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CDKN1C cDNA ORF clone, Homo sapiens(Human)

Gene Symbol CDKN1C
Entrez Gene ID 1028
Full Name cyclin dependent kinase inhibitor 1C
Synonyms BWCR,BWS,KIP2,WBS,p57,p57Kip2
General protein information
Preferred Names

cyclin dependent kinase inhibitor 1C

Names

cyclin-dependent kinase inhibitor 1C
cyclin-dependent kinase inhibitor 1C (p57, Kip2)
cyclin-dependent kinase inhibitor p57

Gene Type protein-coding
Organism Homo sapiens(Human)
Genome

11

11p15.4

Summary This gene is imprinted, with preferential expression of the maternal allele. The encoded protein is a tight-binding, strong inhibitor of several G1 cyclin/Cdk complexes and a negative regulator of cell proliferation. Mutations in this gene are implicated in sporadic cancers and Beckwith-Wiedemann syndorome, suggesting that this gene is a tumor suppressor candidate. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Oct 2010].
Disorder MIM:

600856

Disorder Html: Beckwith-Wiedemann syndrome, 130650 (3)

mRNA and Protein(s)

mRNA Protein Name
NM_001122630.1 NP_001116102.1 cyclin-dependent kinase inhibitor 1C isoform b
NM_000076.2 NP_000067.1 cyclin-dependent kinase inhibitor 1C isoform a
NM_001122631.1 NP_001116103.1 cyclin-dependent kinase inhibitor 1C isoform b
XM_017017088.1 XP_016872577.1 cyclin-dependent kinase inhibitor 1C isoform X1
XM_005252732.4 XP_005252789.1 cyclin-dependent kinase inhibitor 1C isoform X2



Macaca mulatta (rhesus monkey) CDKN1C XP_001117302.2
Homo sapiens (human) CDKN1C NP_000067.1


Related articles in PubMed

Expression of CDKN1C in the bone marrow of patients with myelodysplastic syndrome and secondary acute myeloid leukemia is associated with poor survival after conventional chemotherapy.
Radujkovic A, Dietrich S, Andrulis M, Benner A, Longerich T, Pellagatti A, Nanda K, Giese T, Germing U, Baldus S, Boultwood J, Ho AD, Dreger P, Luft T
International journal of cancer139(6)1402-13(2016 Sep)

Down-regulation of the cyclin-dependent kinase inhibitor p57 is mediated by Jab1/Csn5 in hepatocarcinogenesis.
Guo H, Jing L, Cheng Y, Atsaves V, Lv Y, Wu T, Su R, Zhang Y, Zhang R, Liu W, Rassidakis GZ, Wei Y, Nan K, Claret FX
Hepatology (Baltimore, Md.)63(3)898-913(2016 Mar)

Role of P57KIP2 Immunohistochemical Expression in Histological Diagnosis of Hydatidiform Moles.
Triratanachat S, Nakaporntham P, Tantbirojn P, Shuangshoti S, Lertkhachonsuk R
Asian Pacific journal of cancer prevention : APJCP17(4)2061-6(2016)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Analysis of the chromatin status of Cdkn1c promoter and KvDMR1 in unresponsive compared to responsive cell types showed that their differential responsiveness to the MyoD-dependent induction of the gene does not involve just their methylation status but, rather, the differential H3 lysine 9 dimethylation at KvDMR1.
Title: A cross-talk between DNA methylation and H3 lysine 9 dimethylation at the KvDMR1 region controls the induction of Cdkn1c in muscle cells.

Data provide evidence that SLC22A18 and/or CDKN1C are tumor modifier genes involved in the tumorigenesis of SDHD-mutated paraganglioma.
Title: Parent-of-origin tumourigenesis is mediated by an essential imprinted modifier in SDHD-linked paragangliomas: SLC22A18 and CDKN1C are candidate tumour modifiers.

CDKN1C protein expression in the BM of newly diagnosed, treatment-naive MDS and secondary AML patients was identified as a prognostic factor for poor survival in patients treated with antiproliferative chemotherapy.
Title: Expression of CDKN1C in the bone marrow of patients with myelodysplastic syndrome and secondary acute myeloid leukemia is associated with poor survival after conventional chemotherapy.

The differences in p18(INK4c)and p57(Kip2)activities in chronic myeloid leukemia and normal stem cells suggest a different cell cycle regulation.
Title: CDKIs p18(INK4c) and p57(Kip2) are involved in quiescence of CML leukemic stem cells after treatment with TKI.

Low P57KIP2 Expression is associated with Hydatidiform Moles.
Title: Role of P57KIP2 Immunohistochemical Expression in Histological Diagnosis of Hydatidiform Moles.

The following CDKN1C gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CDKN1C cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID RefSeq Accession Definition **Vector *Turnaround time Price (USD) Select
OHu26977 NM_001122631.1
Latest version!
Homo sapiens cyclin dependent kinase inhibitor 1C (CDKN1C), transcript variant 3, mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$154.50-$216.30
$309.00
OHu26977 NM_001122630.1
Latest version!
Homo sapiens cyclin dependent kinase inhibitor 1C (CDKN1C), transcript variant 2, mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$154.50-$216.30
$309.00
OHu44738 XM_005252732.4
Latest version!
Homo sapiens cyclin-dependent kinase inhibitor 1C (CDKN1C), transcript variant X2, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 7-9 $69.30
$99.00
OHu27234 NM_000076.2
Latest version!
Homo sapiens cyclin dependent kinase inhibitor 1C (CDKN1C), transcript variant 1, mRNA. pcDNA3.1+/C-(K)DYK or customized vector TBD $216.30
$309.00
OHu27234 XM_017017088.1
Latest version!
Homo sapiens cyclin-dependent kinase inhibitor 1C (CDKN1C), transcript variant X1, mRNA. pcDNA3.1+/C-(K)DYK or customized vector TBD $216.30
$309.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.


CloneID OHu26977
Clone ID Related Accession (Same CDS sequence) NM_001122630.1 , NM_001122631.1
Accession Version NM_001122630.1 Latest version! Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 918bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 2017-05-06
Organism Homo sapiens(Human)
Product cyclin-dependent kinase inhibitor 1C isoform b
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC039188.1, AC013791.9, U22398.1 and CD676249.1. Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Variants 2 and 3 both encode isoform b. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: EU570054.1, ERR279839.1595.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2153307, SAMEA2162568 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## imprinted gene :: PMID: 8610162 ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
ATGGAGCGTC TTGTCGCCCG TGGGACCTTC CCAGTACTAG TGCGCACCAG CGCCTGCCGC 
AGCCTCTTCG GGCCGGTGGA CCACGAGGAG CTGAGCCGCG AGCTGCAGGC CCGCCTGGCC
GAGCTGAACG CCGAGGACCA GAACCGCTGG GATTACGACT TCCAGCAGGA CATGCCGCTG
CGGGGCCCTG GACGCCTGCA GTGGACCGAA GTGGACAGCG ACTCGGTGCC CGCGTTCTAC
CGCGAGACGG TGCAGGTGGG GCGCTGCCGC CTGCTGCTGG CGCCGCGGCC CGTCGCGGTC
GCGGTGGCTG TCAGCCCGCC CCTCGAGCCG GCCGCTGAGT CCCTCGACGG CCTCGAGGAG
GCGCCGGAGC AGCTGCCTAG TGTCCCGGTC CCGGCCCCGG CGTCCACCCC GCCCCCAGTC
CCGGTCCTGG CTCCAGCCCC GGCCCCGGCT CCGGCTCCGG TCGCGGCTCC GGTCGCGGCT
CCGGTCGCGG TCGCGGTCCT GGCCCCGGCC CCGGCCCCGG CTCCGGCTCC GGCTCCGGCC
CCGGCTCCAG TCGCGGCCCC GGCCCCAGCC CCGGCCCCGG CCCCGGCCCC GGCCCCCGCC
CCGGCCCCGG CCCCGGACGC GGCGCCTCAA GAGAGCGCCG AGCAGGGCGC GAACCAGGGG
CAGCGCGGCC AGGAGCCTCT CGCTGACCAG CTGCACTCGG GGATTTCGGG ACGTCCCGCG
GCCGGCACCG CGGCCGCCAG CGCCAACGGC GCGGCGATCA AGAAGCTGTC CGGGCCTCTG
ATCTCCGATT TCTTCGCCAA GCGCAAGAGA TCAGCGCCTG AGAAGTCGTC GGGCGATGTC
CCCGCGCCGT GTCCCTCTCC AAGCGCCGCC CCTGGCGTGG GCTCGGTGGA GCAGACCCCG
CGCAAGAGGC TGCGGTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_001116102.1
CDS143..1060
Misc Feature(1)47..49
Misc Feature(2)203..343
Exon (1)1..132
Exon (2)133..929
Exon (3)930..1065
Exon (4)1066..1763
Translation

Target ORF information:

RefSeq Version NM_001122630.1
Organism Homo sapiens(Human)
Definition Homo sapiens cyclin dependent kinase inhibitor 1C (CDKN1C), transcript variant 2, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_001122630.1

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
ATGGAGCGTC TTGTCGCCCG TGGGACCTTC CCAGTACTAG TGCGCACCAG CGCCTGCCGC 
AGCCTCTTCG GGCCGGTGGA CCACGAGGAG CTGAGCCGCG AGCTGCAGGC CCGCCTGGCC
GAGCTGAACG CCGAGGACCA GAACCGCTGG GATTACGACT TCCAGCAGGA CATGCCGCTG
CGGGGCCCTG GACGCCTGCA GTGGACCGAA GTGGACAGCG ACTCGGTGCC CGCGTTCTAC
CGCGAGACGG TGCAGGTGGG GCGCTGCCGC CTGCTGCTGG CGCCGCGGCC CGTCGCGGTC
GCGGTGGCTG TCAGCCCGCC CCTCGAGCCG GCCGCTGAGT CCCTCGACGG CCTCGAGGAG
GCGCCGGAGC AGCTGCCTAG TGTCCCGGTC CCGGCCCCGG CGTCCACCCC GCCCCCAGTC
CCGGTCCTGG CTCCAGCCCC GGCCCCGGCT CCGGCTCCGG TCGCGGCTCC GGTCGCGGCT
CCGGTCGCGG TCGCGGTCCT GGCCCCGGCC CCGGCCCCGG CTCCGGCTCC GGCTCCGGCC
CCGGCTCCAG TCGCGGCCCC GGCCCCAGCC CCGGCCCCGG CCCCGGCCCC GGCCCCCGCC
CCGGCCCCGG CCCCGGACGC GGCGCCTCAA GAGAGCGCCG AGCAGGGCGC GAACCAGGGG
CAGCGCGGCC AGGAGCCTCT CGCTGACCAG CTGCACTCGG GGATTTCGGG ACGTCCCGCG
GCCGGCACCG CGGCCGCCAG CGCCAACGGC GCGGCGATCA AGAAGCTGTC CGGGCCTCTG
ATCTCCGATT TCTTCGCCAA GCGCAAGAGA TCAGCGCCTG AGAAGTCGTC GGGCGATGTC
CCCGCGCCGT GTCCCTCTCC AAGCGCCGCC CCTGGCGTGG GCTCGGTGGA GCAGACCCCG
CGCAAGAGGC TGCGGTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu26977
Clone ID Related Accession (Same CDS sequence) NM_001122630.1 , NM_001122631.1
Accession Version NM_001122631.1 Latest version! Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 918bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 2017-05-06
Organism Homo sapiens(Human)
Product cyclin-dependent kinase inhibitor 1C isoform b
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC039188.1, AC013791.9, U22398.1, BM673714.1 and CD676249.1. Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence and uses an alternate splice junction in the 3' UTR compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Variants 2 and 3 both encode isoform b. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: ERR279848.2569.1, ERR279861.2829.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1968189, SAMEA2142853 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## imprinted gene :: PMID: 8610162 ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
ATGGAGCGTC TTGTCGCCCG TGGGACCTTC CCAGTACTAG TGCGCACCAG CGCCTGCCGC 
AGCCTCTTCG GGCCGGTGGA CCACGAGGAG CTGAGCCGCG AGCTGCAGGC CCGCCTGGCC
GAGCTGAACG CCGAGGACCA GAACCGCTGG GATTACGACT TCCAGCAGGA CATGCCGCTG
CGGGGCCCTG GACGCCTGCA GTGGACCGAA GTGGACAGCG ACTCGGTGCC CGCGTTCTAC
CGCGAGACGG TGCAGGTGGG GCGCTGCCGC CTGCTGCTGG CGCCGCGGCC CGTCGCGGTC
GCGGTGGCTG TCAGCCCGCC CCTCGAGCCG GCCGCTGAGT CCCTCGACGG CCTCGAGGAG
GCGCCGGAGC AGCTGCCTAG TGTCCCGGTC CCGGCCCCGG CGTCCACCCC GCCCCCAGTC
CCGGTCCTGG CTCCAGCCCC GGCCCCGGCT CCGGCTCCGG TCGCGGCTCC GGTCGCGGCT
CCGGTCGCGG TCGCGGTCCT GGCCCCGGCC CCGGCCCCGG CTCCGGCTCC GGCTCCGGCC
CCGGCTCCAG TCGCGGCCCC GGCCCCAGCC CCGGCCCCGG CCCCGGCCCC GGCCCCCGCC
CCGGCCCCGG CCCCGGACGC GGCGCCTCAA GAGAGCGCCG AGCAGGGCGC GAACCAGGGG
CAGCGCGGCC AGGAGCCTCT CGCTGACCAG CTGCACTCGG GGATTTCGGG ACGTCCCGCG
GCCGGCACCG CGGCCGCCAG CGCCAACGGC GCGGCGATCA AGAAGCTGTC CGGGCCTCTG
ATCTCCGATT TCTTCGCCAA GCGCAAGAGA TCAGCGCCTG AGAAGTCGTC GGGCGATGTC
CCCGCGCCGT GTCCCTCTCC AAGCGCCGCC CCTGGCGTGG GCTCGGTGGA GCAGACCCCG
CGCAAGAGGC TGCGGTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_001116103.1
CDS143..1060
Misc Feature(1)47..49
Misc Feature(2)203..343
Exon (1)1..132
Exon (2)133..929
Exon (3)930..1065
Exon (4)1066..1758
Translation

Target ORF information:

RefSeq Version NM_001122631.1
Organism Homo sapiens(Human)
Definition Homo sapiens cyclin dependent kinase inhibitor 1C (CDKN1C), transcript variant 3, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_001122631.1

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
ATGGAGCGTC TTGTCGCCCG TGGGACCTTC CCAGTACTAG TGCGCACCAG CGCCTGCCGC 
AGCCTCTTCG GGCCGGTGGA CCACGAGGAG CTGAGCCGCG AGCTGCAGGC CCGCCTGGCC
GAGCTGAACG CCGAGGACCA GAACCGCTGG GATTACGACT TCCAGCAGGA CATGCCGCTG
CGGGGCCCTG GACGCCTGCA GTGGACCGAA GTGGACAGCG ACTCGGTGCC CGCGTTCTAC
CGCGAGACGG TGCAGGTGGG GCGCTGCCGC CTGCTGCTGG CGCCGCGGCC CGTCGCGGTC
GCGGTGGCTG TCAGCCCGCC CCTCGAGCCG GCCGCTGAGT CCCTCGACGG CCTCGAGGAG
GCGCCGGAGC AGCTGCCTAG TGTCCCGGTC CCGGCCCCGG CGTCCACCCC GCCCCCAGTC
CCGGTCCTGG CTCCAGCCCC GGCCCCGGCT CCGGCTCCGG TCGCGGCTCC GGTCGCGGCT
CCGGTCGCGG TCGCGGTCCT GGCCCCGGCC CCGGCCCCGG CTCCGGCTCC GGCTCCGGCC
CCGGCTCCAG TCGCGGCCCC GGCCCCAGCC CCGGCCCCGG CCCCGGCCCC GGCCCCCGCC
CCGGCCCCGG CCCCGGACGC GGCGCCTCAA GAGAGCGCCG AGCAGGGCGC GAACCAGGGG
CAGCGCGGCC AGGAGCCTCT CGCTGACCAG CTGCACTCGG GGATTTCGGG ACGTCCCGCG
GCCGGCACCG CGGCCGCCAG CGCCAACGGC GCGGCGATCA AGAAGCTGTC CGGGCCTCTG
ATCTCCGATT TCTTCGCCAA GCGCAAGAGA TCAGCGCCTG AGAAGTCGTC GGGCGATGTC
CCCGCGCCGT GTCCCTCTCC AAGCGCCGCC CCTGGCGTGG GCTCGGTGGA GCAGACCCCG
CGCAAGAGGC TGCGGTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu44738
Clone ID Related Accession (Same CDS sequence) XM_005252732.4
Accession Version XM_005252732.4 Latest version! Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 528bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 2016-06-06
Organism Homo sapiens(Human)
Product cyclin-dependent kinase inhibitor 1C isoform X2
Comment MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000011.10) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_005252732.3. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

1
61
121
181
241
301
361
421
481
ATGGAGCGTC TTGTCGCCCG TGGGACCTTC CCAGTACTAG TGCGCACCAG CGCCTGCCGC 
AGCCTCTTCG GGCCGGTGGA CCACGAGGAG CTGAGCCGCG AGCTGCAGGC CCGCCTGGCC
GAGCTGAACG CCGAGGACCA GAACCGCTGG GATTACGACT TCCAGCAGGA CATGCCGCTG
CGGGGCCCTG GACGCCTGCA GTGGACCGAA GTGGACAGCG ACTCGGTGCC CGCGTTCTAC
CGCGAGACGG TGCAGATTTC TTCGCCAAGC GCAAGAGATC AGCGCCTGAG AAGTCGTCGG
GCGATGTCCC CGCGCCGTGT CCCTCTCCAA GCGCCGCCCC TGGCGTGGGC TCGGTGGAGC
AGACCCCGCG CAAGAGGCTG CGGTGAGCCA AAGCCCAAAG AGCCCCGAGG GAACCTGCCG
GGGCAGCGGA CGTTGGAAGG GCGCTGGGCC TCGGCTGGGA CCGTTCATGT AGCAGCAACC
GGCGGCGGCT GCCGCAGAGC AGCGTTCGGT TTTGTTTTTA AATTTTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq XP_005252789.1
CDS182..709
Misc Feature(1)242..382
Translation

Target ORF information:

RefSeq Version XM_005252732.4
Organism Homo sapiens(Human)
Definition Homo sapiens cyclin-dependent kinase inhibitor 1C (CDKN1C), transcript variant X2, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
XM_005252732.4

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
ATGGAGCGTC TTGTCGCCCG TGGGACCTTC CCAGTACTAG TGCGCACCAG CGCCTGCCGC 
AGCCTCTTCG GGCCGGTGGA CCACGAGGAG CTGAGCCGCG AGCTGCAGGC CCGCCTGGCC
GAGCTGAACG CCGAGGACCA GAACCGCTGG GATTACGACT TCCAGCAGGA CATGCCGCTG
CGGGGCCCTG GACGCCTGCA GTGGACCGAA GTGGACAGCG ACTCGGTGCC CGCGTTCTAC
CGCGAGACGG TGCAGATTTC TTCGCCAAGC GCAAGAGATC AGCGCCTGAG AAGTCGTCGG
GCGATGTCCC CGCGCCGTGT CCCTCTCCAA GCGCCGCCCC TGGCGTGGGC TCGGTGGAGC
AGACCCCGCG CAAGAGGCTG CGGTGAGCCA AAGCCCAAAG AGCCCCGAGG GAACCTGCCG
GGGCAGCGGA CGTTGGAAGG GCGCTGGGCC TCGGCTGGGA CCGTTCATGT AGCAGCAACC
GGCGGCGGCT GCCGCAGAGC AGCGTTCGGT TTTGTTTTTA AATTTTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu27234
Clone ID Related Accession (Same CDS sequence) NM_000076.2 , XM_017017088.1
Accession Version NM_000076.2 Latest version! Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 951bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 2017-05-06
Organism Homo sapiens(Human)
Product cyclin-dependent kinase inhibitor 1C isoform a
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC039188.1, U22398.1, AC013791.9 and CD676249.1. This sequence is a reference standard in the RefSeqGene project. On Mar 12, 2008 this sequence version replaced NM_000076.1. Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: U22398.1, ERR279855.2194.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2153307, SAMEA2162568 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## imprinted gene :: PMID: 8610162 ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
ATGTCCGACG CGTCCCTCCG CAGCACATCC ACGATGGAGC GTCTTGTCGC CCGTGGGACC 
TTCCCAGTAC TAGTGCGCAC CAGCGCCTGC CGCAGCCTCT TCGGGCCGGT GGACCACGAG
GAGCTGAGCC GCGAGCTGCA GGCCCGCCTG GCCGAGCTGA ACGCCGAGGA CCAGAACCGC
TGGGATTACG ACTTCCAGCA GGACATGCCG CTGCGGGGCC CTGGACGCCT GCAGTGGACC
GAAGTGGACA GCGACTCGGT GCCCGCGTTC TACCGCGAGA CGGTGCAGGT GGGGCGCTGC
CGCCTGCTGC TGGCGCCGCG GCCCGTCGCG GTCGCGGTGG CTGTCAGCCC GCCCCTCGAG
CCGGCCGCTG AGTCCCTCGA CGGCCTCGAG GAGGCGCCGG AGCAGCTGCC TAGTGTCCCG
GTCCCGGCCC CGGCGTCCAC CCCGCCCCCA GTCCCGGTCC TGGCTCCAGC CCCGGCCCCG
GCTCCGGCTC CGGTCGCGGC TCCGGTCGCG GCTCCGGTCG CGGTCGCGGT CCTGGCCCCG
GCCCCGGCCC CGGCTCCGGC TCCGGCTCCG GCCCCGGCTC CAGTCGCGGC CCCGGCCCCA
GCCCCGGCCC CGGCCCCGGC CCCGGCCCCC GCCCCGGCCC CGGCCCCGGA CGCGGCGCCT
CAAGAGAGCG CCGAGCAGGG CGCGAACCAG GGGCAGCGCG GCCAGGAGCC TCTCGCTGAC
CAGCTGCACT CGGGGATTTC GGGACGTCCC GCGGCCGGCA CCGCGGCCGC CAGCGCCAAC
GGCGCGGCGA TCAAGAAGCT GTCCGGGCCT CTGATCTCCG ATTTCTTCGC CAAGCGCAAG
AGATCAGCGC CTGAGAAGTC GTCGGGCGAT GTCCCCGCGC CGTGTCCCTC TCCAAGCGCC
GCCCCTGGCG TGGGCTCGGT GGAGCAGACC CCGCGCAAGA GGCTGCGGTG A

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_000067.1
CDS277..1227
Misc Feature(1)34..36
Misc Feature(2)370..510
Misc Feature(3)595..597
Misc Feature(4)742..915
Misc Feature(5)1078..1080
Misc Feature(6)1108..1119
Exon (1)1..1096
Exon (2)1097..1232
Exon (3)1233..1930
Translation

Target ORF information:

RefSeq Version NM_000076.2
Organism Homo sapiens(Human)
Definition Homo sapiens cyclin dependent kinase inhibitor 1C (CDKN1C), transcript variant 1, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_000076.2

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
ATGTCCGACG CGTCCCTCCG CAGCACATCC ACGATGGAGC GTCTTGTCGC CCGTGGGACC 
TTCCCAGTAC TAGTGCGCAC CAGCGCCTGC CGCAGCCTCT TCGGGCCGGT GGACCACGAG
GAGCTGAGCC GCGAGCTGCA GGCCCGCCTG GCCGAGCTGA ACGCCGAGGA CCAGAACCGC
TGGGATTACG ACTTCCAGCA GGACATGCCG CTGCGGGGCC CTGGACGCCT GCAGTGGACC
GAAGTGGACA GCGACTCGGT GCCCGCGTTC TACCGCGAGA CGGTGCAGGT GGGGCGCTGC
CGCCTGCTGC TGGCGCCGCG GCCCGTCGCG GTCGCGGTGG CTGTCAGCCC GCCCCTCGAG
CCGGCCGCTG AGTCCCTCGA CGGCCTCGAG GAGGCGCCGG AGCAGCTGCC TAGTGTCCCG
GTCCCGGCCC CGGCGTCCAC CCCGCCCCCA GTCCCGGTCC TGGCTCCAGC CCCGGCCCCG
GCTCCGGCTC CGGTCGCGGC TCCGGTCGCG GCTCCGGTCG CGGTCGCGGT CCTGGCCCCG
GCCCCGGCCC CGGCTCCGGC TCCGGCTCCG GCCCCGGCTC CAGTCGCGGC CCCGGCCCCA
GCCCCGGCCC CGGCCCCGGC CCCGGCCCCC GCCCCGGCCC CGGCCCCGGA CGCGGCGCCT
CAAGAGAGCG CCGAGCAGGG CGCGAACCAG GGGCAGCGCG GCCAGGAGCC TCTCGCTGAC
CAGCTGCACT CGGGGATTTC GGGACGTCCC GCGGCCGGCA CCGCGGCCGC CAGCGCCAAC
GGCGCGGCGA TCAAGAAGCT GTCCGGGCCT CTGATCTCCG ATTTCTTCGC CAAGCGCAAG
AGATCAGCGC CTGAGAAGTC GTCGGGCGAT GTCCCCGCGC CGTGTCCCTC TCCAAGCGCC
GCCCCTGGCG TGGGCTCGGT GGAGCAGACC CCGCGCAAGA GGCTGCGGTG A

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu27234
Clone ID Related Accession (Same CDS sequence) NM_000076.2 , XM_017017088.1
Accession Version XM_017017088.1 Latest version! Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 951bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 2016-06-06
Organism Homo sapiens(Human)
Product cyclin-dependent kinase inhibitor 1C isoform X1
Comment MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000011.10) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
ATGTCCGACG CGTCCCTCCG CAGCACATCC ACGATGGAGC GTCTTGTCGC CCGTGGGACC 
TTCCCAGTAC TAGTGCGCAC CAGCGCCTGC CGCAGCCTCT TCGGGCCGGT GGACCACGAG
GAGCTGAGCC GCGAGCTGCA GGCCCGCCTG GCCGAGCTGA ACGCCGAGGA CCAGAACCGC
TGGGATTACG ACTTCCAGCA GGACATGCCG CTGCGGGGCC CTGGACGCCT GCAGTGGACC
GAAGTGGACA GCGACTCGGT GCCCGCGTTC TACCGCGAGA CGGTGCAGGT GGGGCGCTGC
CGCCTGCTGC TGGCGCCGCG GCCCGTCGCG GTCGCGGTGG CTGTCAGCCC GCCCCTCGAG
CCGGCCGCTG AGTCCCTCGA CGGCCTCGAG GAGGCGCCGG AGCAGCTGCC TAGTGTCCCG
GTCCCGGCCC CGGCGTCCAC CCCGCCCCCA GTCCCGGTCC TGGCTCCAGC CCCGGCCCCG
GCTCCGGCTC CGGTCGCGGC TCCGGTCGCG GCTCCGGTCG CGGTCGCGGT CCTGGCCCCG
GCCCCGGCCC CGGCTCCGGC TCCGGCTCCG GCCCCGGCTC CAGTCGCGGC CCCGGCCCCA
GCCCCGGCCC CGGCCCCGGC CCCGGCCCCC GCCCCGGCCC CGGCCCCGGA CGCGGCGCCT
CAAGAGAGCG CCGAGCAGGG CGCGAACCAG GGGCAGCGCG GCCAGGAGCC TCTCGCTGAC
CAGCTGCACT CGGGGATTTC GGGACGTCCC GCGGCCGGCA CCGCGGCCGC CAGCGCCAAC
GGCGCGGCGA TCAAGAAGCT GTCCGGGCCT CTGATCTCCG ATTTCTTCGC CAAGCGCAAG
AGATCAGCGC CTGAGAAGTC GTCGGGCGAT GTCCCCGCGC CGTGTCCCTC TCCAAGCGCC
GCCCCTGGCG TGGGCTCGGT GGAGCAGACC CCGCGCAAGA GGCTGCGGTG A

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq XP_016872577.1
CDS139..1089
Misc Feature(1)232..372
Translation

Target ORF information:

RefSeq Version XM_017017088.1
Organism Homo sapiens(Human)
Definition Homo sapiens cyclin-dependent kinase inhibitor 1C (CDKN1C), transcript variant X1, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
XM_017017088.1

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
ATGTCCGACG CGTCCCTCCG CAGCACATCC ACGATGGAGC GTCTTGTCGC CCGTGGGACC 
TTCCCAGTAC TAGTGCGCAC CAGCGCCTGC CGCAGCCTCT TCGGGCCGGT GGACCACGAG
GAGCTGAGCC GCGAGCTGCA GGCCCGCCTG GCCGAGCTGA ACGCCGAGGA CCAGAACCGC
TGGGATTACG ACTTCCAGCA GGACATGCCG CTGCGGGGCC CTGGACGCCT GCAGTGGACC
GAAGTGGACA GCGACTCGGT GCCCGCGTTC TACCGCGAGA CGGTGCAGGT GGGGCGCTGC
CGCCTGCTGC TGGCGCCGCG GCCCGTCGCG GTCGCGGTGG CTGTCAGCCC GCCCCTCGAG
CCGGCCGCTG AGTCCCTCGA CGGCCTCGAG GAGGCGCCGG AGCAGCTGCC TAGTGTCCCG
GTCCCGGCCC CGGCGTCCAC CCCGCCCCCA GTCCCGGTCC TGGCTCCAGC CCCGGCCCCG
GCTCCGGCTC CGGTCGCGGC TCCGGTCGCG GCTCCGGTCG CGGTCGCGGT CCTGGCCCCG
GCCCCGGCCC CGGCTCCGGC TCCGGCTCCG GCCCCGGCTC CAGTCGCGGC CCCGGCCCCA
GCCCCGGCCC CGGCCCCGGC CCCGGCCCCC GCCCCGGCCC CGGCCCCGGA CGCGGCGCCT
CAAGAGAGCG CCGAGCAGGG CGCGAACCAG GGGCAGCGCG GCCAGGAGCC TCTCGCTGAC
CAGCTGCACT CGGGGATTTC GGGACGTCCC GCGGCCGGCA CCGCGGCCGC CAGCGCCAAC
GGCGCGGCGA TCAAGAAGCT GTCCGGGCCT CTGATCTCCG ATTTCTTCGC CAAGCGCAAG
AGATCAGCGC CTGAGAAGTC GTCGGGCGAT GTCCCCGCGC CGTGTCCCTC TCCAAGCGCC
GCCCCTGGCG TGGGCTCGGT GGAGCAGACC CCGCGCAAGA GGCTGCGGTG A

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

book

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International journal of cancer139(6)1402-13(2016 Sep)
Radujkovic A,Dietrich S,Andrulis M,Benner A,Longerich T,Pellagatti A,Nanda K,Giese T,Germing U,Baldus S,Boultwood J,Ho AD,Dreger P,Luft T


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Down-regulation of the cyclin-dependent kinase inhibitor p57 is mediated by Jab1/Csn5 in hepatocarcinogenesis.
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Guo H,Jing L,Cheng Y,Atsaves V,Lv Y,Wu T,Su R,Zhang Y,Zhang R,Liu W,Rassidakis GZ,Wei Y,Nan K,Claret FX


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Role of P57KIP2 Immunohistochemical Expression in Histological Diagnosis of Hydatidiform Moles.
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Triratanachat S,Nakaporntham P,Tantbirojn P,Shuangshoti S,Lertkhachonsuk R


 
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