LMAN2 cDNA ORF clone, Homo sapiens(human)
| Gene Symbol | LMAN2 |
| Entrez Gene ID | 10960 |
| Full Name | lectin, mannose binding 2 |
| Synonyms | C5orf8,GP36B,VIP36 |
| General protein information |
|
| Gene Type | protein-coding |
| Organism | Homo sapiens(human) |
| Genome | |
| Summary | This gene encodes a type I transmembrane lectin that shuttles between the endoplasmic reticulum, the Golgi apparatus and the plasma membrane. The encoded protein binds high mannose type glycoproteins and may facilitate their sorting, trafficking and quality control. [provided by RefSeq, Oct 2008]. |
| Disorder MIM: |
mRNA and Protein(s)
| mRNA | Protein | Name |
|---|---|---|
| NM_006816.2 | NP_006807.1 | vesicular integral-membrane protein VIP36 precursor |
| NM_006816.3 | NP_006807.1 | vesicular integral-membrane protein VIP36 precursor |
| Homo sapiens (human) | LMAN2 | NP_006807.1 |
| Pan troglodytes (chimpanzee) | LMAN2 | XP_001141238.1 |
| Gallus gallus (chicken) | LMAN2 | XP_003642101.2 |
| Danio rerio (zebrafish) | lman2 | NP_001075216.2 |
| Canis lupus familiaris (dog) | LMAN2 | NP_001003258.1 |
| Mus musculus (house mouse) | Lman2 | NP_080104.2 |
| Bos taurus (cattle) | LMAN2 | NP_001094779.1 |
| Xenopus tropicalis (tropical clawed frog) | lman2 | NP_001072196.1 |
| Rattus norvegicus (Norway rat) | Lman2 | NP_001108496.1 |
Related articles in PubMed
Adaptor Protein CD2AP and L-type Lectin LMAN2 Regulate Exosome Cargo Protein Trafficking through the Golgi Complex.
Kwon SH, Oh S, Nacke M, Mostov KE, Lipschutz JH
The Journal of biological chemistry291(49)25462-25475(2016 Dec)
Parallel quantification of lectin-glycan interaction using ultrafiltration.
Takeda Y, Seko A, Sakono M, Hachisu M, Koizumi A, Fujikawa K, Ito Y
Carbohydrate research375112-7(2013 Jun)
Site-specific N-linked glycosylation of receptor guanylyl cyclase C regulates ligand binding, ligand-mediated activation and interaction with vesicular integral membrane protein 36, VIP36.
Arshad N, Ballal S, Visweswariah SS
The Journal of biological chemistry288(6)3907-17(2013 Feb)
Genetic associations for activated partial thromboplastin time and prothrombin time, their gene expression profiles, and risk of coronary artery disease.
Tang W, Schwienbacher C, Lopez LM, Ben-Shlomo Y, Oudot-Mellakh T, Johnson AD, Samani NJ, Basu S, G?gele M, Davies G, Lowe GD, Tregouet DA, Tan A, Pankow JS, Tenesa A, Levy D, Volpato CB, Rumley A, Gow AJ, Minelli C, Yarnell JW, Porteous DJ, Starr JM, Gallacher J, Boerwinkle E, Visscher PM, Pramstaller PP, Cushman M, Emilsson V, Plump AS, Matijevic N, Morange PE, Deary IJ, Hicks AA, Folsom AR
American journal of human genetics91(1)152-62(2012 Jul)
VIP36 protein is a target of ectodomain shedding and regulates phagocytosis in macrophage Raw 264.7 cells.
Shirakabe K, Hattori S, Seiki M, Koyasu S, Okada Y
The Journal of biological chemistry286(50)43154-63(2011 Dec)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
data thus reveal a Golgi-traversing pathway for exosomal release of the cargo protein GPRC5B in which CD2AP facilitates the entry and LMAN2 impedes the exit of the flux, respectively.
Title: Adaptor Protein CD2AP and L-type Lectin LMAN2 Regulate Exosome Cargo Protein Trafficking through the Golgi Complex.
Interaction with VIP36 is dependent on glycosylation at the same sites that allow GC-C to fold and bind ligand.
Title: Site-specific N-linked glycosylation of receptor guanylyl cyclase C regulates ligand binding, ligand-mediated activation and interaction with vesicular integral membrane protein 36, VIP36.
Results identify the glycoprotein alpha1-antitrypsin as a cargo of VIP36.
Title: Role of the lectin VIP36 in post-ER quality control of human alpha1-antitrypsin.
selective interaction of VIPL and VIP36 with the deglucosylated trimannose in the D1 branch of high-mannose-type oligosaccharides but with different pH dependence.
Title: Molecular basis of sugar recognition by the human L-type lectins ERGIC-53, VIPL, and VIP36.
VIP36 interacts with molecular chaperone BiP and has a role in the quality control of secretory proteins
Title: Stable interaction of the cargo receptor VIP36 with molecular chaperone BiP.
The following LMAN2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the LMAN2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
| CloneID | OHu09223 |
|
| Clone ID Related Accession (Same CDS sequence) | NM_006816.2 , NM_006816.3 | |
| Accession Version | NM_006816.2 | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 1071bp) Protein sequence SNP |
|
| Vector | pcDNA3.1+/C-(K)DYK or customized vector |  User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2017-11-27 | |
| Organism | Homo sapiens(human) | |
| Product | vesicular integral-membrane protein VIP36 precursor | |
| Comment | Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DC404202.1, BC017263.2 and AK222609.1. On Oct 17, 2008 this sequence version replaced NM_006816.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK222609.1, SRR1163655.641915.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. | |
1 | ATGGCGGCGG AAGGCTGGAT TTGGCGTTGG GGCTGGGGCC GGCGGTGCCT GGGAAGGCCT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | NP_006807.1 |
| CDS | 238..1308 |
| Translation |
Target ORF information:
Target ORF information:
|
 NM_006816.2 |
ORF Insert Sequence:
1 | ATGGCGGCGG AAGGCTGGAT TTGGCGTTGG GGCTGGGGCC GGCGGTGCCT GGGAAGGCCT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| CloneID | OHu09223 |
|
| Clone ID Related Accession (Same CDS sequence) | NM_006816.2 , NM_006816.3 | |
| Accession Version | NM_006816.3 Latest version! | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 1071bp) Protein sequence SNP |
|
| Vector | pcDNA3.1+/C-(K)DYK or customized vector | User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2019-09-26 | |
| Organism | Homo sapiens(human) | |
| Product | vesicular integral-membrane protein VIP36 precursor | |
| Comment | Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DC404202.1, BC017263.2 and AK222609.1. On Nov 22, 2018 this sequence version replaced NM_006816.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR3476690.170632.1, SRR3476690.790902.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000303127.12/ ENSP00000303366.7 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length. | |
1 | ATGGCGGCGG AAGGCTGGAT TTGGCGTTGG GGCTGGGGCC GGCGGTGCCT GGGAAGGCCT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | NP_006807.1 |
| CDS | 22..1092 |
| Translation |
Target ORF information:
Target ORF information:
|
NM_006816.3 |
ORF Insert Sequence:
1 | ATGGCGGCGG AAGGCTGGAT TTGGCGTTGG GGCTGGGGCC GGCGGTGCCT GGGAAGGCCT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
 |
Adaptor Protein CD2AP and L-type Lectin LMAN2 Regulate Exosome Cargo Protein Trafficking through the Golgi Complex. |
|
Parallel quantification of lectin-glycan interaction using ultrafiltration. |
|
Site-specific N-linked glycosylation of receptor guanylyl cyclase C regulates ligand binding, ligand-mediated activation and interaction with vesicular integral membrane protein 36, VIP36. |
|
Genetic associations for activated partial thromboplastin time and prothrombin time, their gene expression profiles, and risk of coronary artery disease. |
|
VIP36 protein is a target of ectodomain shedding and regulates phagocytosis in macrophage Raw 264.7 cells. |