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ERBB2 cDNA ORF clone, Homo sapiens (human)

Gene Symbol ERBB2
Entrez Gene ID 2064
Full Name erb-b2 receptor tyrosine kinase 2
Synonyms CD340, HER-2, HER-2/neu, HER2, MLN 19, NEU, NGL, TKR1
General protein information
Preferred Names
receptor tyrosine-protein kinase erbB-2
Names
receptor tyrosine-protein kinase erbB-2
herstatin
p185erbB2
proto-oncogene Neu
c-erb B2/neu protein
proto-oncogene c-ErbB-2
metastatic lymph node gene 19 protein
neuro/glioblastoma derived oncogene homolog
tyrosine kinase-type cell surface receptor HER2
neuroblastoma/glioblastoma derived oncogene homolog
v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog
NP_001005862.1
NP_004439.2
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

17

17q12

Summary This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized. [provided by RefSeq, Jul 2008]. lac of sum
Disorder MIM:

164870

Disorder Html: Adenocarcinoma of lung, somatic, 211980 (3); Glioblastoma, somatic,

mRNA and Protein(s)

mRNA Protein Name
NM_001289937 NP_001276866 receptor tyrosine-protein kinase erbB-2 isoform d precursor
NM_004448 NP_004439 receptor tyrosine-protein kinase erbB-2 isoform a precursor
NM_001005862 NP_001005862 receptor tyrosine-protein kinase erbB-2 isoform b
NM_001289938 NP_001276867 receptor tyrosine-protein kinase erbB-2 isoform e
NM_001289936 NP_001276865 receptor tyrosine-protein kinase erbB-2 isoform c



Homo sapiens (human) ERBB2 NP_004439.2
Pan troglodytes (chimpanzee) ERBB2 XP_003315512.2
Macaca mulatta (Rhesus monkey) ERBB2 XP_001090430.1
Canis lupus familiaris (dog) ERBB2 NP_001003217.1
Bos taurus (cattle) ERBB2 XP_003587474.1
Mus musculus (house mouse) Erbb2 NP_001003817.1
Rattus norvegicus (Norway rat) Erbb2 NP_058699.2
Gallus gallus (chicken) ERBB2 NP_001038126.1
Danio rerio (zebrafish) erbb2 NP_956413.2
Xenopus (Silurana) tropicalis (western clawed frog) erbb2 XP_002940420.2


GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following ERBB2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the ERBB2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID RefSeq Accession Definition **Vector *Turnaround time Price (USD) Select
OHu24035 NM_001289937 Homo sapiens erb-b2 receptor tyrosine kinase 2 (ERBB2), transcript variant 4, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 20 $559.30
$799.00
OHu27656
NM_004448 Homo sapiens erb-b2 receptor tyrosine kinase 2 (ERBB2), transcript variant 1, mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$634.50-$888.30
$1269.00
OHu27580
NM_001005862 Homo sapiens erb-b2 receptor tyrosine kinase 2 (ERBB2), transcript variant 2, mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$619.50-$867.30
$1239.00
OHu27526 NM_001289938 Homo sapiens erb-b2 receptor tyrosine kinase 2 (ERBB2), transcript variant 5, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 5-7 $307.30
$439.00
OHu23956 NM_001289936 Homo sapiens erb-b2 receptor tyrosine kinase 2 (ERBB2), transcript variant 3, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 20 $643.30
$919.00
Next-day Shipping ORF Clones ( in default vector with tag)
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2-4 Clone 40% OFF
5 or more Clone 50% OFF
All Other ORF Clones
30% OFF

*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.


CloneID OHu24035
Clone ID Related Accession (Same CDS sequence) NM_001289937
Accession Version NM_001289937.1 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 3168bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 13-MAY-2015
Organism Homo sapiens (human)
Product receptor tyrosine-protein kinase erbB-2 isoform d precursor
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DC346286.1, AK313683.1, BC080193.1 and BM678576.1. Transcript Variant: This variant (4) lacks an exon in the 3' coding region, which results in a translational frameshift, compared to variant 1. The resulting isoform (d) has a distinct and shorter C-terminus, compared to isoform a. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK313683.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2145245, SAMEA2147596 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## regulatory uORF :: PMID: 10446211 ##RefSeq-Attributes-END##

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
1741
1801
1861
1921
1981
2041
2101
2161
2221
2281
2341
2401
2461
2521
2581
2641
2701
2761
2821
2881
2941
3001
3061
3121
ATGGAGCTGG CGGCCTTGTG CCGCTGGGGG CTCCTCCTCG CCCTCTTGCC CCCCGGAGCC 
GCGAGCACCC AAGTGTGCAC CGGCACAGAC ATGAAGCTGC GGCTCCCTGC CAGTCCCGAG
ACCCACCTGG ACATGCTCCG CCACCTCTAC CAGGGCTGCC AGGTGGTGCA GGGAAACCTG
GAACTCACCT ACCTGCCCAC CAATGCCAGC CTGTCCTTCC TGCAGGATAT CCAGGAGGTG
CAGGGCTACG TGCTCATCGC TCACAACCAA GTGAGGCAGG TCCCACTGCA GAGGCTGCGG
ATTGTGCGAG GCACCCAGCT CTTTGAGGAC AACTATGCCC TGGCCGTGCT AGACAATGGA
GACCCGCTGA ACAATACCAC CCCTGTCACA GGGGCCTCCC CAGGAGGCCT GCGGGAGCTG
CAGCTTCGAA GCCTCACAGA GATCTTGAAA GGAGGGGTCT TGATCCAGCG GAACCCCCAG
CTCTGCTACC AGGACACGAT TTTGTGGAAG GACATCTTCC ACAAGAACAA CCAGCTGGCT
CTCACACTGA TAGACACCAA CCGCTCTCGG GCCTGCCACC CCTGTTCTCC GATGTGTAAG
GGCTCCCGCT GCTGGGGAGA GAGTTCTGAG GATTGTCAGA GCCTGACGCG CACTGTCTGT
GCCGGTGGCT GTGCCCGCTG CAAGGGGCCA CTGCCCACTG ACTGCTGCCA TGAGCAGTGT
GCTGCCGGCT GCACGGGCCC CAAGCACTCT GACTGCCTGG CCTGCCTCCA CTTCAACCAC
AGTGGCATCT GTGAGCTGCA CTGCCCAGCC CTGGTCACCT ACAACACAGA CACGTTTGAG
TCCATGCCCA ATCCCGAGGG CCGGTATACA TTCGGCGCCA GCTGTGTGAC TGCCTGTCCC
TACAACTACC TTTCTACGGA CGTGGGATCC TGCACCCTCG TCTGCCCCCT GCACAACCAA
GAGGTGACAG CAGAGGATGG AACACAGCGG TGTGAGAAGT GCAGCAAGCC CTGTGCCCGA
GTGTGCTATG GTCTGGGCAT GGAGCACTTG CGAGAGGTGA GGGCAGTTAC CAGTGCCAAT
ATCCAGGAGT TTGCTGGCTG CAAGAAGATC TTTGGGAGCC TGGCATTTCT GCCGGAGAGC
TTTGATGGGG ACCCAGCCTC CAACACTGCC CCGCTCCAGC CAGAGCAGCT CCAAGTGTTT
GAGACTCTGG AAGAGATCAC AGGTTACCTA TACATCTCAG CATGGCCGGA CAGCCTGCCT
GACCTCAGCG TCTTCCAGAA CCTGCAAGTA ATCCGGGGAC GAATTCTGCA CAATGGCGCC
TACTCGCTGA CCCTGCAAGG GCTGGGCATC AGCTGGCTGG GGCTGCGCTC ACTGAGGGAA
CTGGGCAGTG GACTGGCCCT CATCCACCAT AACACCCACC TCTGCTTCGT GCACACGGTG
CCCTGGGACC AGCTCTTTCG GAACCCGCAC CAAGCTCTGC TCCACACTGC CAACCGGCCA
GAGGACGAGT GTGTGGGCGA GGGCCTGGCC TGCCACCAGC TGTGCGCCCG AGGGCACTGC
TGGGGTCCAG GGCCCACCCA GTGTGTCAAC TGCAGCCAGT TCCTTCGGGG CCAGGAGTGC
GTGGAGGAAT GCCGAGTACT GCAGGGGCTC CCCAGGGAGT ATGTGAATGC CAGGCACTGT
TTGCCGTGCC ACCCTGAGTG TCAGCCCCAG AATGGCTCAG TGACCTGTTT TGGACCGGAG
GCTGACCAGT GTGTGGCCTG TGCCCACTAT AAGGACCCTC CCTTCTGCGT GGCCCGCTGC
CCCAGCGGTG TGAAACCTGA CCTCTCCTAC ATGCCCATCT GGAAGTTTCC AGATGAGGAG
GGCGCATGCC AGCCTTGCCC CATCAACTGC ACCCACTCCT GTGTGGACCT GGATGACAAG
GGCTGCCCCG CCGAGCAGAG AGCCAGCCCT CTGACGTCCA TCATCTCTGC GGTGGTTGGC
ATTCTGCTGG TCGTGGTCTT GGGGGTGGTC TTTGGGATCC TCATCAAGCG ACGGCAGCAG
AAGATCCGGA AGTACACGAT GCGGAGACTG CTGCAGGAAA CGGAGCTGGT GGAGCCGCTG
ACACCTAGCG GAGCGATGCC CAACCAGGCG CAGATGCGGA TCCTGAAAGA GACGGAGCTG
AGGAAGGTGA AGGTGCTTGG ATCTGGCGCT TTTGGCACAG TCTACAAGGG CATCTGGATC
CCTGATGGGG AGAATGTGAA AATTCCAGTG GCCATCAAAG TGTTGAGGGA AAACACATCC
CCCAAAGCCA ACAAAGAAAT CTTAGACGAA GCATACGTGA TGGCTGGTGT GGGCTCCCCA
TATGTCTCCC GCCTTCTGGG CATCTGCCTG ACATCCACGG TGCAGCTGGT GACACAGCTT
ATGCCCTATG GCTGCCTCTT AGACCATGTC CGGGAAAACC GCGGACGCCT GGGCTCCCAG
GACCTGCTGA ACTGGTGTAT GCAGATTGCC AAGGGGATGA GCTACCTGGA GGATGTGCGG
CTCGTACACA GGGACTTGGC CGCTCGGAAC GTGCTGGTCA AGAGTCCCAA CCATGTCAAA
ATTACAGACT TCGGGCTGGC TCGGCTGCTG GACATTGACG AGACAGAGTA CCATGCAGAT
GGGGGCAAGG TGCCCATCAA GTGGATGGCG CTGGAGTCCA TTCTCCGCCG GCGGTTCACC
CACCAGAGTG ATGTGTGGAG TTATGGTGTG ACTGTGTGGG AGCTGATGAC TTTTGGGGCC
AAACCTTACG ATGGGATCCC AGCCCGGGAG ATCCCTGACC TGCTGGAAAA GGGGGAGCGG
CTGCCCCAGC CCCCCATCTG CACCATTGAT GTCTACATGA TCATGGTCAA ATGTTGGATG
ATTGACTCTG AATGTCGGCC AAGATTCCGG GAGTTGGTGT CTGAATTCTC CCGCATGGCC
AGGGACCCCC AGCGCTTTGT GGTCATCCAG AATGAGGACT TGGGCCCAGC CAGTCCCTTG
GACAGCACCT TCTACCGCTC ACTGCTGGAG GACGATGACA TGGGGGACCT GGTGGATGCT
GAGGAGTATC TGGTACCCCA GCAGGGCTTC TTCTGTCCAG ACCCTGCCCC GGGCGCTGGG
GGCATGGTCC ACCACAGGCA CCGCAGCTCA TCTACCAGGA ATATGTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_001276866.1
CDS262..3429
Misc Feature(1)236..256(+)
Misc Feature(2)415..780(+)
Misc Feature(3)826..1290(+)
Misc Feature(4)964..1101(+)
Misc Feature(5)1357..1719(+)
Misc Feature(6)1789..>1893(+)
Misc Feature(7)1792..2190(+)
Misc Feature(8)1945..2082(+)
Misc Feature(9)2182..2313(+)
Misc Feature(10)2188..2262(+)
Misc Feature(11)2191..2274(+)
Misc Feature(12)2218..2286(+)
Misc Feature(13)2287..2328(+)
Misc Feature(14)2287..2328(+)
Misc Feature(15)2395..3231(+)
Misc Feature(16)2419..3189(+)
Misc Feature(17)2437..2952(+)
Misc Feature(18)2437..2850(+)
Misc Feature(19)2845..2922(+)
Misc Feature(20)2911..2952(+)
Misc Feature(21)3421..3423(+)
Exon (1)1..334
Gene:ERBB2
Gene Synonym:
Exon (2)335..486
Gene:ERBB2
Gene Synonym:
Exon (3)487..700
Gene:ERBB2
Gene Synonym:
Exon (4)701..835
Gene:ERBB2
Gene Synonym:
Exon (5)836..904
Gene:ERBB2
Gene Synonym:
Exon (6)905..1020
Gene:ERBB2
Gene Synonym:
Exon (7)1021..1162
Gene:ERBB2
Gene Synonym:
Exon (8)1163..1282
Gene:ERBB2
Gene Synonym:
Exon (9)1283..1409
Gene:ERBB2
Gene Synonym:
Exon (10)1410..1483
Gene:ERBB2
Gene Synonym:
Exon (11)1484..1574
Gene:ERBB2
Gene Synonym:
Exon (12)1575..1774
Gene:ERBB2
Gene Synonym:
Exon (13)1775..1907
Gene:ERBB2
Gene Synonym:
Exon (14)1908..1998
Gene:ERBB2
Gene Synonym:
Exon (15)1999..2159
Gene:ERBB2
Gene Synonym:
Exon (16)2160..2207
Gene:ERBB2
Gene Synonym:
Exon (17)2208..2346
Gene:ERBB2
Gene Synonym:
Exon (18)2347..2469
Gene:ERBB2
Gene Synonym:
Exon (19)2470..2568
Gene:ERBB2
Gene Synonym:
Exon (20)2569..2754
Gene:ERBB2
Gene Synonym:
Exon (21)2755..2910
Gene:ERBB2
Gene Synonym:
Exon (22)2911..2986
Gene:ERBB2
Gene Synonym:
Exon (23)2987..3133
Gene:ERBB2
Gene Synonym:
Exon (24)3134..3231
Gene:ERBB2
Gene Synonym:
Exon (25)3232..3420
Gene:ERBB2
Gene Synonym:
Exon (26)3421..4394
Gene:ERBB2
Gene Synonym:
Translation

Target ORF information:

RefSeq Version NM_001289937
Organism Homo sapiens (human)
Definition Homo sapiens erb-b2 receptor tyrosine kinase 2 (ERBB2), transcript variant 4, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_001289937

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
1741
1801
1861
1921
1981
2041
2101
2161
2221
2281
2341
2401
2461
2521
2581
2641
2701
2761
2821
2881
2941
3001
3061
3121
ATGGAGCTGG CGGCCTTGTG CCGCTGGGGG CTCCTCCTCG CCCTCTTGCC CCCCGGAGCC 
GCGAGCACCC AAGTGTGCAC CGGCACAGAC ATGAAGCTGC GGCTCCCTGC CAGTCCCGAG
ACCCACCTGG ACATGCTCCG CCACCTCTAC CAGGGCTGCC AGGTGGTGCA GGGAAACCTG
GAACTCACCT ACCTGCCCAC CAATGCCAGC CTGTCCTTCC TGCAGGATAT CCAGGAGGTG
CAGGGCTACG TGCTCATCGC TCACAACCAA GTGAGGCAGG TCCCACTGCA GAGGCTGCGG
ATTGTGCGAG GCACCCAGCT CTTTGAGGAC AACTATGCCC TGGCCGTGCT AGACAATGGA
GACCCGCTGA ACAATACCAC CCCTGTCACA GGGGCCTCCC CAGGAGGCCT GCGGGAGCTG
CAGCTTCGAA GCCTCACAGA GATCTTGAAA GGAGGGGTCT TGATCCAGCG GAACCCCCAG
CTCTGCTACC AGGACACGAT TTTGTGGAAG GACATCTTCC ACAAGAACAA CCAGCTGGCT
CTCACACTGA TAGACACCAA CCGCTCTCGG GCCTGCCACC CCTGTTCTCC GATGTGTAAG
GGCTCCCGCT GCTGGGGAGA GAGTTCTGAG GATTGTCAGA GCCTGACGCG CACTGTCTGT
GCCGGTGGCT GTGCCCGCTG CAAGGGGCCA CTGCCCACTG ACTGCTGCCA TGAGCAGTGT
GCTGCCGGCT GCACGGGCCC CAAGCACTCT GACTGCCTGG CCTGCCTCCA CTTCAACCAC
AGTGGCATCT GTGAGCTGCA CTGCCCAGCC CTGGTCACCT ACAACACAGA CACGTTTGAG
TCCATGCCCA ATCCCGAGGG CCGGTATACA TTCGGCGCCA GCTGTGTGAC TGCCTGTCCC
TACAACTACC TTTCTACGGA CGTGGGATCC TGCACCCTCG TCTGCCCCCT GCACAACCAA
GAGGTGACAG CAGAGGATGG AACACAGCGG TGTGAGAAGT GCAGCAAGCC CTGTGCCCGA
GTGTGCTATG GTCTGGGCAT GGAGCACTTG CGAGAGGTGA GGGCAGTTAC CAGTGCCAAT
ATCCAGGAGT TTGCTGGCTG CAAGAAGATC TTTGGGAGCC TGGCATTTCT GCCGGAGAGC
TTTGATGGGG ACCCAGCCTC CAACACTGCC CCGCTCCAGC CAGAGCAGCT CCAAGTGTTT
GAGACTCTGG AAGAGATCAC AGGTTACCTA TACATCTCAG CATGGCCGGA CAGCCTGCCT
GACCTCAGCG TCTTCCAGAA CCTGCAAGTA ATCCGGGGAC GAATTCTGCA CAATGGCGCC
TACTCGCTGA CCCTGCAAGG GCTGGGCATC AGCTGGCTGG GGCTGCGCTC ACTGAGGGAA
CTGGGCAGTG GACTGGCCCT CATCCACCAT AACACCCACC TCTGCTTCGT GCACACGGTG
CCCTGGGACC AGCTCTTTCG GAACCCGCAC CAAGCTCTGC TCCACACTGC CAACCGGCCA
GAGGACGAGT GTGTGGGCGA GGGCCTGGCC TGCCACCAGC TGTGCGCCCG AGGGCACTGC
TGGGGTCCAG GGCCCACCCA GTGTGTCAAC TGCAGCCAGT TCCTTCGGGG CCAGGAGTGC
GTGGAGGAAT GCCGAGTACT GCAGGGGCTC CCCAGGGAGT ATGTGAATGC CAGGCACTGT
TTGCCGTGCC ACCCTGAGTG TCAGCCCCAG AATGGCTCAG TGACCTGTTT TGGACCGGAG
GCTGACCAGT GTGTGGCCTG TGCCCACTAT AAGGACCCTC CCTTCTGCGT GGCCCGCTGC
CCCAGCGGTG TGAAACCTGA CCTCTCCTAC ATGCCCATCT GGAAGTTTCC AGATGAGGAG
GGCGCATGCC AGCCTTGCCC CATCAACTGC ACCCACTCCT GTGTGGACCT GGATGACAAG
GGCTGCCCCG CCGAGCAGAG AGCCAGCCCT CTGACGTCCA TCATCTCTGC GGTGGTTGGC
ATTCTGCTGG TCGTGGTCTT GGGGGTGGTC TTTGGGATCC TCATCAAGCG ACGGCAGCAG
AAGATCCGGA AGTACACGAT GCGGAGACTG CTGCAGGAAA CGGAGCTGGT GGAGCCGCTG
ACACCTAGCG GAGCGATGCC CAACCAGGCG CAGATGCGGA TCCTGAAAGA GACGGAGCTG
AGGAAGGTGA AGGTGCTTGG ATCTGGCGCT TTTGGCACAG TCTACAAGGG CATCTGGATC
CCTGATGGGG AGAATGTGAA AATTCCAGTG GCCATCAAAG TGTTGAGGGA AAACACATCC
CCCAAAGCCA ACAAAGAAAT CTTAGACGAA GCATACGTGA TGGCTGGTGT GGGCTCCCCA
TATGTCTCCC GCCTTCTGGG CATCTGCCTG ACATCCACGG TGCAGCTGGT GACACAGCTT
ATGCCCTATG GCTGCCTCTT AGACCATGTC CGGGAAAACC GCGGACGCCT GGGCTCCCAG
GACCTGCTGA ACTGGTGTAT GCAGATTGCC AAGGGGATGA GCTACCTGGA GGATGTGCGG
CTCGTACACA GGGACTTGGC CGCTCGGAAC GTGCTGGTCA AGAGTCCCAA CCATGTCAAA
ATTACAGACT TCGGGCTGGC TCGGCTGCTG GACATTGACG AGACAGAGTA CCATGCAGAT
GGGGGCAAGG TGCCCATCAA GTGGATGGCG CTGGAGTCCA TTCTCCGCCG GCGGTTCACC
CACCAGAGTG ATGTGTGGAG TTATGGTGTG ACTGTGTGGG AGCTGATGAC TTTTGGGGCC
AAACCTTACG ATGGGATCCC AGCCCGGGAG ATCCCTGACC TGCTGGAAAA GGGGGAGCGG
CTGCCCCAGC CCCCCATCTG CACCATTGAT GTCTACATGA TCATGGTCAA ATGTTGGATG
ATTGACTCTG AATGTCGGCC AAGATTCCGG GAGTTGGTGT CTGAATTCTC CCGCATGGCC
AGGGACCCCC AGCGCTTTGT GGTCATCCAG AATGAGGACT TGGGCCCAGC CAGTCCCTTG
GACAGCACCT TCTACCGCTC ACTGCTGGAG GACGATGACA TGGGGGACCT GGTGGATGCT
GAGGAGTATC TGGTACCCCA GCAGGGCTTC TTCTGTCCAG ACCCTGCCCC GGGCGCTGGG
GGCATGGTCC ACCACAGGCA CCGCAGCTCA TCTACCAGGA ATATGTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu27656
Clone ID Related Accession (Same CDS sequence) NM_004448
Accession Version NM_004448.3 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 3768bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 15-MAY-2015
Organism Homo sapiens (human)
Product receptor tyrosine-protein kinase erbB-2 isoform a precursor
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DC346286.1, X03363.1 and BM678576.1. This sequence is a reference standard in the RefSeqGene project. On Feb 11, 2014 this sequence version replaced gi:54792095. Transcript Variant: This variant (1) encodes the longest isoform (a). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: M11730.1, X03363.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## regulatory uORF :: PMID: 10446211 ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
1741
1801
1861
1921
1981
2041
2101
2161
2221
2281
2341
2401
2461
2521
2581
2641
2701
2761
2821
2881
2941
3001
3061
3121
3181
3241
3301
3361
3421
3481
3541
3601
3661
3721
ATGGAGCTGG CGGCCTTGTG CCGCTGGGGG CTCCTCCTCG CCCTCTTGCC CCCCGGAGCC 
GCGAGCACCC AAGTGTGCAC CGGCACAGAC ATGAAGCTGC GGCTCCCTGC CAGTCCCGAG
ACCCACCTGG ACATGCTCCG CCACCTCTAC CAGGGCTGCC AGGTGGTGCA GGGAAACCTG
GAACTCACCT ACCTGCCCAC CAATGCCAGC CTGTCCTTCC TGCAGGATAT CCAGGAGGTG
CAGGGCTACG TGCTCATCGC TCACAACCAA GTGAGGCAGG TCCCACTGCA GAGGCTGCGG
ATTGTGCGAG GCACCCAGCT CTTTGAGGAC AACTATGCCC TGGCCGTGCT AGACAATGGA
GACCCGCTGA ACAATACCAC CCCTGTCACA GGGGCCTCCC CAGGAGGCCT GCGGGAGCTG
CAGCTTCGAA GCCTCACAGA GATCTTGAAA GGAGGGGTCT TGATCCAGCG GAACCCCCAG
CTCTGCTACC AGGACACGAT TTTGTGGAAG GACATCTTCC ACAAGAACAA CCAGCTGGCT
CTCACACTGA TAGACACCAA CCGCTCTCGG GCCTGCCACC CCTGTTCTCC GATGTGTAAG
GGCTCCCGCT GCTGGGGAGA GAGTTCTGAG GATTGTCAGA GCCTGACGCG CACTGTCTGT
GCCGGTGGCT GTGCCCGCTG CAAGGGGCCA CTGCCCACTG ACTGCTGCCA TGAGCAGTGT
GCTGCCGGCT GCACGGGCCC CAAGCACTCT GACTGCCTGG CCTGCCTCCA CTTCAACCAC
AGTGGCATCT GTGAGCTGCA CTGCCCAGCC CTGGTCACCT ACAACACAGA CACGTTTGAG
TCCATGCCCA ATCCCGAGGG CCGGTATACA TTCGGCGCCA GCTGTGTGAC TGCCTGTCCC
TACAACTACC TTTCTACGGA CGTGGGATCC TGCACCCTCG TCTGCCCCCT GCACAACCAA
GAGGTGACAG CAGAGGATGG AACACAGCGG TGTGAGAAGT GCAGCAAGCC CTGTGCCCGA
GTGTGCTATG GTCTGGGCAT GGAGCACTTG CGAGAGGTGA GGGCAGTTAC CAGTGCCAAT
ATCCAGGAGT TTGCTGGCTG CAAGAAGATC TTTGGGAGCC TGGCATTTCT GCCGGAGAGC
TTTGATGGGG ACCCAGCCTC CAACACTGCC CCGCTCCAGC CAGAGCAGCT CCAAGTGTTT
GAGACTCTGG AAGAGATCAC AGGTTACCTA TACATCTCAG CATGGCCGGA CAGCCTGCCT
GACCTCAGCG TCTTCCAGAA CCTGCAAGTA ATCCGGGGAC GAATTCTGCA CAATGGCGCC
TACTCGCTGA CCCTGCAAGG GCTGGGCATC AGCTGGCTGG GGCTGCGCTC ACTGAGGGAA
CTGGGCAGTG GACTGGCCCT CATCCACCAT AACACCCACC TCTGCTTCGT GCACACGGTG
CCCTGGGACC AGCTCTTTCG GAACCCGCAC CAAGCTCTGC TCCACACTGC CAACCGGCCA
GAGGACGAGT GTGTGGGCGA GGGCCTGGCC TGCCACCAGC TGTGCGCCCG AGGGCACTGC
TGGGGTCCAG GGCCCACCCA GTGTGTCAAC TGCAGCCAGT TCCTTCGGGG CCAGGAGTGC
GTGGAGGAAT GCCGAGTACT GCAGGGGCTC CCCAGGGAGT ATGTGAATGC CAGGCACTGT
TTGCCGTGCC ACCCTGAGTG TCAGCCCCAG AATGGCTCAG TGACCTGTTT TGGACCGGAG
GCTGACCAGT GTGTGGCCTG TGCCCACTAT AAGGACCCTC CCTTCTGCGT GGCCCGCTGC
CCCAGCGGTG TGAAACCTGA CCTCTCCTAC ATGCCCATCT GGAAGTTTCC AGATGAGGAG
GGCGCATGCC AGCCTTGCCC CATCAACTGC ACCCACTCCT GTGTGGACCT GGATGACAAG
GGCTGCCCCG CCGAGCAGAG AGCCAGCCCT CTGACGTCCA TCATCTCTGC GGTGGTTGGC
ATTCTGCTGG TCGTGGTCTT GGGGGTGGTC TTTGGGATCC TCATCAAGCG ACGGCAGCAG
AAGATCCGGA AGTACACGAT GCGGAGACTG CTGCAGGAAA CGGAGCTGGT GGAGCCGCTG
ACACCTAGCG GAGCGATGCC CAACCAGGCG CAGATGCGGA TCCTGAAAGA GACGGAGCTG
AGGAAGGTGA AGGTGCTTGG ATCTGGCGCT TTTGGCACAG TCTACAAGGG CATCTGGATC
CCTGATGGGG AGAATGTGAA AATTCCAGTG GCCATCAAAG TGTTGAGGGA AAACACATCC
CCCAAAGCCA ACAAAGAAAT CTTAGACGAA GCATACGTGA TGGCTGGTGT GGGCTCCCCA
TATGTCTCCC GCCTTCTGGG CATCTGCCTG ACATCCACGG TGCAGCTGGT GACACAGCTT
ATGCCCTATG GCTGCCTCTT AGACCATGTC CGGGAAAACC GCGGACGCCT GGGCTCCCAG
GACCTGCTGA ACTGGTGTAT GCAGATTGCC AAGGGGATGA GCTACCTGGA GGATGTGCGG
CTCGTACACA GGGACTTGGC CGCTCGGAAC GTGCTGGTCA AGAGTCCCAA CCATGTCAAA
ATTACAGACT TCGGGCTGGC TCGGCTGCTG GACATTGACG AGACAGAGTA CCATGCAGAT
GGGGGCAAGG TGCCCATCAA GTGGATGGCG CTGGAGTCCA TTCTCCGCCG GCGGTTCACC
CACCAGAGTG ATGTGTGGAG TTATGGTGTG ACTGTGTGGG AGCTGATGAC TTTTGGGGCC
AAACCTTACG ATGGGATCCC AGCCCGGGAG ATCCCTGACC TGCTGGAAAA GGGGGAGCGG
CTGCCCCAGC CCCCCATCTG CACCATTGAT GTCTACATGA TCATGGTCAA ATGTTGGATG
ATTGACTCTG AATGTCGGCC AAGATTCCGG GAGTTGGTGT CTGAATTCTC CCGCATGGCC
AGGGACCCCC AGCGCTTTGT GGTCATCCAG AATGAGGACT TGGGCCCAGC CAGTCCCTTG
GACAGCACCT TCTACCGCTC ACTGCTGGAG GACGATGACA TGGGGGACCT GGTGGATGCT
GAGGAGTATC TGGTACCCCA GCAGGGCTTC TTCTGTCCAG ACCCTGCCCC GGGCGCTGGG
GGCATGGTCC ACCACAGGCA CCGCAGCTCA TCTACCAGGA GTGGCGGTGG GGACCTGACA
CTAGGGCTGG AGCCCTCTGA AGAGGAGGCC CCCAGGTCTC CACTGGCACC CTCCGAAGGG
GCTGGCTCCG ATGTATTTGA TGGTGACCTG GGAATGGGGG CAGCCAAGGG GCTGCAAAGC
CTCCCCACAC ATGACCCCAG CCCTCTACAG CGGTACAGTG AGGACCCCAC AGTACCCCTG
CCCTCTGAGA CTGATGGCTA CGTTGCCCCC CTGACCTGCA GCCCCCAGCC TGAATATGTG
AACCAGCCAG ATGTTCGGCC CCAGCCCCCT TCGCCCCGAG AGGGCCCTCT GCCTGCTGCC
CGACCTGCTG GTGCCACTCT GGAAAGGCCC AAGACTCTCT CCCCAGGGAA GAATGGGGTC
GTCAAAGACG TTTTTGCCTT TGGGGGTGCC GTGGAGAACC CCGAGTACTT GACACCCCAG
GGAGGAGCTG CCCCTCAGCC CCACCCTCCT CCTGCCTTCA GCCCAGCCTT CGACAACCTC
TATTACTGGG ACCAGGACCC ACCAGAGCGG GGGGCTCCAC CCAGCACCTT CAAAGGGACA
CCTACGGCAG AGAACCCAGA GTACCTGGGT CTGGACGTGC CAGTGTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_004439.2
CDS262..4029
Misc Feature(1)236..256(+)
Misc Feature(2)415..780(+)
Misc Feature(3)826..1290(+)
Misc Feature(4)964..1101(+)
Misc Feature(5)1357..1719(+)
Misc Feature(6)1789..>1893(+)
Misc Feature(7)1792..2190(+)
Misc Feature(8)1945..2082(+)
Misc Feature(9)2182..2313(+)
Misc Feature(10)2188..2262(+)
Misc Feature(11)2191..2274(+)
Misc Feature(12)2218..2286(+)
Misc Feature(13)2287..2328(+)
Misc Feature(14)2287..2328(+)
Misc Feature(15)2395..3231(+)
Misc Feature(16)2419..3189(+)
Misc Feature(17)2437..2952(+)
Misc Feature(18)2437..2850(+)
Misc Feature(19)2464..2466(+)
Misc Feature(20)2845..2922(+)
Misc Feature(21)2890..2892(+)
Misc Feature(22)2911..2952(+)
Misc Feature(23)3028..3030(+)
Misc Feature(24)3274..3276(+)
Misc Feature(25)3328..3330(+)
Misc Feature(26)3421..3423(+)
Misc Feature(27)3580..3582(+)
Misc Feature(28)3676..3678(+)
Misc Feature(29)3676..3678(+)
Misc Feature(30)3712..3714(+)
Misc Feature(31)3844..3852(+)
Misc Feature(32)3847..3849(+)
Misc Feature(33)3847..3849(+)
Misc Feature(34)3922..3924(+)
Misc Feature(35)3925..3927(+)
Misc Feature(36)4003..4005(+)
Misc Feature(37)4003..4005(+)
Misc Feature(38)4003..4005(+)
Misc Feature(39)4003..4005(+)
Misc Feature(40)4003..4005(+)
Exon (1)1..334
Gene:ERBB2
Gene Synonym:
Exon (2)335..486
Gene:ERBB2
Gene Synonym:
Exon (3)487..700
Gene:ERBB2
Gene Synonym:
Exon (4)701..835
Gene:ERBB2
Gene Synonym:
Exon (5)836..904
Gene:ERBB2
Gene Synonym:
Exon (6)905..1020
Gene:ERBB2
Gene Synonym:
Exon (7)1021..1162
Gene:ERBB2
Gene Synonym:
Exon (8)1163..1282
Gene:ERBB2
Gene Synonym:
Exon (9)1283..1409
Gene:ERBB2
Gene Synonym:
Exon (10)1410..1483
Gene:ERBB2
Gene Synonym:
Exon (11)1484..1574
Gene:ERBB2
Gene Synonym:
Exon (12)1575..1774
Gene:ERBB2
Gene Synonym:
Exon (13)1775..1907
Gene:ERBB2
Gene Synonym:
Exon (14)1908..1998
Gene:ERBB2
Gene Synonym:
Exon (15)1999..2159
Gene:ERBB2
Gene Synonym:
Exon (16)2160..2207
Gene:ERBB2
Gene Synonym:
Exon (17)2208..2346
Gene:ERBB2
Gene Synonym:
Exon (18)2347..2469
Gene:ERBB2
Gene Synonym:
Exon (19)2470..2568
Gene:ERBB2
Gene Synonym:
Exon (20)2569..2754
Gene:ERBB2
Gene Synonym:
Exon (21)2755..2910
Gene:ERBB2
Gene Synonym:
Exon (22)2911..2986
Gene:ERBB2
Gene Synonym:
Exon (23)2987..3133
Gene:ERBB2
Gene Synonym:
Exon (24)3134..3231
Gene:ERBB2
Gene Synonym:
Exon (25)3232..3420
Gene:ERBB2
Gene Synonym:
Exon (26)3421..3673
Gene:ERBB2
Gene Synonym:
Exon (27)3674..4647
Gene:ERBB2
Gene Synonym:
Translation

Target ORF information:

RefSeq Version NM_004448
Organism Homo sapiens (human)
Definition Homo sapiens erb-b2 receptor tyrosine kinase 2 (ERBB2), transcript variant 1, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_004448

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
1741
1801
1861
1921
1981
2041
2101
2161
2221
2281
2341
2401
2461
2521
2581
2641
2701
2761
2821
2881
2941
3001
3061
3121
3181
3241
3301
3361
3421
3481
3541
3601
3661
3721
ATGGAGCTGG CGGCCTTGTG CCGCTGGGGG CTCCTCCTCG CCCTCTTGCC CCCCGGAGCC 
GCGAGCACCC AAGTGTGCAC CGGCACAGAC ATGAAGCTGC GGCTCCCTGC CAGTCCCGAG
ACCCACCTGG ACATGCTCCG CCACCTCTAC CAGGGCTGCC AGGTGGTGCA GGGAAACCTG
GAACTCACCT ACCTGCCCAC CAATGCCAGC CTGTCCTTCC TGCAGGATAT CCAGGAGGTG
CAGGGCTACG TGCTCATCGC TCACAACCAA GTGAGGCAGG TCCCACTGCA GAGGCTGCGG
ATTGTGCGAG GCACCCAGCT CTTTGAGGAC AACTATGCCC TGGCCGTGCT AGACAATGGA
GACCCGCTGA ACAATACCAC CCCTGTCACA GGGGCCTCCC CAGGAGGCCT GCGGGAGCTG
CAGCTTCGAA GCCTCACAGA GATCTTGAAA GGAGGGGTCT TGATCCAGCG GAACCCCCAG
CTCTGCTACC AGGACACGAT TTTGTGGAAG GACATCTTCC ACAAGAACAA CCAGCTGGCT
CTCACACTGA TAGACACCAA CCGCTCTCGG GCCTGCCACC CCTGTTCTCC GATGTGTAAG
GGCTCCCGCT GCTGGGGAGA GAGTTCTGAG GATTGTCAGA GCCTGACGCG CACTGTCTGT
GCCGGTGGCT GTGCCCGCTG CAAGGGGCCA CTGCCCACTG ACTGCTGCCA TGAGCAGTGT
GCTGCCGGCT GCACGGGCCC CAAGCACTCT GACTGCCTGG CCTGCCTCCA CTTCAACCAC
AGTGGCATCT GTGAGCTGCA CTGCCCAGCC CTGGTCACCT ACAACACAGA CACGTTTGAG
TCCATGCCCA ATCCCGAGGG CCGGTATACA TTCGGCGCCA GCTGTGTGAC TGCCTGTCCC
TACAACTACC TTTCTACGGA CGTGGGATCC TGCACCCTCG TCTGCCCCCT GCACAACCAA
GAGGTGACAG CAGAGGATGG AACACAGCGG TGTGAGAAGT GCAGCAAGCC CTGTGCCCGA
GTGTGCTATG GTCTGGGCAT GGAGCACTTG CGAGAGGTGA GGGCAGTTAC CAGTGCCAAT
ATCCAGGAGT TTGCTGGCTG CAAGAAGATC TTTGGGAGCC TGGCATTTCT GCCGGAGAGC
TTTGATGGGG ACCCAGCCTC CAACACTGCC CCGCTCCAGC CAGAGCAGCT CCAAGTGTTT
GAGACTCTGG AAGAGATCAC AGGTTACCTA TACATCTCAG CATGGCCGGA CAGCCTGCCT
GACCTCAGCG TCTTCCAGAA CCTGCAAGTA ATCCGGGGAC GAATTCTGCA CAATGGCGCC
TACTCGCTGA CCCTGCAAGG GCTGGGCATC AGCTGGCTGG GGCTGCGCTC ACTGAGGGAA
CTGGGCAGTG GACTGGCCCT CATCCACCAT AACACCCACC TCTGCTTCGT GCACACGGTG
CCCTGGGACC AGCTCTTTCG GAACCCGCAC CAAGCTCTGC TCCACACTGC CAACCGGCCA
GAGGACGAGT GTGTGGGCGA GGGCCTGGCC TGCCACCAGC TGTGCGCCCG AGGGCACTGC
TGGGGTCCAG GGCCCACCCA GTGTGTCAAC TGCAGCCAGT TCCTTCGGGG CCAGGAGTGC
GTGGAGGAAT GCCGAGTACT GCAGGGGCTC CCCAGGGAGT ATGTGAATGC CAGGCACTGT
TTGCCGTGCC ACCCTGAGTG TCAGCCCCAG AATGGCTCAG TGACCTGTTT TGGACCGGAG
GCTGACCAGT GTGTGGCCTG TGCCCACTAT AAGGACCCTC CCTTCTGCGT GGCCCGCTGC
CCCAGCGGTG TGAAACCTGA CCTCTCCTAC ATGCCCATCT GGAAGTTTCC AGATGAGGAG
GGCGCATGCC AGCCTTGCCC CATCAACTGC ACCCACTCCT GTGTGGACCT GGATGACAAG
GGCTGCCCCG CCGAGCAGAG AGCCAGCCCT CTGACGTCCA TCATCTCTGC GGTGGTTGGC
ATTCTGCTGG TCGTGGTCTT GGGGGTGGTC TTTGGGATCC TCATCAAGCG ACGGCAGCAG
AAGATCCGGA AGTACACGAT GCGGAGACTG CTGCAGGAAA CGGAGCTGGT GGAGCCGCTG
ACACCTAGCG GAGCGATGCC CAACCAGGCG CAGATGCGGA TCCTGAAAGA GACGGAGCTG
AGGAAGGTGA AGGTGCTTGG ATCTGGCGCT TTTGGCACAG TCTACAAGGG CATCTGGATC
CCTGATGGGG AGAATGTGAA AATTCCAGTG GCCATCAAAG TGTTGAGGGA AAACACATCC
CCCAAAGCCA ACAAAGAAAT CTTAGACGAA GCATACGTGA TGGCTGGTGT GGGCTCCCCA
TATGTCTCCC GCCTTCTGGG CATCTGCCTG ACATCCACGG TGCAGCTGGT GACACAGCTT
ATGCCCTATG GCTGCCTCTT AGACCATGTC CGGGAAAACC GCGGACGCCT GGGCTCCCAG
GACCTGCTGA ACTGGTGTAT GCAGATTGCC AAGGGGATGA GCTACCTGGA GGATGTGCGG
CTCGTACACA GGGACTTGGC CGCTCGGAAC GTGCTGGTCA AGAGTCCCAA CCATGTCAAA
ATTACAGACT TCGGGCTGGC TCGGCTGCTG GACATTGACG AGACAGAGTA CCATGCAGAT
GGGGGCAAGG TGCCCATCAA GTGGATGGCG CTGGAGTCCA TTCTCCGCCG GCGGTTCACC
CACCAGAGTG ATGTGTGGAG TTATGGTGTG ACTGTGTGGG AGCTGATGAC TTTTGGGGCC
AAACCTTACG ATGGGATCCC AGCCCGGGAG ATCCCTGACC TGCTGGAAAA GGGGGAGCGG
CTGCCCCAGC CCCCCATCTG CACCATTGAT GTCTACATGA TCATGGTCAA ATGTTGGATG
ATTGACTCTG AATGTCGGCC AAGATTCCGG GAGTTGGTGT CTGAATTCTC CCGCATGGCC
AGGGACCCCC AGCGCTTTGT GGTCATCCAG AATGAGGACT TGGGCCCAGC CAGTCCCTTG
GACAGCACCT TCTACCGCTC ACTGCTGGAG GACGATGACA TGGGGGACCT GGTGGATGCT
GAGGAGTATC TGGTACCCCA GCAGGGCTTC TTCTGTCCAG ACCCTGCCCC GGGCGCTGGG
GGCATGGTCC ACCACAGGCA CCGCAGCTCA TCTACCAGGA GTGGCGGTGG GGACCTGACA
CTAGGGCTGG AGCCCTCTGA AGAGGAGGCC CCCAGGTCTC CACTGGCACC CTCCGAAGGG
GCTGGCTCCG ATGTATTTGA TGGTGACCTG GGAATGGGGG CAGCCAAGGG GCTGCAAAGC
CTCCCCACAC ATGACCCCAG CCCTCTACAG CGGTACAGTG AGGACCCCAC AGTACCCCTG
CCCTCTGAGA CTGATGGCTA CGTTGCCCCC CTGACCTGCA GCCCCCAGCC TGAATATGTG
AACCAGCCAG ATGTTCGGCC CCAGCCCCCT TCGCCCCGAG AGGGCCCTCT GCCTGCTGCC
CGACCTGCTG GTGCCACTCT GGAAAGGCCC AAGACTCTCT CCCCAGGGAA GAATGGGGTC
GTCAAAGACG TTTTTGCCTT TGGGGGTGCC GTGGAGAACC CCGAGTACTT GACACCCCAG
GGAGGAGCTG CCCCTCAGCC CCACCCTCCT CCTGCCTTCA GCCCAGCCTT CGACAACCTC
TATTACTGGG ACCAGGACCC ACCAGAGCGG GGGGCTCCAC CCAGCACCTT CAAAGGGACA
CCTACGGCAG AGAACCCAGA GTACCTGGGT CTGGACGTGC CAGTGTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu27580
Clone ID Related Accession (Same CDS sequence) NM_001005862
Accession Version NM_001005862.2 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 3678bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 15-MAY-2015
Organism Homo sapiens (human)
Product receptor tyrosine-protein kinase erbB-2 isoform b
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK295195.1, BC110392.1, BC080193.1 and BM678576.1. This sequence is a reference standard in the RefSeqGene project. On Feb 11, 2014 this sequence version replaced gi:54792097. Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The resulting isoform (b) has a shorter N-terminus, compared to isoform a. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
1741
1801
1861
1921
1981
2041
2101
2161
2221
2281
2341
2401
2461
2521
2581
2641
2701
2761
2821
2881
2941
3001
3061
3121
3181
3241
3301
3361
3421
3481
3541
3601
3661
ATGAAGCTGC GGCTCCCTGC CAGTCCCGAG ACCCACCTGG ACATGCTCCG CCACCTCTAC 
CAGGGCTGCC AGGTGGTGCA GGGAAACCTG GAACTCACCT ACCTGCCCAC CAATGCCAGC
CTGTCCTTCC TGCAGGATAT CCAGGAGGTG CAGGGCTACG TGCTCATCGC TCACAACCAA
GTGAGGCAGG TCCCACTGCA GAGGCTGCGG ATTGTGCGAG GCACCCAGCT CTTTGAGGAC
AACTATGCCC TGGCCGTGCT AGACAATGGA GACCCGCTGA ACAATACCAC CCCTGTCACA
GGGGCCTCCC CAGGAGGCCT GCGGGAGCTG CAGCTTCGAA GCCTCACAGA GATCTTGAAA
GGAGGGGTCT TGATCCAGCG GAACCCCCAG CTCTGCTACC AGGACACGAT TTTGTGGAAG
GACATCTTCC ACAAGAACAA CCAGCTGGCT CTCACACTGA TAGACACCAA CCGCTCTCGG
GCCTGCCACC CCTGTTCTCC GATGTGTAAG GGCTCCCGCT GCTGGGGAGA GAGTTCTGAG
GATTGTCAGA GCCTGACGCG CACTGTCTGT GCCGGTGGCT GTGCCCGCTG CAAGGGGCCA
CTGCCCACTG ACTGCTGCCA TGAGCAGTGT GCTGCCGGCT GCACGGGCCC CAAGCACTCT
GACTGCCTGG CCTGCCTCCA CTTCAACCAC AGTGGCATCT GTGAGCTGCA CTGCCCAGCC
CTGGTCACCT ACAACACAGA CACGTTTGAG TCCATGCCCA ATCCCGAGGG CCGGTATACA
TTCGGCGCCA GCTGTGTGAC TGCCTGTCCC TACAACTACC TTTCTACGGA CGTGGGATCC
TGCACCCTCG TCTGCCCCCT GCACAACCAA GAGGTGACAG CAGAGGATGG AACACAGCGG
TGTGAGAAGT GCAGCAAGCC CTGTGCCCGA GTGTGCTATG GTCTGGGCAT GGAGCACTTG
CGAGAGGTGA GGGCAGTTAC CAGTGCCAAT ATCCAGGAGT TTGCTGGCTG CAAGAAGATC
TTTGGGAGCC TGGCATTTCT GCCGGAGAGC TTTGATGGGG ACCCAGCCTC CAACACTGCC
CCGCTCCAGC CAGAGCAGCT CCAAGTGTTT GAGACTCTGG AAGAGATCAC AGGTTACCTA
TACATCTCAG CATGGCCGGA CAGCCTGCCT GACCTCAGCG TCTTCCAGAA CCTGCAAGTA
ATCCGGGGAC GAATTCTGCA CAATGGCGCC TACTCGCTGA CCCTGCAAGG GCTGGGCATC
AGCTGGCTGG GGCTGCGCTC ACTGAGGGAA CTGGGCAGTG GACTGGCCCT CATCCACCAT
AACACCCACC TCTGCTTCGT GCACACGGTG CCCTGGGACC AGCTCTTTCG GAACCCGCAC
CAAGCTCTGC TCCACACTGC CAACCGGCCA GAGGACGAGT GTGTGGGCGA GGGCCTGGCC
TGCCACCAGC TGTGCGCCCG AGGGCACTGC TGGGGTCCAG GGCCCACCCA GTGTGTCAAC
TGCAGCCAGT TCCTTCGGGG CCAGGAGTGC GTGGAGGAAT GCCGAGTACT GCAGGGGCTC
CCCAGGGAGT ATGTGAATGC CAGGCACTGT TTGCCGTGCC ACCCTGAGTG TCAGCCCCAG
AATGGCTCAG TGACCTGTTT TGGACCGGAG GCTGACCAGT GTGTGGCCTG TGCCCACTAT
AAGGACCCTC CCTTCTGCGT GGCCCGCTGC CCCAGCGGTG TGAAACCTGA CCTCTCCTAC
ATGCCCATCT GGAAGTTTCC AGATGAGGAG GGCGCATGCC AGCCTTGCCC CATCAACTGC
ACCCACTCCT GTGTGGACCT GGATGACAAG GGCTGCCCCG CCGAGCAGAG AGCCAGCCCT
CTGACGTCCA TCATCTCTGC GGTGGTTGGC ATTCTGCTGG TCGTGGTCTT GGGGGTGGTC
TTTGGGATCC TCATCAAGCG ACGGCAGCAG AAGATCCGGA AGTACACGAT GCGGAGACTG
CTGCAGGAAA CGGAGCTGGT GGAGCCGCTG ACACCTAGCG GAGCGATGCC CAACCAGGCG
CAGATGCGGA TCCTGAAAGA GACGGAGCTG AGGAAGGTGA AGGTGCTTGG ATCTGGCGCT
TTTGGCACAG TCTACAAGGG CATCTGGATC CCTGATGGGG AGAATGTGAA AATTCCAGTG
GCCATCAAAG TGTTGAGGGA AAACACATCC CCCAAAGCCA ACAAAGAAAT CTTAGACGAA
GCATACGTGA TGGCTGGTGT GGGCTCCCCA TATGTCTCCC GCCTTCTGGG CATCTGCCTG
ACATCCACGG TGCAGCTGGT GACACAGCTT ATGCCCTATG GCTGCCTCTT AGACCATGTC
CGGGAAAACC GCGGACGCCT GGGCTCCCAG GACCTGCTGA ACTGGTGTAT GCAGATTGCC
AAGGGGATGA GCTACCTGGA GGATGTGCGG CTCGTACACA GGGACTTGGC CGCTCGGAAC
GTGCTGGTCA AGAGTCCCAA CCATGTCAAA ATTACAGACT TCGGGCTGGC TCGGCTGCTG
GACATTGACG AGACAGAGTA CCATGCAGAT GGGGGCAAGG TGCCCATCAA GTGGATGGCG
CTGGAGTCCA TTCTCCGCCG GCGGTTCACC CACCAGAGTG ATGTGTGGAG TTATGGTGTG
ACTGTGTGGG AGCTGATGAC TTTTGGGGCC AAACCTTACG ATGGGATCCC AGCCCGGGAG
ATCCCTGACC TGCTGGAAAA GGGGGAGCGG CTGCCCCAGC CCCCCATCTG CACCATTGAT
GTCTACATGA TCATGGTCAA ATGTTGGATG ATTGACTCTG AATGTCGGCC AAGATTCCGG
GAGTTGGTGT CTGAATTCTC CCGCATGGCC AGGGACCCCC AGCGCTTTGT GGTCATCCAG
AATGAGGACT TGGGCCCAGC CAGTCCCTTG GACAGCACCT TCTACCGCTC ACTGCTGGAG
GACGATGACA TGGGGGACCT GGTGGATGCT GAGGAGTATC TGGTACCCCA GCAGGGCTTC
TTCTGTCCAG ACCCTGCCCC GGGCGCTGGG GGCATGGTCC ACCACAGGCA CCGCAGCTCA
TCTACCAGGA GTGGCGGTGG GGACCTGACA CTAGGGCTGG AGCCCTCTGA AGAGGAGGCC
CCCAGGTCTC CACTGGCACC CTCCGAAGGG GCTGGCTCCG ATGTATTTGA TGGTGACCTG
GGAATGGGGG CAGCCAAGGG GCTGCAAAGC CTCCCCACAC ATGACCCCAG CCCTCTACAG
CGGTACAGTG AGGACCCCAC AGTACCCCTG CCCTCTGAGA CTGATGGCTA CGTTGCCCCC
CTGACCTGCA GCCCCCAGCC TGAATATGTG AACCAGCCAG ATGTTCGGCC CCAGCCCCCT
TCGCCCCGAG AGGGCCCTCT GCCTGCTGCC CGACCTGCTG GTGCCACTCT GGAAAGGCCC
AAGACTCTCT CCCCAGGGAA GAATGGGGTC GTCAAAGACG TTTTTGCCTT TGGGGGTGCC
GTGGAGAACC CCGAGTACTT GACACCCCAG GGAGGAGCTG CCCCTCAGCC CCACCCTCCT
CCTGCCTTCA GCCCAGCCTT CGACAACCTC TATTACTGGG ACCAGGACCC ACCAGAGCGG
GGGGCTCCAC CCAGCACCTT CAAAGGGACA CCTACGGCAG AGAACCCAGA GTACCTGGGT
CTGGACGTGC CAGTGTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_001005862.1
CDS577..4254
Misc Feature(1)556..558(+)
Misc Feature(2)640..1005(+)
Misc Feature(3)1051..1515(+)
Misc Feature(4)1189..1326(+)
Misc Feature(5)1582..1944(+)
Misc Feature(6)2014..>2118(+)
Misc Feature(7)2017..2415(+)
Misc Feature(8)2170..2307(+)
Misc Feature(9)2407..2538(+)
Misc Feature(10)2413..2487(+)
Misc Feature(11)2416..2499(+)
Misc Feature(12)2620..3456(+)
Misc Feature(13)2644..3414(+)
Misc Feature(14)2662..3177(+)
Misc Feature(15)2662..3075(+)
Misc Feature(16)3070..3147(+)
Misc Feature(17)3136..3177(+)
Misc Feature(18)3553..3555(+)
Misc Feature(19)3901..3903(+)
Misc Feature(20)4072..4074(+)
Misc Feature(21)4147..4149(+)
Misc Feature(22)4150..4152(+)
Misc Feature(23)4228..4230(+)
Misc Feature(24)4228..4230(+)
Misc Feature(25)4228..4230(+)
Exon (1)1..195
Gene:ERBB2
Gene Synonym:
Exon (2)196..300
Gene:ERBB2
Gene Synonym:
Exon (3)301..365
Gene:ERBB2
Gene Synonym:
Exon (4)366..559
Gene:ERBB2
Gene Synonym:
Exon (5)560..711
Gene:ERBB2
Gene Synonym:
Exon (6)712..925
Gene:ERBB2
Gene Synonym:
Exon (7)926..1060
Gene:ERBB2
Gene Synonym:
Exon (8)1061..1129
Gene:ERBB2
Gene Synonym:
Exon (9)1130..1245
Gene:ERBB2
Gene Synonym:
Exon (10)1246..1387
Gene:ERBB2
Gene Synonym:
Exon (11)1388..1507
Gene:ERBB2
Gene Synonym:
Exon (12)1508..1634
Gene:ERBB2
Gene Synonym:
Exon (13)1635..1708
Gene:ERBB2
Gene Synonym:
Exon (14)1709..1799
Gene:ERBB2
Gene Synonym:
Exon (15)1800..1999
Gene:ERBB2
Gene Synonym:
Exon (16)2000..2132
Gene:ERBB2
Gene Synonym:
Exon (17)2133..2223
Gene:ERBB2
Gene Synonym:
Exon (18)2224..2384
Gene:ERBB2
Gene Synonym:
Exon (19)2385..2432
Gene:ERBB2
Gene Synonym:
Exon (20)2433..2571
Gene:ERBB2
Gene Synonym:
Exon (21)2572..2694
Gene:ERBB2
Gene Synonym:
Exon (22)2695..2793
Gene:ERBB2
Gene Synonym:
Exon (23)2794..2979
Gene:ERBB2
Gene Synonym:
Exon (24)2980..3135
Gene:ERBB2
Gene Synonym:
Exon (25)3136..3211
Gene:ERBB2
Gene Synonym:
Exon (26)3212..3358
Gene:ERBB2
Gene Synonym:
Exon (27)3359..3456
Gene:ERBB2
Gene Synonym:
Exon (28)3457..3645
Gene:ERBB2
Gene Synonym:
Exon (29)3646..3898
Gene:ERBB2
Gene Synonym:
Exon (30)3899..4872
Gene:ERBB2
Gene Synonym:
Translation

Target ORF information:

RefSeq Version NM_001005862
Organism Homo sapiens (human)
Definition Homo sapiens erb-b2 receptor tyrosine kinase 2 (ERBB2), transcript variant 2, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_001005862

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
1741
1801
1861
1921
1981
2041
2101
2161
2221
2281
2341
2401
2461
2521
2581
2641
2701
2761
2821
2881
2941
3001
3061
3121
3181
3241
3301
3361
3421
3481
3541
3601
3661
ATGAAGCTGC GGCTCCCTGC CAGTCCCGAG ACCCACCTGG ACATGCTCCG CCACCTCTAC 
CAGGGCTGCC AGGTGGTGCA GGGAAACCTG GAACTCACCT ACCTGCCCAC CAATGCCAGC
CTGTCCTTCC TGCAGGATAT CCAGGAGGTG CAGGGCTACG TGCTCATCGC TCACAACCAA
GTGAGGCAGG TCCCACTGCA GAGGCTGCGG ATTGTGCGAG GCACCCAGCT CTTTGAGGAC
AACTATGCCC TGGCCGTGCT AGACAATGGA GACCCGCTGA ACAATACCAC CCCTGTCACA
GGGGCCTCCC CAGGAGGCCT GCGGGAGCTG CAGCTTCGAA GCCTCACAGA GATCTTGAAA
GGAGGGGTCT TGATCCAGCG GAACCCCCAG CTCTGCTACC AGGACACGAT TTTGTGGAAG
GACATCTTCC ACAAGAACAA CCAGCTGGCT CTCACACTGA TAGACACCAA CCGCTCTCGG
GCCTGCCACC CCTGTTCTCC GATGTGTAAG GGCTCCCGCT GCTGGGGAGA GAGTTCTGAG
GATTGTCAGA GCCTGACGCG CACTGTCTGT GCCGGTGGCT GTGCCCGCTG CAAGGGGCCA
CTGCCCACTG ACTGCTGCCA TGAGCAGTGT GCTGCCGGCT GCACGGGCCC CAAGCACTCT
GACTGCCTGG CCTGCCTCCA CTTCAACCAC AGTGGCATCT GTGAGCTGCA CTGCCCAGCC
CTGGTCACCT ACAACACAGA CACGTTTGAG TCCATGCCCA ATCCCGAGGG CCGGTATACA
TTCGGCGCCA GCTGTGTGAC TGCCTGTCCC TACAACTACC TTTCTACGGA CGTGGGATCC
TGCACCCTCG TCTGCCCCCT GCACAACCAA GAGGTGACAG CAGAGGATGG AACACAGCGG
TGTGAGAAGT GCAGCAAGCC CTGTGCCCGA GTGTGCTATG GTCTGGGCAT GGAGCACTTG
CGAGAGGTGA GGGCAGTTAC CAGTGCCAAT ATCCAGGAGT TTGCTGGCTG CAAGAAGATC
TTTGGGAGCC TGGCATTTCT GCCGGAGAGC TTTGATGGGG ACCCAGCCTC CAACACTGCC
CCGCTCCAGC CAGAGCAGCT CCAAGTGTTT GAGACTCTGG AAGAGATCAC AGGTTACCTA
TACATCTCAG CATGGCCGGA CAGCCTGCCT GACCTCAGCG TCTTCCAGAA CCTGCAAGTA
ATCCGGGGAC GAATTCTGCA CAATGGCGCC TACTCGCTGA CCCTGCAAGG GCTGGGCATC
AGCTGGCTGG GGCTGCGCTC ACTGAGGGAA CTGGGCAGTG GACTGGCCCT CATCCACCAT
AACACCCACC TCTGCTTCGT GCACACGGTG CCCTGGGACC AGCTCTTTCG GAACCCGCAC
CAAGCTCTGC TCCACACTGC CAACCGGCCA GAGGACGAGT GTGTGGGCGA GGGCCTGGCC
TGCCACCAGC TGTGCGCCCG AGGGCACTGC TGGGGTCCAG GGCCCACCCA GTGTGTCAAC
TGCAGCCAGT TCCTTCGGGG CCAGGAGTGC GTGGAGGAAT GCCGAGTACT GCAGGGGCTC
CCCAGGGAGT ATGTGAATGC CAGGCACTGT TTGCCGTGCC ACCCTGAGTG TCAGCCCCAG
AATGGCTCAG TGACCTGTTT TGGACCGGAG GCTGACCAGT GTGTGGCCTG TGCCCACTAT
AAGGACCCTC CCTTCTGCGT GGCCCGCTGC CCCAGCGGTG TGAAACCTGA CCTCTCCTAC
ATGCCCATCT GGAAGTTTCC AGATGAGGAG GGCGCATGCC AGCCTTGCCC CATCAACTGC
ACCCACTCCT GTGTGGACCT GGATGACAAG GGCTGCCCCG CCGAGCAGAG AGCCAGCCCT
CTGACGTCCA TCATCTCTGC GGTGGTTGGC ATTCTGCTGG TCGTGGTCTT GGGGGTGGTC
TTTGGGATCC TCATCAAGCG ACGGCAGCAG AAGATCCGGA AGTACACGAT GCGGAGACTG
CTGCAGGAAA CGGAGCTGGT GGAGCCGCTG ACACCTAGCG GAGCGATGCC CAACCAGGCG
CAGATGCGGA TCCTGAAAGA GACGGAGCTG AGGAAGGTGA AGGTGCTTGG ATCTGGCGCT
TTTGGCACAG TCTACAAGGG CATCTGGATC CCTGATGGGG AGAATGTGAA AATTCCAGTG
GCCATCAAAG TGTTGAGGGA AAACACATCC CCCAAAGCCA ACAAAGAAAT CTTAGACGAA
GCATACGTGA TGGCTGGTGT GGGCTCCCCA TATGTCTCCC GCCTTCTGGG CATCTGCCTG
ACATCCACGG TGCAGCTGGT GACACAGCTT ATGCCCTATG GCTGCCTCTT AGACCATGTC
CGGGAAAACC GCGGACGCCT GGGCTCCCAG GACCTGCTGA ACTGGTGTAT GCAGATTGCC
AAGGGGATGA GCTACCTGGA GGATGTGCGG CTCGTACACA GGGACTTGGC CGCTCGGAAC
GTGCTGGTCA AGAGTCCCAA CCATGTCAAA ATTACAGACT TCGGGCTGGC TCGGCTGCTG
GACATTGACG AGACAGAGTA CCATGCAGAT GGGGGCAAGG TGCCCATCAA GTGGATGGCG
CTGGAGTCCA TTCTCCGCCG GCGGTTCACC CACCAGAGTG ATGTGTGGAG TTATGGTGTG
ACTGTGTGGG AGCTGATGAC TTTTGGGGCC AAACCTTACG ATGGGATCCC AGCCCGGGAG
ATCCCTGACC TGCTGGAAAA GGGGGAGCGG CTGCCCCAGC CCCCCATCTG CACCATTGAT
GTCTACATGA TCATGGTCAA ATGTTGGATG ATTGACTCTG AATGTCGGCC AAGATTCCGG
GAGTTGGTGT CTGAATTCTC CCGCATGGCC AGGGACCCCC AGCGCTTTGT GGTCATCCAG
AATGAGGACT TGGGCCCAGC CAGTCCCTTG GACAGCACCT TCTACCGCTC ACTGCTGGAG
GACGATGACA TGGGGGACCT GGTGGATGCT GAGGAGTATC TGGTACCCCA GCAGGGCTTC
TTCTGTCCAG ACCCTGCCCC GGGCGCTGGG GGCATGGTCC ACCACAGGCA CCGCAGCTCA
TCTACCAGGA GTGGCGGTGG GGACCTGACA CTAGGGCTGG AGCCCTCTGA AGAGGAGGCC
CCCAGGTCTC CACTGGCACC CTCCGAAGGG GCTGGCTCCG ATGTATTTGA TGGTGACCTG
GGAATGGGGG CAGCCAAGGG GCTGCAAAGC CTCCCCACAC ATGACCCCAG CCCTCTACAG
CGGTACAGTG AGGACCCCAC AGTACCCCTG CCCTCTGAGA CTGATGGCTA CGTTGCCCCC
CTGACCTGCA GCCCCCAGCC TGAATATGTG AACCAGCCAG ATGTTCGGCC CCAGCCCCCT
TCGCCCCGAG AGGGCCCTCT GCCTGCTGCC CGACCTGCTG GTGCCACTCT GGAAAGGCCC
AAGACTCTCT CCCCAGGGAA GAATGGGGTC GTCAAAGACG TTTTTGCCTT TGGGGGTGCC
GTGGAGAACC CCGAGTACTT GACACCCCAG GGAGGAGCTG CCCCTCAGCC CCACCCTCCT
CCTGCCTTCA GCCCAGCCTT CGACAACCTC TATTACTGGG ACCAGGACCC ACCAGAGCGG
GGGGCTCCAC CCAGCACCTT CAAAGGGACA CCTACGGCAG AGAACCCAGA GTACCTGGGT
CTGGACGTGC CAGTGTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu27526
Clone ID Related Accession (Same CDS sequence) NM_001289938
Accession Version NM_001289938.1 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 1812bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 15-MAY-2015
Organism Homo sapiens (human)
Product receptor tyrosine-protein kinase erbB-2 isoform e
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK295195.1 and BC110392.1. This sequence is a reference standard in the RefSeqGene project. Transcript Variant: This variant (5) differs in the 5' and 3' UTRs and has multiple coding region differences, compared to variant 1. The resulting isoform (e) has a shorter N-terminus and a truncated C-terminus, compared to isoform a. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC110392.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END##

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
1741
1801
ATGAAGCTGC GGCTCCCTGC CAGTCCCGAG ACCCACCTGG ACATGCTCCG CCACCTCTAC 
CAGGGCTGCC AGGTGGTGCA GGGAAACCTG GAACTCACCT ACCTGCCCAC CAATGCCAGC
CTGTCCTTCC TGCAGGATAT CCAGGAGGTG CAGGGCTACG TGCTCATCGC TCACAACCAA
GTGAGGCAGG TCCCACTGCA GAGGCTGCGG ATTGTGCGAG GCACCCAGCT CTTTGAGGAC
AACTATGCCC TGGCCGTGCT AGACAATGGA GACCCGCTGA ACAATACCAC CCCTGTCACA
GGGGCCTCCC CAGGAGGCCT GCGGGAGCTG CAGCTTCGAA GCCTCACAGA GATCTTGAAA
GGAGGGGTCT TGATCCAGCG GAACCCCCAG CTCTGCTACC AGGACACGAT TTTGTGGAAG
GACATCTTCC ACAAGAACAA CCAGCTGGCT CTCACACTGA TAGACACCAA CCGCTCTCGG
GCCTGCCACC CCTGTTCTCC GATGTGTAAG GGCTCCCGCT GCTGGGGAGA GAGTTCTGAG
GATTGTCAGA GCCTGACGCG CACTGTCTGT GCCGGTGGCT GTGCCCGCTG CAAGGGGCCA
CTGCCCACTG ACTGCTGCCA TGAGCAGTGT GCTGCCGGCT GCACGGGCCC CAAGCACTCT
GACTGCCTGG CCTGCCTCCA CTTCAACCAC AGTGGCATCT GTGAGCTGCA CTGCCCAGCC
CTGGTCACCT ACAACACAGA CACGTTTGAG TCCATGCCCA ATCCCGAGGG CCGGTATACA
TTCGGCGCCA GCTGTGTGAC TGCCTGTCCC TACAACTACC TTTCTACGGA CGTGGGATCC
TGCACCCTCG TCTGCCCCCT GCACAACCAA GAGGTGACAG CAGAGGATGG AACACAGCGG
TGTGAGAAGT GCAGCAAGCC CTGTGCCCGA GTGTGCTATG GTCTGGGCAT GGAGCACTTG
CGAGAGGTGA GGGCAGTTAC CAGTGCCAAT ATCCAGGAGT TTGCTGGCTG CAAGAAGATC
TTTGGGAGCC TGGCATTTCT GCCGGAGAGC TTTGATGGGG ACCCAGCCTC CAACACTGCC
CCGCTCCAGC CAGAGCAGCT CCAAGTGTTT GAGACTCTGG AAGAGATCAC AGGTTACCTA
TACATCTCAG CATGGCCGGA CAGCCTGCCT GACCTCAGCG TCTTCCAGAA CCTGCAAGTA
ATCCGGGGAC GAATTCTGCA CAATGGCGCC TACTCGCTGA CCCTGCAAGG GCTGGGCATC
AGCTGGCTGG GGCTGCGCTC ACTGAGGGAA CTGGGCAGTG GACTGGCCCT CATCCACCAT
AACACCCACC TCTGCTTCGT GCACACGGTG CCCTGGGACC AGCTCTTTCG GAACCCGCAC
CAAGCTCTGC TCCACACTGC CAACCGGCCA GAGGACGAGT GTGTGGGCGA GGGCCTGGCC
TGCCACCAGC TGTGCGCCCG AGGGCACTGC TGGGGTCCAG GGCCCACCCA GTGTGTCAAC
TGCAGCCAGT TCCTTCGGGG CCAGGAGTGC GTGGAGGAAT GCCGAGTACT GCAGGGGCTC
CCCAGGGAGT ATGTGAATGC CAGGCACTGT TTGCCGTGCC ACCCTGAGTG TCAGCCCCAG
AATGGCTCAG TGACCTGTTT TGGACCGGAG GCTGACCAGT GTGTGGCCTG TGCCCACTAT
AAGGACCCTC CCTTCTGCGT GGCCCGCTGC CCCAGCGGTG TGAAACCTGA CCTCTCCTAC
ATGCCCATCT GGAAGTTTCC AGATGAGGAG GGCGCATGCC AGCCTTGCCC CATCAACTGC
ACCCACTCGT GA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_001276867.1
CDS577..2388
Misc Feature(1)556..558(+)
Misc Feature(2)640..1005(+)
Misc Feature(3)1051..1515(+)
Misc Feature(4)1189..1326(+)
Misc Feature(5)1582..1944(+)
Misc Feature(6)2014..>2118(+)
Misc Feature(7)2017..2385(+)
Misc Feature(8)2170..2307(+)
Exon (1)1..195
Gene:ERBB2
Gene Synonym:
Exon (2)196..300
Gene:ERBB2
Gene Synonym:
Exon (3)301..365
Gene:ERBB2
Gene Synonym:
Exon (4)366..559
Gene:ERBB2
Gene Synonym:
Exon (5)560..711
Gene:ERBB2
Gene Synonym:
Exon (6)712..925
Gene:ERBB2
Gene Synonym:
Exon (7)926..1060
Gene:ERBB2
Gene Synonym:
Exon (8)1061..1129
Gene:ERBB2
Gene Synonym:
Exon (9)1130..1245
Gene:ERBB2
Gene Synonym:
Exon (10)1246..1387
Gene:ERBB2
Gene Synonym:
Exon (11)1388..1507
Gene:ERBB2
Gene Synonym:
Exon (12)1508..1634
Gene:ERBB2
Gene Synonym:
Exon (13)1635..1708
Gene:ERBB2
Gene Synonym:
Exon (14)1709..1799
Gene:ERBB2
Gene Synonym:
Exon (15)1800..1999
Gene:ERBB2
Gene Synonym:
Exon (16)2000..2132
Gene:ERBB2
Gene Synonym:
Exon (17)2133..2223
Gene:ERBB2
Gene Synonym:
Exon (18)2224..2561
Gene:ERBB2
Gene Synonym:
Translation

Target ORF information:

RefSeq Version NM_001289938
Organism Homo sapiens (human)
Definition Homo sapiens erb-b2 receptor tyrosine kinase 2 (ERBB2), transcript variant 5, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_001289938

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
1741
1801
ATGAAGCTGC GGCTCCCTGC CAGTCCCGAG ACCCACCTGG ACATGCTCCG CCACCTCTAC 
CAGGGCTGCC AGGTGGTGCA GGGAAACCTG GAACTCACCT ACCTGCCCAC CAATGCCAGC
CTGTCCTTCC TGCAGGATAT CCAGGAGGTG CAGGGCTACG TGCTCATCGC TCACAACCAA
GTGAGGCAGG TCCCACTGCA GAGGCTGCGG ATTGTGCGAG GCACCCAGCT CTTTGAGGAC
AACTATGCCC TGGCCGTGCT AGACAATGGA GACCCGCTGA ACAATACCAC CCCTGTCACA
GGGGCCTCCC CAGGAGGCCT GCGGGAGCTG CAGCTTCGAA GCCTCACAGA GATCTTGAAA
GGAGGGGTCT TGATCCAGCG GAACCCCCAG CTCTGCTACC AGGACACGAT TTTGTGGAAG
GACATCTTCC ACAAGAACAA CCAGCTGGCT CTCACACTGA TAGACACCAA CCGCTCTCGG
GCCTGCCACC CCTGTTCTCC GATGTGTAAG GGCTCCCGCT GCTGGGGAGA GAGTTCTGAG
GATTGTCAGA GCCTGACGCG CACTGTCTGT GCCGGTGGCT GTGCCCGCTG CAAGGGGCCA
CTGCCCACTG ACTGCTGCCA TGAGCAGTGT GCTGCCGGCT GCACGGGCCC CAAGCACTCT
GACTGCCTGG CCTGCCTCCA CTTCAACCAC AGTGGCATCT GTGAGCTGCA CTGCCCAGCC
CTGGTCACCT ACAACACAGA CACGTTTGAG TCCATGCCCA ATCCCGAGGG CCGGTATACA
TTCGGCGCCA GCTGTGTGAC TGCCTGTCCC TACAACTACC TTTCTACGGA CGTGGGATCC
TGCACCCTCG TCTGCCCCCT GCACAACCAA GAGGTGACAG CAGAGGATGG AACACAGCGG
TGTGAGAAGT GCAGCAAGCC CTGTGCCCGA GTGTGCTATG GTCTGGGCAT GGAGCACTTG
CGAGAGGTGA GGGCAGTTAC CAGTGCCAAT ATCCAGGAGT TTGCTGGCTG CAAGAAGATC
TTTGGGAGCC TGGCATTTCT GCCGGAGAGC TTTGATGGGG ACCCAGCCTC CAACACTGCC
CCGCTCCAGC CAGAGCAGCT CCAAGTGTTT GAGACTCTGG AAGAGATCAC AGGTTACCTA
TACATCTCAG CATGGCCGGA CAGCCTGCCT GACCTCAGCG TCTTCCAGAA CCTGCAAGTA
ATCCGGGGAC GAATTCTGCA CAATGGCGCC TACTCGCTGA CCCTGCAAGG GCTGGGCATC
AGCTGGCTGG GGCTGCGCTC ACTGAGGGAA CTGGGCAGTG GACTGGCCCT CATCCACCAT
AACACCCACC TCTGCTTCGT GCACACGGTG CCCTGGGACC AGCTCTTTCG GAACCCGCAC
CAAGCTCTGC TCCACACTGC CAACCGGCCA GAGGACGAGT GTGTGGGCGA GGGCCTGGCC
TGCCACCAGC TGTGCGCCCG AGGGCACTGC TGGGGTCCAG GGCCCACCCA GTGTGTCAAC
TGCAGCCAGT TCCTTCGGGG CCAGGAGTGC GTGGAGGAAT GCCGAGTACT GCAGGGGCTC
CCCAGGGAGT ATGTGAATGC CAGGCACTGT TTGCCGTGCC ACCCTGAGTG TCAGCCCCAG
AATGGCTCAG TGACCTGTTT TGGACCGGAG GCTGACCAGT GTGTGGCCTG TGCCCACTAT
AAGGACCCTC CCTTCTGCGT GGCCCGCTGC CCCAGCGGTG TGAAACCTGA CCTCTCCTAC
ATGCCCATCT GGAAGTTTCC AGATGAGGAG GGCGCATGCC AGCCTTGCCC CATCAACTGC
ACCCACTCGT GA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu23956
Clone ID Related Accession (Same CDS sequence) NM_001289936
Accession Version NM_001289936.1 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 3723bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 15-MAY-2015
Organism Homo sapiens (human)
Product receptor tyrosine-protein kinase erbB-2 isoform c
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK295195.1, BC080193.1 and BM678576.1. This sequence is a reference standard in the RefSeqGene project. On Feb 11, 2014 this sequence version replaced gi:578830591. Transcript Variant: This variant (3) has an alternate 5' UTR and 5' coding region, compared to variant 1. The resulting isoform (c) has a distinct and shorter N-terminus, compared to isoform a. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK295195.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END##

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
1741
1801
1861
1921
1981
2041
2101
2161
2221
2281
2341
2401
2461
2521
2581
2641
2701
2761
2821
2881
2941
3001
3061
3121
3181
3241
3301
3361
3421
3481
3541
3601
3661
3721
ATGCCCCGGG GGTCCTGGAA GCCACAAGTG TGCACCGGCA CAGACATGAA GCTGCGGCTC 
CCTGCCAGTC CCGAGACCCA CCTGGACATG CTCCGCCACC TCTACCAGGG CTGCCAGGTG
GTGCAGGGAA ACCTGGAACT CACCTACCTG CCCACCAATG CCAGCCTGTC CTTCCTGCAG
GATATCCAGG AGGTGCAGGG CTACGTGCTC ATCGCTCACA ACCAAGTGAG GCAGGTCCCA
CTGCAGAGGC TGCGGATTGT GCGAGGCACC CAGCTCTTTG AGGACAACTA TGCCCTGGCC
GTGCTAGACA ATGGAGACCC GCTGAACAAT ACCACCCCTG TCACAGGGGC CTCCCCAGGA
GGCCTGCGGG AGCTGCAGCT TCGAAGCCTC ACAGAGATCT TGAAAGGAGG GGTCTTGATC
CAGCGGAACC CCCAGCTCTG CTACCAGGAC ACGATTTTGT GGAAGGACAT CTTCCACAAG
AACAACCAGC TGGCTCTCAC ACTGATAGAC ACCAACCGCT CTCGGGCCTG CCACCCCTGT
TCTCCGATGT GTAAGGGCTC CCGCTGCTGG GGAGAGAGTT CTGAGGATTG TCAGAGCCTG
ACGCGCACTG TCTGTGCCGG TGGCTGTGCC CGCTGCAAGG GGCCACTGCC CACTGACTGC
TGCCATGAGC AGTGTGCTGC CGGCTGCACG GGCCCCAAGC ACTCTGACTG CCTGGCCTGC
CTCCACTTCA ACCACAGTGG CATCTGTGAG CTGCACTGCC CAGCCCTGGT CACCTACAAC
ACAGACACGT TTGAGTCCAT GCCCAATCCC GAGGGCCGGT ATACATTCGG CGCCAGCTGT
GTGACTGCCT GTCCCTACAA CTACCTTTCT ACGGACGTGG GATCCTGCAC CCTCGTCTGC
CCCCTGCACA ACCAAGAGGT GACAGCAGAG GATGGAACAC AGCGGTGTGA GAAGTGCAGC
AAGCCCTGTG CCCGAGTGTG CTATGGTCTG GGCATGGAGC ACTTGCGAGA GGTGAGGGCA
GTTACCAGTG CCAATATCCA GGAGTTTGCT GGCTGCAAGA AGATCTTTGG GAGCCTGGCA
TTTCTGCCGG AGAGCTTTGA TGGGGACCCA GCCTCCAACA CTGCCCCGCT CCAGCCAGAG
CAGCTCCAAG TGTTTGAGAC TCTGGAAGAG ATCACAGGTT ACCTATACAT CTCAGCATGG
CCGGACAGCC TGCCTGACCT CAGCGTCTTC CAGAACCTGC AAGTAATCCG GGGACGAATT
CTGCACAATG GCGCCTACTC GCTGACCCTG CAAGGGCTGG GCATCAGCTG GCTGGGGCTG
CGCTCACTGA GGGAACTGGG CAGTGGACTG GCCCTCATCC ACCATAACAC CCACCTCTGC
TTCGTGCACA CGGTGCCCTG GGACCAGCTC TTTCGGAACC CGCACCAAGC TCTGCTCCAC
ACTGCCAACC GGCCAGAGGA CGAGTGTGTG GGCGAGGGCC TGGCCTGCCA CCAGCTGTGC
GCCCGAGGGC ACTGCTGGGG TCCAGGGCCC ACCCAGTGTG TCAACTGCAG CCAGTTCCTT
CGGGGCCAGG AGTGCGTGGA GGAATGCCGA GTACTGCAGG GGCTCCCCAG GGAGTATGTG
AATGCCAGGC ACTGTTTGCC GTGCCACCCT GAGTGTCAGC CCCAGAATGG CTCAGTGACC
TGTTTTGGAC CGGAGGCTGA CCAGTGTGTG GCCTGTGCCC ACTATAAGGA CCCTCCCTTC
TGCGTGGCCC GCTGCCCCAG CGGTGTGAAA CCTGACCTCT CCTACATGCC CATCTGGAAG
TTTCCAGATG AGGAGGGCGC ATGCCAGCCT TGCCCCATCA ACTGCACCCA CTCCTGTGTG
GACCTGGATG ACAAGGGCTG CCCCGCCGAG CAGAGAGCCA GCCCTCTGAC GTCCATCATC
TCTGCGGTGG TTGGCATTCT GCTGGTCGTG GTCTTGGGGG TGGTCTTTGG GATCCTCATC
AAGCGACGGC AGCAGAAGAT CCGGAAGTAC ACGATGCGGA GACTGCTGCA GGAAACGGAG
CTGGTGGAGC CGCTGACACC TAGCGGAGCG ATGCCCAACC AGGCGCAGAT GCGGATCCTG
AAAGAGACGG AGCTGAGGAA GGTGAAGGTG CTTGGATCTG GCGCTTTTGG CACAGTCTAC
AAGGGCATCT GGATCCCTGA TGGGGAGAAT GTGAAAATTC CAGTGGCCAT CAAAGTGTTG
AGGGAAAACA CATCCCCCAA AGCCAACAAA GAAATCTTAG ACGAAGCATA CGTGATGGCT
GGTGTGGGCT CCCCATATGT CTCCCGCCTT CTGGGCATCT GCCTGACATC CACGGTGCAG
CTGGTGACAC AGCTTATGCC CTATGGCTGC CTCTTAGACC ATGTCCGGGA AAACCGCGGA
CGCCTGGGCT CCCAGGACCT GCTGAACTGG TGTATGCAGA TTGCCAAGGG GATGAGCTAC
CTGGAGGATG TGCGGCTCGT ACACAGGGAC TTGGCCGCTC GGAACGTGCT GGTCAAGAGT
CCCAACCATG TCAAAATTAC AGACTTCGGG CTGGCTCGGC TGCTGGACAT TGACGAGACA
GAGTACCATG CAGATGGGGG CAAGGTGCCC ATCAAGTGGA TGGCGCTGGA GTCCATTCTC
CGCCGGCGGT TCACCCACCA GAGTGATGTG TGGAGTTATG GTGTGACTGT GTGGGAGCTG
ATGACTTTTG GGGCCAAACC TTACGATGGG ATCCCAGCCC GGGAGATCCC TGACCTGCTG
GAAAAGGGGG AGCGGCTGCC CCAGCCCCCC ATCTGCACCA TTGATGTCTA CATGATCATG
GTCAAATGTT GGATGATTGA CTCTGAATGT CGGCCAAGAT TCCGGGAGTT GGTGTCTGAA
TTCTCCCGCA TGGCCAGGGA CCCCCAGCGC TTTGTGGTCA TCCAGAATGA GGACTTGGGC
CCAGCCAGTC CCTTGGACAG CACCTTCTAC CGCTCACTGC TGGAGGACGA TGACATGGGG
GACCTGGTGG ATGCTGAGGA GTATCTGGTA CCCCAGCAGG GCTTCTTCTG TCCAGACCCT
GCCCCGGGCG CTGGGGGCAT GGTCCACCAC AGGCACCGCA GCTCATCTAC CAGGAGTGGC
GGTGGGGACC TGACACTAGG GCTGGAGCCC TCTGAAGAGG AGGCCCCCAG GTCTCCACTG
GCACCCTCCG AAGGGGCTGG CTCCGATGTA TTTGATGGTG ACCTGGGAAT GGGGGCAGCC
AAGGGGCTGC AAAGCCTCCC CACACATGAC CCCAGCCCTC TACAGCGGTA CAGTGAGGAC
CCCACAGTAC CCCTGCCCTC TGAGACTGAT GGCTACGTTG CCCCCCTGAC CTGCAGCCCC
CAGCCTGAAT ATGTGAACCA GCCAGATGTT CGGCCCCAGC CCCCTTCGCC CCGAGAGGGC
CCTCTGCCTG CTGCCCGACC TGCTGGTGCC ACTCTGGAAA GGCCCAAGAC TCTCTCCCCA
GGGAAGAATG GGGTCGTCAA AGACGTTTTT GCCTTTGGGG GTGCCGTGGA GAACCCCGAG
TACTTGACAC CCCAGGGAGG AGCTGCCCCT CAGCCCCACC CTCCTCCTGC CTTCAGCCCA
GCCTTCGACA ACCTCTATTA CTGGGACCAG GACCCACCAG AGCGGGGGGC TCCACCCAGC
ACCTTCAAAG GGACACCTAC GGCAGAGAAC CCAGAGTACC TGGGTCTGGA CGTGCCAGTG
TGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_001276865.1
CDS583..4305
Misc Feature(1)556..558(+)
Misc Feature(2)691..1056(+)
Misc Feature(3)1102..1566(+)
Misc Feature(4)1240..1377(+)
Misc Feature(5)1633..1995(+)
Misc Feature(6)2065..>2169(+)
Misc Feature(7)2068..2466(+)
Misc Feature(8)2221..2358(+)
Misc Feature(9)2458..2589(+)
Misc Feature(10)2464..2538(+)
Misc Feature(11)2467..2550(+)
Misc Feature(12)2671..3507(+)
Misc Feature(13)2695..3465(+)
Misc Feature(14)2713..3228(+)
Misc Feature(15)2713..3126(+)
Misc Feature(16)3121..3198(+)
Misc Feature(17)3187..3228(+)
Exon (1)1..195
Gene:ERBB2
Gene Synonym:
Exon (2)196..300
Gene:ERBB2
Gene Synonym:
Exon (3)301..365
Gene:ERBB2
Gene Synonym:
Exon (4)366..559
Gene:ERBB2
Gene Synonym:
Exon (5)560..610
Gene:ERBB2
Gene Synonym:
Exon (6)611..762
Gene:ERBB2
Gene Synonym:
Exon (7)763..976
Gene:ERBB2
Gene Synonym:
Exon (8)977..1111
Gene:ERBB2
Gene Synonym:
Exon (9)1112..1180
Gene:ERBB2
Gene Synonym:
Exon (10)1181..1296
Gene:ERBB2
Gene Synonym:
Exon (11)1297..1438
Gene:ERBB2
Gene Synonym:
Exon (12)1439..1558
Gene:ERBB2
Gene Synonym:
Exon (13)1559..1685
Gene:ERBB2
Gene Synonym:
Exon (14)1686..1759
Gene:ERBB2
Gene Synonym:
Exon (15)1760..1850
Gene:ERBB2
Gene Synonym:
Exon (16)1851..2050
Gene:ERBB2
Gene Synonym:
Exon (17)2051..2183
Gene:ERBB2
Gene Synonym:
Exon (18)2184..2274
Gene:ERBB2
Gene Synonym:
Exon (19)2275..2435
Gene:ERBB2
Gene Synonym:
Exon (20)2436..2483
Gene:ERBB2
Gene Synonym:
Exon (21)2484..2622
Gene:ERBB2
Gene Synonym:
Exon (22)2623..2745
Gene:ERBB2
Gene Synonym:
Exon (23)2746..2844
Gene:ERBB2
Gene Synonym:
Exon (24)2845..3030
Gene:ERBB2
Gene Synonym:
Exon (25)3031..3186
Gene:ERBB2
Gene Synonym:
Exon (26)3187..3262
Gene:ERBB2
Gene Synonym:
Exon (27)3263..3409
Gene:ERBB2
Gene Synonym:
Exon (28)3410..3507
Gene:ERBB2
Gene Synonym:
Exon (29)3508..3696
Gene:ERBB2
Gene Synonym:
Exon (30)3697..3949
Gene:ERBB2
Gene Synonym:
Exon (31)3950..4923
Gene:ERBB2
Gene Synonym:
Translation

Target ORF information:

RefSeq Version NM_001289936
Organism Homo sapiens (human)
Definition Homo sapiens erb-b2 receptor tyrosine kinase 2 (ERBB2), transcript variant 3, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_001289936

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
1741
1801
1861
1921
1981
2041
2101
2161
2221
2281
2341
2401
2461
2521
2581
2641
2701
2761
2821
2881
2941
3001
3061
3121
3181
3241
3301
3361
3421
3481
3541
3601
3661
3721
ATGCCCCGGG GGTCCTGGAA GCCACAAGTG TGCACCGGCA CAGACATGAA GCTGCGGCTC 
CCTGCCAGTC CCGAGACCCA CCTGGACATG CTCCGCCACC TCTACCAGGG CTGCCAGGTG
GTGCAGGGAA ACCTGGAACT CACCTACCTG CCCACCAATG CCAGCCTGTC CTTCCTGCAG
GATATCCAGG AGGTGCAGGG CTACGTGCTC ATCGCTCACA ACCAAGTGAG GCAGGTCCCA
CTGCAGAGGC TGCGGATTGT GCGAGGCACC CAGCTCTTTG AGGACAACTA TGCCCTGGCC
GTGCTAGACA ATGGAGACCC GCTGAACAAT ACCACCCCTG TCACAGGGGC CTCCCCAGGA
GGCCTGCGGG AGCTGCAGCT TCGAAGCCTC ACAGAGATCT TGAAAGGAGG GGTCTTGATC
CAGCGGAACC CCCAGCTCTG CTACCAGGAC ACGATTTTGT GGAAGGACAT CTTCCACAAG
AACAACCAGC TGGCTCTCAC ACTGATAGAC ACCAACCGCT CTCGGGCCTG CCACCCCTGT
TCTCCGATGT GTAAGGGCTC CCGCTGCTGG GGAGAGAGTT CTGAGGATTG TCAGAGCCTG
ACGCGCACTG TCTGTGCCGG TGGCTGTGCC CGCTGCAAGG GGCCACTGCC CACTGACTGC
TGCCATGAGC AGTGTGCTGC CGGCTGCACG GGCCCCAAGC ACTCTGACTG CCTGGCCTGC
CTCCACTTCA ACCACAGTGG CATCTGTGAG CTGCACTGCC CAGCCCTGGT CACCTACAAC
ACAGACACGT TTGAGTCCAT GCCCAATCCC GAGGGCCGGT ATACATTCGG CGCCAGCTGT
GTGACTGCCT GTCCCTACAA CTACCTTTCT ACGGACGTGG GATCCTGCAC CCTCGTCTGC
CCCCTGCACA ACCAAGAGGT GACAGCAGAG GATGGAACAC AGCGGTGTGA GAAGTGCAGC
AAGCCCTGTG CCCGAGTGTG CTATGGTCTG GGCATGGAGC ACTTGCGAGA GGTGAGGGCA
GTTACCAGTG CCAATATCCA GGAGTTTGCT GGCTGCAAGA AGATCTTTGG GAGCCTGGCA
TTTCTGCCGG AGAGCTTTGA TGGGGACCCA GCCTCCAACA CTGCCCCGCT CCAGCCAGAG
CAGCTCCAAG TGTTTGAGAC TCTGGAAGAG ATCACAGGTT ACCTATACAT CTCAGCATGG
CCGGACAGCC TGCCTGACCT CAGCGTCTTC CAGAACCTGC AAGTAATCCG GGGACGAATT
CTGCACAATG GCGCCTACTC GCTGACCCTG CAAGGGCTGG GCATCAGCTG GCTGGGGCTG
CGCTCACTGA GGGAACTGGG CAGTGGACTG GCCCTCATCC ACCATAACAC CCACCTCTGC
TTCGTGCACA CGGTGCCCTG GGACCAGCTC TTTCGGAACC CGCACCAAGC TCTGCTCCAC
ACTGCCAACC GGCCAGAGGA CGAGTGTGTG GGCGAGGGCC TGGCCTGCCA CCAGCTGTGC
GCCCGAGGGC ACTGCTGGGG TCCAGGGCCC ACCCAGTGTG TCAACTGCAG CCAGTTCCTT
CGGGGCCAGG AGTGCGTGGA GGAATGCCGA GTACTGCAGG GGCTCCCCAG GGAGTATGTG
AATGCCAGGC ACTGTTTGCC GTGCCACCCT GAGTGTCAGC CCCAGAATGG CTCAGTGACC
TGTTTTGGAC CGGAGGCTGA CCAGTGTGTG GCCTGTGCCC ACTATAAGGA CCCTCCCTTC
TGCGTGGCCC GCTGCCCCAG CGGTGTGAAA CCTGACCTCT CCTACATGCC CATCTGGAAG
TTTCCAGATG AGGAGGGCGC ATGCCAGCCT TGCCCCATCA ACTGCACCCA CTCCTGTGTG
GACCTGGATG ACAAGGGCTG CCCCGCCGAG CAGAGAGCCA GCCCTCTGAC GTCCATCATC
TCTGCGGTGG TTGGCATTCT GCTGGTCGTG GTCTTGGGGG TGGTCTTTGG GATCCTCATC
AAGCGACGGC AGCAGAAGAT CCGGAAGTAC ACGATGCGGA GACTGCTGCA GGAAACGGAG
CTGGTGGAGC CGCTGACACC TAGCGGAGCG ATGCCCAACC AGGCGCAGAT GCGGATCCTG
AAAGAGACGG AGCTGAGGAA GGTGAAGGTG CTTGGATCTG GCGCTTTTGG CACAGTCTAC
AAGGGCATCT GGATCCCTGA TGGGGAGAAT GTGAAAATTC CAGTGGCCAT CAAAGTGTTG
AGGGAAAACA CATCCCCCAA AGCCAACAAA GAAATCTTAG ACGAAGCATA CGTGATGGCT
GGTGTGGGCT CCCCATATGT CTCCCGCCTT CTGGGCATCT GCCTGACATC CACGGTGCAG
CTGGTGACAC AGCTTATGCC CTATGGCTGC CTCTTAGACC ATGTCCGGGA AAACCGCGGA
CGCCTGGGCT CCCAGGACCT GCTGAACTGG TGTATGCAGA TTGCCAAGGG GATGAGCTAC
CTGGAGGATG TGCGGCTCGT ACACAGGGAC TTGGCCGCTC GGAACGTGCT GGTCAAGAGT
CCCAACCATG TCAAAATTAC AGACTTCGGG CTGGCTCGGC TGCTGGACAT TGACGAGACA
GAGTACCATG CAGATGGGGG CAAGGTGCCC ATCAAGTGGA TGGCGCTGGA GTCCATTCTC
CGCCGGCGGT TCACCCACCA GAGTGATGTG TGGAGTTATG GTGTGACTGT GTGGGAGCTG
ATGACTTTTG GGGCCAAACC TTACGATGGG ATCCCAGCCC GGGAGATCCC TGACCTGCTG
GAAAAGGGGG AGCGGCTGCC CCAGCCCCCC ATCTGCACCA TTGATGTCTA CATGATCATG
GTCAAATGTT GGATGATTGA CTCTGAATGT CGGCCAAGAT TCCGGGAGTT GGTGTCTGAA
TTCTCCCGCA TGGCCAGGGA CCCCCAGCGC TTTGTGGTCA TCCAGAATGA GGACTTGGGC
CCAGCCAGTC CCTTGGACAG CACCTTCTAC CGCTCACTGC TGGAGGACGA TGACATGGGG
GACCTGGTGG ATGCTGAGGA GTATCTGGTA CCCCAGCAGG GCTTCTTCTG TCCAGACCCT
GCCCCGGGCG CTGGGGGCAT GGTCCACCAC AGGCACCGCA GCTCATCTAC CAGGAGTGGC
GGTGGGGACC TGACACTAGG GCTGGAGCCC TCTGAAGAGG AGGCCCCCAG GTCTCCACTG
GCACCCTCCG AAGGGGCTGG CTCCGATGTA TTTGATGGTG ACCTGGGAAT GGGGGCAGCC
AAGGGGCTGC AAAGCCTCCC CACACATGAC CCCAGCCCTC TACAGCGGTA CAGTGAGGAC
CCCACAGTAC CCCTGCCCTC TGAGACTGAT GGCTACGTTG CCCCCCTGAC CTGCAGCCCC
CAGCCTGAAT ATGTGAACCA GCCAGATGTT CGGCCCCAGC CCCCTTCGCC CCGAGAGGGC
CCTCTGCCTG CTGCCCGACC TGCTGGTGCC ACTCTGGAAA GGCCCAAGAC TCTCTCCCCA
GGGAAGAATG GGGTCGTCAA AGACGTTTTT GCCTTTGGGG GTGCCGTGGA GAACCCCGAG
TACTTGACAC CCCAGGGAGG AGCTGCCCCT CAGCCCCACC CTCCTCCTGC CTTCAGCCCA
GCCTTCGACA ACCTCTATTA CTGGGACCAG GACCCACCAG AGCGGGGGGC TCCACCCAGC
ACCTTCAAAG GGACACCTAC GGCAGAGAAC CCAGAGTACC TGGGTCTGGA CGTGCCAGTG
TGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

book

Neoadjuvant chemotherapy-induced changes in immunohistochemical expression of estrogen receptor, progesterone receptor, HER2, and Ki-67 in patients with breast cancer
J BUON 20 (1), 45-49 (2015)
Avci N, Deligonul A, Tolunay S, Cubukcu E, Fatih Olmez O, Ulas A, Hartavi M, Kurt E and Evrensel T.


book

Progesterone receptor status in determining the prognosis of estrogen receptor positive/ HER2 negative breast carcinoma patients
J BUON 20 (1), 28-34 (2015)
Bal O, Yalcintas Arslan U, Durnali A, Uyetrk U, Demirci A, Tastekin D, Ekinci A, Esbah O, Turker I, Uysal Sonmez O and Oksuzoglu B.


book

Superiority of fluorescent in situ hybridization over immunohistochemistry in detection of HER2 gene in carcinoma of the urinary bladder associated with and without schistosomiasis
J Egypt Soc Parasitol 44 (3), 719-731 (2014)
Hammam,O., Wishahi,M., Hindawi,A., Mosaad,M., Akl,M., Khalil,H., Al Ganzoury,H., Badawy,M. and Elesaily,K.


book

[Comparative study of the determination of the HER2 status in gastric cancer in the biopsy and intraoperative specimens]
Arkh. Patol. 76 (6), 22-27 (2014)
Zavalishina,L.E., Andreeva,Iu.Iu., Vinogradov,I.Iu., Danilova,N.V., Kuznetsova,O.A. and Frank,G.A.


book

Translational control by an upstream open reading frame in the HER-2/neu transcript
J. Biol. Chem. 274 (34), 24335-24341 (1999)
Child SJ, Miller MK and Geballe AP.


book

Cell type-dependent and -independent control of HER-2/neu translation
Int. J. Biochem. Cell Biol. 31 (1), 201-213 (1999)
Child SJ, Miller MK and Geballe AP.


book

Expression and characterization of the p85 subunit of the phosphatidylinositol 3-kinase complex and a related p85 beta protein by using the baculovirus expression system
Biochem. J. 288 (PT 2), 395-405 (1992)
Gout I, Dhand R, Panayotou G, Fry MJ, Hiles I, Otsu M and Waterfield MD.


book

Regulated coupling of the Neu receptor to phosphatidylinositol 3'-kinase and its release by oncogenic activation
J. Biol. Chem. 267 (17), 12266-12274 (1992)
Peles E, Lamprecht R, Ben-Levy R, Tzahar E and Yarden Y.


book

G to A polymorphism at amino acid codon 655 of the human erbB-2/HER2 gene
Nucleic Acids Res. 19 (19), 5452 (1991)
Papewalis J, Nikitin AYu and Rajewsky MF.


book

Oncogenic forms of the neu/HER2 tyrosine kinase are permanently coupled to phospholipase C gamma
EMBO J. 10 (8), 2077-2086 (1991)
Peles E, Levy RB, Or E, Ullrich A and Yarden Y.


 
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