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SLCO1B1 cDNA ORF clone, Homo sapiens (human)

Gene Symbol SLCO1B1
Entrez Gene ID 10599
Full Name solute carrier organic anion transporter family, member 1B1
Synonyms HBLRR, LST-1, LST1, OATP-C, OATP1B1, OATP2, OATPC, SLC21A6
General protein information
Preferred Names
solute carrier organic anion transporter family member 1B1
Names
solute carrier organic anion transporter family member 1B1
OATP-2
solute carrier family 21 member 6
liver-specific organic anion transporter 1
sodium-independent organic anion-transporting polypeptide 2
solute carrier family 21 (organic anion transporter), member 6
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

12

12p

Summary This gene encodes a liver-specific member of the organic anion transporter family. The encoded protein is a transmembrane receptor that mediates the sodium-independent uptake of numerous endogenous compounds including bilirubin, 17-beta-glucuronosyl estradiol and leukotriene C4. This protein is also involved in the removal of drug compounds such as statins, bromosulfophthalein and rifampin from the blood into the hepatocytes. Polymorphisms in the gene encoding this protein are associated with impaired transporter function. [provided by RefSeq, Mar 2009]. lac of sum
Disorder MIM:

604843


mRNA and Protein(s)

mRNA Protein Name
NM_006446 NP_006437 solute carrier organic anion transporter family member 1B1



Homo sapiens (human) SLCO1B1 NP_006437.3
Pan troglodytes (chimpanzee) SLCO1B1 XP_520785.2
Macaca mulatta (Rhesus monkey) SLCO1B1 XP_001097704.1
Gallus gallus (chicken) SLCO1B1 XP_416418.3
Xenopus (Silurana) tropicalis (western clawed frog) slco1b3 NP_001027493.1


GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following SLCO1B1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the SLCO1B1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID RefSeq Accession Definition **Vector *Turnaround time Price (USD) Select
OHu22283
NM_006446 Homo sapiens solute carrier organic anion transporter family, member 1B1 (SLCO1B1), mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$189.50-$265.30
$379.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.


CloneID OHu22283
Clone ID Related Accession (Same CDS sequence) NM_006446
Accession Version NM_006446.4 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 2076bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 23-AUG-2015
Organism Homo sapiens (human)
Product solute carrier organic anion transporter family member 1B1
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC020696.1, AF205071.1 and AC022335.8. This sequence is a reference standard in the RefSeqGene project. On Mar 21, 2009 this sequence version replaced gi:141801825. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF205071.1, AB026257.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2145122, SAMEA2155590 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: full length.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
1741
1801
1861
1921
1981
2041
ATGGACCAAA ATCAACATTT GAATAAAACA GCAGAGGCAC AACCTTCAGA GAATAAGAAA 
ACAAGATACT GCAATGGATT GAAGATGTTC TTGGCAGCTC TGTCACTCAG CTTTATTGCT
AAGACACTAG GTGCAATTAT TATGAAAAGT TCCATCATTC ATATAGAACG GAGATTTGAG
ATATCCTCTT CTCTTGTTGG TTTTATTGAC GGAAGCTTTG AAATTGGAAA TTTGCTTGTG
ATTGTATTTG TGAGTTACTT TGGATCCAAA CTACATAGAC CAAAGTTAAT TGGAATCGGT
TGTTTCATTA TGGGAATTGG AGGTGTTTTG ACTGCTTTGC CACATTTCTT CATGGGATAT
TACAGGTATT CTAAAGAAAC TAATATCAAT TCATCAGAAA ATTCAACATC GACCTTATCC
ACTTGTTTAA TTAATCAAAT TTTATCACTC AATAGAGCAT CACCTGAGAT AGTGGGAAAA
GGTTGTTTAA AGGAATCTGG GTCATACATG TGGATATATG TGTTCATGGG TAATATGCTT
CGTGGAATAG GGGAGACTCC CATAGTACCA TTGGGGCTTT CTTACATTGA TGATTTCGCT
AAAGAAGGAC ATTCTTCTTT GTATTTAGGT ATATTGAATG CAATAGCAAT GATTGGTCCA
ATCATTGGCT TTACCCTGGG ATCTCTGTTT TCTAAAATGT ACGTGGATAT TGGATATGTA
GATCTAAGCA CTATCAGGAT AACTCCTACT GATTCTCGAT GGGTTGGAGC TTGGTGGCTT
AATTTCCTTG TGTCTGGACT ATTCTCCATT ATTTCTTCCA TACCATTCTT TTTCTTGCCC
CAAACTCCAA ATAAACCACA AAAAGAAAGA AAAGCTTCAC TGTCTTTGCA TGTGCTGGAA
ACAAATGATG AAAAGGATCA AACAGCTAAT TTGACCAATC AAGGAAAAAA TATTACCAAA
AATGTGACTG GTTTTTTCCA GTCTTTTAAA AGCATCCTTA CTAATCCCCT GTATGTTATG
TTTGTGCTTT TGACGTTGTT ACAAGTAAGC AGCTATATTG GTGCTTTTAC TTATGTCTTC
AAATACGTAG AGCAACAGTA TGGTCAGCCT TCATCTAAGG CTAACATCTT ATTGGGAGTC
ATAACCATAC CTATTTTTGC AAGTGGAATG TTTTTAGGAG GATATATCAT TAAAAAATTC
AAACTGAACA CCGTTGGAAT TGCCAAATTC TCATGTTTTA CTGCTGTGAT GTCATTGTCC
TTTTACCTAT TATATTTTTT CATACTCTGT GAAAACAAAT CAGTTGCCGG ACTAACCATG
ACCTATGATG GAAATAATCC AGTGACATCT CATAGAGATG TACCACTTTC TTATTGCAAC
TCAGACTGCA ATTGTGATGA AAGTCAATGG GAACCAGTCT GTGGAAACAA TGGAATAACT
TACATCTCAC CCTGTCTAGC AGGTTGCAAA TCTTCAAGTG GCAATAAAAA GCCTATAGTG
TTTTACAACT GCAGTTGTTT GGAAGTAACT GGTCTCCAGA ACAGAAATTA CTCAGCCCAT
TTGGGTGAAT GCCCAAGAGA TGATGCTTGT ACAAGGAAAT TTTACTTTTT TGTTGCAATA
CAAGTCTTGA ATTTATTTTT CTCTGCACTT GGAGGCACCT CACATGTCAT GCTGATTGTT
AAAATTGTTC AACCTGAATT GAAATCACTT GCACTGGGTT TCCACTCAAT GGTTATACGA
GCACTAGGAG GAATTCTAGC TCCAATATAT TTTGGGGCTC TGATTGATAC AACGTGTATA
AAGTGGTCCA CCAACAACTG TGGCACACGT GGGTCATGTA GGACATATAA TTCCACATCA
TTTTCAAGGG TCTACTTGGG CTTGTCTTCA ATGTTAAGAG TCTCATCACT TGTTTTATAT
ATTATATTAA TTTATGCCAT GAAGAAAAAA TATCAAGAGA AAGATATCAA TGCATCAGAA
AATGGAAGTG TCATGGATGA AGCAAACTTA GAATCCTTAA ATAAAAATAA ACATTTTGTC
CCTTCTGCTG GGGCAGATAG TGAAACACAT TGTTAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_006437.3
CDS105..2180
Misc Feature(1)1..1(+)
Misc Feature(2)45..47(+)
Misc Feature(3)183..1970(+)
Misc Feature(4)189..248(+)
Misc Feature(5)195..>1385(+)
Misc Feature(6)237..1274(+)
Misc Feature(7)306..368(+)
Misc Feature(8)387..461(+)
Misc Feature(9)609..695(+)
Misc Feature(10)753..815(+)
Misc Feature(11)870..944(+)
Misc Feature(12)981..983(+)
Misc Feature(13)987..989(+)
Misc Feature(14)1098..1163(+)
Misc Feature(15)1224..1295(+)
Misc Feature(16)1308..1379(+)
Misc Feature(17)1467..1628(+)
Misc Feature(18)1716..1784(+)
Misc Feature(19)1812..1889(+)
Misc Feature(20)1992..2045(+)
Misc Feature(21)2118..2120(+)
Misc Feature(22)2148..2150(+)
Exon (1)1..43
Gene:SLCO1B1
Gene Synonym:
Exon (2)44..188
Gene:SLCO1B1
Gene Synonym:
Exon (3)189..330
Gene:SLCO1B1
Gene Synonym:
Exon (4)331..463
Gene:SLCO1B1
Gene Synonym:
Exon (5)464..585
Gene:SLCO1B1
Gene Synonym:
Exon (6)586..732
Gene:SLCO1B1
Gene Synonym:
Exon (7)733..831
Gene:SLCO1B1
Gene Synonym:
Exon (8)832..1074
Gene:SLCO1B1
Gene Synonym:
Exon (9)1075..1239
Gene:SLCO1B1
Gene Synonym:
Exon (10)1240..1435
Gene:SLCO1B1
Gene Synonym:
Exon (11)1436..1601
Gene:SLCO1B1
Gene Synonym:
Exon (12)1602..1786
Gene:SLCO1B1
Gene Synonym:
Exon (13)1787..1851
Gene:SLCO1B1
Gene Synonym:
Exon (14)1852..1969
Gene:SLCO1B1
Gene Synonym:
Exon (15)1970..2787
Gene:SLCO1B1
Gene Synonym:
Translation

Target ORF information:

RefSeq Version NM_006446
Organism Homo sapiens (human)
Definition Homo sapiens solute carrier organic anion transporter family, member 1B1 (SLCO1B1), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_006446

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
1741
1801
1861
1921
1981
2041
ATGGACCAAA ATCAACATTT GAATAAAACA GCAGAGGCAC AACCTTCAGA GAATAAGAAA 
ACAAGATACT GCAATGGATT GAAGATGTTC TTGGCAGCTC TGTCACTCAG CTTTATTGCT
AAGACACTAG GTGCAATTAT TATGAAAAGT TCCATCATTC ATATAGAACG GAGATTTGAG
ATATCCTCTT CTCTTGTTGG TTTTATTGAC GGAAGCTTTG AAATTGGAAA TTTGCTTGTG
ATTGTATTTG TGAGTTACTT TGGATCCAAA CTACATAGAC CAAAGTTAAT TGGAATCGGT
TGTTTCATTA TGGGAATTGG AGGTGTTTTG ACTGCTTTGC CACATTTCTT CATGGGATAT
TACAGGTATT CTAAAGAAAC TAATATCAAT TCATCAGAAA ATTCAACATC GACCTTATCC
ACTTGTTTAA TTAATCAAAT TTTATCACTC AATAGAGCAT CACCTGAGAT AGTGGGAAAA
GGTTGTTTAA AGGAATCTGG GTCATACATG TGGATATATG TGTTCATGGG TAATATGCTT
CGTGGAATAG GGGAGACTCC CATAGTACCA TTGGGGCTTT CTTACATTGA TGATTTCGCT
AAAGAAGGAC ATTCTTCTTT GTATTTAGGT ATATTGAATG CAATAGCAAT GATTGGTCCA
ATCATTGGCT TTACCCTGGG ATCTCTGTTT TCTAAAATGT ACGTGGATAT TGGATATGTA
GATCTAAGCA CTATCAGGAT AACTCCTACT GATTCTCGAT GGGTTGGAGC TTGGTGGCTT
AATTTCCTTG TGTCTGGACT ATTCTCCATT ATTTCTTCCA TACCATTCTT TTTCTTGCCC
CAAACTCCAA ATAAACCACA AAAAGAAAGA AAAGCTTCAC TGTCTTTGCA TGTGCTGGAA
ACAAATGATG AAAAGGATCA AACAGCTAAT TTGACCAATC AAGGAAAAAA TATTACCAAA
AATGTGACTG GTTTTTTCCA GTCTTTTAAA AGCATCCTTA CTAATCCCCT GTATGTTATG
TTTGTGCTTT TGACGTTGTT ACAAGTAAGC AGCTATATTG GTGCTTTTAC TTATGTCTTC
AAATACGTAG AGCAACAGTA TGGTCAGCCT TCATCTAAGG CTAACATCTT ATTGGGAGTC
ATAACCATAC CTATTTTTGC AAGTGGAATG TTTTTAGGAG GATATATCAT TAAAAAATTC
AAACTGAACA CCGTTGGAAT TGCCAAATTC TCATGTTTTA CTGCTGTGAT GTCATTGTCC
TTTTACCTAT TATATTTTTT CATACTCTGT GAAAACAAAT CAGTTGCCGG ACTAACCATG
ACCTATGATG GAAATAATCC AGTGACATCT CATAGAGATG TACCACTTTC TTATTGCAAC
TCAGACTGCA ATTGTGATGA AAGTCAATGG GAACCAGTCT GTGGAAACAA TGGAATAACT
TACATCTCAC CCTGTCTAGC AGGTTGCAAA TCTTCAAGTG GCAATAAAAA GCCTATAGTG
TTTTACAACT GCAGTTGTTT GGAAGTAACT GGTCTCCAGA ACAGAAATTA CTCAGCCCAT
TTGGGTGAAT GCCCAAGAGA TGATGCTTGT ACAAGGAAAT TTTACTTTTT TGTTGCAATA
CAAGTCTTGA ATTTATTTTT CTCTGCACTT GGAGGCACCT CACATGTCAT GCTGATTGTT
AAAATTGTTC AACCTGAATT GAAATCACTT GCACTGGGTT TCCACTCAAT GGTTATACGA
GCACTAGGAG GAATTCTAGC TCCAATATAT TTTGGGGCTC TGATTGATAC AACGTGTATA
AAGTGGTCCA CCAACAACTG TGGCACACGT GGGTCATGTA GGACATATAA TTCCACATCA
TTTTCAAGGG TCTACTTGGG CTTGTCTTCA ATGTTAAGAG TCTCATCACT TGTTTTATAT
ATTATATTAA TTTATGCCAT GAAGAAAAAA TATCAAGAGA AAGATATCAA TGCATCAGAA
AATGGAAGTG TCATGGATGA AGCAAACTTA GAATCCTTAA ATAAAAATAA ACATTTTGTC
CCTTCTGCTG GGGCAGATAG TGAAACACAT TGTTAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

book

Impact of SLCO1B1 521T > C variant on leucovorin rescue and risk of relapse in childhood acute lymphoblastic leukemia treated with high-dose methotrexate
Pediatr Blood Cancer 61 (12), 2203-2207 (2014)
Zhang HN, He XL, Wang C, Wang Y, Chen YJ, Li JX, Niu CH and Gao P.


book

SLC19A1, SLC46A1 and SLCO1B1 polymorphisms as predictors of methotrexate-related toxicity in Portuguese rheumatoid arthritis patients
Toxicol. Sci. 142 (1), 196-209 (2014)
Lima A, Bernardes M, Azevedo R, Monteiro J, Sousa H, Medeiros R and Seabra V.


book

Expression and activity of ABCG2, but not ABCB1 or OATP1B1, are associated with cholesterol levels: evidence from in vitro and in vivo experiments
Pharmacogenomics 15 (8), 1091-1104 (2014)
To KK, Hu M and Tomlinson B.


book

Characterization of the human OATP-C (SLC21A6) gene promoter and regulation of liver-specific OATP genes by hepatocyte nuclear factor 1 alpha
J. Biol. Chem. 276 (40), 37206-37214 (2001)
Jung D, Hagenbuch B, Gresh L, Pontoglio M, Meier PJ and Kullak-Ublick GA.


book

Localization and genomic organization of a new hepatocellular organic anion transporting polypeptide
J. Biol. Chem. 275 (30), 23161-23168 (2000)
Konig J, Cui Y, Nies AT and Keppler D.


book

Molecular identification and characterization of novel members of the human organic anion transporter (OATP) family
Biochem. Biophys. Res. Commun. 273 (1), 251-260 (2000)
Tamai I, Nezu J, Uchino H, Sai Y, Oku A, Shimane M and Tsuji A.


book

A novel human organic anion transporting polypeptide localized to the basolateral hepatocyte membrane
Am. J. Physiol. Gastrointest. Liver Physiol. 278 (1), G156-G164 (2000)
Konig J, Cui Y, Nies AT and Keppler D.


book

A novel human hepatic organic anion transporting polypeptide (OATP2). Identification of a liver-specific human organic anion transporting polypeptide and identification of rat and human hydroxymethylglutaryl-CoA reductase inhibitor transporters
J. Biol. Chem. 274 (52), 37161-37168 (1999)
Hsiang B, Zhu Y, Wang Z, Wu Y, Sasseville V, Yang WP and Kirchgessner TG.


book

Identification of a novel gene family encoding human liver-specific organic anion transporter LST-1
J. Biol. Chem. 274 (24), 17159-17163 (1999)
Abe T, Kakyo M, Tokui T, Nakagomi R, Nishio T, Nakai D, Nomura H, Unno M, Suzuki M, Naitoh T, Matsuno S and Yawo H.


book

Rotor Syndrome
(in) Pagon RA, Adam MP, Ardinger HH, Wallace SE, Amemiya A, Bean LJH, Bird TD, Dolan CR, Fong CT, Smith RJH and Stephens K (Eds.); GENEREVIEWS(R); (1993)
Jirsa,M., Knisely,A.S., Schinkel,A. and Kmoch,S.


 
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