Gene Symbol | SPRY3 |
Entrez Gene ID | 10251 |
Full Name | sprouty RTK signaling antagonist 3 |
Synonyms | spry-3 |
General protein information |
|
Gene Type | protein-coding |
Organism | Homo sapiens(human) |
Genome | |
Disorder MIM: |
ORF » Species Summary » Homo sapiens » SPRY3 cDNA ORF clone
Gene Symbol | SPRY3 |
Entrez Gene ID | 10251 |
Full Name | sprouty RTK signaling antagonist 3 |
Synonyms | spry-3 |
General protein information |
|
Gene Type | protein-coding |
Organism | Homo sapiens(human) |
Genome | |
Disorder MIM: |
mRNA | Protein | Name |
---|---|---|
XM_011531100.1 | XP_011529402.1 | protein sprouty homolog 3 isoform X1 |
XM_011531101.1 | XP_011529403.1 | protein sprouty homolog 3 isoform X1 |
XM_011531099.1 | XP_011529401.1 | protein sprouty homolog 3 isoform X1 |
XM_011531098.1 | XP_011529400.1 | protein sprouty homolog 3 isoform X1 |
NM_001304990.1 | NP_001291919.1 | protein sprouty homolog 3 |
NM_005840.2 | NP_005831.1 | protein sprouty homolog 3 |
Canis lupus familiaris (dog) | SPRY3 | XP_005642107.1 |
Homo sapiens (human) | SPRY3 | NP_005831.1 |
SPRY3 | XP_001099973.1 | |
Mus musculus (house mouse) | Spry3 | NP_001025464.1 |
Rattus norvegicus (Norway rat) | Spry3 | NP_001102533.1 |
Danio rerio (zebrafish) | LOC100003704 | XP_005170333.1 |
Gallus gallus (chicken) | SPRY3 | NP_001073204.1 |
Pan troglodytes (chimpanzee) | SPRY3 | XP_003317849.1 |
Bos taurus (cattle) | SPRY3 | XP_005227708.1 |
Xenopus tropicalis (tropical clawed frog) | spry3 | NP_001163980.1 |
Regulation of SPRY3 by X chromosome and PAR2-linked promoters in an autism susceptibility region.
Ning Z, McLellan AS, Ball M, Wynne F, O'Neill C, Mills W, Quinn JP, Kleinjan DA, Anney RJ, Carmody RJ, O'Keeffe G, Moore T
Human molecular genetics24(18)5126-41(2015 Sep)
A functional interaction between sprouty proteins and caveolin-1.
Cabrita MA, J?ggi F, Widjaja SP, Christofori G
The Journal of biological chemistry281(39)29201-12(2006 Sep)
Maintenance of X- and Y-inactivation of the pseudoautosomal (PAR2) gene SPRY3 is independent from DNA methylation and associated to multiple layers of epigenetic modifications.
De Bonis ML, Cerase A, Matarazzo MR, Ferraro M, Strazzullo M, Hansen RS, Chiurazzi P, Neri G, D'Esposito M
Human molecular genetics15(7)1123-32(2006 Apr)
Human placental Hofbauer cells express sprouty proteins: a possible modulating mechanism of villous branching.
Anteby EY, Natanson-Yaron S, Greenfield C, Goldman-Wohl D, Haimov-Kochman R, Holzer H, Yagel S
Placenta26(6)476-83(2005 Jul)
The cysteine-rich sprouty translocation domain targets mitogen-activated protein kinase inhibitory proteins to phosphatidylinositol 4,5-bisphosphate in plasma membranes.
Lim J, Yusoff P, Wong ES, Chandramouli S, Lao DH, Fong CW, Guy GR
Molecular and cellular biology22(22)7953-66(2002 Nov)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
SPRY3 is a candidate susceptibility locus for autism and related or over-lapping disorders such as ataxia.
Title: Regulation of SPRY3 by X chromosome and PAR2-linked promoters in an autism susceptibility region.
the Sprouty/Caveolin-1 interaction modulates signaling in a growth factor- and Sprouty isoform-specific manner
Title: A functional interaction between sprouty proteins and caveolin-1.
Spry 1, 2 and 3 expression was observed in placental tissue from all three trimesters
Title: Human placental Hofbauer cells express sprouty proteins: a possible modulating mechanism of villous branching.
The following SPRY3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the SPRY3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
Online Only Promotion
Up to 50% OFF! Starting
from $49/clone
CloneID | OHu05135 | |
Clone ID Related Accession (Same CDS sequence) | XM_011531100.1 , XM_011531101.1 , XM_011531099.1 , XM_011531098.1 , NM_001304990.1 , NM_005840.2 | |
Accession Version | NM_001304990.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 867bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-08-04 | |
Organism | Homo sapiens(human) | |
Product | protein sprouty homolog 3 | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from DA102958.1, AK289543.1, AK125483.1, AK094610.1, AJ271735.1, KC877984.1, KF495814.1, KC877988.1 and BU164699.1. On Feb 13, 2015 this sequence version replaced XM_005274642.2. Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. This variant is only expected to be expressed from the X chromosome. Variants 1 and 2 encode the same protein. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## Transcript exon combination :: DA102958.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2142670, SAMEA2144335 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGGATGCTG CGGTGACAGA TGATTTTCAA CAAATTCTGC CTATTGAACA GCTGCGCTCT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001291919.1 |
CDS | 365..1231 |
Translation |
Target ORF information:
Target ORF information:
|
NM_001304990.1 |
1 | ATGGATGCTG CGGTGACAGA TGATTTTCAA CAAATTCTGC CTATTGAACA GCTGCGCTCT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu05135 | |
Clone ID Related Accession (Same CDS sequence) | XM_011531100.1 , XM_011531101.1 , XM_011531099.1 , XM_011531098.1 , NM_001304990.1 , NM_005840.2 | |
Accession Version | NM_005840.2 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 867bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-09-21 | |
Organism | Homo sapiens(human) | |
Product | protein sprouty homolog 3 | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK289543.1, AK125483.1, AK094610.1, AJ271735.1, KC877984.1, KF495814.1, KC877988.1 and BU164699.1. On Feb 13, 2015 this sequence version replaced NM_005840.1. Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## Transcript exon combination :: SRR1803612.184083.1, SRR1660805.156080.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1968189 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end. |
1 | ATGGATGCTG CGGTGACAGA TGATTTTCAA CAAATTCTGC CTATTGAACA GCTGCGCTCT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_005831.1 |
CDS | 509..1375 |
Translation |
Target ORF information:
Target ORF information:
|
NM_005840.2 |
1 | ATGGATGCTG CGGTGACAGA TGATTTTCAA CAAATTCTGC CTATTGAACA GCTGCGCTCT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu05135 | |
Clone ID Related Accession (Same CDS sequence) | XM_011531100.1 , XM_011531101.1 , XM_011531099.1 , XM_011531098.1 , NM_001304990.1 , NM_005840.2 | |
Accession Version | XM_011531100.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 867bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2015-03-11 | |
Organism | Homo sapiens(Human) | |
Product | protein sprouty homolog 3 isoform X1 | |
Comment |
1 | ATGGATGCTG CGGTGACAGA TGATTTTCAA CAAATTCTGC CTATTGAACA GCTGCGCTCT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_011529402.1 |
Translation |
Target ORF information:
Target ORF information:
|
XM_011531100.1 |
1 | ATGGATGCTG CGGTGACAGA TGATTTTCAA CAAATTCTGC CTATTGAACA GCTGCGCTCT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu05135 | |
Clone ID Related Accession (Same CDS sequence) | XM_011531100.1 , XM_011531101.1 , XM_011531099.1 , XM_011531098.1 , NM_001304990.1 , NM_005840.2 | |
Accession Version | XM_011531101.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 867bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2015-03-11 | |
Organism | Homo sapiens(Human) | |
Product | protein sprouty homolog 3 isoform X1 | |
Comment |
1 | ATGGATGCTG CGGTGACAGA TGATTTTCAA CAAATTCTGC CTATTGAACA GCTGCGCTCT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_011529403.1 |
Translation |
Target ORF information:
Target ORF information:
|
XM_011531101.1 |
1 | ATGGATGCTG CGGTGACAGA TGATTTTCAA CAAATTCTGC CTATTGAACA GCTGCGCTCT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu05135 | |
Clone ID Related Accession (Same CDS sequence) | XM_011531100.1 , XM_011531101.1 , XM_011531099.1 , XM_011531098.1 , NM_001304990.1 , NM_005840.2 | |
Accession Version | XM_011531099.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 867bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2015-03-11 | |
Organism | Homo sapiens(Human) | |
Product | protein sprouty homolog 3 isoform X1 | |
Comment |
1 | ATGGATGCTG CGGTGACAGA TGATTTTCAA CAAATTCTGC CTATTGAACA GCTGCGCTCT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_011529401.1 |
Translation |
Target ORF information:
Target ORF information:
|
XM_011531099.1 |
1 | ATGGATGCTG CGGTGACAGA TGATTTTCAA CAAATTCTGC CTATTGAACA GCTGCGCTCT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu05135 | |
Clone ID Related Accession (Same CDS sequence) | XM_011531100.1 , XM_011531101.1 , XM_011531099.1 , XM_011531098.1 , NM_001304990.1 , NM_005840.2 | |
Accession Version | XM_011531098.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 867bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2015-03-11 | |
Organism | Homo sapiens(Human) | |
Product | protein sprouty homolog 3 isoform X1 | |
Comment |
1 | ATGGATGCTG CGGTGACAGA TGATTTTCAA CAAATTCTGC CTATTGAACA GCTGCGCTCT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_011529400.1 |
Translation |
Target ORF information:
Target ORF information:
|
XM_011531098.1 |
1 | ATGGATGCTG CGGTGACAGA TGATTTTCAA CAAATTCTGC CTATTGAACA GCTGCGCTCT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Regulation of SPRY3 by X chromosome and PAR2-linked promoters in an autism susceptibility region. |
A functional interaction between sprouty proteins and caveolin-1. |
Maintenance of X- and Y-inactivation of the pseudoautosomal (PAR2) gene SPRY3 is independent from DNA methylation and associated to multiple layers of epigenetic modifications. |
Human placental Hofbauer cells express sprouty proteins: a possible modulating mechanism of villous branching. |
The cysteine-rich sprouty translocation domain targets mitogen-activated protein kinase inhibitory proteins to phosphatidylinositol 4,5-bisphosphate in plasma membranes. |