THRSP cDNA ORF clone, Bos taurus(cattle)

Gene
Clones
gRNAs

Gene Symbol	THRSP
Entrez Gene ID	515940
Full Name	thyroid hormone responsive
General protein information	Preferred Names thyroid hormone responsive Names thyroid hormone-inducible hepatic protein thyroid hormone responsive (SPOT14 homolog, rat) thyroid hormone-responsive protein
Gene Type	protein-coding
Organism	Bos taurus(cattle)

mRNA and Protein(s)

mRNA Protein Name

NM_001040533.1 NP_001035623.1 thyroid hormone-inducible hepatic protein
Pathways from BioSystems

mRNA	Protein	Name
NM_001040533.1	NP_001035623.1	thyroid hormone-inducible hepatic protein

Homologies

Pan troglodytes (chimpanzee)	THRSP	XP_522120.1
Rattus norvegicus (Norway rat)	Thrsp	NP_036835.2
	THRSP	XP_001092657.1
Mus musculus (house mouse)	Thrsp	NP_033407.1
Homo sapiens (human)	THRSP	NP_003242.1
Canis lupus familiaris (dog)	THRSP	XP_005633501.1
Bos taurus (cattle)	THRSP	NP_001035623.1

Gene Ontology
Bibliography

Related articles in PubMed

Increased expression of thyroid hormone responsive protein (THRSP) is the result but not the cause of higher intramuscular fat content in cattle.
Schering L, Albrecht E, Komolka K, K?hn C, Maak S
International journal of biological sciences13(5)532-544(2017)

Thyroid hormone responsive protein spot 14 enhances lipogenesis in bovine mammary epithelial cells.
Cui Y, Liu Z, Sun X, Hou X, Qu B, Zhao F, Gao X, Sun Z, Li Q
In vitro cellular & developmental biology. Animal51(6)586-94(2015 Jun)

Association of bovine fatty acid composition with novel missense nucleotide polymorphism in the thyroid hormone-responsive (THRSP) gene.
La B, Oh D, Lee Y, Shin S, Lee C, Chung E, Yeo J
Animal genetics44(1)118(2013 Feb)

A whole-genome assembly of the domestic cow, Bos taurus.
Zimin AV, Delcher AL, Florea L, Kelley DR, Schatz MC, Puiu D, Hanrahan F, Pertea G, Van Tassell CP, Sonstegard TS, Mar?ais G, Roberts M, Subramanian P, Yorke JA, Salzberg SL
Genome biology10(4)R42(2009)

SREBP1 and thyroid hormone responsive spot 14 (S14) are involved in the regulation of bovine mammary lipid synthesis during diet-induced milk fat depression and treatment with CLA.
Harvatine KJ, Bauman DE
The Journal of nutrition136(10)2468-74(2006 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

THRSP may regulate expression of PPARgamma and SREBP1 and can regulate milk fat synthesis by directly affecting the activity of some classical lipogenic enzymes.
Title: Thyroid hormone responsive protein spot 14 enhances lipogenesis in bovine mammary epithelial cells.

The authors report exonic nucleotide sequence variants in the THRSP gene and evaluate their associations with fatty acid composition in Korean cattle.
Title: Association of bovine fatty acid composition with novel missense nucleotide polymorphism in the thyroid hormone-responsive (THRSP) gene.

Study provides strong support for a central role of sterol response element binding protein 1(SREBP1) and S14 in the regulation of milk fat synthesis.
Title: SREBP1 and thyroid hormone responsive spot 14 (S14) are involved in the regulation of bovine mammary lipid synthesis during diet-induced milk fat depression and treatment with CLA.

The following THRSP gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the THRSP cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OBa37964	NM_001040533.1 Latest version!	Bos taurus thyroid hormone responsive (THRSP), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$104.30 $149.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

THRSP ( NM_001040533.1 ) cDNA ORF clone, Bos taurus(cattle) -> NP_001035623.1 Bos taurus thyroid hormone responsive (THRSP), mRNA.

Price & Availability↑

CloneID	OBa37964
Clone ID Related Accession (Same CDS sequence)	NM_001040533.1
Accession Version	NM_001040533.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 453bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-05-13
Organism	Bos taurus(cattle)
Product	thyroid hormone-inducible hepatic protein
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AY656814.1. On May 10, 2006 this sequence version replaced XM_594050.2. ##Evidence-Data-START## Transcript exon combination :: AY656814.1, DV776011.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN03145413, SAMN03145438 [ECO:0000348] ##Evidence-Data-END##

ATGCAGGTGC TGACCAAGCG CTACCCCAAG AACTGCCTGC TGACCGTCAT GGACCGGTAC 
CTGGCCGTGG TGCGCAACAT GGAGCAGGTG GTGATGATCC CCAGTCTTCT GCGGGACATG 
CAGCTGAGCA CACACGGGTA CCATGCCCAG GCGGGCGCCT CCGATCTCTA CAACTACTTC 
ACCATGCTCA AGGCCATCCG CATGGATATG GAGCACGGGC TGCTGCCCCG GCAGGAGTGG 
CAGGCCAAGG TGGCAGGTGG CAAAGCCGAG GGAGCTGAGA CTGAAGCTGG AGAGATGGAA 
GAGGCTGAGG AGGAGAGCGT GTTGGGGCAG CTGGACCTGG AAGCCCAGTT CCACCTGCAC 
TTCGCTAGCC TTCATCATAT CCTCACCCAT CTTACCCTGA AAGCGGAGGA GGTGACAAGG 
AGATACCAGG AGAAAATGGG ACAGGCCGTG TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001035623.1
CDS	43..495
Translation	MQVLTKRYPKNCLLTVMDRYLAVVRNMEQVVMIPSLLRDMQLSTHGYHAQAGASDLYNYFTMLKAIRMDMEHGLLPRQEWQAKVAGGKAEGAETEAGEMEEAEEESVLGQLDLEAQFHLHFASLHHILTHLTLKAEEVTRRYQEKMGQAV

Target ORF information:

RefSeq Version	NM_001040533.1
Organism	Bos taurus(cattle)
Definition	Bos taurus thyroid hormone responsive (THRSP), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001040533.1

ORF Insert Sequence:

ATGCAGGTGC TGACCAAGCG CTACCCCAAG AACTGCCTGC TGACCGTCAT GGACCGGTAC 
CTGGCCGTGG TGCGCAACAT GGAGCAGGTG GTGATGATCC CCAGTCTTCT GCGGGACATG 
CAGCTGAGCA CACACGGGTA CCATGCCCAG GCGGGCGCCT CCGATCTCTA CAACTACTTC 
ACCATGCTCA AGGCCATCCG CATGGATATG GAGCACGGGC TGCTGCCCCG GCAGGAGTGG 
CAGGCCAAGG TGGCAGGTGG CAAAGCCGAG GGAGCTGAGA CTGAAGCTGG AGAGATGGAA 
GAGGCTGAGG AGGAGAGCGT GTTGGGGCAG CTGGACCTGG AAGCCCAGTT CCACCTGCAC 
TTCGCTAGCC TTCATCATAT CCTCACCCAT CTTACCCTGA AAGCGGAGGA GGTGACAAGG 
AGATACCAGG AGAAAATGGG ACAGGCCGTG TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Increased expression of thyroid hormone responsive protein (THRSP) is the result but not the cause of higher intramuscular fat content in cattle.
International journal of biological sciences13(5)532-544(2017)
Schering L,Albrecht E,Komolka K,K?hn C,Maak S

Thyroid hormone responsive protein spot 14 enhances lipogenesis in bovine mammary epithelial cells.
In vitro cellular & developmental biology. Animal51(6)586-94(2015 Jun)
Cui Y,Liu Z,Sun X,Hou X,Qu B,Zhao F,Gao X,Sun Z,Li Q

Association of bovine fatty acid composition with novel missense nucleotide polymorphism in the thyroid hormone-responsive (THRSP) gene.
Animal genetics44(1)118(2013 Feb)
La B,Oh D,Lee Y,Shin S,Lee C,Chung E,Yeo J

A whole-genome assembly of the domestic cow, Bos taurus.
Genome biology10(4)R42(2009)
Zimin AV,Delcher AL,Florea L,Kelley DR,Schatz MC,Puiu D,Hanrahan F,Pertea G,Van Tassell CP,Sonstegard TS,Mar?ais G,Roberts M,Subramanian P,Yorke JA,Salzberg SL

SREBP1 and thyroid hormone responsive spot 14 (S14) are involved in the regulation of bovine mammary lipid synthesis during diet-induced milk fat depression and treatment with CLA.
The Journal of nutrition136(10)2468-74(2006 Oct)
Harvatine KJ,Bauman DE

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THRSP cDNA ORF clone, Bos taurus(cattle)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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