Gene Symbol | FFAR3 |
Entrez Gene ID | 2865 |
Full Name | free fatty acid receptor 3 |
Synonyms | FFA3R,GPR41,GPR42 |
General protein information |
|
Gene Type | protein-coding |
Organism | Homo sapiens(human) |
Genome | |
Disorder MIM: |
ORF » Species Summary » Homo sapiens » FFAR3 cDNA ORF clone
Gene Symbol | FFAR3 |
Entrez Gene ID | 2865 |
Full Name | free fatty acid receptor 3 |
Synonyms | FFA3R,GPR41,GPR42 |
General protein information |
|
Gene Type | protein-coding |
Organism | Homo sapiens(human) |
Genome | |
Disorder MIM: |
mRNA | Protein | Name |
---|---|---|
NM_005304.4 | NP_005295.1 | free fatty acid receptor 3 |
NM_005304.3 | NP_005295.1 | free fatty acid receptor 3 |
XM_011526858.2 | XP_011525160.1 | free fatty acid receptor 3 isoform X1 |
NM_005304.5 | NP_005295.1 | free fatty acid receptor 3 |
Canis lupus familiaris (dog) | FFAR3 | XP_005616768.1 |
Pan troglodytes (chimpanzee) | FFAR3 | XP_001159667.1 |
Bos taurus (cattle) | FFAR3 | NP_001138705.1 |
Homo sapiens (human) | FFAR3 | NP_005295.1 |
FFAR3 | XP_001094758.1 | |
Mus musculus (house mouse) | Ffar3 | NP_001028488.1 |
Rattus norvegicus (Norway rat) | Ffar3 | NP_001102382.1 |
Danio rerio (zebrafish) | LOC100333904 | XP_002665089.1 |
Xenopus tropicalis (tropical clawed frog) | LOC100489919 | XP_002938262.1 |
Xenopus tropicalis (tropical clawed frog) | LOC100489751 | XP_002938261.2 |
Xenopus tropicalis (tropical clawed frog) | LOC101735161 | XP_004920890.1 |
FFAR2-FFAR3 receptor heteromerization modulates short-chain fatty acid sensing.
Ang Z, Xiong D, Wu M, Ding JL
FASEB journal : official publication of the Federation of American Societies for Experimental Biology32(1)289-303(2018 Jan)
IL-1? and TNF? inhibit GPR120 (FFAR4) and stimulate GPR84 (EX33) and GPR41 (FFAR3) fatty acid receptor expression in human adipocytes: implications for the anti-inflammatory action of n-3 fatty acids.
Muredda L, K?pczy?ska MA, Zaibi MS, Alomar SY, Trayhurn P
Archives of physiology and biochemistry1-12(2017 Aug)
Short-chain fatty acids, GPR41 and GPR43 ligands, inhibit TNF-?-induced MCP-1 expression by modulating p38 and JNK signaling pathways in human renal cortical epithelial cells.
Kobayashi M, Mikami D, Kimura H, Kamiyama K, Morikawa Y, Yokoi S, Kasuno K, Takahashi N, Taniguchi T, Iwano M
Biochemical and biophysical research communications486(2)499-505(2017 04)
Soluble Fibre Meal Challenge Reduces Airway Inflammation and Expression of GPR43 and GPR41 in Asthma.
Halnes I, Baines KJ, Berthon BS, MacDonald-Wicks LK, Gibson PG, Wood LG
Nutrients9(1)(2017 Jan)
Human GPR42 is a transcribed multisite variant that exhibits copy number polymorphism and is functional when heterologously expressed.
Puhl HL 3rd, Won YJ, Lu VB, Ikeda SR
Scientific reports512880(2015 Aug)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
Short-chain fatty acids lowered TNF-alpha-induced MCP-1 expression by reducing phosphorylation of p38 MAPK and JNK in a GPR41/GRP43-dependent manner in renal cortical epithelial cells.
Title: Short-chain fatty acids, GPR41 and GPR43 ligands, inhibit TNF-?-induced MCP-1 expression by modulating p38 and JNK signaling pathways in human renal cortical epithelial cells.
a single dose of soluble fibre was able to significantly reduce airway inflammation in stable asthma by downregulating GPR43 and GPR41
Title: Soluble Fibre Meal Challenge Reduces Airway Inflammation and Expression of GPR43 and GPR41 in Asthma.
Our data suggest that GPR42 be reclassified as a functioning gene and that recognition of sequence and copy number polymorphism of the FFAR3/GPR42 complex be considered during genetic and pharmacological investigation of these receptors.
Title: Human GPR42 is a transcribed multisite variant that exhibits copy number polymorphism and is functional when heterologously expressed.
FFAR3 is expressed in pancreatic beta cells and mediates an inhibition of insulin secretion by coupling to Gi-type G proteins.
Title: Loss of FFA2 and FFA3 increases insulin secretion and improves glucose tolerance in type 2 diabetes.
a significant correlation between a higher body mass index and lower methylation in the promoter region of FFAR3 in type 2 diabetes and obesity patients
Title: Effects of short chain fatty acid producing bacteria on epigenetic regulation of FFAR3 in type 2 diabetes and obesity.
The following FFAR3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the FFAR3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
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CloneID | OHu24442 | |
Clone ID Related Accession (Same CDS sequence) | NM_005304.4 , NM_005304.3 , NM_005304.5 | |
Accession Version | NM_005304.4 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1041bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-02-25 | |
Organism | Homo sapiens(human) | |
Product | free fatty acid receptor 3 | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from DR004234.1, BC035657.1 and AC002511.1. On Jan 18, 2017 this sequence version replaced NM_005304.3. Sequence Note:. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC035657.1, AK290710.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGGATACAG GCCCCGACCA GTCCTACTTC TCCGGCAATC ACTGGTTCGT CTTCTCGGTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_005295.1 |
CDS | 202..1242 |
Translation |
Target ORF information:
Target ORF information:
|
NM_005304.4 |
1 | ATGGATACAG GCCCCGACCA GTCCTACTTC TCCGGCAATC ACTGGTTCGT CTTCTCGGTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu24442 | |
Clone ID Related Accession (Same CDS sequence) | NM_005304.4 , NM_005304.3 , NM_005304.5 | |
Accession Version | NM_005304.3 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1041bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2015-08-03 | |
Organism | Homo sapiens(Human) | |
Product | free fatty acid receptor 3 | |
Comment |
1 | ATGGATACAG GCCCCGACCA GTCCTACTTC TCCGGCAATC ACTGGTTCGT CTTCTCGGTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_005295.1 |
Translation |
Target ORF information:
Target ORF information:
|
NM_005304.3 |
1 | ATGGATACAG GCCCCGACCA GTCCTACTTC TCCGGCAATC ACTGGTTCGT CTTCTCGGTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu24442 | |
Clone ID Related Accession (Same CDS sequence) | NM_005304.4 , NM_005304.3 , NM_005304.5 | |
Accession Version | NM_005304.5 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1041bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-10-20 | |
Organism | Homo sapiens(human) | |
Product | free fatty acid receptor 3 | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from DR004234.1, BC035657.1 and AC002511.1. On May 17, 2019 this sequence version replaced NM_005304.4. Sequence Note:. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC035657.1, AK290710.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000327809.5/ ENSP00000328230.3 RefSeq Select criteria :: based on conservation, expression ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end. |
1 | ATGGATACAG GCCCCGACCA GTCCTACTTC TCCGGCAATC ACTGGTTCGT CTTCTCGGTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_005295.1 |
CDS | 202..1242 |
Translation |
Target ORF information:
Target ORF information:
|
NM_005304.5 |
1 | ATGGATACAG GCCCCGACCA GTCCTACTTC TCCGGCAATC ACTGGTTCGT CTTCTCGGTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu58029 | |
Clone ID Related Accession (Same CDS sequence) | XM_011526858.2 | |
Accession Version | XM_011526858.2 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1152bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-12-05 | |
Organism | Homo sapiens(human) | |
Product | free fatty acid receptor 3 isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000019.10) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_011526858.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGAGGAGGG AGGCACGCAG TTGTGGAATT TGTTCCCCTT TTAGCATGCT GACCAGCCCT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_011525160.1 |
CDS | 321..1472 |
Translation |
Target ORF information:
Target ORF information:
|
XM_011526858.2 |
1 | ATGAGGAGGG AGGCACGCAG TTGTGGAATT TGTTCCCCTT TTAGCATGCT GACCAGCCCT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
FFAR2-FFAR3 receptor heteromerization modulates short-chain fatty acid sensing. |
IL-1? and TNF? inhibit GPR120 (FFAR4) and stimulate GPR84 (EX33) and GPR41 (FFAR3) fatty acid receptor expression in human adipocytes: implications for the anti-inflammatory action of n-3 fatty acids. |
Short-chain fatty acids, GPR41 and GPR43 ligands, inhibit TNF-?-induced MCP-1 expression by modulating p38 and JNK signaling pathways in human renal cortical epithelial cells. |
Soluble Fibre Meal Challenge Reduces Airway Inflammation and Expression of GPR43 and GPR41 in Asthma. |
Human GPR42 is a transcribed multisite variant that exhibits copy number polymorphism and is functional when heterologously expressed. |