ASB12 cDNA ORF clone, Homo sapiens(human)
Gene Symbol | ASB12 |
Entrez Gene ID | 142689 |
Full Name | ankyrin repeat and SOCS box containing 12 |
General protein information |
|
Gene Type | protein-coding |
Organism | Homo sapiens(human) |
Genome | |
Summary | The protein encoded by this gene is a member of the ankyrin repeat and SOCS box-containing (ASB) family of proteins. They contain ankyrin repeat sequence and a SOCS box domain. The SOCS box serves to couple suppressor of cytokine signalling (SOCS) proteins and their binding partners with the elongin B and C complex, possibly targeting them for degradation. [provided by RefSeq, Jan 2011]. |
Disorder MIM: |
mRNA and Protein(s)
mRNA | Protein | Name |
---|---|---|
NM_130388.3 | NP_569059.3 | ankyrin repeat and SOCS box protein 12 |
NM_130388.4 | NP_569059.3 | ankyrin repeat and SOCS box protein 12 |

Bos taurus (cattle) | ASB12 | NP_001179154.1 |
Mus musculus (house mouse) | Asb12 | NP_543134.1 |
Gallus gallus (chicken) | ASB12 | NP_001264599.1 |
Homo sapiens (human) | ASB12 | NP_569059.3 |
Pan troglodytes (chimpanzee) | ASB12 | XP_529011.1 |
Canis lupus familiaris (dog) | ASB12 | XP_005641472.1 |
Rattus norvegicus (Norway rat) | Asb12 | NP_001032444.1 |
Danio rerio (zebrafish) | asb12b | NP_001004009.1 |
LOC707931 | XP_001097027.1 | |
Danio rerio (zebrafish) | asb12a | NP_001119848.1 |
Xenopus tropicalis (tropical clawed frog) | asb12.2 | NP_001039222.1 |

Related articles in PubMed
ASB proteins interact with Cullin5 and Rbx2 to form E3 ubiquitin ligase complexes.
Kohroki J, Nishiyama T, Nakamura T, Masuho Y
FEBS letters579(30)6796-802(2005 Dec)
The SOCS box: a tale of destruction and degradation.
Kile BT, Schulman BA, Alexander WS, Nicola NA, Martin HM, Hilton DJ
Trends in biochemical sciences27(5)235-41(2002 May)
Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence.
Adams MD, Kerlavage AR, Fleischmann RD, Fuldner RA, Bult CJ, Lee NH, Kirkness EF, Weinstock KG, Gocayne JD, White O
Nature377(6547 Suppl)3-174(1995 Sep)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
The following ASB12 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the ASB12 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OHu17875![]() |
|
Clone ID Related Accession (Same CDS sequence) | NM_130388.3 , NM_130388.4 | |
Accession Version | NM_130388.3 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 957bp) Protein sequence SNP |
|
Vector | pcDNA3.1+/C-(K)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2017-12-27 | |
Organism | Homo sapiens(human) | |
Product | ankyrin repeat and SOCS box protein 12 | |
Comment | Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA560184.1, AK096896.1, BC069555.1 and AA349954.1. This sequence is a reference standard in the RefSeqGene project. On Jan 29, 2011 this sequence version replaced NM_130388.2. ##Evidence-Data-START## Transcript exon combination :: AK096896.1, ERR279827.7118.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2151741, SAMEA2154361 [ECO:0000348] ##Evidence-Data-END## |
1 | ATGAGAATAG TTCTCCAATT AGCCAAGATG AACCTCATGG ACATCACCAA GATCTTCTCC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_569059.3 |
CDS | 194..1150 |
Translation |

Target ORF information:
Target ORF information:
|
![]() |

ORF Insert Sequence:
1 | ATGAGAATAG TTCTCCAATT AGCCAAGATG AACCTCATGG ACATCACCAA GATCTTCTCC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu17875![]() |
|
Clone ID Related Accession (Same CDS sequence) | NM_130388.3 , NM_130388.4 | |
Accession Version | NM_130388.4 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 957bp) Protein sequence SNP |
|
Vector | pcDNA3.1+/C-(K)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-09-26 | |
Organism | Homo sapiens(human) | |
Product | ankyrin repeat and SOCS box protein 12 | |
Comment | Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK096896.1, BC069555.1 and AA349954.1. This sequence is a reference standard in the RefSeqGene project. On Nov 23, 2018 this sequence version replaced NM_130388.3. ##Evidence-Data-START## Transcript exon combination :: AK096896.1, SRR5189655.143303.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2151741, SAMEA2154361 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000362002.3/ ENSP00000355195.2 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length. |
1 | ATGAGAATAG TTCTCCAATT AGCCAAGATG AACCTCATGG ACATCACCAA GATCTTCTCC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_569059.3 |
CDS | 170..1126 |
Translation |

Target ORF information:
Target ORF information:
|
![]() |

ORF Insert Sequence:
1 | ATGAGAATAG TTCTCCAATT AGCCAAGATG AACCTCATGG ACATCACCAA GATCTTCTCC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
![]() |
ASB proteins interact with Cullin5 and Rbx2 to form E3 ubiquitin ligase complexes. |
![]() |
The SOCS box: a tale of destruction and degradation. |
![]() |
Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence. |