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ALDH2 cDNA ORF clone, Homo sapiens(Human)

Gene Symbol ALDH2
Entrez Gene ID 217
Full Name aldehyde dehydrogenase 2 family (mitochondrial)
Synonyms ALDH-E2,ALDHI,ALDM
General protein information
Preferred Names

aldehyde dehydrogenase 2 family (mitochondrial)

Names

aldehyde dehydrogenase, mitochondrial
ALDH class 2
acetaldehyde dehydrogenase 2
liver mitochondrial ALDH
nucleus-encoded mitochondrial aldehyde dehydrogenase 2

Gene Type protein-coding
Organism Homo sapiens(Human)
Genome

12

12q24.12

Summary This protein belongs to the aldehyde dehydrogenase family of proteins. Aldehyde dehydrogenase is the second enzyme of the major oxidative pathway of alcohol metabolism. Two major liver isoforms of aldehyde dehydrogenase, cytosolic and mitochondrial, can be distinguished by their electrophoretic mobilities, kinetic properties, and subcellular localizations. Most Caucasians have two major isozymes, while approximately 50% of East Asians have the cytosolic isozyme but not the mitochondrial isozyme. A remarkably higher frequency of acute alcohol intoxication among East Asians than among Caucasians could be related to the absence of a catalytically active form of the mitochondrial isozyme. The increased exposure to acetaldehyde in individuals with the catalytically inactive form may also confer greater susceptibility to many types of cancer. This gene encodes a mitochondrial isoform, which has a low Km for acetaldehydes, and is localized in mitochondrial matrix. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Nov 2016].
Disorder MIM:

100650

Disorder Html: Alcohol sensitivity, acute, 610251 (3); {Hangover, susceptibility

mRNA and Protein(s)

mRNA Protein Name
NM_000690.3 NP_000681.2 aldehyde dehydrogenase, mitochondrial isoform 1 precursor
NM_001204889.1 NP_001191818.1 aldehyde dehydrogenase, mitochondrial isoform 2 precursor



Bos taurus (cattle) ALDH2 NP_001068835.1
Gallus gallus (chicken) ALDH2 XP_415171.3
Kluyveromyces lactis KLLA0C07777g XP_452546.1
Neurospora crassa NCU03415 XP_956862.1
Pan troglodytes (chimpanzee) ALDH2 XP_509379.3
Danio rerio (zebrafish) aldh2l XP_002662252.1
Danio rerio (zebrafish) aldh2.2 NP_998466.2
Anopheles gambiae (African malaria mosquito) AgaP_AGAP003652 XP_313425.3
Caenorhabditis elegans (roundworm) alh-1 NP_498081.2
Arabidopsis thaliana (thale cress) ALDH2B4 NP_190383.1
Xenopus tropicalis (tropical clawed frog) aldh2 NP_001004907.1
Canis lupus familiaris (dog) ALDH2 XP_853628.1
Eremothecium gossypii AGOS_ACL044W NP_983360.1
Mus musculus (house mouse) Aldh2 NP_033786.1
Drosophila melanogaster (fruit fly) Aldh NP_609285.1
Magnaporthe oryzae (rice blast fungus) MGG_03900 XP_003719976.1
Macaca mulatta (rhesus monkey) ALDH2 XP_002808038.1
Homo sapiens (human) ALDH2 NP_000681.2
Rattus norvegicus (Norway rat) Aldh2 NP_115792.1
Danio rerio (zebrafish) aldh2.1 NP_956784.1
Caenorhabditis elegans (roundworm) alh-2 NP_503467.2
Saccharomyces cerevisiae (baker's yeast) ALD5 NP_010996.2
Schizosaccharomyces pombe (fission yeast) SPAC9E9.09c NP_594582.1


Related articles in PubMed

Association between ALDH2 Glu487Lys polymorphism and the risk of esophageal cancer.
Liu K, Song G, Zhu X, Yang X, Shen Y, Wang W, Shi G, Li Q, Duan Y, Zhao Y, Feng G
Medicine96(16)e6111(2017 Apr)

ALDH2 polymorphism and alcohol-related cancers in Asians: a public health perspective.
Chang JS, Hsiao JR, Chen CH
Journal of biomedical science24(1)19(2017 Mar)

Aldehyde dehydrogenase 2 activation and coevolution of its εPKC-mediated phosphorylation sites.
Nene A, Chen CH, Disatnik MH, Cruz L, Mochly-Rosen D
Journal of biomedical science24(1)3(2017 Jan)

Analysis of ADH1B Arg47His, ALDH2 Glu487Lys, and CYP4502E1 polymorphisms in gastric cancer risk and interaction with environmental factors.
Chen ZH, Xian JF, Luo LP
Genetics and molecular research : GMR15(4)(2016 Dec)

The Pathogenesis of Alcohol-Induced Airflow Limitation in Acetaldehyde Dehydrogenase 2-Deficient Mice.
Shimoda T, Obase Y, Matsuse H, Asai S, Iwanaga T
International archives of allergy and immunology171(3-4)276-284(2016)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Meta-analysis showed that a strong association exists between ALDH2 Glu487Lys polymorphism and the risk of esophageal cancer
Title: Association between ALDH2 Glu487Lys polymorphism and the risk of esophageal cancer.

The high prevalence of ALDH2*2 allele in East Asian populations may have important public health implications and may be utilized to reduce the occurrence of alcohol-related cancers among East Asians
Title: ALDH2 polymorphism and alcohol-related cancers in Asians: a public health perspective.

epsilonPKC phosphorylation and its coevolution with ALDH2 play an important role in the regulation and protection of ALDH2 enzyme activity.
Title: Aldehyde dehydrogenase 2 activation and coevolution of its εPKC-mediated phosphorylation sites.

Study indicate that ALDH2 Glu487Lys and CYP4502E1 polymorphisms could be risk factors for the development of gastric cancer in the Chinese population.
Title: Analysis of ADH1B Arg47His, ALDH2 Glu487Lys, and CYP4502E1 polymorphisms in gastric cancer risk and interaction with environmental factors.

alcohol dehydrogenase 1B (class I) beta polypeptide alcohol dehydrogenase 1B ADH beta subunit alcohol dehydrogenase 2 (class I) beta polypeptide alcohol dehydrogenase subunit beta aldehyde reductase epididymis secretory protein Li 117
Title: Genetic variations of aldehyde dehydrogenase 2 and alcohol dehydrogenase 1B are associated with the etiology of atrial fibrillation in Japanese.

The following ALDH2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the ALDH2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID RefSeq Accession Definition **Vector *Turnaround time Price (USD) Select
OHu23457 NM_000690.3
Latest version!
Homo sapiens aldehyde dehydrogenase 2 family (mitochondrial) (ALDH2), transcript variant 1, mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$49.50-$69.30
$99.00
OHu23602 NM_001204889.1
Latest version!
Homo sapiens aldehyde dehydrogenase 2 family (mitochondrial) (ALDH2), transcript variant 2, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 7-9 $223.30
$319.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.


CloneID OHu23457
Clone ID Related Accession (Same CDS sequence) NM_000690.3
Accession Version NM_000690.3 Latest version! Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 1554bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 2017-05-07
Organism Homo sapiens(Human)
Product aldehyde dehydrogenase, mitochondrial isoform 1 precursor
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DC353712.1, BC002967.1 and CB851683.1. This sequence is a reference standard in the RefSeqGene project. On Mar 11, 2011 this sequence version replaced NM_000690.2. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803613.276687.1, SRR1163655.616854.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta ##RefSeq-Attributes-END## COMPLETENESS: full length.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
ATGTTGCGCG CTGCCGCCCG CTTCGGGCCC CGCCTGGGCC GCCGCCTCTT GTCAGCCGCC 
GCCACCCAGG CCGTGCCTGC CCCCAACCAG CAGCCCGAGG TCTTCTGCAA CCAGATTTTC
ATAAACAATG AATGGCACGA TGCCGTCAGC AGGAAAACAT TCCCCACCGT CAATCCGTCC
ACTGGAGAGG TCATCTGTCA GGTAGCTGAA GGGGACAAGG AAGATGTGGA CAAGGCAGTG
AAGGCCGCCC GGGCCGCCTT CCAGCTGGGC TCACCTTGGC GCCGCATGGA CGCATCACAC
AGGGGCCGGC TGCTGAACCG CCTGGCCGAT CTGATCGAGC GGGACCGGAC CTACCTGGCG
GCCTTGGAGA CCCTGGACAA TGGCAAGCCC TATGTCATCT CCTACCTGGT GGATTTGGAC
ATGGTCCTCA AATGTCTCCG GTATTATGCC GGCTGGGCTG ATAAGTACCA CGGGAAAACC
ATCCCCATTG ACGGAGACTT CTTCAGCTAC ACACGCCATG AACCTGTGGG GGTGTGCGGG
CAGATCATTC CGTGGAATTT CCCGCTCCTG ATGCAAGCAT GGAAGCTGGG CCCAGCCTTG
GCAACTGGAA ACGTGGTTGT GATGAAGGTA GCTGAGCAGA CACCCCTCAC CGCCCTCTAT
GTGGCCAACC TGATCAAGGA GGCTGGCTTT CCCCCTGGTG TGGTCAACAT TGTGCCTGGA
TTTGGCCCCA CGGCTGGGGC CGCCATTGCC TCCCATGAGG ATGTGGACAA AGTGGCATTC
ACAGGCTCCA CTGAGATTGG CCGCGTAATC CAGGTTGCTG CTGGGAGCAG CAACCTCAAG
AGAGTGACCT TGGAGCTGGG GGGGAAGAGC CCCAACATCA TCATGTCAGA TGCCGATATG
GATTGGGCCG TGGAACAGGC CCACTTCGCC CTGTTCTTCA ACCAGGGCCA GTGCTGCTGT
GCCGGCTCCC GGACCTTCGT GCAGGAGGAC ATCTATGATG AGTTTGTGGA GCGGAGCGTT
GCCCGGGCCA AGTCTCGGGT GGTCGGGAAC CCCTTTGATA GCAAGACCGA GCAGGGGCCG
CAGGTGGATG AAACTCAGTT TAAGAAGATC CTCGGCTACA TCAACACGGG GAAGCAAGAG
GGGGCGAAGC TGCTGTGTGG TGGGGGCATT GCTGCTGACC GTGGTTACTT CATCCAGCCC
ACTGTGTTTG GAGATGTGCA GGATGGCATG ACCATCGCCA AGGAGGAGAT CTTCGGGCCA
GTGATGCAGA TCCTGAAGTT CAAGACCATA GAGGAGGTTG TTGGGAGAGC CAACAATTCC
ACGTACGGGC TGGCCGCAGC TGTCTTCACA AAGGATTTGG ACAAGGCCAA TTACCTGTCC
CAGGCCCTCC AGGCGGGCAC TGTGTGGGTC AACTGCTATG ATGTGTTTGG AGCCCAGTCA
CCCTTTGGTG GCTACAAGAT GTCGGGGAGT GGCCGGGAGT TGGGCGAGTA CGGGCTGCAG
GCATACACTG AAGTGAAAAC TGTCACAGTC AAAGTGCCTC AGAAGAACTC ATAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_000681.2
CDS97..1650
Misc Feature(1)85..87
Misc Feature(2)103..1644
Misc Feature(3)187..1629
Misc Feature(4)250..252
Misc Feature(5)313..315
Misc Feature(6)328..330
Misc Feature(7)order(361..366,376..378,385..387,391..393,403..405,526..528,535..540,550..552,556..561,568..582,586..591,598..621,898..900,907..909,916..921,928..933,937..939,952..954,1447..1449,1453..1455,1474..1476,1483..1485,1489..1512,1531..1539,1546..1557,1561..1563,1570..1572,1585..1587,1606..1623,1627..1629)
Misc Feature(8)571..573
Misc Feature(9)order(640..651,721..723,730..732,820..822,832..837,874..876,883..885,892..894,952..957,1051..1053,1192..1194,1201..1203,1342..1344)
Misc Feature(10)order(652..654,949..951,1042..1044,1051..1053)
Misc Feature(11)652..654
Misc Feature(12)1198..1200
Misc Feature(13)1243..1245
Misc Feature(14)1372..1374
Misc Feature(15)1378..1380
Misc Feature(16)1447..1449
Exon (1)1..210
Exon (2)211..315
Exon (3)316..456
Exon (4)457..536
Exon (5)537..648
Exon (6)649..777
Exon (7)778..891
Exon (8)892..994
Exon (9)995..1179
Exon (10)1180..1344
Exon (11)1345..1502
Exon (12)1503..1617
Exon (13)1618..2060
Translation

Target ORF information:

RefSeq Version NM_000690.3
Organism Homo sapiens(Human)
Definition Homo sapiens aldehyde dehydrogenase 2 family (mitochondrial) (ALDH2), transcript variant 1, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_000690.3

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
ATGTTGCGCG CTGCCGCCCG CTTCGGGCCC CGCCTGGGCC GCCGCCTCTT GTCAGCCGCC 
GCCACCCAGG CCGTGCCTGC CCCCAACCAG CAGCCCGAGG TCTTCTGCAA CCAGATTTTC
ATAAACAATG AATGGCACGA TGCCGTCAGC AGGAAAACAT TCCCCACCGT CAATCCGTCC
ACTGGAGAGG TCATCTGTCA GGTAGCTGAA GGGGACAAGG AAGATGTGGA CAAGGCAGTG
AAGGCCGCCC GGGCCGCCTT CCAGCTGGGC TCACCTTGGC GCCGCATGGA CGCATCACAC
AGGGGCCGGC TGCTGAACCG CCTGGCCGAT CTGATCGAGC GGGACCGGAC CTACCTGGCG
GCCTTGGAGA CCCTGGACAA TGGCAAGCCC TATGTCATCT CCTACCTGGT GGATTTGGAC
ATGGTCCTCA AATGTCTCCG GTATTATGCC GGCTGGGCTG ATAAGTACCA CGGGAAAACC
ATCCCCATTG ACGGAGACTT CTTCAGCTAC ACACGCCATG AACCTGTGGG GGTGTGCGGG
CAGATCATTC CGTGGAATTT CCCGCTCCTG ATGCAAGCAT GGAAGCTGGG CCCAGCCTTG
GCAACTGGAA ACGTGGTTGT GATGAAGGTA GCTGAGCAGA CACCCCTCAC CGCCCTCTAT
GTGGCCAACC TGATCAAGGA GGCTGGCTTT CCCCCTGGTG TGGTCAACAT TGTGCCTGGA
TTTGGCCCCA CGGCTGGGGC CGCCATTGCC TCCCATGAGG ATGTGGACAA AGTGGCATTC
ACAGGCTCCA CTGAGATTGG CCGCGTAATC CAGGTTGCTG CTGGGAGCAG CAACCTCAAG
AGAGTGACCT TGGAGCTGGG GGGGAAGAGC CCCAACATCA TCATGTCAGA TGCCGATATG
GATTGGGCCG TGGAACAGGC CCACTTCGCC CTGTTCTTCA ACCAGGGCCA GTGCTGCTGT
GCCGGCTCCC GGACCTTCGT GCAGGAGGAC ATCTATGATG AGTTTGTGGA GCGGAGCGTT
GCCCGGGCCA AGTCTCGGGT GGTCGGGAAC CCCTTTGATA GCAAGACCGA GCAGGGGCCG
CAGGTGGATG AAACTCAGTT TAAGAAGATC CTCGGCTACA TCAACACGGG GAAGCAAGAG
GGGGCGAAGC TGCTGTGTGG TGGGGGCATT GCTGCTGACC GTGGTTACTT CATCCAGCCC
ACTGTGTTTG GAGATGTGCA GGATGGCATG ACCATCGCCA AGGAGGAGAT CTTCGGGCCA
GTGATGCAGA TCCTGAAGTT CAAGACCATA GAGGAGGTTG TTGGGAGAGC CAACAATTCC
ACGTACGGGC TGGCCGCAGC TGTCTTCACA AAGGATTTGG ACAAGGCCAA TTACCTGTCC
CAGGCCCTCC AGGCGGGCAC TGTGTGGGTC AACTGCTATG ATGTGTTTGG AGCCCAGTCA
CCCTTTGGTG GCTACAAGAT GTCGGGGAGT GGCCGGGAGT TGGGCGAGTA CGGGCTGCAG
GCATACACTG AAGTGAAAAC TGTCACAGTC AAAGTGCCTC AGAAGAACTC ATAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu23602
Clone ID Related Accession (Same CDS sequence) NM_001204889.1
Accession Version NM_001204889.1 Latest version! Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 1413bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 2017-05-07
Organism Homo sapiens(Human)
Product aldehyde dehydrogenase, mitochondrial isoform 2 precursor
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DC353712.1, AK301375.1, BC002967.1 and CB851683.1. Transcript Variant: This variant (2) lacks an in-frame exon in the 5' coding region, compared to variant 1, and encodes a shorter isoform (2), compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803617.255690.1, SRR1803615.152846.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta ##RefSeq-Attributes-END## COMPLETENESS: full length.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
ATGTTGCGCG CTGCCGCCCG CTTCGGGCCC CGCCTGGGCC GCCGCCTCTT GTCAGCCGCC 
GCCACCCAGG CCGTGCCTGC CCCCAACCAG CAGCCCGAGG TCTTCTGCAA CCAGATTTTC
ATAAACAATG AATGGCACGA TGCCGTCAGC AGGAAAACAT TCCCCACCGT CAATCCGTCC
ACTGGAGAGG TCATCTGTCA GGTAGCTGAA GGGGACAAGG CCTTGGAGAC CCTGGACAAT
GGCAAGCCCT ATGTCATCTC CTACCTGGTG GATTTGGACA TGGTCCTCAA ATGTCTCCGG
TATTATGCCG GCTGGGCTGA TAAGTACCAC GGGAAAACCA TCCCCATTGA CGGAGACTTC
TTCAGCTACA CACGCCATGA ACCTGTGGGG GTGTGCGGGC AGATCATTCC GTGGAATTTC
CCGCTCCTGA TGCAAGCATG GAAGCTGGGC CCAGCCTTGG CAACTGGAAA CGTGGTTGTG
ATGAAGGTAG CTGAGCAGAC ACCCCTCACC GCCCTCTATG TGGCCAACCT GATCAAGGAG
GCTGGCTTTC CCCCTGGTGT GGTCAACATT GTGCCTGGAT TTGGCCCCAC GGCTGGGGCC
GCCATTGCCT CCCATGAGGA TGTGGACAAA GTGGCATTCA CAGGCTCCAC TGAGATTGGC
CGCGTAATCC AGGTTGCTGC TGGGAGCAGC AACCTCAAGA GAGTGACCTT GGAGCTGGGG
GGGAAGAGCC CCAACATCAT CATGTCAGAT GCCGATATGG ATTGGGCCGT GGAACAGGCC
CACTTCGCCC TGTTCTTCAA CCAGGGCCAG TGCTGCTGTG CCGGCTCCCG GACCTTCGTG
CAGGAGGACA TCTATGATGA GTTTGTGGAG CGGAGCGTTG CCCGGGCCAA GTCTCGGGTG
GTCGGGAACC CCTTTGATAG CAAGACCGAG CAGGGGCCGC AGGTGGATGA AACTCAGTTT
AAGAAGATCC TCGGCTACAT CAACACGGGG AAGCAAGAGG GGGCGAAGCT GCTGTGTGGT
GGGGGCATTG CTGCTGACCG TGGTTACTTC ATCCAGCCCA CTGTGTTTGG AGATGTGCAG
GATGGCATGA CCATCGCCAA GGAGGAGATC TTCGGGCCAG TGATGCAGAT CCTGAAGTTC
AAGACCATAG AGGAGGTTGT TGGGAGAGCC AACAATTCCA CGTACGGGCT GGCCGCAGCT
GTCTTCACAA AGGATTTGGA CAAGGCCAAT TACCTGTCCC AGGCCCTCCA GGCGGGCACT
GTGTGGGTCA ACTGCTATGA TGTGTTTGGA GCCCAGTCAC CCTTTGGTGG CTACAAGATG
TCGGGGAGTG GCCGGGAGTT GGGCGAGTAC GGGCTGCAGG CATACACTGA AGTGAAAACT
GTCACAGTCA AAGTGCCTCA GAAGAACTCA TAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_001191818.1
CDS97..1509
Misc Feature(1)85..87
Misc Feature(2)103..1503
Misc Feature(3)187..1488
Misc Feature(4)order(385..387,394..399,409..411,415..420,427..441,445..450,457..480,757..759,766..768,775..780,787..792,796..798,811..813,1306..1308,1312..1314,1333..1335,1342..1344,1348..1371,1390..1398,1405..1416,1420..1422,1429..1431,1444..1446,1465..1482,1486..1488)
Misc Feature(5)order(499..510,580..582,589..591,679..681,691..696,733..735,742..744,751..753,811..816,910..912,1051..1053,1060..1062,1201..1203)
Misc Feature(6)order(511..513,808..810,901..903,910..912)
Exon (1)1..210
Exon (2)211..315
Exon (3)316..395
Exon (4)396..507
Exon (5)508..636
Exon (6)637..750
Exon (7)751..853
Exon (8)854..1038
Exon (9)1039..1203
Exon (10)1204..1361
Exon (11)1362..1476
Exon (12)1477..1919
Translation

Target ORF information:

RefSeq Version NM_001204889.1
Organism Homo sapiens(Human)
Definition Homo sapiens aldehyde dehydrogenase 2 family (mitochondrial) (ALDH2), transcript variant 2, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_001204889.1

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
ATGTTGCGCG CTGCCGCCCG CTTCGGGCCC CGCCTGGGCC GCCGCCTCTT GTCAGCCGCC 
GCCACCCAGG CCGTGCCTGC CCCCAACCAG CAGCCCGAGG TCTTCTGCAA CCAGATTTTC
ATAAACAATG AATGGCACGA TGCCGTCAGC AGGAAAACAT TCCCCACCGT CAATCCGTCC
ACTGGAGAGG TCATCTGTCA GGTAGCTGAA GGGGACAAGG CCTTGGAGAC CCTGGACAAT
GGCAAGCCCT ATGTCATCTC CTACCTGGTG GATTTGGACA TGGTCCTCAA ATGTCTCCGG
TATTATGCCG GCTGGGCTGA TAAGTACCAC GGGAAAACCA TCCCCATTGA CGGAGACTTC
TTCAGCTACA CACGCCATGA ACCTGTGGGG GTGTGCGGGC AGATCATTCC GTGGAATTTC
CCGCTCCTGA TGCAAGCATG GAAGCTGGGC CCAGCCTTGG CAACTGGAAA CGTGGTTGTG
ATGAAGGTAG CTGAGCAGAC ACCCCTCACC GCCCTCTATG TGGCCAACCT GATCAAGGAG
GCTGGCTTTC CCCCTGGTGT GGTCAACATT GTGCCTGGAT TTGGCCCCAC GGCTGGGGCC
GCCATTGCCT CCCATGAGGA TGTGGACAAA GTGGCATTCA CAGGCTCCAC TGAGATTGGC
CGCGTAATCC AGGTTGCTGC TGGGAGCAGC AACCTCAAGA GAGTGACCTT GGAGCTGGGG
GGGAAGAGCC CCAACATCAT CATGTCAGAT GCCGATATGG ATTGGGCCGT GGAACAGGCC
CACTTCGCCC TGTTCTTCAA CCAGGGCCAG TGCTGCTGTG CCGGCTCCCG GACCTTCGTG
CAGGAGGACA TCTATGATGA GTTTGTGGAG CGGAGCGTTG CCCGGGCCAA GTCTCGGGTG
GTCGGGAACC CCTTTGATAG CAAGACCGAG CAGGGGCCGC AGGTGGATGA AACTCAGTTT
AAGAAGATCC TCGGCTACAT CAACACGGGG AAGCAAGAGG GGGCGAAGCT GCTGTGTGGT
GGGGGCATTG CTGCTGACCG TGGTTACTTC ATCCAGCCCA CTGTGTTTGG AGATGTGCAG
GATGGCATGA CCATCGCCAA GGAGGAGATC TTCGGGCCAG TGATGCAGAT CCTGAAGTTC
AAGACCATAG AGGAGGTTGT TGGGAGAGCC AACAATTCCA CGTACGGGCT GGCCGCAGCT
GTCTTCACAA AGGATTTGGA CAAGGCCAAT TACCTGTCCC AGGCCCTCCA GGCGGGCACT
GTGTGGGTCA ACTGCTATGA TGTGTTTGGA GCCCAGTCAC CCTTTGGTGG CTACAAGATG
TCGGGGAGTG GCCGGGAGTT GGGCGAGTAC GGGCTGCAGG CATACACTGA AGTGAAAACT
GTCACAGTCA AAGTGCCTCA GAAGAACTCA TAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

book

Association between ALDH2 Glu487Lys polymorphism and the risk of esophageal cancer.
Medicine96(16)e6111(2017 Apr)
Liu K,Song G,Zhu X,Yang X,Shen Y,Wang W,Shi G,Li Q,Duan Y,Zhao Y,Feng G


book

ALDH2 polymorphism and alcohol-related cancers in Asians: a public health perspective.
Journal of biomedical science24(1)19(2017 Mar)
Chang JS,Hsiao JR,Chen CH


book

Aldehyde dehydrogenase 2 activation and coevolution of its εPKC-mediated phosphorylation sites.
Journal of biomedical science24(1)3(2017 Jan)
Nene A,Chen CH,Disatnik MH,Cruz L,Mochly-Rosen D


book

Analysis of ADH1B Arg47His, ALDH2 Glu487Lys, and CYP4502E1 polymorphisms in gastric cancer risk and interaction with environmental factors.
Genetics and molecular research : GMR15(4)(2016 Dec)
Chen ZH,Xian JF,Luo LP


book

The Pathogenesis of Alcohol-Induced Airflow Limitation in Acetaldehyde Dehydrogenase 2-Deficient Mice.
International archives of allergy and immunology171(3-4)276-284(2016)
Shimoda T,Obase Y,Matsuse H,Asai S,Iwanaga T


 
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