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ELAVL1 cDNA ORF clone, Homo sapiens(Human)

Gene Symbol ELAVL1
Entrez Gene ID 1994
Full Name ELAV like RNA binding protein 1
Synonyms ELAV1,HUR,Hua,MelG
General protein information
Preferred Names

ELAV like RNA binding protein 1

Names

ELAV-like protein 1
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R)
Hu antigen R
embryonic lethal, abnormal vision, drosophila, homolog-like 1
hu-antigen R

Gene Type protein-coding
Organism Homo sapiens(Human)
Genome

19

19p13.2

Summary The protein encoded by this gene is a member of the ELAVL family of RNA-binding proteins that contain several RNA recognition motifs, and selectively bind AU-rich elements (AREs) found in the 3' untranslated regions of mRNAs. AREs signal degradation of mRNAs as a means to regulate gene expression, thus by binding AREs, the ELAVL family of proteins play a role in stabilizing ARE-containing mRNAs. This gene has been implicated in a variety of biological processes and has been linked to a number of diseases, including cancer. It is highly expressed in many cancers, and could be potentially useful in cancer diagnosis, prognosis, and therapy. [provided by RefSeq, Sep 2012].
Disorder MIM:

603466


mRNA and Protein(s)

mRNA Protein Name
NM_001419.2 NP_001410.2 ELAV-like protein 1



Gallus gallus (chicken) ELAVL1 NP_990164.1
Danio rerio (zebrafish) hug NP_570984.1
Canis lupus familiaris (dog) ELAVL1 XP_854218.1
Rattus norvegicus (Norway rat) Elavl1 NP_001102318.1
Xenopus tropicalis (tropical clawed frog) elavl1 NP_001005461.1
Homo sapiens (human) ELAVL1 NP_001410.2
Bos taurus (cattle) ELAVL1 NP_001069922.1
Macaca mulatta (rhesus monkey) ELAVL1 XP_001092907.2
Pan troglodytes (chimpanzee) ELAVL1 XP_001156587.2
Mus musculus (house mouse) Elavl1 NP_034615.2


Related articles in PubMed

HuR promotes the molecular signature and phenotype of activated microglia: Implications for amyotrophic lateral sclerosis and other neurodegenerative diseases.
Matsye P, Zheng L, Si Y, Kim S, Luo W, Crossman DK, Bratcher PE, King PH
Glia65(6)945-963(2017 Jun)

HuR in pheochromocytomas and paragangliomas - overexpression in verified malignant tumors.
Leijon H, Salmenkivi K, Heiskanen I, Hagström J, Louhimo J, Heikkilä P, Ristimäki A, Paavonen T, Metso S, Mäenpää H, Haglund C, Arola J
APMIS : acta pathologica, microbiologica, et immunologica Scandinavica124(9)757-63(2016 Sep)

Posttranscriptional regulation of 14-3-3ζ by RNA-binding protein HuR modulating intestinal epithelial restitution after wounding.
Hansraj NZ, Xiao L, Wu J, Chen G, Turner DJ, Wang JY, Rao JN
Physiological reports4(13)(2016 Jul)

Folate receptor-targeted nanoparticle delivery of HuR-RNAi suppresses lung cancer cell proliferation and migration.
Muralidharan R, Babu A, Amreddy N, Basalingappa K, Mehta M, Chen A, Zhao YD, Kompella UB, Munshi A, Ramesh R
Journal of nanobiotechnology14(1)47(2016 Jun)

A Feed-Forward Regulatory Loop between HuR and the Long Noncoding RNA HOTAIR Promotes Head and Neck Squamous Cell Carcinoma Progression and Metastasis.
Xu CZ, Jiang C, Wu Q, Liu L, Yan X, Shi R
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology40(5)1039-1051(2016)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Results show that HuR is a key regulator of many genes that make up the molecular signature of activated microglia, including increased production of proinflammatory cytokines, chemokines, and migration-associated factors
Title: HuR promotes the molecular signature and phenotype of activated microglia: Implications for amyotrophic lateral sclerosis and other neurodegenerative diseases.

Sensitization of colon carcinoma cells to radiation-induced cell death and DNA-damage by HuR knockdown critically depends on caspase-2.
Title: Silencing of the mRNA-binding protein HuR increases the sensitivity of colorectal cancer cells to ionizing radiation through upregulation of caspase-2.

results suggest that lnc-Sox5, which was stabilized by HuR, could regulate carcinogenesis of tongue cancer and may serve as a predicted target for tongue carcinoma therapies
Title: HuR Stabilizes lnc-Sox5 mRNA to Promote Tongue Carcinogenesis.

These results suggest that the post-transcriptional regulation of ATX expression by HuR and AUF1 modulates cancer cell migration.
Title: Autotaxin Expression Is Regulated at the Post-transcriptional Level by the RNA-binding Proteins HuR and AUF1.

the existence of a regulatory loop in which the expression of HOTAIR and HuR is reciprocally and temporally regulated during the metastasis and progression of head and neck squamous cell carcinoma, is reported.
Title: A Feed-Forward Regulatory Loop between HuR and the Long Noncoding RNA HOTAIR Promotes Head and Neck Squamous Cell Carcinoma Progression and Metastasis.

The following ELAVL1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the ELAVL1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID RefSeq Accession Definition **Vector *Turnaround time Price (USD) Select
OHu23723 NM_001419.2
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Homo sapiens ELAV like RNA binding protein 1 (ELAVL1), mRNA. pcDNA3.1+/C-(K)DYK or customized vector
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$309.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.


CloneID OHu23723
Clone ID Related Accession (Same CDS sequence) NM_001419.2
Accession Version NM_001419.2 Latest version! Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 981bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 2017-05-07
Organism Homo sapiens(Human)
Product ELAV-like protein 1
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BU542524.1, BC003376.2, W37464.1, AI375368.1, AL713686.1, AW139417.1, BM696191.1 and BM664469.1. On Nov 7, 2003 this sequence version replaced NM_001419.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1163655.172621.1, SRR1163655.276325.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01820689 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
ATGTCTAATG GTTATGAAGA CCACATGGCC GAAGACTGCA GGGGTGACAT CGGGAGAACG 
AATTTGATCG TCAACTACCT CCCTCAGAAC ATGACCCAGG ATGAGTTACG AAGCCTGTTC
AGCAGCATTG GTGAAGTTGA ATCTGCAAAA CTTATTCGGG ATAAAGTAGC AGGACACAGC
TTGGGCTATG GCTTTGTGAA CTACGTGACC GCGAAGGATG CAGAGAGAGC GATCAACACG
CTGAACGGCT TGAGGCTCCA GTCAAAAACC ATTAAGGTGT CGTATGCTCG CCCGAGCTCA
GAGGTGATCA AAGACGCCAA CTTGTACATC AGCGGGCTCC CGCGGACCAT GACCCAGAAG
GACGTAGAAG ACATGTTCTC TCGGTTTGGG CGGATCATCA ACTCGCGGGT CCTCGTGGAT
CAGACTACAG GTTTGTCCAG AGGGGTTGCG TTTATCCGGT TTGACAAACG GTCGGAGGCA
GAAGAGGCAA TTACCAGTTT CAATGGTCAT AAACCCCCAG GTTCCTCTGA GCCCATCACA
GTGAAGTTTG CAGCCAACCC CAACCAGAAC AAAAACGTGG CACTCCTCTC GCAGCTGTAC
CACTCGCCAG CGCGACGGTT CGGAGGCCCC GTTCACCACC AGGCGCAGAG ATTCAGGTTC
TCCCCCATGG GCGTCGATCA CATGAGCGGG CTCTCTGGCG TCAACGTGCC AGGAAACGCC
TCCTCCGGCT GGTGCATTTT CATCTACAAC CTGGGGCAGG ATGCCGACGA GGGGATCCTC
TGGCAGATGT TTGGGCCGTT TGGTGCCGTC ACCAATGTGA AAGTGATCCG CGACTTCAAC
ACCAACAAGT GCAAAGGGTT TGGCTTTGTG ACCATGACAA ACTATGAAGA AGCCGCGATG
GCCATAGCCA GCCTGAACGG CTACCGCCTG GGGGACAAAA TCTTACAGGT TTCCTTCAAA
ACCAACAAGT CCCACAAATA A

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_001410.2
CDS168..1148
Misc Feature(1)171..173
Misc Feature(2)171..173
Misc Feature(3)222..1145
Misc Feature(4)222..455
Misc Feature(5)order(228..230,234..236,240..245,252..254,315..317,321..323,345..350,354..356,360..362,432..437,441..443,453..455)
Misc Feature(6)465..467
Misc Feature(7)483..734
Misc Feature(8)order(486..488,492..494,564..569,573..575,579..581,606..608,618..620,624..626,711..713,717..722)
Misc Feature(9)639..641
Misc Feature(10)756..758
Misc Feature(11)756..758
Misc Feature(12)765..767
Misc Feature(13)765..767
Misc Feature(14)771..773
Misc Feature(15)771..773
Misc Feature(16)783..785
Misc Feature(17)816..818
Misc Feature(18)816..818
Misc Feature(19)828..830
Misc Feature(20)894..1145
Misc Feature(21)1119..1121
Exon (1)1..151
Exon (2)152..339
Exon (3)340..443
Exon (4)444..597
Exon (5)598..823
Exon (6)824..6058
Translation

Target ORF information:

RefSeq Version NM_001419.2
Organism Homo sapiens(Human)
Definition Homo sapiens ELAV like RNA binding protein 1 (ELAVL1), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_001419.2

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
ATGTCTAATG GTTATGAAGA CCACATGGCC GAAGACTGCA GGGGTGACAT CGGGAGAACG 
AATTTGATCG TCAACTACCT CCCTCAGAAC ATGACCCAGG ATGAGTTACG AAGCCTGTTC
AGCAGCATTG GTGAAGTTGA ATCTGCAAAA CTTATTCGGG ATAAAGTAGC AGGACACAGC
TTGGGCTATG GCTTTGTGAA CTACGTGACC GCGAAGGATG CAGAGAGAGC GATCAACACG
CTGAACGGCT TGAGGCTCCA GTCAAAAACC ATTAAGGTGT CGTATGCTCG CCCGAGCTCA
GAGGTGATCA AAGACGCCAA CTTGTACATC AGCGGGCTCC CGCGGACCAT GACCCAGAAG
GACGTAGAAG ACATGTTCTC TCGGTTTGGG CGGATCATCA ACTCGCGGGT CCTCGTGGAT
CAGACTACAG GTTTGTCCAG AGGGGTTGCG TTTATCCGGT TTGACAAACG GTCGGAGGCA
GAAGAGGCAA TTACCAGTTT CAATGGTCAT AAACCCCCAG GTTCCTCTGA GCCCATCACA
GTGAAGTTTG CAGCCAACCC CAACCAGAAC AAAAACGTGG CACTCCTCTC GCAGCTGTAC
CACTCGCCAG CGCGACGGTT CGGAGGCCCC GTTCACCACC AGGCGCAGAG ATTCAGGTTC
TCCCCCATGG GCGTCGATCA CATGAGCGGG CTCTCTGGCG TCAACGTGCC AGGAAACGCC
TCCTCCGGCT GGTGCATTTT CATCTACAAC CTGGGGCAGG ATGCCGACGA GGGGATCCTC
TGGCAGATGT TTGGGCCGTT TGGTGCCGTC ACCAATGTGA AAGTGATCCG CGACTTCAAC
ACCAACAAGT GCAAAGGGTT TGGCTTTGTG ACCATGACAA ACTATGAAGA AGCCGCGATG
GCCATAGCCA GCCTGAACGG CTACCGCCTG GGGGACAAAA TCTTACAGGT TTCCTTCAAA
ACCAACAAGT CCCACAAATA A

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

book

HuR promotes the molecular signature and phenotype of activated microglia: Implications for amyotrophic lateral sclerosis and other neurodegenerative diseases.
Glia65(6)945-963(2017 Jun)
Matsye P,Zheng L,Si Y,Kim S,Luo W,Crossman DK,Bratcher PE,King PH


book

HuR in pheochromocytomas and paragangliomas - overexpression in verified malignant tumors.
APMIS : acta pathologica, microbiologica, et immunologica Scandinavica124(9)757-63(2016 Sep)
Leijon H,Salmenkivi K,Heiskanen I,Hagström J,Louhimo J,Heikkilä P,Ristimäki A,Paavonen T,Metso S,Mäenpää H,Haglund C,Arola J


book

Posttranscriptional regulation of 14-3-3ζ by RNA-binding protein HuR modulating intestinal epithelial restitution after wounding.
Physiological reports4(13)(2016 Jul)
Hansraj NZ,Xiao L,Wu J,Chen G,Turner DJ,Wang JY,Rao JN


book

Folate receptor-targeted nanoparticle delivery of HuR-RNAi suppresses lung cancer cell proliferation and migration.
Journal of nanobiotechnology14(1)47(2016 Jun)
Muralidharan R,Babu A,Amreddy N,Basalingappa K,Mehta M,Chen A,Zhao YD,Kompella UB,Munshi A,Ramesh R


book

A Feed-Forward Regulatory Loop between HuR and the Long Noncoding RNA HOTAIR Promotes Head and Neck Squamous Cell Carcinoma Progression and Metastasis.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology40(5)1039-1051(2016)
Xu CZ,Jiang C,Wu Q,Liu L,Yan X,Shi R


 
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