UCN3 cDNA ORF clone, Homo sapiens(human)
| Gene Symbol | UCN3 |
| Entrez Gene ID | 114131 |
| Full Name | urocortin 3 |
| Synonyms | SCP,SPC,UCNIII |
| General protein information |
|
| Gene Type | protein-coding |
| Organism | Homo sapiens(human) |
| Genome | |
| Summary | This gene encodes a member of the sauvagine/corticotropin-releasing factor/urotensin I family of proteins. The encoded preproprotein is proteolytically processed to generate the mature peptide hormone, which is secreted by pancreatic beta and alpha cells. This hormone is an endogenous ligand for corticotropin-releasing factor receptor 2 and may regulate insulin secretion in response to plasma glucose levels. Patients with type 2 diabetes exhibit reduced levels of the encoded protein in beta cells. In the brain, the encoded protein may be responsible for the effects of stress on appetite. [provided by RefSeq, May 2016]. |
| Disorder MIM: |
mRNA and Protein(s)
| mRNA | Protein | Name |
|---|---|---|
| NM_053049.3 | NP_444277.2 | urocortin-3 preproprotein |
| NM_053049.4 | NP_444277.2 | urocortin-3 preproprotein |
| Bos taurus (cattle) | UCN3 | NP_001069995.1 |
| Danio rerio (zebrafish) | ucn3l | NP_001076423.1 |
| Xenopus tropicalis (tropical clawed frog) | LOC100488336 | XP_002931892.1 |
| Homo sapiens (human) | UCN3 | NP_444277.2 |
| Rattus norvegicus (Norway rat) | Ucn3 | NP_001073677.1 |
| Pan troglodytes (chimpanzee) | UCN3 | XP_507632.2 |
| UCN3 | XP_001104616.1 | |
| Canis lupus familiaris (dog) | UCN3 | XP_003638933.1 |
| Mus musculus (house mouse) | Ucn3 | NP_112540.2 |
| Gallus gallus (chicken) | UCN3 | XP_001231711.1 |
Related articles in PubMed
Cardiac CRFR1 Expression Is Elevated in Human Heart Failure and Modulated by Genetic Variation and Alternative Splicing.
Pilbrow AP, Lewis KA, Perrin MH, Sweet WE, Moravec CS, Tang WH, Huising MO, Troughton RW, Cameron VA
Endocrinology157(12)4865-4874(2016 Dec)
Cardiovascular effects of urocortin 2 and urocortin 3 in patients with chronic heart failure.
Stirrat CG, Venkatasubramanian S, Pawade T, Mitchell AJ, Shah AS, Lang NN, Newby DE
British journal of clinical pharmacology82(4)974-82(2016 Oct)
Antiamnesic properties of analogs and mimetics of the tripeptide human urocortin 3.
Telegdy G, Kov?cs AK, R?kosi K, Zar?ndi M, T?th GK
Amino acids48(9)2261-6(2016 Sep)
Increased circulating urocortin-3 levels is associated with polycystic ovary syndrome.
Temur M, Yilmaz ?, Aksun S, ?z?n ?zbay P, Calan M, K?me T, Karakulak M, Korkmaz HA
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology32(3)218-22(2016)
Corticotropin Releasing Hormone and Urocortin 3 Stimulate Vascular Endothelial Growth Factor Expression through the cAMP/CREB Pathway.
Rhee SH, Ma EL, Lee Y, Tach? Y, Pothoulakis C, Im E
The Journal of biological chemistry290(43)26194-203(2015 Oct)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
In summary, cardiac expression of CRFR1, CRF, and Ucn3 genes is elevated in heart failure and may contribute to the activation of the CRF/Ucn system in these patients.
Title: Cardiac CRFR1 Expression Is Elevated in Human Heart Failure and Modulated by Genetic Variation and Alternative Splicing.
examination of the local and systemic cardiovascular effects of urocortin 2 and urocortin 3 in healthy subjects and patients with heart failure
Title: Cardiovascular effects of urocortin 2 and urocortin 3 in patients with chronic heart failure.
Antiamnesic properties of analogs and mimetics of the tripeptide human urocortin 3
Title: Antiamnesic properties of analogs and mimetics of the tripeptide human urocortin 3.
circulating levels elevated and positively correlated with C-reactive protein in polycystic ovary syndrome
Title: Increased circulating urocortin-3 levels is associated with polycystic ovary syndrome.
results show that activation of CRH receptors by CRH ligands stimulates VEGF-A expression in intestinal epithelial cells through the cAMP/CREB pathway
Title: Corticotropin Releasing Hormone and Urocortin 3 Stimulate Vascular Endothelial Growth Factor Expression through the cAMP/CREB Pathway.
The following UCN3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the UCN3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
| CloneID | OHu31078 | |
| Clone ID Related Accession (Same CDS sequence) | NM_053049.3 , NM_053049.4 | |
| Accession Version | NM_053049.3 | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 486bp) Protein sequence SNP |
|
| Vector | pcDNA3.1+/C-(K)DYK or customized vector |  User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2017-12-17 | |
| Organism | Homo sapiens(human) | |
| Product | urocortin-3 preproprotein | |
| Comment | Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BQ777111.1, BQ776877.1, BQ778217.1, AY026949.1, AL683826.14 and CK821206.1. On May 12, 2016 this sequence version replaced NM_053049.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC100867.2, BQ777111.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1966682, SAMEA1968540 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. | |
1 | ATGCTGATGC CGGTCCACTT CCTGCTGCTC CTGCTGCTGC TCCTGGGGGG CCCCAGGACA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | NP_444277.2 |
| CDS | 229..714 |
| Translation |
Target ORF information:
Target ORF information:
|
 NM_053049.3 |
ORF Insert Sequence:
1 | ATGCTGATGC CGGTCCACTT CCTGCTGCTC CTGCTGCTGC TCCTGGGGGG CCCCAGGACA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| CloneID | OHu31078 | |
| Clone ID Related Accession (Same CDS sequence) | NM_053049.3 , NM_053049.4 | |
| Accession Version | NM_053049.4 Latest version! | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 486bp) Protein sequence SNP |
|
| Vector | pcDNA3.1+/C-(K)DYK or customized vector | User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2019-09-26 | |
| Organism | Homo sapiens(human) | |
| Product | urocortin-3 preproprotein | |
| Comment | Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL683826.14, BQ777111.1, BQ776877.1, BQ778217.1, AY026949.1 and CK821206.1. On Nov 23, 2018 this sequence version replaced NM_053049.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC100867.2, BQ777111.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1966682, SAMEA1968540 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000380433.5/ ENSP00000369798.3 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length. | |
1 | ATGCTGATGC CGGTCCACTT CCTGCTGCTC CTGCTGCTGC TCCTGGGGGG CCCCAGGACA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | NP_444277.2 |
| CDS | 272..757 |
| Translation |
Target ORF information:
Target ORF information:
|
NM_053049.4 |
ORF Insert Sequence:
1 | ATGCTGATGC CGGTCCACTT CCTGCTGCTC CTGCTGCTGC TCCTGGGGGG CCCCAGGACA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
 |
Cardiac CRFR1 Expression Is Elevated in Human Heart Failure and Modulated by Genetic Variation and Alternative Splicing. |
|
Cardiovascular effects of urocortin 2 and urocortin 3 in patients with chronic heart failure. |
|
Antiamnesic properties of analogs and mimetics of the tripeptide human urocortin 3. |
|
Increased circulating urocortin-3 levels is associated with polycystic ovary syndrome. |
|
Corticotropin Releasing Hormone and Urocortin 3 Stimulate Vascular Endothelial Growth Factor Expression through the cAMP/CREB Pathway. |