CHMP2B cDNA ORF clone, Drosophila melanogaster(fruit fly)

Gene
Clones
gRNAs

Gene Symbol	CHMP2B
Entrez Gene ID	38599
Full Name	Charged multivesicular body protein 2b
Synonyms	CG4618,Dmel\CG4618,cg4618
General protein information	Preferred Names Charged multivesicular body protein 2b Names CG4618 gene product from transcript CG4618-RA CG4618-PA CHMP2B-PA charged multivesicular body protein 2b
Gene Type	protein-coding
Organism	Drosophila melanogaster(fruit fly)
Genome	Chromosome: 3L Map Location: 64C7-64C7

mRNA and Protein(s)

mRNA Protein Name

NM_139690.4 NP_647947.1 charged multivesicular body protein 2b
Pathways from BioSystems

mRNA	Protein	Name
NM_139690.4	NP_647947.1	charged multivesicular body protein 2b

Homologies

Pan troglodytes (chimpanzee)	CHMP2B	XP_003950194.1
Bos taurus (cattle)	CHMP2B	NP_001030549.1
Rattus norvegicus (Norway rat)	Chmp2b	XP_343996.5
Gallus gallus (chicken)	CHMP2B	NP_001025963.1
Danio rerio (zebrafish)	chmp2bb	NP_998069.1
Drosophila melanogaster (fruit fly)	CHMP2B	NP_647947.1
Arabidopsis thaliana (thale cress)	VPS2.3	NP_563696.1
Oryza sativa (rice)	Os10g0476400	NP_001064848.1
Xenopus tropicalis (tropical clawed frog)	chmp2b	NP_998866.1
Homo sapiens (human)	CHMP2B	NP_054762.2
Canis lupus familiaris (dog)	CHMP2B	XP_544799.3
Caenorhabditis elegans (roundworm)	C01A2.4	NP_493357.2
	CHMP2B	XP_001104518.1
Mus musculus (house mouse)	Chmp2b	NP_081155.1

Gene Ontology
Bibliography

Related articles in PubMed

Gene Model Annotations for Drosophila melanogaster: Impact of High-Throughput Data.
Matthews BB, Dos Santos G, Crosby MA, Emmert DB, St Pierre SE, Gramates LS, Zhou P, Schroeder AJ, Falls K, Strelets V, Russo SM, Gelbart WM,
G3 (Bethesda, Md.)5(8)1721-36(2015 Jun)

Gene Model Annotations for Drosophila melanogaster: The Rule-Benders.
Crosby MA, Gramates LS, Dos Santos G, Matthews BB, St Pierre SE, Zhou P, Schroeder AJ, Falls K, Emmert DB, Russo SM, Gelbart WM,
G3 (Bethesda, Md.)5(8)1737-49(2015 Jun)

Sequence finishing and mapping of Drosophila melanogaster heterochromatin.
Hoskins RA, Carlson JW, Kennedy C, Acevedo D, Evans-Holm M, Frise E, Wan KH, Park S, Mendez-Lago M, Rossi F, Villasante A, Dimitri P, Karpen GH, Celniker SE
Science (New York, N.Y.)316(5831)1625-8(2007 Jun)

The Release 5.1 annotation of Drosophila melanogaster heterochromatin.
Smith CD, Shu S, Mungall CJ, Karpen GH
Science (New York, N.Y.)316(5831)1586-91(2007 Jun)

Combined evidence annotation of transposable elements in genome sequences.
Quesneville H, Bergman CM, Andrieu O, Autard D, Nouaud D, Ashburner M, Anxolabehere D
PLoS computational biology1(2)166-75(2005 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The results demonstrate that CHMP2B(Intron5) preferentially affects different receptor signaling pathways in a cellular and developmental context-dependent manner.
Title: Expression of mutant CHMP2B, an ESCRT-III component involved in frontotemporal dementia, causes eye deformities due to Notch misregulation in Drosophila.

Data show that syntaxin 13 (syx13) is a geneti modifier of the mutant CHMP2B (CHMP2BIntron5) eye phenotype.
Title: Syntaxin 13, a genetic modifier of mutant CHMP2B in frontotemporal dementia, is required for autophagosome maturation.

Spn5 is a regulator of the Toll pathway and CHMP2B (CG4618) toxicity and the Toll pathway is a major signaling pathway misregulated by mutant CHMP2B in vivo.
Title: Genetic screen identifies serpin5 as a regulator of the toll pathway and CHMP2B toxicity associated with frontotemporal dementia.

The following CHMP2B gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CHMP2B cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OFa17572	NM_139690.4 Latest version!	Drosophila melanogaster charged multivesicular body protein 2b (CHMP2B), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$174.30 $249.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

CHMP2B ( NM_139690.4 ) cDNA ORF clone, Drosophila melanogaster(fruit fly) -> NP_647947.1 Drosophila melanogaster charged multivesicular body protein 2b (CHMP2B), mRNA.

Price & Availability↑

CloneID	OFa17572
Clone ID Related Accession (Same CDS sequence)	NM_139690.4
Accession Version	NM_139690.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 639bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-04-24
Organism	Drosophila melanogaster(fruit fly)
Product	charged multivesicular body protein 2b
Comment	Comment: REVIEWED REFSEQ: This record has been curated by FlyBase. This record is derived from an annotated genomic sequence (NT_037436). On Jan 16, 2013 this sequence version replaced NM_139690.3. ##Genome-Annotation-Data-START## Annotation Provider :: FlyBase Annotation Status :: Full annotation Annotation Version :: Release 6.26 URL :: http://flybase.org ##Genome-Annotation-Data-END##

ATGTTCAACA ATATTTTCGG AAAGAAACCC ACCGTGAAGG AGCAGCAGCG GGAGAATGAC 
CGATCGCTGC GCAAGGCCAC CAGGGACATC GAACGGGAGC GCAGGAAAAT GGAGGAGGAG 
GAGCGCAAGC TGGAGCTGGA GATCCGACGG AATGCCGCCG CTGGGAACAA CGATGCCTGC 
CGCATTCTGG CCAAGCAGCT GGTGGAGATC AGGAAGCAGA AATCACGCAC ATACGCAGCA 
GCGGGCAAGA TTCAGTCCAT TGGCTACCAG AACAAGAACA TGGGCGCCAA TATCGCCCTA 
AGCGAAGCCA TGGGCACCAC GGCCAAGACG ATGGGTGAAA TGAATAAGGT GATGCGACCG 
GAGGCCATCG GGGAAACAGT GCGCCAGTTC CAGGCGGCCA ACATGAAGAT GGAAATGACC 
GACGAGATGA TCAACGACAC GCTGGACGAC ATGCTGAATG AGTCCGGCGA CGAGGAGGAG 
TCCAATGCCG TAGTCAACAA GGTGCTCGAC GAGATCGGCA TCGAGATCTC CGGCAAGATG 
TCCAGCATCC CGGCCACGGG ATCCTCAGAC TTTGAGACGA GTGGCAAGCG CACCGAGAAG 
GACATTGCCG ATCAACTGGC CAAGCTGCGC TCCTCTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_647947.1
CDS	127..765
Translation	MFNNIFGKKPTVKEQQRENDRSLRKATRDIERERRKMEEEERKLELEIRRNAAAGNNDACRILAKQLVEIRKQKSRTYAAAGKIQSIGYQNKNMGANIALSEAMGTTAKTMGEMNKVMRPEAIGETVRQFQAANMKMEMTDEMINDTLDDMLNESGDEEESNAVVNKVLDEIGIEISGKMSSIPATGSSDFETSGKRTEKDIADQLAKLRSS

Target ORF information:

RefSeq Version	NM_139690.4
Organism	Drosophila melanogaster(fruit fly)
Definition	Drosophila melanogaster charged multivesicular body protein 2b (CHMP2B), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_139690.4

ORF Insert Sequence:

ATGTTCAACA ATATTTTCGG AAAGAAACCC ACCGTGAAGG AGCAGCAGCG GGAGAATGAC 
CGATCGCTGC GCAAGGCCAC CAGGGACATC GAACGGGAGC GCAGGAAAAT GGAGGAGGAG 
GAGCGCAAGC TGGAGCTGGA GATCCGACGG AATGCCGCCG CTGGGAACAA CGATGCCTGC 
CGCATTCTGG CCAAGCAGCT GGTGGAGATC AGGAAGCAGA AATCACGCAC ATACGCAGCA 
GCGGGCAAGA TTCAGTCCAT TGGCTACCAG AACAAGAACA TGGGCGCCAA TATCGCCCTA 
AGCGAAGCCA TGGGCACCAC GGCCAAGACG ATGGGTGAAA TGAATAAGGT GATGCGACCG 
GAGGCCATCG GGGAAACAGT GCGCCAGTTC CAGGCGGCCA ACATGAAGAT GGAAATGACC 
GACGAGATGA TCAACGACAC GCTGGACGAC ATGCTGAATG AGTCCGGCGA CGAGGAGGAG 
TCCAATGCCG TAGTCAACAA GGTGCTCGAC GAGATCGGCA TCGAGATCTC CGGCAAGATG 
TCCAGCATCC CGGCCACGGG ATCCTCAGAC TTTGAGACGA GTGGCAAGCG CACCGAGAAG 
GACATTGCCG ATCAACTGGC CAAGCTGCGC TCCTCTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Gene Model Annotations for Drosophila melanogaster: Impact of High-Throughput Data.
G3 (Bethesda, Md.)5(8)1721-36(2015 Jun)
Matthews BB,Dos Santos G,Crosby MA,Emmert DB,St Pierre SE,Gramates LS,Zhou P,Schroeder AJ,Falls K,Strelets V,Russo SM,Gelbart WM,

Gene Model Annotations for Drosophila melanogaster: The Rule-Benders.
G3 (Bethesda, Md.)5(8)1737-49(2015 Jun)
Crosby MA,Gramates LS,Dos Santos G,Matthews BB,St Pierre SE,Zhou P,Schroeder AJ,Falls K,Emmert DB,Russo SM,Gelbart WM,

Sequence finishing and mapping of Drosophila melanogaster heterochromatin.
Science (New York, N.Y.)316(5831)1625-8(2007 Jun)
Hoskins RA,Carlson JW,Kennedy C,Acevedo D,Evans-Holm M,Frise E,Wan KH,Park S,Mendez-Lago M,Rossi F,Villasante A,Dimitri P,Karpen GH,Celniker SE

The Release 5.1 annotation of Drosophila melanogaster heterochromatin.
Science (New York, N.Y.)316(5831)1586-91(2007 Jun)
Smith CD,Shu S,Mungall CJ,Karpen GH

Combined evidence annotation of transposable elements in genome sequences.
PLoS computational biology1(2)166-75(2005 Jul)
Quesneville H,Bergman CM,Andrieu O,Autard D,Nouaud D,Ashburner M,Anxolabehere D

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CHMP2B cDNA ORF clone, Drosophila melanogaster(fruit fly)

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Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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