Gene Symbol | ocrl |
Entrez Gene ID | 777716 |
Full Name | oculocerebrorenal syndrome of Lowe |
Synonyms | wu:fi09g03,zgc:152864 |
General protein information |
|
Gene Type | protein-coding |
Organism | Danio rerio(zebrafish) |
ORF » Species Summary » Danio rerio » ocrl cDNA ORF clone
Gene Symbol | ocrl |
Entrez Gene ID | 777716 |
Full Name | oculocerebrorenal syndrome of Lowe |
Synonyms | wu:fi09g03,zgc:152864 |
General protein information |
|
Gene Type | protein-coding |
Organism | Danio rerio(zebrafish) |
mRNA | Protein | Name |
---|---|---|
XM_009291139.3 | XP_009289414.1 | inositol polyphosphate 5-phosphatase OCRL-1 isoform X1 |
XM_009291139.2 | XP_009289414.1 | inositol polyphosphate 5-phosphatase OCRL-1 isoform X1 |
NM_001077764.2 | NP_001071232.2 | inositol polyphosphate 5-phosphatase OCRL-1 |
Homo sapiens (human) | OCRL | NP_000267.2 |
Pan troglodytes (chimpanzee) | OCRL | XP_003317719.2 |
Rattus norvegicus (Norway rat) | Ocrl | NP_001101726.2 |
Canis lupus familiaris (dog) | OCRL | XP_852376.2 |
Mus musculus (house mouse) | Ocrl | NP_796189.2 |
Xenopus tropicalis (tropical clawed frog) | ocrl | XP_004919252.1 |
Gallus gallus (chicken) | OCRL | XP_004940632.1 |
Danio rerio (zebrafish) | LOC100329312 | XP_003199958.1 |
OCRL | XP_002806438.1 | |
Danio rerio (zebrafish) | ocrl | NP_001071232.1 |
Drosophila melanogaster (fruit fly) | Ocrl | NP_569962.2 |
Anopheles gambiae (African malaria mosquito) | AgaP_AGAP010556 | XP_558090.3 |
Bos taurus (cattle) | OCRL | NP_001095661.1 |
Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database.
Pasquier J, Cabau C, Nguyen T, Jouanno E, Severac D, Braasch I, Journot L, Pontarotti P, Klopp C, Postlethwait JH, Guiguen Y, Bobe J
BMC genomics17368(2016 05)
Apela Regulates Fluid Homeostasis by Binding to the APJ Receptor to Activate Gi Signaling.
Deng C, Chen H, Yang N, Feng Y, Hsueh AJ
The Journal of biological chemistry290(30)18261-8(2015 Jul)
The Lowe syndrome protein OCRL1 is required for endocytosis in the zebrafish pronephric tubule.
Oltrabella F, Pietka G, Ramirez IB, Mironov A, Starborg T, Drummond IA, Hinchliffe KA, Lowe M
PLoS genetics11(4)e1005058(2015 Apr)
Compensatory Role of Inositol 5-Phosphatase INPP5B to OCRL in Primary Cilia Formation in Oculocerebrorenal Syndrome of Lowe.
Luo N, Kumar A, Conwell M, Weinreb RN, Anderson R, Sun Y
PloS one8(6)e66727(2013)
Lowe syndrome: Between primary cilia assembly and Rac1-mediated membrane remodeling.
Madhivanan K, Mukherjee D, Aguilar RC
Communicative & integrative biology5(6)641-4(2012 Nov)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
OCRL1 is required for renal tubular endocytosis.
Title: The Lowe syndrome protein OCRL1 is required for endocytosis in the zebrafish pronephric tubule.
Knockdown of OCRL1 in zebrafish caused developmental defects consistent with disruption of ciliary function.
Title: OCRL1 modulates cilia length in renal epithelial cells.
results indicate a novel role for OCRL1 in neural development, and support a model whereby dysregulation of phosphoinositide metabolism and clathrin-mediated membrane traffic leads to the neurological symptoms of Lowe syndrome
Title: Impaired neural development in a zebrafish model for Lowe syndrome.
The following ocrl gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the ocrl cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | ODa46586 | |
Clone ID Related Accession (Same CDS sequence) | XM_009291139.3 , XM_009291139.2 | |
Accession Version | XM_009291139.3 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 2886bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2017-06-14 | |
Organism | Danio rerio(zebrafish) | |
Product | inositol polyphosphate 5-phosphatase OCRL-1 isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_007125.7) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 15, 2017 this sequence version replaced XM_009291139.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Danio rerio Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.4 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGATGGAAC CTTCATTTGG GATTTCCGAA AGCCAGTGTA TAGCCACTGT TAGAGGACAT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_009289414.1 |
CDS | 330..3215 |
Translation |
Target ORF information:
Target ORF information:
|
XM_009291139.3 |
1 | ATGATGGAAC CTTCATTTGG GATTTCCGAA AGCCAGTGTA TAGCCACTGT TAGAGGACAT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | ODa46586 | |
Clone ID Related Accession (Same CDS sequence) | XM_009291139.3 , XM_009291139.2 | |
Accession Version | XM_009291139.2 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 2886bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-06-23 | |
Organism | Danio rerio(Zebrafish) | |
Product | inositol polyphosphate 5-phosphatase OCRL-1 isoform X1 | |
Comment | MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_007125.6) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 24, 2016 this sequence version replaced XM_009291139.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Danio rerio Annotation Release 105 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGATGGAAC CTTCATTTGG GATTTCCGAA AGCCAGTGTA TAGCCACTGT TAGAGGACAT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_009289414.1 |
CDS | 327..3212 |
Translation |
Target ORF information:
Target ORF information:
|
XM_009291139.2 |
1 | ATGATGGAAC CTTCATTTGG GATTTCCGAA AGCCAGTGTA TAGCCACTGT TAGAGGACAT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | ODa53342 | |
Clone ID Related Accession (Same CDS sequence) | NM_001077764.2 | |
Accession Version | NM_001077764.2 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 2862bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-04-07 | |
Organism | Danio rerio(zebrafish) | |
Product | inositol polyphosphate 5-phosphatase OCRL-1 | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from FP016208.12. On May 26, 2016 this sequence version replaced NM_001077764.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## Transcript exon combination :: GDQH01017112.1, BC125826.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA2168446, SAMEA2168447 [ECO:0000350] ##Evidence-Data-END## |
1 | ATGATGGAAC CTTCATTTGG GATTTCCGAA AGCCAGTGTA TAGCCACTGT TAGAGGACAT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001071232.2 |
CDS | 50..2911 |
Translation |
Target ORF information:
Target ORF information:
|
NM_001077764.2 |
1 | ATGATGGAAC CTTCATTTGG GATTTCCGAA AGCCAGTGTA TAGCCACTGT TAGAGGACAT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. |
Apela Regulates Fluid Homeostasis by Binding to the APJ Receptor to Activate Gi Signaling. |
The Lowe syndrome protein OCRL1 is required for endocytosis in the zebrafish pronephric tubule. |
Compensatory Role of Inositol 5-Phosphatase INPP5B to OCRL in Primary Cilia Formation in Oculocerebrorenal Syndrome of Lowe. |
Lowe syndrome: Between primary cilia assembly and Rac1-mediated membrane remodeling. |