A interacts with VAPB via its transmembrane regions, recycles between the ER and Golgi and is mainly localized to the ER-Golgi intermediate compartments in hippocampal neurons.
Title: The ALS8 protein VAPB interacts with the ER-Golgi recycling protein YIF1A and regulates membrane delivery into dendrites.
The results suggested that neuronal cells have a particular requirement for VAPB proteolysis and that reduced levels of processed polypeptides may contribute to the neurodegeneration associated with amyotrophic lateral sclerosis type 8.
Title: The ALS8-associated mutant VAPB(P56S) is resistant to proteolysis in neurons.
The following Vapb gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Vapb cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
| CloneID | ORa05271 | |
| Clone ID Related Accession (Same CDS sequence) | NM_021847.3 | |
| Accession Version | NM_021847.3 Latest version! | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 732bp) Protein sequence SNP |
|
| Vector | pcDNA3.1+/C-(K)DYK or customized vector |  User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2019-02-15 | |
| Organism | Rattus norvegicus(Norway rat) | |
| Product | vesicle-associated membrane protein-associated protein B | |
| Comment | Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AF086631.1. On Jun 10, 2007 this sequence version replaced NM_021847.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF086631.1, BC065576.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END## | |
1 | ATGGCGAAGG TGGAGCAGGT CCTGAGTCTC GAGCCACAGC ACGAGCTCAA GTTCCGAGGT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | NP_068619.1 |
| CDS | 1..732 |
| Translation |
Target ORF information:
Target ORF information:
|
 NM_021847.3 |
ORF Insert Sequence:
1 | ATGGCGAAGG TGGAGCAGGT CCTGAGTCTC GAGCCACAGC ACGAGCTCAA GTTCCGAGGT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| CloneID | ORa60527 | |
| Clone ID Related Accession (Same CDS sequence) | XM_006235706.3 | |
| Accession Version | XM_006235706.3 Latest version! | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 876bp) Protein sequence SNP |
|
| Vector | pcDNA3.1+/C-(K)DYK or customized vector | User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2016-07-25 | |
| Organism | Rattus norvegicus(Norway rat) | |
| Product | vesicle-associated membrane protein-associated protein B isoform X1 | |
| Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005102.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_006235706.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## | |
1 | ATGTGTGTAT TCATATTTCT ATTCACTAAT TTTAAGGTCC AGAAAGCAAC AGGGTCCGTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | XP_006235768.3 |
| CDS | 1..876 |
| Translation |
Target ORF information:
Target ORF information:
|
XM_006235706.3 |
ORF Insert Sequence:
1 | ATGTGTGTAT TCATATTTCT ATTCACTAAT TTTAAGGTCC AGAAAGCAAC AGGGTCCGTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
 |
E-cadherin interactome complexity and robustness resolved by quantitative proteomics. |
|
STARD3 or STARD3NL and VAP form a novel molecular tether between late endosomes and the ER. |
|
The ALS8 protein VAPB interacts with the ER-Golgi recycling protein YIF1A and regulates membrane delivery into dendrites. |
|
VAPB interacts with the mitochondrial protein PTPIP51 to regulate calcium homeostasis. |
|
The ALS8-associated mutant VAPB(P56S) is resistant to proteolysis in neurons. |