Fsn cDNA ORF clone, Drosophila melanogaster(fruit fly)

Gene
Clones
gRNAs

Summary

Gene Symbol	Fsn
Entrez Gene ID	36460
Full Name	F-box synaptic protein
Synonyms	BEST:GH20696,CG4643,DFsn,Dmel\CG4643,FBXO2,Wals,dFsn,fsn
General protein information	Preferred Names F-box synaptic protein Names CG4643 gene product from transcript CG4643-RA CG4643-PA CG4643-PB Fsn-PA Fsn-PB wallenstein
Gene Type	protein-coding
Organism	Drosophila melanogaster(fruit fly)
Genome	Chromosome: 2R Map Location: 49F10-49F10

mRNA and Protein(s)

mRNA	Protein	Name
NM_137005.2	NP_610849.1	F-box synaptic protein, isoform A
NM_165973.2	NP_725266.1	F-box synaptic protein, isoform B

Pathways from BioSystems

Homologies

Homo sapiens (human)	FBXO45	NP_001099043.1
Drosophila melanogaster (fruit fly)	Fsn	NP_725266.1
Caenorhabditis elegans (roundworm)	fsn-1	NP_498046.1
Mus musculus (house mouse)	Fbxo45	NP_775615.2
Rattus norvegicus (Norway rat)	Fbxo45	XP_006248538.1
Gallus gallus (chicken)	FBXO45	XP_001232841.3
Danio rerio (zebrafish)	fbxo45	NP_956889.1
Canis lupus familiaris (dog)	FBXO45	XP_851899.2
Bos taurus (cattle)	FBXO45	NP_001193687.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP012460	XP_309899.3
Xenopus tropicalis (tropical clawed frog)	fbxo45	NP_001135592.1

Gene Ontology
Bibliography

Related articles in PubMed

Gene Model Annotations for Drosophila melanogaster: Impact of High-Throughput Data.
Matthews BB, Dos Santos G, Crosby MA, Emmert DB, St Pierre SE, Gramates LS, Zhou P, Schroeder AJ, Falls K, Strelets V, Russo SM, Gelbart WM,
G3 (Bethesda, Md.)5(8)1721-36(2015 Jun)

Gene Model Annotations for Drosophila melanogaster: The Rule-Benders.
Crosby MA, Gramates LS, Dos Santos G, Matthews BB, St Pierre SE, Zhou P, Schroeder AJ, Falls K, Emmert DB, Russo SM, Gelbart WM,
G3 (Bethesda, Md.)5(8)1737-49(2015 Jun)

Sequence finishing and mapping of Drosophila melanogaster heterochromatin.
Hoskins RA, Carlson JW, Kennedy C, Acevedo D, Evans-Holm M, Frise E, Wan KH, Park S, Mendez-Lago M, Rossi F, Villasante A, Dimitri P, Karpen GH, Celniker SE
Science (New York, N.Y.)316(5831)1625-8(2007 Jun)

The Release 5.1 annotation of Drosophila melanogaster heterochromatin.
Smith CD, Shu S, Mungall CJ, Karpen GH
Science (New York, N.Y.)316(5831)1586-91(2007 Jun)

Combined evidence annotation of transposable elements in genome sequences.
Quesneville H, Bergman CM, Andrieu O, Autard D, Nouaud D, Ashburner M, Anxolabehere D
PLoS computational biology1(2)166-75(2005 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Data suggest that Fsn- and Gus-containing E3 ligase complexes contribute to establishing a fine-tuned steady state of Vasa ubiquitination that influences the kinetics of posterior Vasa deployment.
Title: Regulation of Drosophila vasa in vivo through paralogous cullin-RING E3 ligase specificity receptors.

The F-box protein DFsn binds the ubiquitin ligase Highwire and is required to down-regulate the levels of the Wallenda/DLK kinase and restrain synaptic terminal growth.
Title: DFsn collaborates with Highwire to down-regulate the Wallenda/DLK kinase and restrain synaptic terminal growth.

The following Fsn gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Fsn cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OFa12976	NM_165973.2 Latest version!	Drosophila melanogaster F-box synaptic protein (Fsn), transcript variant B, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$174.30 $249.00
OFa12976	NM_137005.2 Latest version!	Drosophila melanogaster F-box synaptic protein (Fsn), transcript variant A, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$174.30 $249.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Fsn ( NM_137005.2 ) cDNA ORF clone, Drosophila melanogaster(fruit fly) -> NP_610849.1 Drosophila melanogaster F-box synaptic protein (Fsn), transcript variant A, mRNA.

Price & Availability↑

CloneID	OFa12976
Clone ID Related Accession (Same CDS sequence)	NM_137005.2 , NM_165973.2
Accession Version	NM_137005.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 768bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-04-24
Organism	Drosophila melanogaster(fruit fly)
Product	F-box synaptic protein, isoform A
Comment	Comment: REVIEWED REFSEQ: This record has been curated by FlyBase. This record is derived from an annotated genomic sequence (NT_033778). On Jan 16, 2013 this sequence version replaced NM_137005.1. ##Genome-Annotation-Data-START## Annotation Provider :: FlyBase Annotation Status :: Full annotation Annotation Version :: Release 6.26 URL :: http://flybase.org ##Genome-Annotation-Data-END##

ATGGTCGATC CGGTGGCGGC GCTGTGCAAT TACAATGTGC TGGAGGTAAT CTTCTCCTAC 
CTGGAGCTGG ACGACCTCAG TCATTGCTCG CAGGTGTGCA AAAGTTGGTA CCACTTCCTC 
AACGACGAGA ACAGCGACGT CTGGCGCTGG CACTGCCTGA ACAAGCTGCC CAAGGAGTCC 
CTCAAATCGG ACCTGCTGGC CTCCGTCTCC ACGTACAAGA CGAAGCTGCG GGCCTATTTT 
CACGCCTGGA GCCCCAACGA CTGTTCGAGG AATGTGTACA TTAAGCCGAA CGGATTCACC 
CTGCATCGCA ATCCCGTGGC GCAGAGCACA GACGCGGCCC GGGGCAAGAT AGGATTCCGC 
CACGGTCGTC ACACCTGGGA GGTGATATGG GAGGGACCGC TGGGCACTGT GGCCGTCATC 
GGCATATCTA CCAAGGAGGC GGCTCTACAG TGTCACGGCT ATGTGGCTCT GCTCGGCTCC 
GACGACCAGA GCTGGGGCTG GAATCTGGTC GAGAACCACC TGCTGCACAA CGGCGACATG 
CAGGGCAGTT ACCCGCTGCT GAACAATGCT CCCAAGTACC AAGTGGGCGA GCGGATACGC 
GTCATTCTCG ACTGCGAGGA CAACACCTTG TCGTTCGAGA AGAACTACGA GTTCCTCGGT 
GTGGCCTTCC GGGGCCTGCC GGACAAAAAG CTCTATCCCA CAGTATCCGC TGTCTACGGC 
AATACCGAGG TCTCGATGGT CTATCTGGGC ACGCCGTTGG ACGGATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_610849.1
CDS	177..944
Translation	MVDPVAALCNYNVLEVIFSYLELDDLSHCSQVCKSWYHFLNDENSDVWRWHCLNKLPKESLKSDLLASVSTYKTKLRAYFHAWSPNDCSRNVYIKPNGFTLHRNPVAQSTDAARGKIGFRHGRHTWEVIWEGPLGTVAVIGISTKEAALQCHGYVALLGSDDQSWGWNLVENHLLHNGDMQGSYPLLNNAPKYQVGERIRVILDCEDNTLSFEKNYEFLGVAFRGLPDKKLYPTVSAVYGNTEVSMVYLGTPLDG

Target ORF information:

RefSeq Version	NM_137005.2
Organism	Drosophila melanogaster(fruit fly)
Definition	Drosophila melanogaster F-box synaptic protein (Fsn), transcript variant A, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_137005.2

ORF Insert Sequence:

ATGGTCGATC CGGTGGCGGC GCTGTGCAAT TACAATGTGC TGGAGGTAAT CTTCTCCTAC 
CTGGAGCTGG ACGACCTCAG TCATTGCTCG CAGGTGTGCA AAAGTTGGTA CCACTTCCTC 
AACGACGAGA ACAGCGACGT CTGGCGCTGG CACTGCCTGA ACAAGCTGCC CAAGGAGTCC 
CTCAAATCGG ACCTGCTGGC CTCCGTCTCC ACGTACAAGA CGAAGCTGCG GGCCTATTTT 
CACGCCTGGA GCCCCAACGA CTGTTCGAGG AATGTGTACA TTAAGCCGAA CGGATTCACC 
CTGCATCGCA ATCCCGTGGC GCAGAGCACA GACGCGGCCC GGGGCAAGAT AGGATTCCGC 
CACGGTCGTC ACACCTGGGA GGTGATATGG GAGGGACCGC TGGGCACTGT GGCCGTCATC 
GGCATATCTA CCAAGGAGGC GGCTCTACAG TGTCACGGCT ATGTGGCTCT GCTCGGCTCC 
GACGACCAGA GCTGGGGCTG GAATCTGGTC GAGAACCACC TGCTGCACAA CGGCGACATG 
CAGGGCAGTT ACCCGCTGCT GAACAATGCT CCCAAGTACC AAGTGGGCGA GCGGATACGC 
GTCATTCTCG ACTGCGAGGA CAACACCTTG TCGTTCGAGA AGAACTACGA GTTCCTCGGT 
GTGGCCTTCC GGGGCCTGCC GGACAAAAAG CTCTATCCCA CAGTATCCGC TGTCTACGGC 
AATACCGAGG TCTCGATGGT CTATCTGGGC ACGCCGTTGG ACGGATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Fsn ( NM_165973.2 ) cDNA ORF clone, Drosophila melanogaster(fruit fly) -> NP_725266.1 Drosophila melanogaster F-box synaptic protein (Fsn), transcript variant B, mRNA.

Price & Availability↑

CloneID	OFa12976
Clone ID Related Accession (Same CDS sequence)	NM_137005.2 , NM_165973.2
Accession Version	NM_165973.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 768bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-04-24
Organism	Drosophila melanogaster(fruit fly)
Product	F-box synaptic protein, isoform B
Comment	Comment: REVIEWED REFSEQ: This record has been curated by FlyBase. This record is derived from an annotated genomic sequence (NT_033778). On Jan 16, 2013 this sequence version replaced NM_165973.1. ##Genome-Annotation-Data-START## Annotation Provider :: FlyBase Annotation Status :: Full annotation Annotation Version :: Release 6.26 URL :: http://flybase.org ##Genome-Annotation-Data-END##

ATGGTCGATC CGGTGGCGGC GCTGTGCAAT TACAATGTGC TGGAGGTAAT CTTCTCCTAC 
CTGGAGCTGG ACGACCTCAG TCATTGCTCG CAGGTGTGCA AAAGTTGGTA CCACTTCCTC 
AACGACGAGA ACAGCGACGT CTGGCGCTGG CACTGCCTGA ACAAGCTGCC CAAGGAGTCC 
CTCAAATCGG ACCTGCTGGC CTCCGTCTCC ACGTACAAGA CGAAGCTGCG GGCCTATTTT 
CACGCCTGGA GCCCCAACGA CTGTTCGAGG AATGTGTACA TTAAGCCGAA CGGATTCACC 
CTGCATCGCA ATCCCGTGGC GCAGAGCACA GACGCGGCCC GGGGCAAGAT AGGATTCCGC 
CACGGTCGTC ACACCTGGGA GGTGATATGG GAGGGACCGC TGGGCACTGT GGCCGTCATC 
GGCATATCTA CCAAGGAGGC GGCTCTACAG TGTCACGGCT ATGTGGCTCT GCTCGGCTCC 
GACGACCAGA GCTGGGGCTG GAATCTGGTC GAGAACCACC TGCTGCACAA CGGCGACATG 
CAGGGCAGTT ACCCGCTGCT GAACAATGCT CCCAAGTACC AAGTGGGCGA GCGGATACGC 
GTCATTCTCG ACTGCGAGGA CAACACCTTG TCGTTCGAGA AGAACTACGA GTTCCTCGGT 
GTGGCCTTCC GGGGCCTGCC GGACAAAAAG CTCTATCCCA CAGTATCCGC TGTCTACGGC 
AATACCGAGG TCTCGATGGT CTATCTGGGC ACGCCGTTGG ACGGATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_725266.1
CDS	170..937
Translation	MVDPVAALCNYNVLEVIFSYLELDDLSHCSQVCKSWYHFLNDENSDVWRWHCLNKLPKESLKSDLLASVSTYKTKLRAYFHAWSPNDCSRNVYIKPNGFTLHRNPVAQSTDAARGKIGFRHGRHTWEVIWEGPLGTVAVIGISTKEAALQCHGYVALLGSDDQSWGWNLVENHLLHNGDMQGSYPLLNNAPKYQVGERIRVILDCEDNTLSFEKNYEFLGVAFRGLPDKKLYPTVSAVYGNTEVSMVYLGTPLDG

Target ORF information:

RefSeq Version	NM_165973.2
Organism	Drosophila melanogaster(fruit fly)
Definition	Drosophila melanogaster F-box synaptic protein (Fsn), transcript variant B, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_165973.2

ORF Insert Sequence:

ATGGTCGATC CGGTGGCGGC GCTGTGCAAT TACAATGTGC TGGAGGTAAT CTTCTCCTAC 
CTGGAGCTGG ACGACCTCAG TCATTGCTCG CAGGTGTGCA AAAGTTGGTA CCACTTCCTC 
AACGACGAGA ACAGCGACGT CTGGCGCTGG CACTGCCTGA ACAAGCTGCC CAAGGAGTCC 
CTCAAATCGG ACCTGCTGGC CTCCGTCTCC ACGTACAAGA CGAAGCTGCG GGCCTATTTT 
CACGCCTGGA GCCCCAACGA CTGTTCGAGG AATGTGTACA TTAAGCCGAA CGGATTCACC 
CTGCATCGCA ATCCCGTGGC GCAGAGCACA GACGCGGCCC GGGGCAAGAT AGGATTCCGC 
CACGGTCGTC ACACCTGGGA GGTGATATGG GAGGGACCGC TGGGCACTGT GGCCGTCATC 
GGCATATCTA CCAAGGAGGC GGCTCTACAG TGTCACGGCT ATGTGGCTCT GCTCGGCTCC 
GACGACCAGA GCTGGGGCTG GAATCTGGTC GAGAACCACC TGCTGCACAA CGGCGACATG 
CAGGGCAGTT ACCCGCTGCT GAACAATGCT CCCAAGTACC AAGTGGGCGA GCGGATACGC 
GTCATTCTCG ACTGCGAGGA CAACACCTTG TCGTTCGAGA AGAACTACGA GTTCCTCGGT 
GTGGCCTTCC GGGGCCTGCC GGACAAAAAG CTCTATCCCA CAGTATCCGC TGTCTACGGC 
AATACCGAGG TCTCGATGGT CTATCTGGGC ACGCCGTTGG ACGGATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Gene Model Annotations for Drosophila melanogaster: Impact of High-Throughput Data.
G3 (Bethesda, Md.)5(8)1721-36(2015 Jun)
Matthews BB,Dos Santos G,Crosby MA,Emmert DB,St Pierre SE,Gramates LS,Zhou P,Schroeder AJ,Falls K,Strelets V,Russo SM,Gelbart WM,

Gene Model Annotations for Drosophila melanogaster: The Rule-Benders.
G3 (Bethesda, Md.)5(8)1737-49(2015 Jun)
Crosby MA,Gramates LS,Dos Santos G,Matthews BB,St Pierre SE,Zhou P,Schroeder AJ,Falls K,Emmert DB,Russo SM,Gelbart WM,

Sequence finishing and mapping of Drosophila melanogaster heterochromatin.
Science (New York, N.Y.)316(5831)1625-8(2007 Jun)
Hoskins RA,Carlson JW,Kennedy C,Acevedo D,Evans-Holm M,Frise E,Wan KH,Park S,Mendez-Lago M,Rossi F,Villasante A,Dimitri P,Karpen GH,Celniker SE

The Release 5.1 annotation of Drosophila melanogaster heterochromatin.
Science (New York, N.Y.)316(5831)1586-91(2007 Jun)
Smith CD,Shu S,Mungall CJ,Karpen GH

Combined evidence annotation of transposable elements in genome sequences.
PLoS computational biology1(2)166-75(2005 Jul)
Quesneville H,Bergman CM,Andrieu O,Autard D,Nouaud D,Ashburner M,Anxolabehere D

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Fsn cDNA ORF clone, Drosophila melanogaster(fruit fly)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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