GDI2 cDNA ORF clone, Homo sapiens(human)
| Gene Symbol | GDI2 |
| Entrez Gene ID | 2665 |
| Full Name | GDP dissociation inhibitor 2 |
| Synonyms | HEL-S-46e,RABGDIB |
| General protein information |
|
| Gene Type | protein-coding |
| Organism | Homo sapiens(human) |
| Genome | |
| Summary | GDP dissociation inhibitors are proteins that regulate the GDP-GTP exchange reaction of members of the rab family, small GTP-binding proteins of the ras superfamily, that are involved in vesicular trafficking of molecules between cellular organelles. GDIs slow the rate of dissociation of GDP from rab proteins and release GDP from membrane-bound rabs. GDI2 is ubiquitously expressed. The GDI2 gene contains many repetitive elements indicating that it may be prone to inversion/deletion rearrangements. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]. |
| Disorder MIM: |
mRNA and Protein(s)
| mRNA | Protein | Name |
|---|---|---|
| NM_001115156.1 | NP_001108628.1 | rab GDP dissociation inhibitor beta isoform 2 |
| Pan troglodytes (chimpanzee) | GDI2 | XP_507638.3 |
| Rattus norvegicus (Norway rat) | Gdi2 | NP_058972.2 |
| Oryza sativa (rice) | Os03g0277000 | NP_001049717.1 |
| Canis lupus familiaris (dog) | GDI2 | NP_001003184.1 |
| Bos taurus (cattle) | GDI2 | NP_001028934.1 |
| Arabidopsis thaliana (thale cress) | AT5G09550 | NP_196517.3 |
| Xenopus tropicalis (tropical clawed frog) | gdi2 | NP_001005676.1 |
| Mus musculus (house mouse) | Gdi2 | NP_032138.3 |
| Danio rerio (zebrafish) | gdi2 | NP_955949.1 |
| Homo sapiens (human) | GDI2 | NP_001485.2 |
| GDI2 | XP_001105854.1 | |
| Gallus gallus (chicken) | GDI2 | NP_990335.1 |
Related articles in PubMed
GSK3?-Dzip1-Rab8 cascade regulates ciliogenesis after mitosis.
Zhang B, Zhang T, Wang G, Wang G, Chi W, Jiang Q, Zhang C
PLoS biology13(4)e1002129(2015 Apr)
Genome-wide association study identifies two susceptibility loci for osteosarcoma.
Savage SA, Mirabello L, Wang Z, Gastier-Foster JM, Gorlick R, Khanna C, Flanagan AM, Tirabosco R, Andrulis IL, Wunder JS, Gokgoz N, Pati?o-Garcia A, Sierrases?maga L, Lecanda F, Kurucu N, Ilhan IE, Sari N, Serra M, Hattinger C, Picci P, Spector LG, Barkauskas DA, Marina N, de Toledo SR, Petrilli AS, Amary MF, Halai D, Thomas DM, Douglass C, Meltzer PS, Jacobs K, Chung CC, Berndt SI, Purdue MP, Caporaso NE, Tucker M, Rothman N, Landi MT, Silverman DT, Kraft P, Hunter DJ, Malats N, Kogevinas M, Wacholder S, Troisi R, Helman L, Fraumeni JF Jr, Yeager M, Hoover RN, Chanock SJ
Nature genetics45(7)799-803(2013 Jul)
The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts.
Baltz AG, Munschauer M, Schwanh?usser B, Vasile A, Murakawa Y, Schueler M, Youngs N, Penfold-Brown D, Drew K, Milek M, Wyler E, Bonneau R, Selbach M, Dieterich C, Landthaler M
Molecular cell46(5)674-90(2012 Jun)
Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for ?-Pix in negative regulation of focal adhesion maturation.
Kuo JC, Han X, Hsiao CT, Yates JR 3rd, Waterman CM
Nature cell biology13(4)383-93(2011 Apr)
Structural mechanism of host Rab1 activation by the bifunctional Legionella type IV effector SidM/DrrA.
Zhu Y, Hu L, Zhou Y, Yao Q, Liu L, Shao F
Proceedings of the National Academy of Sciences of the United States of America107(10)4699-704(2010 Mar)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
The increased levels of cyclin I and GDI2 found to be associated with pancreatic carcinoma were further confirmed by Western blot analyses in an independent series of serum samples and/or pancreatic juice samples
Title: Serum proteomic-based analysis of pancreatic carcinoma for the identification of potential cancer biomarkers.
Observational study of gene-disease association. (HuGE Navigator)
Title: A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.
Reduction of nucleoside diphosphate kinase B, Rab GDP-dissociation inhibitor beta and histidine triad nucleotide-binding protein in fetal Down syndrome brain.
Title: Reduction of nucleoside diphosphate kinase B, Rab GDP-dissociation inhibitor beta and histidine triad nucleotide-binding protein in fetal Down syndrome brain.
The following GDI2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the GDI2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
| CloneID | OHu08950 | |
| Clone ID Related Accession (Same CDS sequence) | NM_001115156.1 | |
| Accession Version | NM_001115156.1 Latest version! | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 1203bp) Protein sequence SNP |
|
| Vector | pcDNA3.1-C-(k)DYK or customized vector |  User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2019-06-07 | |
| Organism | Homo sapiens(human) | |
| Product | rab GDP dissociation inhibitor beta isoform 2 | |
| Comment | Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA069966.1, AK312485.1 and BC005145.2. Transcript Variant: This variant (2) lacks an in-frame exon in the 5' coding region, compared to variant 1, resulting in a shorter protein, compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BX648038.1, SRR1803614.204165.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: full length. | |
1 | ATGAATGAGG AGTACGACGT GATCGTGCTG GGCACCGGCC TGACGGAATG TATCCTGTCA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | NP_001108628.1 |
| CDS | 292..1494 |
| Translation |
Target ORF information:
Target ORF information:
|
 NM_001115156.1 |
ORF Insert Sequence:
1 | ATGAATGAGG AGTACGACGT GATCGTGCTG GGCACCGGCC TGACGGAATG TATCCTGTCA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
 |
GSK3?-Dzip1-Rab8 cascade regulates ciliogenesis after mitosis. |
|
Genome-wide association study identifies two susceptibility loci for osteosarcoma. |
|
The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. |
|
Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for ?-Pix in negative regulation of focal adhesion maturation. |
|
Structural mechanism of host Rab1 activation by the bifunctional Legionella type IV effector SidM/DrrA. |