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GHRHR cDNA ORF clone, Homo sapiens(Human)

Gene Symbol GHRHR
Entrez Gene ID 2692
Full Name growth hormone releasing hormone receptor
Synonyms GHRFR,GRFR,IGHD1B
General protein information
Preferred Names

growth hormone releasing hormone receptor

Names

growth hormone-releasing hormone receptor
GHRH receptor
GRF receptor
growth hormone releasing hormone receptor variant 1
growth hormone releasing hormone receptor variant 2
growth hormone releasing hormone receptor variant 3
growth hormone releasing hormone receptor variant 4

Gene Type protein-coding
Organism Homo sapiens(Human)
Genome

7

7p14.3

Summary This gene encodes a receptor for growth hormone-releasing hormone. Binding of this hormone to the receptor leads to synthesis and release of growth hormone. Mutations in this gene have been associated with isolated growth hormone deficiency (IGHD), also known as Dwarfism of Sindh, a disorder characterized by short stature. [provided by RefSeq, Jun 2010].
Disorder MIM:

139191

Disorder Html: Growth hormone deficiency, isolated, type IB, 612781 (3)

mRNA and Protein(s)

mRNA Protein Name
NM_000823.3 NP_000814.2 growth hormone-releasing hormone receptor precursor
XM_011515263.1 XP_011513565.1 growth hormone-releasing hormone receptor isoform X1



Homo sapiens (human) GHRHR NP_000814.2
Mus musculus (house mouse) Ghrhr NP_001003685.2
Rattus norvegicus (Norway rat) Ghrhr NP_036982.1
Pan troglodytes (chimpanzee) GHRHR XP_519027.3
Canis lupus familiaris (dog) GHRHR XP_539502.3
Bos taurus (cattle) GHRHR NP_851363.1
Gallus gallus (chicken) GHRHR NP_001032923.1
Danio rerio (zebrafish) ghrhrl NP_001075951.1


Related articles in PubMed

Older individuals heterozygous for a growth hormone-releasing hormone receptor gene mutation are shorter than normal subjects.
Aguiar-Oliveira MH, Cardoso-Filho MA, Pereira RM, Oliveira CR, Souza AH, Santos EG, Campos VC, Valença EH, de Oliveira FT, Oliveira-Neto LA, Gois-Junior MB, Oliveira-Santos AA, Salvatori R
Journal of human genetics60(6)335-8(2015 Jun)

Expression of a splice variant of the receptor for GHRH in 3T3 fibroblasts activates cell proliferation responses to GHRH analogs.
Kiaris H, Schally AV, Busto R, Halmos G, Artavanis-Tsakonas S, Varga JL
Proceedings of the National Academy of Sciences of the United States of America99(1)196-200(2002 Jan)

Isolation and sequencing of cDNAs for splice variants of growth hormone-releasing hormone receptors from human cancers.
Rekasi Z, Czompoly T, Schally AV, Halmos G
Proceedings of the National Academy of Sciences of the United States of America97(19)10561-6(2000 Sep)

Phenotype and genetic analysis of a syndrome caused by an inactivating mutation in the growth hormone-releasing hormone receptor: Dwarfism of Sindh.
Maheshwari HG, Silverman BL, Dupuis J, Baumann G
The Journal of clinical endocrinology and metabolism83(11)4065-74(1998 Nov)

Structure and regulation of the human growth hormone-releasing hormone receptor gene.
Petersenn S, Rasch AC, Heyens M, Schulte HM
Molecular endocrinology (Baltimore, Md.)12(2)233-47(1998 Feb)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The pP79L mutation is associated with the compromise in function, with the residual partial activity explaining the mild phenotype.
Title: Partial Loss of Function of the GHRH Receptor Leads to Mild Growth Hormone Deficiency.

This is the first report to demonstrate the GHRH-R codon 72 mutation in Sri Lankan patients with confirmed growth hormone deficiency.
Title: Growth hormone releasing hormone receptor codon 72 mutation in a cohort of Sri Lankan patients with growth hormone deficiency.

This study shows that GHRH-R is expressed by the majority of malignant mixed Mullerian tumors in both epithelial and mesenchymal components
Title: GHRH Receptor Expression in Malignant Mixed Müllerian Tumors: A Potentially Targetable Biopredictor.

GHRH and GHRH-R loops are involved in placental choriocarcinoma cell line viability and apoptosis through Akt and eIF2a pathways.
Title: Impact of Axis of GHRH and GHRH Receptor on Cell Viability and Apoptosis of the Placental Choriocarcinoma Cell Line.

A reduced stature in older subjects heterozygous for the c.57+1G>A GHRHR mutation, indicating different effects of heterozygosis through lifespan.
Title: Older individuals heterozygous for a growth hormone-releasing hormone receptor gene mutation are shorter than normal subjects.

The following GHRHR gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the GHRHR cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID RefSeq Accession Definition **Vector *Turnaround time Price (USD) Select
OHu18044 NM_000823.3
Latest version!
Homo sapiens growth hormone releasing hormone receptor (GHRHR), mRNA. pcDNA3.1+/C-(K)DYK or customized vector 5-7 $223.30
$319.00
OHu57966 XM_011515263.1
Latest version!
Homo sapiens growth hormone releasing hormone receptor (GHRHR), transcript variant X1, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 7-9 $223.30
$319.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.


CloneID OHu18044
Clone ID Related Accession (Same CDS sequence) NM_000823.3
Accession Version NM_000823.3 Latest version! Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 1272bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 2017-05-08
Organism Homo sapiens(Human)
Product growth hormone-releasing hormone receptor precursor
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from L09237.1 and DB348314.1. This sequence is a reference standard in the RefSeqGene project. On Jun 2, 2010 this sequence version replaced NM_000823.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: L09237.1, L01406.1 [ECO:0000332] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
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361
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481
541
601
661
721
781
841
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961
1021
1081
1141
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ATGGACCGCC GGATGTGGGG GGCCCACGTC TTCTGCGTGT TGAGCCCGTT ACCGACCGTA 
TTGGGCCACA TGCACCCAGA ATGTGACTTC ATCACCCAGC TGAGAGAGGA TGAGAGTGCC
TGTCTACAAG CAGCAGAGGA GATGCCCAAC ACCACCCTGG GCTGCCCTGC GACCTGGGAT
GGGCTGCTGT GCTGGCCAAC GGCAGGCTCT GGCGAGTGGG TCACCCTCCC CTGCCCGGAT
TTCTTCTCTC ACTTCAGCTC AGAGTCAGGG GCTGTGAAAC GGGATTGTAC TATCACTGGC
TGGTCTGAGC CCTTTCCACC TTACCCTGTG GCCTGCCCTG TGCCTCTGGA GCTGCTGGCT
GAGGAGGAAT CTTACTTCTC CACAGTGAAG ATTATCTACA CCGTGGGCCA TAGCATCTCT
ATTGTAGCCC TCTTCGTGGC CATCACCATC CTGGTTGCTC TCAGGAGGCT CCACTGCCCC
CGGAACTACG TCCACACCCA GCTGTTCACC ACTTTTATCC TCAAGGCGGG AGCTGTGTTC
CTGAAGGATG CTGCCCTTTT CCACAGCGAC GACACTGACC ACTGCAGCTT CTCCACTGTT
CTATGCAAGG TCTCTGTGGC CGCCTCCCAT TTCGCCACCA TGACCAACTT CAGCTGGCTG
TTGGCAGAAG CCGTCTACCT GAACTGCCTC CTGGCCTCCA CCTCCCCCAG CTCAAGGAGA
GCCTTCTGGT GGCTGGTTCT CGCTGGCTGG GGGCTGCCCG TGCTCTTCAC TGGCACGTGG
GTGAGCTGCA AACTGGCCTT CGAGGACATC GCGTGCTGGG ACCTGGACGA CACCTCCCCC
TACTGGTGGA TCATCAAAGG GCCCATTGTC CTCTCGGTCG GGGTGAACTT TGGGCTTTTT
CTCAATATTA TCCGCATCCT GGTGAGGAAA CTGGAGCCAG CTCAGGGCAG CCTCCATACC
CAGTCTCAGT ATTGGCGTCT CTCCAAGTCG ACACTTTTCC TGATCCCACT CTTTGGAATT
CACTACATCA TCTTCAACTT CCTGCCAGAC AATGCTGGCC TGGGCATCCG CCTCCCCCTG
GAGCTGGGAC TGGGTTCCTT CCAGGGCTTC ATTGTTGCCA TCCTCTACTG CTTCCTCAAC
CAAGAGGTGA GGACTGAGAT CTCACGGAAG TGGCATGGCC ATGACCCTGA GCTTCTGCCA
GCCTGGAGGA CCCGTGCTAA GTGGACCACG CCTTCCCGCT CGGCGGCAAA GGTGCTGACA
TCTATGTGCT AG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_000814.2
CDS49..1320
Misc Feature(1)202..384
Misc Feature(2)424..1164
Misc Feature(3)445..504
Misc Feature(4)535..591
Misc Feature(5)661..729
Misc Feature(6)769..834
Misc Feature(7)889..960
Misc Feature(8)1036..1092
Misc Feature(9)1132..1191
Exon (1)1..105
Exon (2)106..208
Exon (3)209..316
Exon (4)317..414
Exon (5)415..512
Exon (6)513..645
Exon (7)646..799
Exon (8)800..860
Exon (9)861..930
Exon (10)931..1022
Exon (11)1023..1152
Exon (12)1153..1194
Exon (13)1195..1607
Translation

Target ORF information:

RefSeq Version NM_000823.3
Organism Homo sapiens(Human)
Definition Homo sapiens growth hormone releasing hormone receptor (GHRHR), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_000823.3

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
ATGGACCGCC GGATGTGGGG GGCCCACGTC TTCTGCGTGT TGAGCCCGTT ACCGACCGTA 
TTGGGCCACA TGCACCCAGA ATGTGACTTC ATCACCCAGC TGAGAGAGGA TGAGAGTGCC
TGTCTACAAG CAGCAGAGGA GATGCCCAAC ACCACCCTGG GCTGCCCTGC GACCTGGGAT
GGGCTGCTGT GCTGGCCAAC GGCAGGCTCT GGCGAGTGGG TCACCCTCCC CTGCCCGGAT
TTCTTCTCTC ACTTCAGCTC AGAGTCAGGG GCTGTGAAAC GGGATTGTAC TATCACTGGC
TGGTCTGAGC CCTTTCCACC TTACCCTGTG GCCTGCCCTG TGCCTCTGGA GCTGCTGGCT
GAGGAGGAAT CTTACTTCTC CACAGTGAAG ATTATCTACA CCGTGGGCCA TAGCATCTCT
ATTGTAGCCC TCTTCGTGGC CATCACCATC CTGGTTGCTC TCAGGAGGCT CCACTGCCCC
CGGAACTACG TCCACACCCA GCTGTTCACC ACTTTTATCC TCAAGGCGGG AGCTGTGTTC
CTGAAGGATG CTGCCCTTTT CCACAGCGAC GACACTGACC ACTGCAGCTT CTCCACTGTT
CTATGCAAGG TCTCTGTGGC CGCCTCCCAT TTCGCCACCA TGACCAACTT CAGCTGGCTG
TTGGCAGAAG CCGTCTACCT GAACTGCCTC CTGGCCTCCA CCTCCCCCAG CTCAAGGAGA
GCCTTCTGGT GGCTGGTTCT CGCTGGCTGG GGGCTGCCCG TGCTCTTCAC TGGCACGTGG
GTGAGCTGCA AACTGGCCTT CGAGGACATC GCGTGCTGGG ACCTGGACGA CACCTCCCCC
TACTGGTGGA TCATCAAAGG GCCCATTGTC CTCTCGGTCG GGGTGAACTT TGGGCTTTTT
CTCAATATTA TCCGCATCCT GGTGAGGAAA CTGGAGCCAG CTCAGGGCAG CCTCCATACC
CAGTCTCAGT ATTGGCGTCT CTCCAAGTCG ACACTTTTCC TGATCCCACT CTTTGGAATT
CACTACATCA TCTTCAACTT CCTGCCAGAC AATGCTGGCC TGGGCATCCG CCTCCCCCTG
GAGCTGGGAC TGGGTTCCTT CCAGGGCTTC ATTGTTGCCA TCCTCTACTG CTTCCTCAAC
CAAGAGGTGA GGACTGAGAT CTCACGGAAG TGGCATGGCC ATGACCCTGA GCTTCTGCCA
GCCTGGAGGA CCCGTGCTAA GTGGACCACG CCTTCCCGCT CGGCGGCAAA GGTGCTGACA
TCTATGTGCT AG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu57966
Clone ID Related Accession (Same CDS sequence) XM_011515263.1
Accession Version XM_011515263.1 Latest version! Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 1080bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 2016-06-06
Organism Homo sapiens(Human)
Product growth hormone-releasing hormone receptor isoform X1
Comment MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000007.14) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
ATGGTCCCTG GCACCCCCAG CCCCCTCCTG GGGAGAGGGA AGGAGTTGTG GCTAGAGAGT 
CTTGCTTGCC TCCCAGGGGC TGTGAAACGG GATTGTACTA TCACTGGCTG GTCTGAGCCC
TTTCCACCTT ACCCTGTGGC CTGCCCTGTG CCTCTGGAGC TGCTGGCTGA GGAGGAATCT
TACTTCTCCA CAGTGAAGAT TATCTACACC GTGGGCCATA GCATCTCTAT TGTAGCCCTC
TTCGTGGCCA TCACCATCCT GGTTGCTCTC AGGAGGCTCC ACTGCCCCCG GAACTACGTC
CACACCCAGC TGTTCACCAC TTTTATCCTC AAGGCGGGAG CTGTGTTCCT GAAGGATGCT
GCCCTTTTCC ACAGCGACGA CACTGACCAC TGCAGCTTCT CCACTGTTCT ATGCAAGGTC
TCTGTGGCCG CCTCCCATTT CGCCACCATG ACCAACTTCA GCTGGCTGTT GGCAGAAGCC
GTCTACCTGA ACTGCCTCCT GGCCTCCACC TCCCCCAGCT CAAGGAGAGC CTTCTGGTGG
CTGGTTCTCG CTGGCTGGGG GCTGCCCGTG CTCTTCACTG GCACGTGGGT GAGCTGCAAA
CTGGCCTTCG AGGACATCGC GTGCTGGGAC CTGGACGACA CCTCCCCCTA CTGGTGGATC
ATCAAAGGGC CCATTGTCCT CTCGGTCGGG GTGAACTTTG GGCTTTTTCT CAATATTATC
CGCATCCTGG TGAGGAAACT GGAGCCAGCT CAGGGCAGCC TCCATACCCA GTCTCAGTAT
TGGCGTCTCT CCAAGTCGAC ACTTTTCCTG ATCCCACTCT TTGGAATTCA CTACATCATC
TTCAACTTCC TGCCAGACAA TGCTGGCCTG GGCATCCGCC TCCCCCTGGA GCTGGGACTG
GGTTCCTTCC AGGGCTTCAT TGTTGCCATC CTCTACTGCT TCCTCAACCA AGAGGTGAGG
ACTGAGATCT CACGGAAGTG GCATGGCCAT GACCCTGAGC TTCTGCCAGC CTGGAGGACC
CGTGCTAAGT GGACCACGCC TTCCCGCTCG GCGGCAAAGG TGCTGACATC TATGTGCTAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq XP_011513565.1
CDS259..1338
Misc Feature(1)442..1182
Translation

Target ORF information:

RefSeq Version XM_011515263.1
Organism Homo sapiens(Human)
Definition Homo sapiens growth hormone releasing hormone receptor (GHRHR), transcript variant X1, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
XM_011515263.1

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
ATGGTCCCTG GCACCCCCAG CCCCCTCCTG GGGAGAGGGA AGGAGTTGTG GCTAGAGAGT 
CTTGCTTGCC TCCCAGGGGC TGTGAAACGG GATTGTACTA TCACTGGCTG GTCTGAGCCC
TTTCCACCTT ACCCTGTGGC CTGCCCTGTG CCTCTGGAGC TGCTGGCTGA GGAGGAATCT
TACTTCTCCA CAGTGAAGAT TATCTACACC GTGGGCCATA GCATCTCTAT TGTAGCCCTC
TTCGTGGCCA TCACCATCCT GGTTGCTCTC AGGAGGCTCC ACTGCCCCCG GAACTACGTC
CACACCCAGC TGTTCACCAC TTTTATCCTC AAGGCGGGAG CTGTGTTCCT GAAGGATGCT
GCCCTTTTCC ACAGCGACGA CACTGACCAC TGCAGCTTCT CCACTGTTCT ATGCAAGGTC
TCTGTGGCCG CCTCCCATTT CGCCACCATG ACCAACTTCA GCTGGCTGTT GGCAGAAGCC
GTCTACCTGA ACTGCCTCCT GGCCTCCACC TCCCCCAGCT CAAGGAGAGC CTTCTGGTGG
CTGGTTCTCG CTGGCTGGGG GCTGCCCGTG CTCTTCACTG GCACGTGGGT GAGCTGCAAA
CTGGCCTTCG AGGACATCGC GTGCTGGGAC CTGGACGACA CCTCCCCCTA CTGGTGGATC
ATCAAAGGGC CCATTGTCCT CTCGGTCGGG GTGAACTTTG GGCTTTTTCT CAATATTATC
CGCATCCTGG TGAGGAAACT GGAGCCAGCT CAGGGCAGCC TCCATACCCA GTCTCAGTAT
TGGCGTCTCT CCAAGTCGAC ACTTTTCCTG ATCCCACTCT TTGGAATTCA CTACATCATC
TTCAACTTCC TGCCAGACAA TGCTGGCCTG GGCATCCGCC TCCCCCTGGA GCTGGGACTG
GGTTCCTTCC AGGGCTTCAT TGTTGCCATC CTCTACTGCT TCCTCAACCA AGAGGTGAGG
ACTGAGATCT CACGGAAGTG GCATGGCCAT GACCCTGAGC TTCTGCCAGC CTGGAGGACC
CGTGCTAAGT GGACCACGCC TTCCCGCTCG GCGGCAAAGG TGCTGACATC TATGTGCTAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

book

Older individuals heterozygous for a growth hormone-releasing hormone receptor gene mutation are shorter than normal subjects.
Journal of human genetics60(6)335-8(2015 Jun)
Aguiar-Oliveira MH,Cardoso-Filho MA,Pereira RM,Oliveira CR,Souza AH,Santos EG,Campos VC,Valença EH,de Oliveira FT,Oliveira-Neto LA,Gois-Junior MB,Oliveira-Santos AA,Salvatori R


book

Expression of a splice variant of the receptor for GHRH in 3T3 fibroblasts activates cell proliferation responses to GHRH analogs.
Proceedings of the National Academy of Sciences of the United States of America99(1)196-200(2002 Jan)
Kiaris H,Schally AV,Busto R,Halmos G,Artavanis-Tsakonas S,Varga JL


book

Isolation and sequencing of cDNAs for splice variants of growth hormone-releasing hormone receptors from human cancers.
Proceedings of the National Academy of Sciences of the United States of America97(19)10561-6(2000 Sep)
Rekasi Z,Czompoly T,Schally AV,Halmos G


book

Phenotype and genetic analysis of a syndrome caused by an inactivating mutation in the growth hormone-releasing hormone receptor: Dwarfism of Sindh.
The Journal of clinical endocrinology and metabolism83(11)4065-74(1998 Nov)
Maheshwari HG,Silverman BL,Dupuis J,Baumann G


book

Structure and regulation of the human growth hormone-releasing hormone receptor gene.
Molecular endocrinology (Baltimore, Md.)12(2)233-47(1998 Feb)
Petersenn S,Rasch AC,Heyens M,Schulte HM


 
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