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ASB12 cDNA ORF clone, Homo sapiens(human)

Summary

Gene Symbol ASB12
Entrez Gene ID 142689
Full Name ankyrin repeat and SOCS box containing 12
General protein information
Preferred Names

ankyrin repeat and SOCS box containing 12

Names

ankyrin repeat and SOCS box protein 12
ankyrin repeat domain-containing SOCS box protein Asb-12
Gene Type protein-coding
Organism Homo sapiens(human)
Genome

X

Xq11.2
Summary The protein encoded by this gene is a member of the ankyrin repeat and SOCS box-containing (ASB) family of proteins. They contain ankyrin repeat sequence and a SOCS box domain. The SOCS box serves to couple suppressor of cytokine signalling (SOCS) proteins and their binding partners with the elongin B and C complex, possibly targeting them for degradation. [provided by RefSeq, Jan 2011].
Disorder MIM:

300891


Reference Sequences (RefSeq)

mRNA and Protein(s)

mRNA Protein Name
NM_130388.3 NP_569059.3 ankyrin repeat and SOCS box protein 12
NM_130388.4 NP_569059.3 ankyrin repeat and SOCS box protein 12

Pathways from BioSystems


Homologies


Bos taurus (cattle) ASB12 NP_001179154.1
Mus musculus (house mouse) Asb12 NP_543134.1
Gallus gallus (chicken) ASB12 NP_001264599.1
Homo sapiens (human) ASB12 NP_569059.3
Pan troglodytes (chimpanzee) ASB12 XP_529011.1
Canis lupus familiaris (dog) ASB12 XP_005641472.1
Rattus norvegicus (Norway rat) Asb12 NP_001032444.1
Danio rerio (zebrafish) asb12b NP_001004009.1
LOC707931 XP_001097027.1
Danio rerio (zebrafish) asb12a NP_001119848.1
Xenopus tropicalis (tropical clawed frog) asb12.2 NP_001039222.1

Gene Ontology


Bibliography

Related articles in PubMed

ASB proteins interact with Cullin5 and Rbx2 to form E3 ubiquitin ligase complexes.
Kohroki J, Nishiyama T, Nakamura T, Masuho Y
FEBS letters579(30)6796-802(2005 Dec)

The SOCS box: a tale of destruction and degradation.
Kile BT, Schulman BA, Alexander WS, Nicola NA, Martin HM, Hilton DJ
Trends in biochemical sciences27(5)235-41(2002 May)

Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence.
Adams MD, Kerlavage AR, Fleischmann RD, Fuldner RA, Bult CJ, Lee NH, Kirkness EF, Weinstock KG, Gocayne JD, White O
Nature377(6547 Suppl)3-174(1995 Sep)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following ASB12 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the ASB12 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID Accession No. Definition **Vector *Turnaround time Price (USD) Select
OHu17875 NM_130388.4
Latest version!		 Homo sapiens ankyrin repeat and SOCS box containing 12 (ASB12), mRNA. pcDNA3.1-C-(k)DYK or customized vector
in pcDNA3.1-C-(k)DYK 		$154.50-$216.30
$309.00
View Old Accession Versions >>
OHu17875 NM_130388.3 Homo sapiens ankyrin repeat and SOCS box containing 12 (ASB12), mRNA. pcDNA3.1-C-(k)DYK or customized vector
in pcDNA3.1-C-(k)DYK 		$154.50-$216.30
$309.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)


CloneID OHu17875
Clone ID Related Accession (Same CDS sequence) NM_130388.3 , NM_130388.4
Accession Version NM_130388.3 Documents for ORF clone product in default vector
Sequence Information ORF Nucleotide Sequence (Length: 957bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ™ Seamless cloning technology
Insert Structure linear
Update Date 2017-12-27
Organism Homo sapiens(human)
Product ankyrin repeat and SOCS box protein 12
Comment Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA560184.1, AK096896.1, BC069555.1 and AA349954.1. This sequence is a reference standard in the RefSeqGene project. On Jan 29, 2011 this sequence version replaced NM_130388.2. ##Evidence-Data-START## Transcript exon combination :: AK096896.1, ERR279827.7118.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2151741, SAMEA2154361 [ECO:0000348] ##Evidence-Data-END## 

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
ATGAGAATAG TTCTCCAATT AGCCAAGATG AACCTCATGG ACATCACCAA GATCTTCTCC 
CTCCTGCAGC CCGACAAGGA GGAGGAGGAC ACTGACACAG AGGAGAAGCA GGCTCTCAAT 
CAAGCAGTGT ATGACAACGA CTCCTATACT TTGGACCAGC TTTTGCGCCA GGAGCGTTAC 
AAACGTTTCA TCAACAGCAG GAGTGGCTGG GGTGTTCCTG GGACACCCTT GCGCTTGGCT 
GCTTCTTATG GCCACTTGAG CTGTTTGCAA GTCCTCTTAG CCCATGGTGC TGATGTTGAC 
AGCTTGGATG TCAAGGCACA GACGCCACTT TTCACTGCTG TCAGTCATGG CCATCTGGAC 
TGTGTACGTG TGCTTTTGGA AGCTGGTGCC TCTCCTGGTG GTAGCATCTA CAACAACTGT 
TCTCCCGTGC TCACAGCTGC CCGTGATGGT GCTGTTGCTA TCCTGCAGGA GCTCCTAGAC 
CATGGTGCAG AGGCCAACGT CAAAGCTAAA CTACCAGTCT GGGCATCAAA CATAGCTTCA 
TGTTCTGGCC CCCTCTATTT GGCCGCAGTC TACGGGCACC TGGACTGTTT CCGCCTGCTT 
TTGCTCCACG GGGCAGACCC TGACTACAAC TGCACTGACC AGGGCCTATT GGCTCGTGTC 
CCAAGACCCC GCACCCTCCT TGAAATCTGC CTCCATCATA ATTGTGAGCC AGAGTATATC 
CAGCTGTTAA TCGATTTTGG TGCTAATATC TACCTTCCAT CTCTCTCCCT TGACCTGACC 
TCACAAGATG ATAAAGGCAT TGCATTGCTG CTACAGGCCC GAGCCACTCC ACGGTCACTT 
CTATCACAGG TCCGTTTAGT CGTCCGCAGA GCCTTGTGCC AGGCTGGCCA GCCACAAGCC 
ATCAACCAGC TGGATATTCC TCCCATGTTG ATTAGCTACC TAAAACACCA ACTGTAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_569059.3
CDS194..1150
Translation

Target ORF information:

RefSeq Version NM_130388.3
Organism Homo sapiens(human)
Definition Homo sapiens ankyrin repeat and SOCS box containing 12 (ASB12), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
 NM_130388.3

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
ATGAGAATAG TTCTCCAATT AGCCAAGATG AACCTCATGG ACATCACCAA GATCTTCTCC 
CTCCTGCAGC CCGACAAGGA GGAGGAGGAC ACTGACACAG AGGAGAAGCA GGCTCTCAAT 
CAAGCAGTGT ATGACAACGA CTCCTATACT TTGGACCAGC TTTTGCGCCA GGAGCGTTAC 
AAACGTTTCA TCAACAGCAG GAGTGGCTGG GGTGTTCCTG GGACACCCTT GCGCTTGGCT 
GCTTCTTATG GCCACTTGAG CTGTTTGCAA GTCCTCTTAG CCCATGGTGC TGATGTTGAC 
AGCTTGGATG TCAAGGCACA GACGCCACTT TTCACTGCTG TCAGTCATGG CCATCTGGAC 
TGTGTACGTG TGCTTTTGGA AGCTGGTGCC TCTCCTGGTG GTAGCATCTA CAACAACTGT 
TCTCCCGTGC TCACAGCTGC CCGTGATGGT GCTGTTGCTA TCCTGCAGGA GCTCCTAGAC 
CATGGTGCAG AGGCCAACGT CAAAGCTAAA CTACCAGTCT GGGCATCAAA CATAGCTTCA 
TGTTCTGGCC CCCTCTATTT GGCCGCAGTC TACGGGCACC TGGACTGTTT CCGCCTGCTT 
TTGCTCCACG GGGCAGACCC TGACTACAAC TGCACTGACC AGGGCCTATT GGCTCGTGTC 
CCAAGACCCC GCACCCTCCT TGAAATCTGC CTCCATCATA ATTGTGAGCC AGAGTATATC 
CAGCTGTTAA TCGATTTTGG TGCTAATATC TACCTTCCAT CTCTCTCCCT TGACCTGACC 
TCACAAGATG ATAAAGGCAT TGCATTGCTG CTACAGGCCC GAGCCACTCC ACGGTCACTT 
CTATCACAGG TCCGTTTAGT CGTCCGCAGA GCCTTGTGCC AGGCTGGCCA GCCACAAGCC 
ATCAACCAGC TGGATATTCC TCCCATGTTG ATTAGCTACC TAAAACACCA ACTGTAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu17875
Clone ID Related Accession (Same CDS sequence) NM_130388.3 , NM_130388.4
Accession Version NM_130388.4 Latest version! Documents for ORF clone product in default vector
Sequence Information ORF Nucleotide Sequence (Length: 957bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ™ Seamless cloning technology
Insert Structure linear
Update Date 2019-09-26
Organism Homo sapiens(human)
Product ankyrin repeat and SOCS box protein 12
Comment Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK096896.1, BC069555.1 and AA349954.1. This sequence is a reference standard in the RefSeqGene project. On Nov 23, 2018 this sequence version replaced NM_130388.3. ##Evidence-Data-START## Transcript exon combination :: AK096896.1, SRR5189655.143303.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2151741, SAMEA2154361 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000362002.3/ ENSP00000355195.2 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length. 

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
ATGAGAATAG TTCTCCAATT AGCCAAGATG AACCTCATGG ACATCACCAA GATCTTCTCC 
CTCCTGCAGC CCGACAAGGA GGAGGAGGAC ACTGACACAG AGGAGAAGCA GGCTCTCAAT 
CAAGCAGTGT ATGACAACGA CTCCTATACT TTGGACCAGC TTTTGCGCCA GGAGCGTTAC 
AAACGTTTCA TCAACAGCAG GAGTGGCTGG GGTGTTCCTG GGACACCCTT GCGCTTGGCT 
GCTTCTTATG GCCACTTGAG CTGTTTGCAA GTCCTCTTAG CCCATGGTGC TGATGTTGAC 
AGCTTGGATG TCAAGGCACA GACGCCACTT TTCACTGCTG TCAGTCATGG CCATCTGGAC 
TGTGTACGTG TGCTTTTGGA AGCTGGTGCC TCTCCTGGTG GTAGCATCTA CAACAACTGT 
TCTCCCGTGC TCACAGCTGC CCGTGATGGT GCTGTTGCTA TCCTGCAGGA GCTCCTAGAC 
CATGGTGCAG AGGCCAACGT CAAAGCTAAA CTACCAGTCT GGGCATCAAA CATAGCTTCA 
TGTTCTGGCC CCCTCTATTT GGCCGCAGTC TACGGGCACC TGGACTGTTT CCGCCTGCTT 
TTGCTCCACG GGGCAGACCC TGACTACAAC TGCACTGACC AGGGCCTATT GGCTCGTGTC 
CCAAGACCCC GCACCCTCCT TGAAATCTGC CTCCATCATA ATTGTGAGCC AGAGTATATC 
CAGCTGTTAA TCGATTTTGG TGCTAATATC TACCTTCCAT CTCTCTCCCT TGACCTGACC 
TCACAAGATG ATAAAGGCAT TGCATTGCTG CTACAGGCCC GAGCCACTCC ACGGTCACTT 
CTATCACAGG TCCGTTTAGT CGTCCGCAGA GCCTTGTGCC AGGCTGGCCA GCCACAAGCC 
ATCAACCAGC TGGATATTCC TCCCATGTTG ATTAGCTACC TAAAACACCA ACTGTAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_569059.3
CDS170..1126
Translation

Target ORF information:

RefSeq Version NM_130388.4
Organism Homo sapiens(human)
Definition Homo sapiens ankyrin repeat and SOCS box containing 12 (ASB12), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
 NM_130388.4

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
ATGAGAATAG TTCTCCAATT AGCCAAGATG AACCTCATGG ACATCACCAA GATCTTCTCC 
CTCCTGCAGC CCGACAAGGA GGAGGAGGAC ACTGACACAG AGGAGAAGCA GGCTCTCAAT 
CAAGCAGTGT ATGACAACGA CTCCTATACT TTGGACCAGC TTTTGCGCCA GGAGCGTTAC 
AAACGTTTCA TCAACAGCAG GAGTGGCTGG GGTGTTCCTG GGACACCCTT GCGCTTGGCT 
GCTTCTTATG GCCACTTGAG CTGTTTGCAA GTCCTCTTAG CCCATGGTGC TGATGTTGAC 
AGCTTGGATG TCAAGGCACA GACGCCACTT TTCACTGCTG TCAGTCATGG CCATCTGGAC 
TGTGTACGTG TGCTTTTGGA AGCTGGTGCC TCTCCTGGTG GTAGCATCTA CAACAACTGT 
TCTCCCGTGC TCACAGCTGC CCGTGATGGT GCTGTTGCTA TCCTGCAGGA GCTCCTAGAC 
CATGGTGCAG AGGCCAACGT CAAAGCTAAA CTACCAGTCT GGGCATCAAA CATAGCTTCA 
TGTTCTGGCC CCCTCTATTT GGCCGCAGTC TACGGGCACC TGGACTGTTT CCGCCTGCTT 
TTGCTCCACG GGGCAGACCC TGACTACAAC TGCACTGACC AGGGCCTATT GGCTCGTGTC 
CCAAGACCCC GCACCCTCCT TGAAATCTGC CTCCATCATA ATTGTGAGCC AGAGTATATC 
CAGCTGTTAA TCGATTTTGG TGCTAATATC TACCTTCCAT CTCTCTCCCT TGACCTGACC 
TCACAAGATG ATAAAGGCAT TGCATTGCTG CTACAGGCCC GAGCCACTCC ACGGTCACTT 
CTATCACAGG TCCGTTTAGT CGTCCGCAGA GCCTTGTGCC AGGCTGGCCA GCCACAAGCC 
ATCAACCAGC TGGATATTCC TCCCATGTTG ATTAGCTACC TAAAACACCA ACTGTAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

PubMed

book

ASB proteins interact with Cullin5 and Rbx2 to form E3 ubiquitin ligase complexes.
FEBS letters579(30)6796-802(2005 Dec)
Kohroki J,Nishiyama T,Nakamura T,Masuho Y


book

The SOCS box: a tale of destruction and degradation.
Trends in biochemical sciences27(5)235-41(2002 May)
Kile BT,Schulman BA,Alexander WS,Nicola NA,Martin HM,Hilton DJ


book

Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence.
Nature377(6547 Suppl)3-174(1995 Sep)
Adams MD,Kerlavage AR,Fleischmann RD,Fuldner RA,Bult CJ,Lee NH,Kirkness EF,Weinstock KG,Gocayne JD,White O