Gene Symbol | GCM2 |
Entrez Gene ID | 449615 |
Full Name | glial cells missing homolog 2 (Drosophila) |
Synonyms | GCMb,Gcm-2 |
General protein information |
|
Gene Type | protein-coding |
Organism | Danio rerio(Zebrafish) |
ORF » Species Summary » Danio rerio » GCM2 cDNA ORF clone
gRNAs
Gene Symbol | GCM2 |
Entrez Gene ID | 449615 |
Full Name | glial cells missing homolog 2 (Drosophila) |
Synonyms | GCMb,Gcm-2 |
General protein information |
|
Gene Type | protein-coding |
Organism | Danio rerio(Zebrafish) |
mRNA | Protein | Name |
---|---|---|
XM_005162569.4 | XP_005162626.1 | chorion-specific transcription factor GCMb isoform X1 |
NM_001005603.1 | NP_001005603.1 | chorion-specific transcription factor GCMb |
XM_005162569.3 | XP_005162626.1 | chorion-specific transcription factor GCMb isoform X1 |
Xenopus tropicalis (tropical clawed frog) | gcm2 | XP_002932714.1 |
GCM2 | XP_001088392.1 | |
Rattus norvegicus (Norway rat) | Gcm2 | NP_001099575.1 |
Danio rerio (zebrafish) | gcm2 | NP_001005603.1 |
Homo sapiens (human) | GCM2 | NP_004743.1 |
Bos taurus (cattle) | GCM2 | XP_002697663.2 |
Mus musculus (house mouse) | Gcm2 | NP_032130.2 |
Gallus gallus (chicken) | GCM2 | NP_001008480.1 |
Pan troglodytes (chimpanzee) | GCM2 | XP_518235.2 |
Canis lupus familiaris (dog) | GCM2 | XP_545339.3 |
A missense mutation in zbtb17 blocks the earliest steps of T cell differentiation in zebrafish.
Lawir DF, Iwanami N, Schorpp M, Boehm T
Scientific reports744145(2017 Mar)
Transcriptomic, proteomic, and metabolomic landscape of positional memory in the caudal fin of zebrafish.
Rabinowitz JS, Robitaille AM, Wang Y, Ray CA, Thummel R, Gu H, Djukovic D, Raftery D, Berndt JD, Moon RT
Proceedings of the National Academy of Sciences of the United States of America114(5)E717-E726(2017 Jan)
Forward Genetic Screens in Zebrafish Identify Pre-mRNA-Processing Pathways Regulating Early T Cell Development.
Iwanami N, Sikora K, Richter AS, M?nnich M, Guerri L, Soza-Ried C, Lawir DF, Mateos F, Hess I, O'Meara CP, Schorpp M, Boehm T
Cell reports17(9)2259-2270(2016 11)
RFX transcription factors are essential for hearing in mice.
Elkon R, Milon B, Morrison L, Shah M, Vijayakumar S, Racherla M, Leitch CC, Silipino L, Hadi S, Weiss-Gayet M, Barras E, Schmid CD, Ait-Lounis A, Barnes A, Song Y, Eisenman DJ, Eliyahu E, Frolenkov GI, Strome SE, Durand B, Zaghloul NA, Jones SM, Reith W, Hertzano R
Nature communications68549(2015 Oct)
An Essential Role for Parathyroid Hormone in Gill Formation and Differentiation of Ion-Transporting Cells in Developing Zebrafish.
Kwong RW, Perry SF
Endocrinology156(7)2384-94(2015 Jul)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
PTH1 morphants failed to express gcm2. Coinjection of PTH1 morpholino with gcm2 capped RNA rescued the phenotypes observed in the PTH1 morphants, suggesting that the defects in PTH1-deficient fish were caused, at least in part, by the suppression of gcm2.
Title: An Essential Role for Parathyroid Hormone in Gill Formation and Differentiation of Ion-Transporting Cells in Developing Zebrafish.
Overexpression of gcm2 mRNA resulted in a significant increase in the numbers of ecac-expressing ionocytes and Ca2+ uptake.
Title: A role for transcription factor glial cell missing 2 in Ca2+ homeostasis in zebrafish, Danio rerio.
merovingian mutants showed an acidified extracellular environment in the vicinity of both inner ear and lateral line hair cells.
Title: The zebrafish merovingian mutant reveals a role for pH regulation in hair cell toxicity and function.
role of Shh signalling in patterning the pharyngeal pouches and in restricting the expression of the parathyroid marker Gcm2 in the pharyngeal epithelium
Title: Shh signalling restricts the expression of Gcm2 and controls the position of the developing parathyroids.
Results suggest that an acquisition of enhancers for the expression of gcm2 contributes to a diversity of ionocytes in zebrafish during evolution.
Title: Acquisition of glial cells missing 2 enhancers contributes to a diversity of ionocytes in zebrafish.
The following GCM2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the GCM2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | ODa01353 | |
Clone ID Related Accession (Same CDS sequence) | NM_001005603.1 | |
Accession Version | NM_001005603.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1491bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-04-07 | |
Organism | Danio rerio(zebrafish) | |
Product | chorion-specific transcription factor GCMb | |
Comment | Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AB099697.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AB099697.1, AY217729.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA4476742, SAMEA4476750 [ECO:0000348] ##Evidence-Data-END## |
1 | ATGTCCAAAT CCTCAGATCA GTTTGACAGC TCAGACTGCG TGTGTTCATT CGGGATGAAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001005603.1 |
CDS | 321..1811 |
Translation |
Target ORF information:
Target ORF information:
|
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1 | ATGTCCAAAT CCTCAGATCA GTTTGACAGC TCAGACTGCG TGTGTTCATT CGGGATGAAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | ODa28356 | |
Clone ID Related Accession (Same CDS sequence) | XM_005162569.4 , XM_005162569.3 | |
Accession Version | XM_005162569.4 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1437bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2017-06-14 | |
Organism | Danio rerio(zebrafish) | |
Product | chorion-specific transcription factor GCMb isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_007135.7) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 15, 2017 this sequence version replaced XM_005162569.3. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Danio rerio Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.4 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGAAGTTGA CTTGGGATAT AAACGACCCC AAGCTTCCAC AGGACACGAA GCAGTATGAT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_005162626.1 |
CDS | 381..1817 |
Translation |
Target ORF information:
Target ORF information:
|
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1 | ATGAAGTTGA CTTGGGATAT AAACGACCCC AAGCTTCCAC AGGACACGAA GCAGTATGAT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | ODa28356 | |
Clone ID Related Accession (Same CDS sequence) | XM_005162569.4 , XM_005162569.3 | |
Accession Version | XM_005162569.3 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1437bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-06-23 | |
Organism | Danio rerio(Zebrafish) | |
Product | chorion-specific transcription factor GCMb isoform X1 | |
Comment | MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_007135.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 24, 2016 this sequence version replaced XM_005162569.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Danio rerio Annotation Release 105 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGAAGTTGA CTTGGGATAT AAACGACCCC AAGCTTCCAC AGGACACGAA GCAGTATGAT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_005162626.1 |
CDS | 460..1896 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGAAGTTGA CTTGGGATAT AAACGACCCC AAGCTTCCAC AGGACACGAA GCAGTATGAT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
A missense mutation in zbtb17 blocks the earliest steps of T cell differentiation in zebrafish. |
Transcriptomic, proteomic, and metabolomic landscape of positional memory in the caudal fin of zebrafish. |
Forward Genetic Screens in Zebrafish Identify Pre-mRNA-Processing Pathways Regulating Early T Cell Development. |
RFX transcription factors are essential for hearing in mice. |
An Essential Role for Parathyroid Hormone in Gill Formation and Differentiation of Ion-Transporting Cells in Developing Zebrafish. |