Gene Symbol | Angpt2 |
Entrez Gene ID | 89805 |
Full Name | angiopoietin 2 |
Synonyms | Agpt2,Ang-2 |
General protein information |
|
Gene Type | protein-coding |
Organism | Rattus norvegicus(Norway rat) |
Genome |
ORF » Species Summary » Rattus norvegicus » Angpt2 cDNA ORF clone
Gene Symbol | Angpt2 |
Entrez Gene ID | 89805 |
Full Name | angiopoietin 2 |
Synonyms | Agpt2,Ang-2 |
General protein information |
|
Gene Type | protein-coding |
Organism | Rattus norvegicus(Norway rat) |
Genome |
mRNA | Protein | Name |
---|---|---|
NM_134454.1 | NP_604449.1 | angiopoietin-2 precursor |
Canis lupus familiaris (dog) | ANGPT2 | NP_001041591.1 |
Mus musculus (house mouse) | Angpt2 | NP_031452.2 |
Rattus norvegicus (Norway rat) | Angpt2 | NP_604449.1 |
ANGPT2 | XP_001097949.1 | |
Gallus gallus (chicken) | ANGPT2 | NP_990148.1 |
Xenopus tropicalis (tropical clawed frog) | LOC100485272 | XP_004911625.1 |
Homo sapiens (human) | ANGPT2 | NP_001112359.1 |
Danio rerio (zebrafish) | angpt2a | NP_001265754.1 |
Pan troglodytes (chimpanzee) | ANGPT2 | XP_001145488.1 |
Bos taurus (cattle) | ANGPT2 | NP_001092325.1 |
Myoendothelial gap junctions mediate regulation of angiopoietin-2-induced vascular hyporeactivity after hypoxia through connexin 43-gated cAMP transfer.
Xu J, Yang G, Li T, Liu L
American journal of physiology. Cell physiology313(3)C262-C273(2017 Sep)
Hydrogen sulfide ameliorates acute lung injury induced by infrarenal aortic cross-clamping by inhibiting inflammation and angiopoietin 2 release.
Tang B, Ma L, Yao X, Tan G, Han P, Yu T, Liu B, Sun X
Journal of vascular surgery65(2)501-508.e1(2017 Feb)
Overexpression of angiopoietin-2 in rats and patients with liver fibrosis. Therapeutic consequences of its inhibition.
Pauta M, Ribera J, Melgar-Lesmes P, Casals G, Rodr?guez-Vita J, Reichenbach V, Fernandez-Varo G, Morales-Romero B, Bataller R, Michelena J, Altamirano J, Jim?nez W, Morales-Ruiz M
Liver international : official journal of the International Association for the Study of the Liver35(4)1383-92(2015 Apr)
Angiopoietin and vascular endothelial growth factor expression in colorectal disease models.
Liu WX, Gu SZ, Zhang S, Ren Y, Sang LX, Dai C
World journal of gastroenterology21(9)2645-50(2015 Mar)
Angiogenesis-related biomarkers in patients with alcoholic liver disease: their association with liver disease complications and outcome.
Kasztelan-Szczerbinska B, Surdacka A, Slomka M, Rolinski J, Celinski K, Cichoz-Lach H, Madro A, Szczerbinski M
Mediators of inflammation2014673032(2014)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
Based on these findings, we propose that Cx43 was the Cx isoform involved in MEGJ-mediated VEC-dependent regulation of Ang-2, which induces iNOS protein expression and vascular hyporeactivity after hypoxia.
Title: Myoendothelial gap junctions mediate regulation of angiopoietin-2-induced vascular hyporeactivity after hypoxia through connexin 43-gated cAMP transfer.
H2S may play a protective role in infrarenal aortic clamping induced acute lung injury in rats by inhibiting inflammation and Ang2 release.
Title: Hydrogen sulfide ameliorates acute lung injury induced by infrarenal aortic cross-clamping by inhibiting inflammation and angiopoietin 2 release.
Inhibition of angiopoietin-2 is an effective and safe treatment for liver fibrosis in CCl4 -treated rats, acting mainly through the induction of vessel normalization and the attenuation of hepatic inflammatory infiltrate.
Title: Overexpression of angiopoietin-2 in rats and patients with liver fibrosis. Therapeutic consequences of its inhibition.
Increased expression of Ang-1, Ang-2, Tie-2, and VEGF in ulcerative colitis-derived colorectal cancer might lead to chronic colitis and pathologic angiogenesis in rats.
Title: Angiopoietin and vascular endothelial growth factor expression in colorectal disease models.
oxygen-glucose deprivation could induce the expressions of VEGF, Ang-1, and Ang-2, with the expression of Shh signaling components increased.
Title: Sonic hedgehog (Shh) regulates the expression of angiogenic growth factors in oxygen-glucose-deprived astrocytes by mediating the nuclear receptor NR2F2.
The following Angpt2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Angpt2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | ORa01410 | |
Clone ID Related Accession (Same CDS sequence) | NM_134454.1 | |
Accession Version | NM_134454.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1491bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-11-13 | |
Organism | Rattus norvegicus(Norway rat) | |
Product | angiopoietin-2 precursor | |
Comment | Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC161931.1. On or before Sep 7, 2008 this sequence version replaced XM_344544.3, XM_001065522.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC161931.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END## |
1 | ATGTGGCAGA TTGTTTTCCT AACTTTTGGC TGTGATCTTG TCTTGGCCTC AGCCTACAAT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_604449.1 |
CDS | 72..1562 |
Translation |
Target ORF information:
Target ORF information:
|
NM_134454.1 |
1 | ATGTGGCAGA TTGTTTTCCT AACTTTTGGC TGTGATCTTG TCTTGGCCTC AGCCTACAAT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Myoendothelial gap junctions mediate regulation of angiopoietin-2-induced vascular hyporeactivity after hypoxia through connexin 43-gated cAMP transfer. |
Hydrogen sulfide ameliorates acute lung injury induced by infrarenal aortic cross-clamping by inhibiting inflammation and angiopoietin 2 release. |
Overexpression of angiopoietin-2 in rats and patients with liver fibrosis. Therapeutic consequences of its inhibition. |
Angiopoietin and vascular endothelial growth factor expression in colorectal disease models. |
Angiogenesis-related biomarkers in patients with alcoholic liver disease: their association with liver disease complications and outcome. |