List by Alphabet: A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Fc fusion proteins

Fc fusion proteins are a type of engineered protein made by fusing the Fc (fragment crystallizable) region of an antibody to another protein of interest. This fusion combines the functional properties of the protein of interest with the beneficial properties of the Fc region of an antibody. Here are key aspects of Fc fusion proteins:

1. Fc Region: The Fc region is the tail part of an antibody molecule, responsible for binding to cell receptors and proteins of the immune system. It confers stability and solubility to the antibody and can extend the half-life of the molecule in the bloodstream.

2. Enhanced Stability and Half-Life: One of the main advantages of Fc fusion proteins is their increased stability and prolonged half-life in the bloodstream. This is due to the Fc region's ability to bind to the neonatal Fc receptor (FcRn), which protects it from degradation.

3. Improved Efficacy: >The Fc region can enhance the efficacy of the fused protein by increasing its solubility and promoting better distribution within the body.

4. Diverse Applications: Fc fusion proteins have a wide range of applications, including as therapeutic agents in various diseases. They are commonly used in the treatment of autoimmune diseases, inflammatory disorders, and in some cases, in oncology.

5. Reduced Immunogenicity: The use of the human Fc region can reduce the immunogenicity of the therapeutic protein, meaning it is less likely to be attacked by the patient's immune system.

6. Examples of Fc Fusion Proteins: Etanercept, used in the treatment of rheumatoid arthritis and other autoimmune conditions, is a well-known Fc fusion protein that combines the Fc region of an IgG1 antibody with the soluble form of the TNF receptor. Another example is Aflibercept, used in the treatment of macular degeneration, which fuses the Fc region with VEGF-binding domains.

7. Production: Like monoclonal antibodies, Fc fusion proteins are typically produced using recombinant DNA technology in cell culture systems.

8. Regulatory Approval: Fc fusion proteins are considered biologic drugs and must undergo rigorous testing and clinical trials to gain regulatory approval.

Overall, Fc fusion proteins represent a significant advancement in biotherapeutics, offering the potential for more effective and longer-lasting treatments for a variety of diseases.


Related Biology Tools

  • GenSmart™ Codon Optimization

    GenSmart Optimization is a free online tool for performing codon optimization to improve gene expression. GenScript's patented algorithms are integrated into the tool to optimize the computing capability of high-performance sequence generation.

    Learn More

  • DNA Construct Design Tool

    GenSmart™ Design is a free online DNA construct design tool developed by GenScript. GenSmart™ Design has two design modules, the Create Construct module for individual plasmid design and the Create Library module for DNA library design.

    Learn More

  • Codon Frequency Tables

    This online tool shows commonly used genetic codon frequency table in expression host organisms including Escherichia coli and other common host organisms.

    Learn More

Service and Products

Antibody Production Services

Comprehensive custom antibody production services including monoclonal and polyclonal antibody production services with industry leading turnaround times.

Polyclonal Antibody Services

The fastest custom polyclonal antibody production services in the industry with unmatched guarantees.

Custom Monoclonal Antibody Development Services

Developing custom monoclonal antibodies with standard or fully custom protocols including everything from antigen synthesis to antibody scale-up options.

Phospho-Specific Antibody Services

Guaranteed ELISA titer of ≥ 1:64,000 and < 10% cross reactivity with non-phospho peptide.

Immunoassay Development Services

Our custom immunoassay development service offering comprehensive high-throughput assay development with fast turnaround and high efficiency.

Large-scale Antibody Manufacturing

Our large-scale antibody manufacturing services offer polyclonal and monoclonal antibody production of gram quantities for industrial antibody yields.

COVID-19 Reagent Antibodies

On demand SARS-CoV-2 control mAbs ideal for diagnostics, therapeutic, and vaccine development.

If you know of any terms that have been omitted from this glossary that you feel would be useful to include, please send detail to the Editorial Office at GenScript: [email protected]

If your term is adopted, we will send 1,000 EzCoupon points to your GenScript account.
feedback

Do you like the current new website?

Hate

Dislike

Neutral

Like

Love

*