fng cDNA ORF clone, Drosophila melanogaster(fruit fly)

Gene
Clones
gRNAs

Summary

Gene Symbol	fng
Entrez Gene ID	40314
Full Name	fringe
Synonyms	CG10580,D-Fng,D-fng,Dfng,Dmel\CG10580,Fng,Frg,fg,frg,l(3)rG554
General protein information	Preferred Names fringe Names CG10580 gene product from transcript CG10580-RA CG10580-PA fng-PA
Gene Type	protein-coding
Organism	Drosophila melanogaster(fruit fly)
Genome	Chromosome: 3L Map Location: 78A1-78A1\|3-47 cM

mRNA and Protein(s)

mRNA	Protein	Name
NM_079467.3	NP_524191.1	fringe

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	RFNG	XP_540495.4
Bos taurus (cattle)	RFNG	XP_002696180.2
Drosophila melanogaster (fruit fly)	fng	NP_524191.1
Mus musculus (house mouse)	Rfng	NP_033079.1
Rattus norvegicus (Norway rat)	Rfng	NP_068621.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP006439	XP_316475.4
Xenopus tropicalis (tropical clawed frog)	rfng	XP_002937356.2
Danio rerio (zebrafish)	rfng	NP_001038801.1
Homo sapiens (human)	RFNG	NP_002908.1
	LOC719330	XP_002800683.1
Gallus gallus (chicken)	RFNG	NP_990278.1

Gene Ontology
Bibliography

Related articles in PubMed

Gene Model Annotations for Drosophila melanogaster: Impact of High-Throughput Data.
Matthews BB, Dos Santos G, Crosby MA, Emmert DB, St Pierre SE, Gramates LS, Zhou P, Schroeder AJ, Falls K, Strelets V, Russo SM, Gelbart WM,
G3 (Bethesda, Md.)5(8)1721-36(2015 Jun)

Gene Model Annotations for Drosophila melanogaster: The Rule-Benders.
Crosby MA, Gramates LS, Dos Santos G, Matthews BB, St Pierre SE, Zhou P, Schroeder AJ, Falls K, Emmert DB, Russo SM, Gelbart WM,
G3 (Bethesda, Md.)5(8)1737-49(2015 Jun)

Sequence finishing and mapping of Drosophila melanogaster heterochromatin.
Hoskins RA, Carlson JW, Kennedy C, Acevedo D, Evans-Holm M, Frise E, Wan KH, Park S, Mendez-Lago M, Rossi F, Villasante A, Dimitri P, Karpen GH, Celniker SE
Science (New York, N.Y.)316(5831)1625-8(2007 Jun)

The Release 5.1 annotation of Drosophila melanogaster heterochromatin.
Smith CD, Shu S, Mungall CJ, Karpen GH
Science (New York, N.Y.)316(5831)1586-91(2007 Jun)

Combined evidence annotation of transposable elements in genome sequences.
Quesneville H, Bergman CM, Andrieu O, Autard D, Nouaud D, Ashburner M, Anxolabehere D
PLoS computational biology1(2)166-75(2005 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Mapping Sites of O-Glycosylation and Fringe Elongation on Drosophila Notch.
Title: Mapping Sites of O-Glycosylation and Fringe Elongation on Drosophila Notch.

The function of Chi and dLMO on Notch signaling is dependent on the regulation of fng transcription.
Title: Chi and dLMO function antagonistically on Notch signaling through directly regulation of fng transcription.

Fringe modulated Notch-ligand cis interactions during Drosophila development.
Title: Fringe proteins modulate Notch-ligand cis and trans interactions to specify signaling states.

FOXO-mediated regulation of fringe links the insulin and Notch signaling pathways in the germline stem cell niche.
Title: FOXO/Fringe is necessary for maintenance of the germline stem cell niche in response to insulin insufficiency.

Eaat1 expression is promoted by Fringe-mediated neuron-glial communication during development and suggest that Eaat1 plays an essential role in regulating central nervous system neural circuits that control locomotion in Drosophila
Title: Drosophila glial glutamate transporter Eaat1 is regulated by fringe-mediated notch signaling and is essential for larval locomotion.

The following fng gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the fng cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OFa21154	NM_079467.3 Latest version!	Drosophila melanogaster fringe (fng), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$258.30 $369.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

fng ( NM_079467.3 ) cDNA ORF clone, Drosophila melanogaster(fruit fly) -> NP_524191.1 Drosophila melanogaster fringe (fng), mRNA.

Price & Availability↑

CloneID	OFa21154
Clone ID Related Accession (Same CDS sequence)	NM_079467.3
Accession Version	NM_079467.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1239bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-04-24
Organism	Drosophila melanogaster(fruit fly)
Product	fringe
Comment	Comment: REVIEWED REFSEQ: This record has been curated by FlyBase. This record is derived from an annotated genomic sequence (NT_037436). On Jan 16, 2013 this sequence version replaced NM_079467.2. ##Genome-Annotation-Data-START## Annotation Provider :: FlyBase Annotation Status :: Full annotation Annotation Version :: Release 6.26 URL :: http://flybase.org ##Genome-Annotation-Data-END##

ATGATGAGCC TGACTGTGCT CTCGCCACCG CAACGTTTTA AGCGAATCCT GCAAGCCATG 
ATGTTAGCCG TCGCCGTCGT CTATATGACC CTACTGCTCT ACCAGAGCGC CTACGGATAT 
CCGGGCATCC AAGTGCCGCA CAGCCAGGTG GATGCCCTTG CCAGCGAAGC CGTGACCACA 
CATCGCGACC AGCTGCTCCA GGACTACGTG CAGTCCTCCA CGCCCACCCA GCCGGGGGCT 
GGAGCTCCGG CCGCCTCCCC CACCACCGTC ATAATCCGCA AGGATATACG CAGCTTCAAT 
TTCAGCGACA TCGAGGTCAG TGAGCGGCCC ACGGCCACGC TGCTAACAGA ATTGGCCAGA 
AGGAGCCGGA ATGGGGAACT GCTCCGCGAT CTGTCCCAAA GAGCGGTGAC GGCGACACCA 
CAGCCGCCGG TCACCGAGTT GGATGACATT TTCATCAGCG TAAAGACGAC GAAGAACTAT 
CACGACACCC GGCTGGCGTT GATCATCAAG ACCTGGTTCC AATTGGCCCG CGATCAGACC 
TGGTTCTTCA CGGACACCGA TGATCACTAC TACCAGGAGA AGACAAAGGG CCATCTCATC 
AACACGAAAT GCTCACAGGG CCATTTTCGC AAGGCGCTTT GCTGCAAAAT GTCCGCTGAA 
TTGGATGTCT TCCTGGAGAG TGGCAAAAAG TGGTTCTGTC ACTTCGACGA TGACAACTAT 
GTCAATGTGC CGAGGCTGGT CAAACTGCTG GACGAGTATA GCCCCAGTGT GGATTGGTAT 
CTGGGCAAGC CGAGCATCTC GTCGCCGCTG GAGATCCACT TGGACAGCAA GAACACGACA 
ACAAACAAGA AGATAACCTT CTGGTTCGCC ACTGGCGGCG CTGGCTTCTG CCTCAGTCGA 
GCCCTGACTT TAAAAATGCT ACCCATAGCA GGTGGTGGCA AGTTTATCAG CATTGGCGAC 
AAGATACGTT TTCCGGATGA TGTCACAATG GGTTTTATTA TTGAACACCT TCTGAAAGTT 
CCTCTAACCG TGGTGGACAA CTTCCACTCG CATTTGGAGC CCATGGAGTT CATACGCCAG 
GATACGTTCC AGGACCAGGT GTCCTTCAGC TATGCCCACA TGAAAAACCA GTGGAACGTG 
ATCAAGGTGG ACGGCTTCGA TATGAAAACC GATCCCAAGC GCTTCTACTC CCTGCACTGC 
CAGCTTTTCC CCTACTTCAG CTTCTGCCCG CCCAGATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_524191.1
CDS	212..1450
Translation	MMSLTVLSPPQRFKRILQAMMLAVAVVYMTLLLYQSAYGYPGIQVPHSQVDALASEAVTTHRDQLLQDYVQSSTPTQPGAGAPAASPTTVIIRKDIRSFNFSDIEVSERPTATLLTELARRSRNGELLRDLSQRAVTATPQPPVTELDDIFISVKTTKNYHDTRLALIIKTWFQLARDQTWFFTDTDDHYYQEKTKGHLINTKCSQGHFRKALCCKMSAELDVFLESGKKWFCHFDDDNYVNVPRLVKLLDEYSPSVDWYLGKPSISSPLEIHLDSKNTTTNKKITFWFATGGAGFCLSRALTLKMLPIAGGGKFISIGDKIRFPDDVTMGFIIEHLLKVPLTVVDNFHSHLEPMEFIRQDTFQDQVSFSYAHMKNQWNVIKVDGFDMKTDPKRFYSLHCQLFPYFSFCPPR

Target ORF information:

RefSeq Version	NM_079467.3
Organism	Drosophila melanogaster(fruit fly)
Definition	Drosophila melanogaster fringe (fng), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_079467.3

ORF Insert Sequence:

ATGATGAGCC TGACTGTGCT CTCGCCACCG CAACGTTTTA AGCGAATCCT GCAAGCCATG 
ATGTTAGCCG TCGCCGTCGT CTATATGACC CTACTGCTCT ACCAGAGCGC CTACGGATAT 
CCGGGCATCC AAGTGCCGCA CAGCCAGGTG GATGCCCTTG CCAGCGAAGC CGTGACCACA 
CATCGCGACC AGCTGCTCCA GGACTACGTG CAGTCCTCCA CGCCCACCCA GCCGGGGGCT 
GGAGCTCCGG CCGCCTCCCC CACCACCGTC ATAATCCGCA AGGATATACG CAGCTTCAAT 
TTCAGCGACA TCGAGGTCAG TGAGCGGCCC ACGGCCACGC TGCTAACAGA ATTGGCCAGA 
AGGAGCCGGA ATGGGGAACT GCTCCGCGAT CTGTCCCAAA GAGCGGTGAC GGCGACACCA 
CAGCCGCCGG TCACCGAGTT GGATGACATT TTCATCAGCG TAAAGACGAC GAAGAACTAT 
CACGACACCC GGCTGGCGTT GATCATCAAG ACCTGGTTCC AATTGGCCCG CGATCAGACC 
TGGTTCTTCA CGGACACCGA TGATCACTAC TACCAGGAGA AGACAAAGGG CCATCTCATC 
AACACGAAAT GCTCACAGGG CCATTTTCGC AAGGCGCTTT GCTGCAAAAT GTCCGCTGAA 
TTGGATGTCT TCCTGGAGAG TGGCAAAAAG TGGTTCTGTC ACTTCGACGA TGACAACTAT 
GTCAATGTGC CGAGGCTGGT CAAACTGCTG GACGAGTATA GCCCCAGTGT GGATTGGTAT 
CTGGGCAAGC CGAGCATCTC GTCGCCGCTG GAGATCCACT TGGACAGCAA GAACACGACA 
ACAAACAAGA AGATAACCTT CTGGTTCGCC ACTGGCGGCG CTGGCTTCTG CCTCAGTCGA 
GCCCTGACTT TAAAAATGCT ACCCATAGCA GGTGGTGGCA AGTTTATCAG CATTGGCGAC 
AAGATACGTT TTCCGGATGA TGTCACAATG GGTTTTATTA TTGAACACCT TCTGAAAGTT 
CCTCTAACCG TGGTGGACAA CTTCCACTCG CATTTGGAGC CCATGGAGTT CATACGCCAG 
GATACGTTCC AGGACCAGGT GTCCTTCAGC TATGCCCACA TGAAAAACCA GTGGAACGTG 
ATCAAGGTGG ACGGCTTCGA TATGAAAACC GATCCCAAGC GCTTCTACTC CCTGCACTGC 
CAGCTTTTCC CCTACTTCAG CTTCTGCCCG CCCAGATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Gene Model Annotations for Drosophila melanogaster: Impact of High-Throughput Data.
G3 (Bethesda, Md.)5(8)1721-36(2015 Jun)
Matthews BB,Dos Santos G,Crosby MA,Emmert DB,St Pierre SE,Gramates LS,Zhou P,Schroeder AJ,Falls K,Strelets V,Russo SM,Gelbart WM,

Gene Model Annotations for Drosophila melanogaster: The Rule-Benders.
G3 (Bethesda, Md.)5(8)1737-49(2015 Jun)
Crosby MA,Gramates LS,Dos Santos G,Matthews BB,St Pierre SE,Zhou P,Schroeder AJ,Falls K,Emmert DB,Russo SM,Gelbart WM,

Sequence finishing and mapping of Drosophila melanogaster heterochromatin.
Science (New York, N.Y.)316(5831)1625-8(2007 Jun)
Hoskins RA,Carlson JW,Kennedy C,Acevedo D,Evans-Holm M,Frise E,Wan KH,Park S,Mendez-Lago M,Rossi F,Villasante A,Dimitri P,Karpen GH,Celniker SE

The Release 5.1 annotation of Drosophila melanogaster heterochromatin.
Science (New York, N.Y.)316(5831)1586-91(2007 Jun)
Smith CD,Shu S,Mungall CJ,Karpen GH

Combined evidence annotation of transposable elements in genome sequences.
PLoS computational biology1(2)166-75(2005 Jul)
Quesneville H,Bergman CM,Andrieu O,Autard D,Nouaud D,Ashburner M,Anxolabehere D

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fng cDNA ORF clone, Drosophila melanogaster(fruit fly)

Gene

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Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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