imd cDNA ORF clone, Drosophila melanogaster(fruit fly)

Gene
Clones
gRNAs

Summary

Gene Symbol	imd
Entrez Gene ID	44339
Full Name	immune deficiency
Synonyms	BG5,CG5576,Dmel\CG5576,IMD,Imd,anon-WO0172774.166,shadok
General protein information	Preferred Names immune deficiency Names CG5576 gene product from transcript CG5576-RB CG5576-PA CG5576-PB imd-PA imd-PB immune deficient immunodeficiency
Gene Type	protein-coding
Organism	Drosophila melanogaster(fruit fly)
Genome	Chromosome: 2R Map Location: 55C8-55C8

mRNA and Protein(s)

mRNA	Protein	Name
NM_133166.4	NP_573394.1	immune deficiency, isoform A
NM_001299643.1	NP_001286572.1	immune deficiency, isoform B

Pathways from BioSystems

Homologies

Anopheles gambiae (African malaria mosquito)	IMD	XP_001688608.1
Drosophila melanogaster (fruit fly)	imd	NP_573394.1

Gene Ontology
Bibliography

Related articles in PubMed

Gene Model Annotations for Drosophila melanogaster: Impact of High-Throughput Data.
Matthews BB, Dos Santos G, Crosby MA, Emmert DB, St Pierre SE, Gramates LS, Zhou P, Schroeder AJ, Falls K, Strelets V, Russo SM, Gelbart WM,
G3 (Bethesda, Md.)5(8)1721-36(2015 Jun)

Gene Model Annotations for Drosophila melanogaster: The Rule-Benders.
Crosby MA, Gramates LS, Dos Santos G, Matthews BB, St Pierre SE, Zhou P, Schroeder AJ, Falls K, Emmert DB, Russo SM, Gelbart WM,
G3 (Bethesda, Md.)5(8)1737-49(2015 Jun)

Sequence finishing and mapping of Drosophila melanogaster heterochromatin.
Hoskins RA, Carlson JW, Kennedy C, Acevedo D, Evans-Holm M, Frise E, Wan KH, Park S, Mendez-Lago M, Rossi F, Villasante A, Dimitri P, Karpen GH, Celniker SE
Science (New York, N.Y.)316(5831)1625-8(2007 Jun)

The Release 5.1 annotation of Drosophila melanogaster heterochromatin.
Smith CD, Shu S, Mungall CJ, Karpen GH
Science (New York, N.Y.)316(5831)1586-91(2007 Jun)

Combined evidence annotation of transposable elements in genome sequences.
Quesneville H, Bergman CM, Andrieu O, Autard D, Nouaud D, Ashburner M, Anxolabehere D
PLoS computational biology1(2)166-75(2005 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Protofibrils of peptidoglycan receptors PGRP-LC and PGRP-LE seed immune deficiency protein (Imd) amyloid polymerization via Imd RIP homotypic interaction motif (RHIM), and the formation of functional Imd amyloid fibril is required for NF-kappaB signaling.
Title: Peptidoglycan-Sensing Receptors Trigger the Formation of Functional Amyloids of the Adaptor Protein Imd to Initiate Drosophila NF-?B Signaling.

interdomain cleavage of Dredd is not required for Imd or Relish processing and is not observed during immune stimulation
Title: The caspase-8 homolog Dredd cleaves Imd and Relish but is not inhibited by p35.

the IMD/Relish signaling pathway is a central regulator of microbiota-mediated transcriptional response
Title: Drosophila microbiota modulates host metabolic gene expression via IMD/NF-?B signaling.

Using the Drosophila model and mutations in the Toll and Imd pathways, authors showed that neither pathway is required for expression of the dengue virus-blocking phenotype in the Drosophila host.
Title: The toll and Imd pathways are not required for wolbachia-mediated dengue virus interference.

Faf inhibits the IMD pathway by modulating the state of Imd ubiquitination and/or stability.
Title: fat facets induces polyubiquitination of Imd and inhibits the innate immune response in Drosophila.

The following imd gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the imd cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OFa11345	NM_001299643.1 Latest version!	Drosophila melanogaster immune deficiency (imd), transcript variant B, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$174.30 $249.00
OFa11345	NM_133166.4 Latest version!	Drosophila melanogaster immune deficiency (imd), transcript variant A, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$174.30 $249.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

imd ( NM_133166.4 ) cDNA ORF clone, Drosophila melanogaster(fruit fly) -> NP_573394.1 Drosophila melanogaster immune deficiency (imd), transcript variant A, mRNA.

Price & Availability↑

CloneID	OFa11345
Clone ID Related Accession (Same CDS sequence)	NM_133166.4 , NM_001299643.1
Accession Version	NM_133166.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 822bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-04-24
Organism	Drosophila melanogaster(fruit fly)
Product	immune deficiency, isoform A
Comment	Comment: REVIEWED REFSEQ: This record has been curated by FlyBase. This record is derived from an annotated genomic sequence (NT_033778). On Jul 15, 2014 this sequence version replaced NM_133166.3. ##Genome-Annotation-Data-START## Annotation Provider :: FlyBase Annotation Status :: Full annotation Annotation Version :: Release 6.26 URL :: http://flybase.org ##Genome-Annotation-Data-END##

ATGTCAAAGC TCAGGAACCT GTTGCCCACA ATCTTTGGCG GGAAGGAGGC ACAGAATCCG 
ACACCCGTCG AGGGACGCCT GGAAAAGGAC GCAGCTCCCG TGGACGACAA CGAACCAGAT 
AACAACAACA GCGGAGCCCT GGCGCTGCCC TCCACCGCTG GCACGCCCAC AGCCTCCTCG 
GATCTGACCG AATCCGTGCT GCGCGAGCTC AGCGACCCAA ACTACAATTC AATGGATGTG 
GTGCATTCCG CCAATATTCC GGGCACTCTC AGTAACGTCC AGACAAACAA CACCATGAAC 
GTACACAGCG CCCAGCAACA GGTGGTCATG AACTTCTCGA ATGCCAATAA TCTGCACTTC 
GGCTCCGTCT ACAACTTCAA CCAAAACTTG AGCGCCTGCA GCTCGCGAAA GGGTAGCACC 
AGTACCGCAG AGGAGTCGGT CGCCTCTCCA GACGGTAAGC CGCGGGCAAG TGCGACGCGC 
AAAACGGTCA GCATTGTGGC CATGATGCAG TCACAAGAGG AACCGGATGT GCGCCTGCTC 
GATGTGGTTT CCACGCACTT GGGCGAGGGC TGGAAGCAGG TGATGCGGGA TCTTGGCATG 
TCGGAAGGAC AGATCGACCA GGCCATAATC GATCACCAAA TGCATGGCAA TATTAGAGAG 
GTGATATACC AGCTGTTGCT CCAGTGGATT CGAAGCTCGG CGGACGGTGT GGCCACCGTT 
GGACGACTTA CTACACTGCT GTGGGAGTCC CAGCATCGCG ACTGCGTGCA GCGCATGAAA 
CTGGTTTGGA AGGCACTGGA GAAGCGCAAG ACAAACAGCT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_573394.1
CDS	123..944
Translation	MSKLRNLLPTIFGGKEAQNPTPVEGRLEKDAAPVDDNEPDNNNSGALALPSTAGTPTASSDLTESVLRELSDPNYNSMDVVHSANIPGTLSNVQTNNTMNVHSAQQQVVMNFSNANNLHFGSVYNFNQNLSACSSRKGSTSTAEESVASPDGKPRASATRKTVSIVAMMQSQEEPDVRLLDVVSTHLGEGWKQVMRDLGMSEGQIDQAIIDHQMHGNIREVIYQLLLQWIRSSADGVATVGRLTTLLWESQHRDCVQRMKLVWKALEKRKTNS

Target ORF information:

RefSeq Version	NM_133166.4
Organism	Drosophila melanogaster(fruit fly)
Definition	Drosophila melanogaster immune deficiency (imd), transcript variant A, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_133166.4

ORF Insert Sequence:

ATGTCAAAGC TCAGGAACCT GTTGCCCACA ATCTTTGGCG GGAAGGAGGC ACAGAATCCG 
ACACCCGTCG AGGGACGCCT GGAAAAGGAC GCAGCTCCCG TGGACGACAA CGAACCAGAT 
AACAACAACA GCGGAGCCCT GGCGCTGCCC TCCACCGCTG GCACGCCCAC AGCCTCCTCG 
GATCTGACCG AATCCGTGCT GCGCGAGCTC AGCGACCCAA ACTACAATTC AATGGATGTG 
GTGCATTCCG CCAATATTCC GGGCACTCTC AGTAACGTCC AGACAAACAA CACCATGAAC 
GTACACAGCG CCCAGCAACA GGTGGTCATG AACTTCTCGA ATGCCAATAA TCTGCACTTC 
GGCTCCGTCT ACAACTTCAA CCAAAACTTG AGCGCCTGCA GCTCGCGAAA GGGTAGCACC 
AGTACCGCAG AGGAGTCGGT CGCCTCTCCA GACGGTAAGC CGCGGGCAAG TGCGACGCGC 
AAAACGGTCA GCATTGTGGC CATGATGCAG TCACAAGAGG AACCGGATGT GCGCCTGCTC 
GATGTGGTTT CCACGCACTT GGGCGAGGGC TGGAAGCAGG TGATGCGGGA TCTTGGCATG 
TCGGAAGGAC AGATCGACCA GGCCATAATC GATCACCAAA TGCATGGCAA TATTAGAGAG 
GTGATATACC AGCTGTTGCT CCAGTGGATT CGAAGCTCGG CGGACGGTGT GGCCACCGTT 
GGACGACTTA CTACACTGCT GTGGGAGTCC CAGCATCGCG ACTGCGTGCA GCGCATGAAA 
CTGGTTTGGA AGGCACTGGA GAAGCGCAAG ACAAACAGCT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

imd ( NM_001299643.1 ) cDNA ORF clone, Drosophila melanogaster(fruit fly) -> NP_001286572.1 Drosophila melanogaster immune deficiency (imd), transcript variant B, mRNA.

Price & Availability↑

CloneID	OFa11345
Clone ID Related Accession (Same CDS sequence)	NM_133166.4 , NM_001299643.1
Accession Version	NM_001299643.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 822bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-04-24
Organism	Drosophila melanogaster(fruit fly)
Product	immune deficiency, isoform B
Comment	Comment: REVIEWED REFSEQ: This record has been curated by FlyBase. This record is derived from an annotated genomic sequence (NT_033778). ##Genome-Annotation-Data-START## Annotation Provider :: FlyBase Annotation Status :: Full annotation Annotation Version :: Release 6.26 URL :: http://flybase.org ##Genome-Annotation-Data-END##

ATGTCAAAGC TCAGGAACCT GTTGCCCACA ATCTTTGGCG GGAAGGAGGC ACAGAATCCG 
ACACCCGTCG AGGGACGCCT GGAAAAGGAC GCAGCTCCCG TGGACGACAA CGAACCAGAT 
AACAACAACA GCGGAGCCCT GGCGCTGCCC TCCACCGCTG GCACGCCCAC AGCCTCCTCG 
GATCTGACCG AATCCGTGCT GCGCGAGCTC AGCGACCCAA ACTACAATTC AATGGATGTG 
GTGCATTCCG CCAATATTCC GGGCACTCTC AGTAACGTCC AGACAAACAA CACCATGAAC 
GTACACAGCG CCCAGCAACA GGTGGTCATG AACTTCTCGA ATGCCAATAA TCTGCACTTC 
GGCTCCGTCT ACAACTTCAA CCAAAACTTG AGCGCCTGCA GCTCGCGAAA GGGTAGCACC 
AGTACCGCAG AGGAGTCGGT CGCCTCTCCA GACGGTAAGC CGCGGGCAAG TGCGACGCGC 
AAAACGGTCA GCATTGTGGC CATGATGCAG TCACAAGAGG AACCGGATGT GCGCCTGCTC 
GATGTGGTTT CCACGCACTT GGGCGAGGGC TGGAAGCAGG TGATGCGGGA TCTTGGCATG 
TCGGAAGGAC AGATCGACCA GGCCATAATC GATCACCAAA TGCATGGCAA TATTAGAGAG 
GTGATATACC AGCTGTTGCT CCAGTGGATT CGAAGCTCGG CGGACGGTGT GGCCACCGTT 
GGACGACTTA CTACACTGCT GTGGGAGTCC CAGCATCGCG ACTGCGTGCA GCGCATGAAA 
CTGGTTTGGA AGGCACTGGA GAAGCGCAAG ACAAACAGCT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001286572.1
CDS	321..1142
Translation	MSKLRNLLPTIFGGKEAQNPTPVEGRLEKDAAPVDDNEPDNNNSGALALPSTAGTPTASSDLTESVLRELSDPNYNSMDVVHSANIPGTLSNVQTNNTMNVHSAQQQVVMNFSNANNLHFGSVYNFNQNLSACSSRKGSTSTAEESVASPDGKPRASATRKTVSIVAMMQSQEEPDVRLLDVVSTHLGEGWKQVMRDLGMSEGQIDQAIIDHQMHGNIREVIYQLLLQWIRSSADGVATVGRLTTLLWESQHRDCVQRMKLVWKALEKRKTNS

Target ORF information:

RefSeq Version	NM_001299643.1
Organism	Drosophila melanogaster(fruit fly)
Definition	Drosophila melanogaster immune deficiency (imd), transcript variant B, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001299643.1

ORF Insert Sequence:

ATGTCAAAGC TCAGGAACCT GTTGCCCACA ATCTTTGGCG GGAAGGAGGC ACAGAATCCG 
ACACCCGTCG AGGGACGCCT GGAAAAGGAC GCAGCTCCCG TGGACGACAA CGAACCAGAT 
AACAACAACA GCGGAGCCCT GGCGCTGCCC TCCACCGCTG GCACGCCCAC AGCCTCCTCG 
GATCTGACCG AATCCGTGCT GCGCGAGCTC AGCGACCCAA ACTACAATTC AATGGATGTG 
GTGCATTCCG CCAATATTCC GGGCACTCTC AGTAACGTCC AGACAAACAA CACCATGAAC 
GTACACAGCG CCCAGCAACA GGTGGTCATG AACTTCTCGA ATGCCAATAA TCTGCACTTC 
GGCTCCGTCT ACAACTTCAA CCAAAACTTG AGCGCCTGCA GCTCGCGAAA GGGTAGCACC 
AGTACCGCAG AGGAGTCGGT CGCCTCTCCA GACGGTAAGC CGCGGGCAAG TGCGACGCGC 
AAAACGGTCA GCATTGTGGC CATGATGCAG TCACAAGAGG AACCGGATGT GCGCCTGCTC 
GATGTGGTTT CCACGCACTT GGGCGAGGGC TGGAAGCAGG TGATGCGGGA TCTTGGCATG 
TCGGAAGGAC AGATCGACCA GGCCATAATC GATCACCAAA TGCATGGCAA TATTAGAGAG 
GTGATATACC AGCTGTTGCT CCAGTGGATT CGAAGCTCGG CGGACGGTGT GGCCACCGTT 
GGACGACTTA CTACACTGCT GTGGGAGTCC CAGCATCGCG ACTGCGTGCA GCGCATGAAA 
CTGGTTTGGA AGGCACTGGA GAAGCGCAAG ACAAACAGCT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Gene Model Annotations for Drosophila melanogaster: Impact of High-Throughput Data.
G3 (Bethesda, Md.)5(8)1721-36(2015 Jun)
Matthews BB,Dos Santos G,Crosby MA,Emmert DB,St Pierre SE,Gramates LS,Zhou P,Schroeder AJ,Falls K,Strelets V,Russo SM,Gelbart WM,

Gene Model Annotations for Drosophila melanogaster: The Rule-Benders.
G3 (Bethesda, Md.)5(8)1737-49(2015 Jun)
Crosby MA,Gramates LS,Dos Santos G,Matthews BB,St Pierre SE,Zhou P,Schroeder AJ,Falls K,Emmert DB,Russo SM,Gelbart WM,

Sequence finishing and mapping of Drosophila melanogaster heterochromatin.
Science (New York, N.Y.)316(5831)1625-8(2007 Jun)
Hoskins RA,Carlson JW,Kennedy C,Acevedo D,Evans-Holm M,Frise E,Wan KH,Park S,Mendez-Lago M,Rossi F,Villasante A,Dimitri P,Karpen GH,Celniker SE

The Release 5.1 annotation of Drosophila melanogaster heterochromatin.
Science (New York, N.Y.)316(5831)1586-91(2007 Jun)
Smith CD,Shu S,Mungall CJ,Karpen GH

Combined evidence annotation of transposable elements in genome sequences.
PLoS computational biology1(2)166-75(2005 Jul)
Quesneville H,Bergman CM,Andrieu O,Autard D,Nouaud D,Ashburner M,Anxolabehere D

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imd cDNA ORF clone, Drosophila melanogaster(fruit fly)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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