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CPT2 cDNA ORF clone, Homo sapiens(Human)

Gene Symbol CPT2
Entrez Gene ID 1376
Full Name carnitine palmitoyltransferase 2
Synonyms CPT1,CPTASE,IIAE4
General protein information
Preferred Names

carnitine palmitoyltransferase 2

Names

carnitine O-palmitoyltransferase 2, mitochondrial
CPT II
carnitine palmitoyltransferase II
testicular secretory protein Li 13

Gene Type protein-coding
Organism Homo sapiens(Human)
Genome

1

1p32.3

Summary The protein encoded by this gene is a nuclear protein which is transported to the mitochondrial inner membrane. Together with carnitine palmitoyltransferase I, the encoded protein oxidizes long-chain fatty acids in the mitochondria. Defects in this gene are associated with mitochondrial long-chain fatty-acid (LCFA) oxidation disorders. [provided by RefSeq, Jul 2008].
Disorder MIM:

600650

Disorder Html: Myopathy due to CPT II deficiency, 255110 (3); CPT deficiency,

mRNA and Protein(s)

mRNA Protein Name
NM_001330589.1 NP_001317518.1 carnitine O-palmitoyltransferase 2, mitochondrial isoform 2 precursor
NM_000098.2 NP_000089.1 carnitine O-palmitoyltransferase 2, mitochondrial isoform 1 precursor



Bos taurus (cattle) CPT2 NP_001039354.1
Caenorhabditis elegans (roundworm) cpt-2 NP_001040977.1
Saccharomyces cerevisiae (baker's yeast) YAT1 NP_009420.1
Eremothecium gossypii AGOS_AER224W NP_985081.1
Magnaporthe oryzae (rice blast fungus) MGG_06981 XP_003709730.1
Anopheles gambiae (African malaria mosquito) AgaP_AGAP008907 XP_552786.2
Macaca mulatta (rhesus monkey) CPT2 XP_001112489.1
Homo sapiens (human) CPT2 NP_000089.1
Pan troglodytes (chimpanzee) CPT2 XP_001148628.1
Gallus gallus (chicken) CPT2 NP_001026458.2
Danio rerio (zebrafish) cpt2 NP_001007448.1
Neurospora crassa NCU01611 XP_956522.1
Rattus norvegicus (Norway rat) Cpt2 NP_037062.1
Drosophila melanogaster (fruit fly) CG2107 NP_647756.1
Xenopus tropicalis (tropical clawed frog) cpt2 NP_989193.1
Canis lupus familiaris (dog) CPT2 XP_546705.1
Mus musculus (house mouse) Cpt2 NP_034079.2
Kluyveromyces lactis KLLA0C04169g XP_452383.1


Related articles in PubMed

Muscle Carnitine Palmitoyltransferase II Deficiency: A Review of Enzymatic Controversy and Clinical Features.
Lehmann D, Motlagh L, Robaa D, Zierz S
International journal of molecular sciences18(1)(2017 Jan)

Genetic evaluation of AMPD1, CPT2, and PGYM metabolic enzymes in patients with chronic fatigue syndrome.
Maltese PE, Venturini L, Poplavskaya E, Bertelli M, Cecchin S, Granato M, Nikulina SY, Salmina A, Aksyutina N, Capelli E, Ricevuti G, Lorusso L
Genetics and molecular research : GMR15(3)(2016 Jul)

Carnitine palmitoyl transferase 2 polymorphism may be associated with enterovirus 71 severe infection in a Chinese population.
Liu P, Liu X, Hu J, Han Z, Li F, Wang Y, Song L, Chen Z
Archives of virology161(5)1217-27(2016 May)

The Carnitine Palmitoyl Transferase (CPT) System and Possible Relevance for Neuropsychiatric and Neurological Conditions.
Virmani A, Pinto L, Bauermann O, Zerelli S, Diedenhofen A, Binienda ZK, Ali SF, van der Leij FR
Molecular neurobiology52(2)826-36(2015 Oct)

Abbreviated half-lives and impaired fuel utilization in carnitine palmitoyltransferase II variant fibroblasts.
Yao M, Cai M, Yao D, Xu X, Yang R, Li Y, Zhang Y, Kido H, Yao D
PloS one10(3)e0119936(2015)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The clinical presentation of patients with muscle carnitine palmitoyltransferase II deficiency is discussed in this review in line with enzymatic features. The thermolability of the mutant enzyme might explain why symptoms in muscle CPT II deficiency mainly occur during prolonged exercise, infections and exposure to cold. [review]
Title: Muscle Carnitine Palmitoyltransferase II Deficiency: A Review of Enzymatic Controversy and Clinical Features.

this study shows that upregulation of the citrate pathway and down-regulation of carnitine/acylcarnitine carrier gene in cells from children with Down syndrome
Title: The contribution of the citrate pathway to oxidative stress in Down syndrome.

Variations in AMPD1, CPT2, and PGYM genes are not associated with the onset, susceptibility, or severity of chronic fatigue syndrome.
Title: Genetic evaluation of AMPD1, CPT2, and PGYM metabolic enzymes in patients with chronic fatigue syndrome.

polymorphism may be associated with severity of EV71 infection
Title: Carnitine palmitoyl transferase 2 polymorphism may be associated with enterovirus 71 severe infection in a Chinese population.

CPT2 is active inside the mitochondrial matrix to recover acyl-CoA from a process generally known as the carnitine shuttle. This protein is expressed in a constitutive way in all cells and tissues.
Title: The Carnitine Palmitoyl Transferase (CPT) System and Possible Relevance for Neuropsychiatric and Neurological Conditions.

The following CPT2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CPT2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID RefSeq Accession Definition **Vector *Turnaround time Price (USD) Select
OHu17939 NM_000098.2
Latest version!
Homo sapiens carnitine palmitoyltransferase 2 (CPT2), transcript variant 1, mRNA. pcDNA3.1+/C-(K)DYK or customized vector TBD $69.30
$99.00
OHu33029 NM_001330589.1
Latest version!
Homo sapiens carnitine palmitoyltransferase 2 (CPT2), transcript variant 2, mRNA. pcDNA3.1+/C-(K)DYK or customized vector TBD $307.30
$439.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.


CloneID OHu17939
Clone ID Related Accession (Same CDS sequence) NM_000098.2
Accession Version NM_000098.2 Latest version! Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 1977bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 2017-05-07
Organism Homo sapiens(Human)
Product carnitine O-palmitoyltransferase 2, mitochondrial isoform 1 precursor
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from U09648.1, AL606760.9 and BU629852.1. This sequence is a reference standard in the RefSeqGene project. On Mar 12, 2008 this sequence version replaced NM_000098.1. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: HM005553.1, SRR1803612.118722.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta ##RefSeq-Attributes-END## COMPLETENESS: full length.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
1741
1801
1861
1921
ATGGTGCCCC GCCTGCTGCT GCGCGCCTGG CCCCGGGGCC CCGCGGTTGG TCCGGGAGCC 
CCCAGTCGGC CCCTCAGCGC CGGCTCCGGG CCCGGCCAGT ACCTGCAGCG CAGCATCGTG
CCCACCATGC ACTACCAGGA CAGCCTGCCC AGGCTGCCTA TTCCCAAACT TGAAGACACC
ATTAGGAGAT ACCTCAGTGC ACAGAAGCCT CTCTTGAATG ATGGCCAGTT CAGGAAAACA
GAACAATTTT GCAAGAGTTT TGAAAATGGG ATTGGAAAAG AACTGCATGA GCAGCTGGTT
GCTCTGGACA AACAGAATAA ACATACAAGC TACATTTCGG GACCCTGGTT TGATATGTAC
CTATCTGCTC GAGACTCCGT TGTTCTGAAC TTTAATCCAT TTATGGCTTT CAATCCTGAC
CCAAAATCTG AGTATAATGA CCAGCTCACC CGGGCAACCA ACATGACTGT TTCTGCCATC
CGGTTTCTGA AGACACTCCG GGCTGGCCTT CTGGAGCCAG AAGTGTTCCA CTTGAACCCT
GCAAAAAGTG ACACTATCAC CTTCAAGAGA CTCATACGCT TTGTGCCTTC CTCTCTGTCC
TGGTATGGGG CCTACCTGGT CAATGCGTAT CCCCTGGATA TGTCCCAGTA TTTTCGGCTT
TTCAACTCAA CTCGTTTACC CAAACCCAGT CGGGATGAAC TCTTCACTGA TGACAAGGCC
AGACACCTCC TGGTCCTAAG GAAAGGAAAT TTTTATATCT TTGATGTCCT GGATCAAGAT
GGGAACATTG TGAGCCCCTC GGAAATCCAG GCACATCTGA AGTACATTCT CTCAGACAGC
AGCCCCGCCC CCGAGTTTCC CCTGGCATAC CTGACCAGTG AGAACCGAGA CATCTGGGCA
GAGCTCAGGC AGAAGCTGAT GAGTAGTGGC AATGAGGAGA GCCTGAGGAA AGTGGACTCG
GCAGTGTTCT GTCTCTGCCT AGATGACTTC CCCATTAAGG ACCTTGTCCA CTTGTCCCAC
AATATGCTGC ATGGGGATGG CACAAACCGC TGGTTTGATA AATCCTTTAA CCTCATTATC
GCCAAGGATG GCTCTACTGC CGTCCACTTT GAGCACTCTT GGGGTGATGG TGTGGCAGTG
CTCAGATTTT TTAATGAAGT ATTTAAAGAC AGCACTCAGA CCCCTGCCGT CACTCCACAG
AGCCAGCCAG CTACCACTGA CTCTACTGTC ACGGTGCAGA AACTCAACTT CGAGCTGACT
GATGCCTTAA AGACTGGCAT CACAGCTGCT AAGGAAAAGT TTGATGCCAC CATGAAAACC
CTCACTATTG ACTGCGTCCA GTTTCAGAGA GGAGGCAAAG AATTCCTGAA GAAGCAAAAG
CTGAGCCCTG ACGCAGTTGC CCAGCTGGCA TTCCAGATGG CCTTCCTGCG GCAGTACGGG
CAGACAGTGG CCACCTACGA GTCCTGTAGC ACTGCCGCAT TCAAGCACGG CCGCACTGAG
ACCATCCGCC CGGCCTCCGT CTATACAAAG AGGTGCTCTG AGGCCTTTGT CAGGGAGCCC
TCCAGGCACA GTGCTGGTGA GCTTCAGCAG ATGATGGTTG AGTGCTCCAA GTACCATGGC
CAGCTGACCA AAGAAGCAGC AATGGGCCAG GGCTTTGACC GACACTTGTT TGCTCTGCGG
CATCTGGCAG CAGCCAAAGG GATCATCTTG CCTGAGCTCT ACCTGGACCC TGCATACGGG
CAGATAAACC ACAATGTCCT GTCCACGAGC ACACTGAGCA GCCCAGCAGT GAACCTTGGG
GGCTTTGCCC CTGTGGTCTC TGATGGCTTT GGTGTTGGGT ATGCTGTTCA TGACAACTGG
ATAGGCTGCA ATGTCTCTTC CTACCCAGGC CGCAATGCCC GGGAGTTTCT CCAATGTGTG
GAGAAGGCCT TAGAAGACAT GTTTGATGCC TTAGAAGGCA AATCCATCAA AAGTTAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_000089.1
CDS516..2492
Misc Feature(1)417..419
Misc Feature(2)660..2459
Misc Feature(3)720..722
Misc Feature(4)750..752
Misc Feature(5)768..770
Misc Feature(6)1230..1232
Misc Feature(7)1230..1232
Misc Feature(8)1428..1430
Misc Feature(9)1785..1787
Misc Feature(10)1830..1832
Misc Feature(11)1869..1907
Misc Feature(12)2043..2045
Misc Feature(13)2043..2045
Misc Feature(14)2145..2147
Misc Feature(15)2145..2147
Exon (1)1..667
Exon (2)668..748
Exon (3)749..855
Exon (4)856..2160
Exon (5)2161..3094
Translation

Target ORF information:

RefSeq Version NM_000098.2
Organism Homo sapiens(Human)
Definition Homo sapiens carnitine palmitoyltransferase 2 (CPT2), transcript variant 1, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_000098.2

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
1741
1801
1861
1921
ATGGTGCCCC GCCTGCTGCT GCGCGCCTGG CCCCGGGGCC CCGCGGTTGG TCCGGGAGCC 
CCCAGTCGGC CCCTCAGCGC CGGCTCCGGG CCCGGCCAGT ACCTGCAGCG CAGCATCGTG
CCCACCATGC ACTACCAGGA CAGCCTGCCC AGGCTGCCTA TTCCCAAACT TGAAGACACC
ATTAGGAGAT ACCTCAGTGC ACAGAAGCCT CTCTTGAATG ATGGCCAGTT CAGGAAAACA
GAACAATTTT GCAAGAGTTT TGAAAATGGG ATTGGAAAAG AACTGCATGA GCAGCTGGTT
GCTCTGGACA AACAGAATAA ACATACAAGC TACATTTCGG GACCCTGGTT TGATATGTAC
CTATCTGCTC GAGACTCCGT TGTTCTGAAC TTTAATCCAT TTATGGCTTT CAATCCTGAC
CCAAAATCTG AGTATAATGA CCAGCTCACC CGGGCAACCA ACATGACTGT TTCTGCCATC
CGGTTTCTGA AGACACTCCG GGCTGGCCTT CTGGAGCCAG AAGTGTTCCA CTTGAACCCT
GCAAAAAGTG ACACTATCAC CTTCAAGAGA CTCATACGCT TTGTGCCTTC CTCTCTGTCC
TGGTATGGGG CCTACCTGGT CAATGCGTAT CCCCTGGATA TGTCCCAGTA TTTTCGGCTT
TTCAACTCAA CTCGTTTACC CAAACCCAGT CGGGATGAAC TCTTCACTGA TGACAAGGCC
AGACACCTCC TGGTCCTAAG GAAAGGAAAT TTTTATATCT TTGATGTCCT GGATCAAGAT
GGGAACATTG TGAGCCCCTC GGAAATCCAG GCACATCTGA AGTACATTCT CTCAGACAGC
AGCCCCGCCC CCGAGTTTCC CCTGGCATAC CTGACCAGTG AGAACCGAGA CATCTGGGCA
GAGCTCAGGC AGAAGCTGAT GAGTAGTGGC AATGAGGAGA GCCTGAGGAA AGTGGACTCG
GCAGTGTTCT GTCTCTGCCT AGATGACTTC CCCATTAAGG ACCTTGTCCA CTTGTCCCAC
AATATGCTGC ATGGGGATGG CACAAACCGC TGGTTTGATA AATCCTTTAA CCTCATTATC
GCCAAGGATG GCTCTACTGC CGTCCACTTT GAGCACTCTT GGGGTGATGG TGTGGCAGTG
CTCAGATTTT TTAATGAAGT ATTTAAAGAC AGCACTCAGA CCCCTGCCGT CACTCCACAG
AGCCAGCCAG CTACCACTGA CTCTACTGTC ACGGTGCAGA AACTCAACTT CGAGCTGACT
GATGCCTTAA AGACTGGCAT CACAGCTGCT AAGGAAAAGT TTGATGCCAC CATGAAAACC
CTCACTATTG ACTGCGTCCA GTTTCAGAGA GGAGGCAAAG AATTCCTGAA GAAGCAAAAG
CTGAGCCCTG ACGCAGTTGC CCAGCTGGCA TTCCAGATGG CCTTCCTGCG GCAGTACGGG
CAGACAGTGG CCACCTACGA GTCCTGTAGC ACTGCCGCAT TCAAGCACGG CCGCACTGAG
ACCATCCGCC CGGCCTCCGT CTATACAAAG AGGTGCTCTG AGGCCTTTGT CAGGGAGCCC
TCCAGGCACA GTGCTGGTGA GCTTCAGCAG ATGATGGTTG AGTGCTCCAA GTACCATGGC
CAGCTGACCA AAGAAGCAGC AATGGGCCAG GGCTTTGACC GACACTTGTT TGCTCTGCGG
CATCTGGCAG CAGCCAAAGG GATCATCTTG CCTGAGCTCT ACCTGGACCC TGCATACGGG
CAGATAAACC ACAATGTCCT GTCCACGAGC ACACTGAGCA GCCCAGCAGT GAACCTTGGG
GGCTTTGCCC CTGTGGTCTC TGATGGCTTT GGTGTTGGGT ATGCTGTTCA TGACAACTGG
ATAGGCTGCA ATGTCTCTTC CTACCCAGGC CGCAATGCCC GGGAGTTTCT CCAATGTGTG
GAGAAGGCCT TAGAAGACAT GTTTGATGCC TTAGAAGGCA AATCCATCAA AAGTTAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu33029
Clone ID Related Accession (Same CDS sequence) NM_001330589.1
Accession Version NM_001330589.1 Latest version! Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 1908bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 2017-04-24
Organism Homo sapiens(Human)
Product carnitine O-palmitoyltransferase 2, mitochondrial isoform 2 precursor
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL606760.9. On Aug 29, 2016 this sequence version replaced XM_005270484.1. Transcript Variant: This variant (2) uses an alternate in-frame splice junction compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660809.95817.1, SRR1803616.236243.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta ##RefSeq-Attributes-END## COMPLETENESS: full length.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
1741
1801
1861
ATGGTGCCCC GCCTGCTGCT GCGCGCCTGG CCCCGGGGCC CCGCGGTTGG TCCGGGAGCC 
CCCAGTCGGC CCCTCAGCGC CGGCTCCGGG CCCGGCCAGT ACCTGCAGCG CAGCATCGTG
CCCACCATGC ACTACCAGGA CAGCCTGCCC AGGCTGCCTA TTCCCAAACT TGAAGACACC
ATTAGGAGAT ACCTCAGTGC ACAGAAGCCT CTCTTGAATG ATGGCCAGTT CAGGAAAACA
GAACAATTTT GCAAGAGTTT TGAAAATGGG ATTGGAAAAG AACTGCATGA GCAGCTGGTT
GCTCTGGACA AACAGAATAA ACATACAAGC TACATTTCGG GACCCTGGTT TGATATGTAC
CTATCTGCTC GAGACTCCGT TGTTCTGAAC TTTAATCCAT TTATGGCTTT CAATCCTGAC
CCAAAATCTG AGTATAATGA CCAGCTCACC CGGGCAACCA ACATGACTGT TTCTGCCATC
CGGTTTCTGA AGACACTCCG GGCTGGCCTT CTGGAGCCAG AAGTGTTCCA CTTGAACCCT
GCAAAAAGTG ACACTATCAC CTTCAAGAGA CTCATACGCT TTGTGCCTTC CTCTCTGTCC
TGGTATGGGG CCTACCTGGT CAATGCGTAT CCCCTGGATA TGTCCCAGTA TTTTCGGCTT
TTCAACTCAA CTCGTTTACC CAAACCCAGT CGGGATGAAC TCTTCACTGA TGACAAGGCC
AGACACCTCC TGGTCCTAAG GAAAGGAAAT TTTTATATCT TTGATGTCCT GGATCAAGAT
GGGAACATTG TGAGCCCCTC GGAAATCCAG GCACATCTGA AGTACATTCT CTCAGACAGC
AGCCCCGCCC CCGAGTTTCC CCTGGCATAC CTGACCAGTG AGAACCGAGA CATCTGGGCA
GAGCTCAGGC AGAAGCTGAT GAGTAGTGGC AATGAGGAGA GCCTGAGGAA AGTGGACTCG
GCAGTGTTCT GTCTCTGCCT AGATGACTTC CCCATTAAGG ACCTTGTCCA CTTGTCCCAC
AATATGCTGC ATGGGGATGG CACAAACCGC TGGTTTGATA AATCCTTTAA CCTCATTATC
GCCAAGGATG GCTCTACTGC CGTCCACTTT GAGCACTCTT GGGGTGATGG TGTGGCAGTG
CTCAGATTTT TTAATGAAGT ATTTAAAGAC AGCACTCAGA CCCCTGCCGT CACTCCACAG
AGCCAGCCAG CTACCACTGA CTCTACTGTC ACGGTGCAGA AACTCAACTT CGAGCTGACT
GATGCCTTAA AGACTGGCAT CACAGCTGCT AAGGAAAAGT TTGATGCCAC CATGAAAACC
CTCACTATTG ACTGCGTCCA GTTTCAGAGA GGAGGCAAAG AATTCCTGAA GAAGCAAAAG
CTGAGCCCTG ACGCAGTTGC CCAGCTGGCA TTCCAGATGG CCTTCCTGCG GCAGTACGGG
CAGACAGTGG CCACCTACGA GTCCTGTAGC ACTGCCGCAT TCAAGCACGG CCGCACTGAG
ACCATCCGCC CGGCCTCCGT CTATACAAAG AGGTGCTCTG AGGCCTTTGT CAGGGAGCCC
TCCAGGCACA GTGCTGGCCA GGGCTTTGAC CGACACTTGT TTGCTCTGCG GCATCTGGCA
GCAGCCAAAG GGATCATCTT GCCTGAGCTC TACCTGGACC CTGCATACGG GCAGATAAAC
CACAATGTCC TGTCCACGAG CACACTGAGC AGCCCAGCAG TGAACCTTGG GGGCTTTGCC
CCTGTGGTCT CTGATGGCTT TGGTGTTGGG TATGCTGTTC ATGACAACTG GATAGGCTGC
AATGTCTCTT CCTACCCAGG CCGCAATGCC CGGGAGTTTC TCCAATGTGT GGAGAAGGCC
TTAGAAGACA TGTTTGATGC CTTAGAAGGC AAATCCATCA AAAGTTAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_001317518.1
CDS516..2423
Misc Feature(1)417..419
Misc Feature(2)660..2390
Exon (1)1..667
Exon (2)668..748
Exon (3)749..855
Exon (4)856..2091
Exon (5)2092..3025
Translation

Target ORF information:

RefSeq Version NM_001330589.1
Organism Homo sapiens(Human)
Definition Homo sapiens carnitine palmitoyltransferase 2 (CPT2), transcript variant 2, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_001330589.1

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
1741
1801
1861
ATGGTGCCCC GCCTGCTGCT GCGCGCCTGG CCCCGGGGCC CCGCGGTTGG TCCGGGAGCC 
CCCAGTCGGC CCCTCAGCGC CGGCTCCGGG CCCGGCCAGT ACCTGCAGCG CAGCATCGTG
CCCACCATGC ACTACCAGGA CAGCCTGCCC AGGCTGCCTA TTCCCAAACT TGAAGACACC
ATTAGGAGAT ACCTCAGTGC ACAGAAGCCT CTCTTGAATG ATGGCCAGTT CAGGAAAACA
GAACAATTTT GCAAGAGTTT TGAAAATGGG ATTGGAAAAG AACTGCATGA GCAGCTGGTT
GCTCTGGACA AACAGAATAA ACATACAAGC TACATTTCGG GACCCTGGTT TGATATGTAC
CTATCTGCTC GAGACTCCGT TGTTCTGAAC TTTAATCCAT TTATGGCTTT CAATCCTGAC
CCAAAATCTG AGTATAATGA CCAGCTCACC CGGGCAACCA ACATGACTGT TTCTGCCATC
CGGTTTCTGA AGACACTCCG GGCTGGCCTT CTGGAGCCAG AAGTGTTCCA CTTGAACCCT
GCAAAAAGTG ACACTATCAC CTTCAAGAGA CTCATACGCT TTGTGCCTTC CTCTCTGTCC
TGGTATGGGG CCTACCTGGT CAATGCGTAT CCCCTGGATA TGTCCCAGTA TTTTCGGCTT
TTCAACTCAA CTCGTTTACC CAAACCCAGT CGGGATGAAC TCTTCACTGA TGACAAGGCC
AGACACCTCC TGGTCCTAAG GAAAGGAAAT TTTTATATCT TTGATGTCCT GGATCAAGAT
GGGAACATTG TGAGCCCCTC GGAAATCCAG GCACATCTGA AGTACATTCT CTCAGACAGC
AGCCCCGCCC CCGAGTTTCC CCTGGCATAC CTGACCAGTG AGAACCGAGA CATCTGGGCA
GAGCTCAGGC AGAAGCTGAT GAGTAGTGGC AATGAGGAGA GCCTGAGGAA AGTGGACTCG
GCAGTGTTCT GTCTCTGCCT AGATGACTTC CCCATTAAGG ACCTTGTCCA CTTGTCCCAC
AATATGCTGC ATGGGGATGG CACAAACCGC TGGTTTGATA AATCCTTTAA CCTCATTATC
GCCAAGGATG GCTCTACTGC CGTCCACTTT GAGCACTCTT GGGGTGATGG TGTGGCAGTG
CTCAGATTTT TTAATGAAGT ATTTAAAGAC AGCACTCAGA CCCCTGCCGT CACTCCACAG
AGCCAGCCAG CTACCACTGA CTCTACTGTC ACGGTGCAGA AACTCAACTT CGAGCTGACT
GATGCCTTAA AGACTGGCAT CACAGCTGCT AAGGAAAAGT TTGATGCCAC CATGAAAACC
CTCACTATTG ACTGCGTCCA GTTTCAGAGA GGAGGCAAAG AATTCCTGAA GAAGCAAAAG
CTGAGCCCTG ACGCAGTTGC CCAGCTGGCA TTCCAGATGG CCTTCCTGCG GCAGTACGGG
CAGACAGTGG CCACCTACGA GTCCTGTAGC ACTGCCGCAT TCAAGCACGG CCGCACTGAG
ACCATCCGCC CGGCCTCCGT CTATACAAAG AGGTGCTCTG AGGCCTTTGT CAGGGAGCCC
TCCAGGCACA GTGCTGGCCA GGGCTTTGAC CGACACTTGT TTGCTCTGCG GCATCTGGCA
GCAGCCAAAG GGATCATCTT GCCTGAGCTC TACCTGGACC CTGCATACGG GCAGATAAAC
CACAATGTCC TGTCCACGAG CACACTGAGC AGCCCAGCAG TGAACCTTGG GGGCTTTGCC
CCTGTGGTCT CTGATGGCTT TGGTGTTGGG TATGCTGTTC ATGACAACTG GATAGGCTGC
AATGTCTCTT CCTACCCAGG CCGCAATGCC CGGGAGTTTC TCCAATGTGT GGAGAAGGCC
TTAGAAGACA TGTTTGATGC CTTAGAAGGC AAATCCATCA AAAGTTAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

book

Muscle Carnitine Palmitoyltransferase II Deficiency: A Review of Enzymatic Controversy and Clinical Features.
International journal of molecular sciences18(1)(2017 Jan)
Lehmann D,Motlagh L,Robaa D,Zierz S


book

Genetic evaluation of AMPD1, CPT2, and PGYM metabolic enzymes in patients with chronic fatigue syndrome.
Genetics and molecular research : GMR15(3)(2016 Jul)
Maltese PE,Venturini L,Poplavskaya E,Bertelli M,Cecchin S,Granato M,Nikulina SY,Salmina A,Aksyutina N,Capelli E,Ricevuti G,Lorusso L


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Carnitine palmitoyl transferase 2 polymorphism may be associated with enterovirus 71 severe infection in a Chinese population.
Archives of virology161(5)1217-27(2016 May)
Liu P,Liu X,Hu J,Han Z,Li F,Wang Y,Song L,Chen Z


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The Carnitine Palmitoyl Transferase (CPT) System and Possible Relevance for Neuropsychiatric and Neurological Conditions.
Molecular neurobiology52(2)826-36(2015 Oct)
Virmani A,Pinto L,Bauermann O,Zerelli S,Diedenhofen A,Binienda ZK,Ali SF,van der Leij FR


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Abbreviated half-lives and impaired fuel utilization in carnitine palmitoyltransferase II variant fibroblasts.
PloS one10(3)e0119936(2015)
Yao M,Cai M,Yao D,Xu X,Yang R,Li Y,Zhang Y,Kido H,Yao D


 
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