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Ucn3 cDNA ORF clone, Rattus norvegicus(Norway rat)

Summary

Gene Symbol Ucn3
Entrez Gene ID 498791
Full Name urocortin 3
Synonyms RGD1562213
General protein information
Preferred Names

urocortin 3

Names

urocortin-3
urocortin 3 (stresscopin)
Gene Type protein-coding
Organism Rattus norvegicus(Norway rat)
Genome

17

17q12.2

Reference Sequences (RefSeq)

mRNA and Protein(s)

mRNA Protein Name
XM_017600645.1 XP_017456134.1 urocortin-3 isoform X1
NM_001080208.1 NP_001073677.1 urocortin-3 precursor

Pathways from BioSystems


Homologies


Bos taurus (cattle) UCN3 NP_001069995.1
Danio rerio (zebrafish) ucn3l NP_001076423.1
Xenopus tropicalis (tropical clawed frog) LOC100488336 XP_002931892.1
Homo sapiens (human) UCN3 NP_444277.2
Rattus norvegicus (Norway rat) Ucn3 NP_001073677.1
Pan troglodytes (chimpanzee) UCN3 XP_507632.2
UCN3 XP_001104616.1
Canis lupus familiaris (dog) UCN3 XP_003638933.1
Mus musculus (house mouse) Ucn3 NP_112540.2
Gallus gallus (chicken) UCN3 XP_001231711.1

Gene Ontology


Bibliography

Related articles in PubMed

Stress-activated afferent inputs into the anterior parvicellular part of the paraventricular nucleus of the hypothalamus: Insights into urocortin 3 neuron activation.
van-Hover C, Li C
Brain research161129-43(2015 Jun)

Urocortin 3 activates AMPK and AKT pathways and enhances glucose disposal in rat skeletal muscle.
Roustit MM, Vaughan JM, Jamieson PM, Cleasby ME
The Journal of endocrinology223(2)143-54(2014 Nov)

Urocortin 3 expression at baseline and during inflammation in the colon: corticotropin releasing factor receptors cross-talk.
Mahajan S, Liao M, Barkan P, Takahashi K, Bhargava A
Peptides5458-66(2014 Apr)

Urocortin 3 elevates cytosolic calcium in nucleus ambiguus neurons.
Brailoiu GC, Deliu E, Tica AA, Chitravanshi VC, Brailoiu E
Journal of neurochemistry122(6)1129-36(2012 Sep)

Alteration of antral and proximal colonic motility induced by chronic psychological stress involves central urocortin 3 and vasopressin in rats.
Ataka K, Nagaishi K, Asakawa A, Inui A, Fujimiya M
American journal of physiology. Gastrointestinal and liver physiology303(4)G519-28(2012 Aug)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Study showed that acute stress rapidly stimulates Urocortin 3 expression in the paraventricular nucleus of the hypothalamus (PVHap) and identified specific stress-sensitive brain areas that project to the PVHap.
Title: Stress-activated afferent inputs into the anterior parvicellular part of the paraventricular nucleus of the hypothalamus: Insights into urocortin 3 neuron activation.

UCN3 expression enhances glucose disposal and signalling in muscle by an autocrine/paracrine mechanism that is separate from its pro-hypertrophic effects.
Title: Urocortin 3 activates AMPK and AKT pathways and enhances glucose disposal in rat skeletal muscle.

Ucn3 does not have an overt role in ameliorating histopathological inflammation in colon.
Title: Urocortin 3 expression at baseline and during inflammation in the colon: corticotropin releasing factor receptors cross-talk.

A novel divalent calcium ion-mobilizing effect of urocortin 3 in vagal pre-ganglionic neurons of the nucleus ambiguus provides a cellular mechanism for this peptide's role in parasympathetic cardiac regulation.
Title: Urocortin 3 elevates cytosolic calcium in nucleus ambiguus neurons.

Chronic psychological stress disrupted fasted motility in the antrum and colon via central urocortin 3/arginine vasopression pathways.
Title: Alteration of antral and proximal colonic motility induced by chronic psychological stress involves central urocortin 3 and vasopressin in rats.

The following Ucn3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Ucn3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID Accession No. Definition **Vector *Turnaround time Price (USD) Select
ORa10655 NM_001080208.1
Latest version!		 Rattus norvegicus urocortin 3 (Ucn3), mRNA. pcDNA3.1+/C-(K)DYK or customized vector 7-9 $69.30
$99.00
ORa10655 XM_017600645.1
Latest version!		 Rattus norvegicus urocortin 3 (Ucn3), transcript variant X1, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 7-9 $69.30
$99.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone 30% OFF
2-4 Clone 40% OFF
5 or more Clone 50% OFF
All Other ORF Clones
30% OFF

*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)


CloneID ORa10655
Clone ID Related Accession (Same CDS sequence) XM_017600645.1 , NM_001080208.1
Accession Version NM_001080208.1 Latest version! Documents for ORF clone product in default vector
Sequence Information ORF Nucleotide Sequence (Length: 495bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ™ Seamless cloning technology
Insert Structure linear
Update Date 2018-05-27
Organism Rattus norvegicus(Norway rat)
Product urocortin-3 precursor
Comment Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from EF078967.1. On or before Jan 15, 2007 this sequence version replaced XM_574076.2, XM_001068553.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: EF078967.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN02642611 [ECO:0000348] ##Evidence-Data-END## 

1
61
121
181
241
301
361
421
481
ATGCTGATGC CCACTTACTT CCTGCTGCTT CTGCTGCTGC TCCTAGGGGG CCCAAGGACA 
AGCCTCTCCC ACAAGTTCTA CAACGCAGGA CCAGTCTTCA GCTGCCTCAA CACAGCCCTG 
TCTGAGGTCA AGAAGAACAA GCTGGAGGAT GTGCCGGTGC TGAGCAAGAA GAACTTTGGC 
TACCTGCCCA CACAAGACCC TTCGGGAGAA GAAGAGGATG AACAAAAACA CATCAAGAAC 
AAAAGAACTT TCTCAGACGC TGTGGGTGGG AATGGAGGTA GAAGCATCCG GTACAGATAC 
CAATCCCAAG CACAGCCCAA AGGAAAGCTG TACCCGGACA AGGTCAAAAA CGACCGGGGC 
ACCAAGTTCA CTCTGTCCCT CGACGTTCCC ACTAACATCA TGAACATCCT CTTCAACATT 
GACAAGGCCA AGAATTTGCG AGCCAAGGCA GCGGCCAATG CTCAACTCAT GGCACAGATT 
GGGAAAAAGA AATAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_001073677.1
CDS29..523
Translation

Target ORF information:

RefSeq Version NM_001080208.1
Organism Rattus norvegicus(Norway rat)
Definition Rattus norvegicus urocortin 3 (Ucn3), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
 NM_001080208.1

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
ATGCTGATGC CCACTTACTT CCTGCTGCTT CTGCTGCTGC TCCTAGGGGG CCCAAGGACA 
AGCCTCTCCC ACAAGTTCTA CAACGCAGGA CCAGTCTTCA GCTGCCTCAA CACAGCCCTG 
TCTGAGGTCA AGAAGAACAA GCTGGAGGAT GTGCCGGTGC TGAGCAAGAA GAACTTTGGC 
TACCTGCCCA CACAAGACCC TTCGGGAGAA GAAGAGGATG AACAAAAACA CATCAAGAAC 
AAAAGAACTT TCTCAGACGC TGTGGGTGGG AATGGAGGTA GAAGCATCCG GTACAGATAC 
CAATCCCAAG CACAGCCCAA AGGAAAGCTG TACCCGGACA AGGTCAAAAA CGACCGGGGC 
ACCAAGTTCA CTCTGTCCCT CGACGTTCCC ACTAACATCA TGAACATCCT CTTCAACATT 
GACAAGGCCA AGAATTTGCG AGCCAAGGCA GCGGCCAATG CTCAACTCAT GGCACAGATT 
GGGAAAAAGA AATAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID ORa10655
Clone ID Related Accession (Same CDS sequence) XM_017600645.1 , NM_001080208.1
Accession Version XM_017600645.1 Latest version! Documents for ORF clone product in default vector
Sequence Information ORF Nucleotide Sequence (Length: 495bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ™ Seamless cloning technology
Insert Structure linear
Update Date 2016-07-25
Organism Rattus norvegicus(Norway rat)
Product urocortin-3 isoform X1
Comment Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005116.4) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## 

1
61
121
181
241
301
361
421
481
ATGCTGATGC CCACTTACTT CCTGCTGCTT CTGCTGCTGC TCCTAGGGGG CCCAAGGACA 
AGCCTCTCCC ACAAGTTCTA CAACGCAGGA CCAGTCTTCA GCTGCCTCAA CACAGCCCTG 
TCTGAGGTCA AGAAGAACAA GCTGGAGGAT GTGCCGGTGC TGAGCAAGAA GAACTTTGGC 
TACCTGCCCA CACAAGACCC TTCGGGAGAA GAAGAGGATG AACAAAAACA CATCAAGAAC 
AAAAGAACTT TCTCAGACGC TGTGGGTGGG AATGGAGGTA GAAGCATCCG GTACAGATAC 
CAATCCCAAG CACAGCCCAA AGGAAAGCTG TACCCGGACA AGGTCAAAAA CGACCGGGGC 
ACCAAGTTCA CTCTGTCCCT CGACGTTCCC ACTAACATCA TGAACATCCT CTTCAACATT 
GACAAGGCCA AGAATTTGCG AGCCAAGGCA GCGGCCAATG CTCAACTCAT GGCACAGATT 
GGGAAAAAGA AATAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq XP_017456134.1
CDS315..809
Translation

Target ORF information:

RefSeq Version XM_017600645.1
Organism Rattus norvegicus(Norway rat)
Definition Rattus norvegicus urocortin 3 (Ucn3), transcript variant X1, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
 XM_017600645.1

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
ATGCTGATGC CCACTTACTT CCTGCTGCTT CTGCTGCTGC TCCTAGGGGG CCCAAGGACA 
AGCCTCTCCC ACAAGTTCTA CAACGCAGGA CCAGTCTTCA GCTGCCTCAA CACAGCCCTG 
TCTGAGGTCA AGAAGAACAA GCTGGAGGAT GTGCCGGTGC TGAGCAAGAA GAACTTTGGC 
TACCTGCCCA CACAAGACCC TTCGGGAGAA GAAGAGGATG AACAAAAACA CATCAAGAAC 
AAAAGAACTT TCTCAGACGC TGTGGGTGGG AATGGAGGTA GAAGCATCCG GTACAGATAC 
CAATCCCAAG CACAGCCCAA AGGAAAGCTG TACCCGGACA AGGTCAAAAA CGACCGGGGC 
ACCAAGTTCA CTCTGTCCCT CGACGTTCCC ACTAACATCA TGAACATCCT CTTCAACATT 
GACAAGGCCA AGAATTTGCG AGCCAAGGCA GCGGCCAATG CTCAACTCAT GGCACAGATT 
GGGAAAAAGA AATAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

PubMed

book

Stress-activated afferent inputs into the anterior parvicellular part of the paraventricular nucleus of the hypothalamus: Insights into urocortin 3 neuron activation.
Brain research161129-43(2015 Jun)
van-Hover C,Li C


book

Urocortin 3 activates AMPK and AKT pathways and enhances glucose disposal in rat skeletal muscle.
The Journal of endocrinology223(2)143-54(2014 Nov)
Roustit MM,Vaughan JM,Jamieson PM,Cleasby ME


book

Urocortin 3 expression at baseline and during inflammation in the colon: corticotropin releasing factor receptors cross-talk.
Peptides5458-66(2014 Apr)
Mahajan S,Liao M,Barkan P,Takahashi K,Bhargava A


book

Urocortin 3 elevates cytosolic calcium in nucleus ambiguus neurons.
Journal of neurochemistry122(6)1129-36(2012 Sep)
Brailoiu GC,Deliu E,Tica AA,Chitravanshi VC,Brailoiu E


book

Alteration of antral and proximal colonic motility induced by chronic psychological stress involves central urocortin 3 and vasopressin in rats.
American journal of physiology. Gastrointestinal and liver physiology303(4)G519-28(2012 Aug)
Ataka K,Nagaishi K,Asakawa A,Inui A,Fujimiya M