Gene Symbol
HCLS1
Entrez Gene ID
3059
Full Name
hematopoietic cell-specific Lyn substrate 1
Synonyms
CTTNL,HS1,lckBP1,p75
General protein information
Preferred Nameshematopoietic cell-specific Lyn substrate 1
Nameshematopoietic lineage cell-specific protein
Gene Type
protein-coding
Organism
Homo sapiens(human)
Genome
Chromosome: 3
Map Location: 3q13.33
Disorder MIM:
601306
mRNA and Protein(s)
mRNA
Protein
Name
NM_005335.5
NP_005326.2
hematopoietic lineage cell-specific protein isoform 1
NM_001292041.1
NP_001278970.1
hematopoietic lineage cell-specific protein isoform 2
NM_001292041.2
NP_001278970.2
hematopoietic lineage cell-specific protein isoform 2
NM_005335.6
NP_005326.3
hematopoietic lineage cell-specific protein isoform 1
Homo sapiens (human)
HCLS1
NP_005326.2
Mus musculus (house mouse)
Hcls1
NP_032251.2
Rattus norvegicus (Norway rat)
Hcls1
NP_001011898.1
Bos taurus (cattle)
HCLS1
NP_001030229.1
Gallus gallus (chicken)
HCLS1
NP_001026572.1
Pan troglodytes (chimpanzee)
HCLS1
XP_516684.2
HCLS1
XP_001111514.1
Canis lupus familiaris (dog)
HCLS1
XP_005639607.1
Related articles in PubMed
Wnt5a induces ROR1 to complex with HS1 to enhance migration of chronic lymphocytic leukemia cells.
Hasan MK, Yu J, Chen L, Cui B, Widhopf Ii GF, Rassenti L, Shen Z, Briggs SP, Kipps TJ Leukemia31(12)2615-2622(2017 Dec)
Exome sequencing reveals recurrent germ line variants in patients with familial Waldenstr?m macroglobulinemia.
Roccaro AM, Sacco A, Shi J, Chiarini M, Perilla-Glen A, Manier S, Glavey S, Aljawai Y, Mishima Y, Kawano Y, Moschetta M, Correll M, Improgo MR, Brown JR, Imberti L, Rossi G, Castillo JJ, Treon SP, Freedman ML, Van Allen EM, Hide W, Hiller E, Rainville I, Ghobrial IM Blood127(21)2598-606(2016 05)
SDF1?-induced interaction of the adapter proteins Nck and HS1 facilitates actin polymerization and migration in T?cells.
Lettau M, Kabelitz D, Janssen O European journal of immunology45(2)551-61(2015 Feb)
Phosphoproteome analyses reveal specific implications of Hcls1, p21-activated kinase 1 and Ezrin in proliferation of a myeloid progenitor cell line downstream of wild-type and ITD mutant Fms-like tyrosine kinase 3 receptors.
Habif G, Grasset MF, Kieffer-Jaquinod S, Kuhn L, Mouchiroud G, Gobert-Gosse S Journal of proteomics78231-44(2013 Jan)
Interactions among HCLS1, HAX1 and LEF-1 proteins are essential for G-CSF-triggered granulopoiesis.
Skokowa J, Klimiankou M, Klimenkova O, Lan D, Gupta K, Hussein K, Carrizosa E, Kusnetsova I, Li Z, Sustmann C, Ganser A, Zeidler C, Kreipe HH, Burkhardt J, Grosschedl R, Welte K Nature medicine18(10)1550-9(2012 Oct)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
The following HCLS1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the HCLS1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+ /C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID
OHu107365
Clone ID Related Accession (Same CDS sequence)
NM_005335.6
Accession Version
NM_005335.6 Latest version!
Documents for ORF clone product in default vector
Sequence Information
ORF Nucleotide Sequence (Length: 1461bp)
Protein sequence
SNP
Vector
pcDNA3.1+ /C-(K)DYK or customized vector
User Manual
Clone information
Clone Map
MSDS
Tag on pcDNA3.1+ /C-(K)DYK
C terminal DYKDDDDK tags
ORF Insert Method
CloneEZ™ Seamless cloning technology
Insert Structure
linear
Update Date
2019-09-26
Organism
Homo sapiens(human)
Product
hematopoietic lineage cell-specific protein isoform 1
Comment
Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC133750.2. On Nov 23, 2018 this sequence version replaced NM_005335.5.
Transcript Variant: This variant (1) represents the longer transcript and encodes the longer protein (isoform 1).
Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: SRR1163657.362337.1, SRR3476690.455893.1 [ECO:0000332]
RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350]
##Evidence-Data-END##
##RefSeq-Attributes-START##
MANE Ensembl match :: ENST00000314583.8/ ENSP00000320176.3
RefSeq Select criteria :: based on conservation, expression, longest protein
##RefSeq-Attributes-END##
COMPLETENESS: full length.
1 61 121 181 241 301 361 421 481 541 601 661 721 781 841 901 961 1021 1081 1141 1201 1261 1321 1381 1441 ATGTGGAAGT CTGTAGTGGG CCATGATGTG TCTGTTTCCG TGGAGACCCA GGGTGATGAT TGGGACACAG ATCCTGACTT TGTGAATGAC ATCTCTGAAA AGGAGCAACG ATGGGGAGCC AAGACCATCG AGGGGTCTGG ACGCACAGAA CACATCAACA TCCACCAGCT GAGGAACAAA GTATCAGAGG AGCATGATGT TCTCAGGAAG AAAGAGATGG AGTCAGGGCC CAAAGCATCC CATGGCTATG GAGGTCGGTT TGGAGTAGAA AGAGACCGAA TGGACAAGAG TGCAGTGGGC CATGAGTATG TTGCCGAGGT GGAGAAGCAC TCTTCTCAGA CGGATGCTGC CAAAGGCTTT GGGGGCAAGT ACGGAGTTGA GAGGGACAGG GCAGACAAGT CAGCAGTCGG CTTTGATTAT AAAGGAGAAG TGGAGAAGCA CACATCTCAG AAAGATTACT CTCGTGGCTT TGGTGGCCGG TACGGGGTGG AGAAGGATAA ATGGGACAAA GCAGCTCTGG GATATGACTA CAAGGGAGAG ACGGAGAAAC ACGAGTCCCA GAGAGATTAT GCCAAGGGCT TTGGTGGCCA GTATGGAATC CAGAAGGACC GAGTGGATAA GAGCGCTGTC GGCTTCAATG AAATGGAGGC CCCGACCACA GCTTATAAGA AGACGACGCC CATAGAAGCC GCTTCTAGTG GTACCCGTGG GCTGAAGGCG AAATTTGAGT CCATGGCTGA GGAGAAGAGG AAGCGAGAGG AAGAGGAGAA GGCACAGCAG GTGGCCAGGA GGCAACAGGA GCGAAAGGCT GTGACAAAGA GGAGCCCTGA GGCTCCACAG CCAGTGATAG CTATGGAAGA GCCAGCAGTA CCGGCCCCAC TGCCCAAGAA AATCTCCTCA GAGGCCTGGC CTCCAGTTGG GACTCCTCCA TCATCAGAGT CTGAGCCTGT GAGAACCAGC AGGGAACACC CAGTGCCCTT GCTGCCCATT AGGCAGACTC TCCCGGAGGA CAATGAGGAG CCCCCAGCTC TGCCCCCTAG GACTCTGGAA GGCCTCCAGG TGGAGGAAGA GCCAGTGTAC GAAGCAGAGC CTGAGCCTGA GCCCGAGCCT GAGCCCGAGC CTGAGAATGA CTATGAGGAC GTTGAGGAGA TGGACAGGCA TGAGCAGGAG GATGAACCAG AGGGGGACTA TGAGGAGGTG CTCGAGCCTG AAGATTCTTC TTTTTCTTCT GCTCTGGCTG GATCATCAGG CTGCCCGGCT GGGGCTGGGG CTGGGGCTGT GGCTCTGGGG ATCTCAGCTG TGGCTGTATA TGATTACCAA GGAGAGGGAA GTGATGAGCT TTCCTTTGAT CCGGACGACG TAATCACTGA CATTGAGATG GTGGACGAGG GCTGGTGGCG GGGACGTTGC CATGGCCACT TTGGACTCTT CCCTGCAAAT TATGTCAAGC TTCTGGAGTG A
The stop codons will be deleted if pcDNA3.1+ /C-(K)DYK vector is selected.
RefSeq
NP_005326.3
CDS 85..1545
Translation
Target ORF information:
RefSeq Version NM_005335.6
Organism Homo sapiens(human)
Definition Homo sapiens hematopoietic cell-specific Lyn substrate 1 (HCLS1), transcript variant 1, mRNA.
Target ORF information:
Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+ /C-(K)DYK
NM_005335.6
ORF Insert Sequence:
1 61 121 181 241 301 361 421 481 541 601 661 721 781 841 901 961 1021 1081 1141 1201 1261 1321 1381 1441 ATGTGGAAGT CTGTAGTGGG CCATGATGTG TCTGTTTCCG TGGAGACCCA GGGTGATGAT TGGGACACAG ATCCTGACTT TGTGAATGAC ATCTCTGAAA AGGAGCAACG ATGGGGAGCC AAGACCATCG AGGGGTCTGG ACGCACAGAA CACATCAACA TCCACCAGCT GAGGAACAAA GTATCAGAGG AGCATGATGT TCTCAGGAAG AAAGAGATGG AGTCAGGGCC CAAAGCATCC CATGGCTATG GAGGTCGGTT TGGAGTAGAA AGAGACCGAA TGGACAAGAG TGCAGTGGGC CATGAGTATG TTGCCGAGGT GGAGAAGCAC TCTTCTCAGA CGGATGCTGC CAAAGGCTTT GGGGGCAAGT ACGGAGTTGA GAGGGACAGG GCAGACAAGT CAGCAGTCGG CTTTGATTAT AAAGGAGAAG TGGAGAAGCA CACATCTCAG AAAGATTACT CTCGTGGCTT TGGTGGCCGG TACGGGGTGG AGAAGGATAA ATGGGACAAA GCAGCTCTGG GATATGACTA CAAGGGAGAG ACGGAGAAAC ACGAGTCCCA GAGAGATTAT GCCAAGGGCT TTGGTGGCCA GTATGGAATC CAGAAGGACC GAGTGGATAA GAGCGCTGTC GGCTTCAATG AAATGGAGGC CCCGACCACA GCTTATAAGA AGACGACGCC CATAGAAGCC GCTTCTAGTG GTACCCGTGG GCTGAAGGCG AAATTTGAGT CCATGGCTGA GGAGAAGAGG AAGCGAGAGG AAGAGGAGAA GGCACAGCAG GTGGCCAGGA GGCAACAGGA GCGAAAGGCT GTGACAAAGA GGAGCCCTGA GGCTCCACAG CCAGTGATAG CTATGGAAGA GCCAGCAGTA CCGGCCCCAC TGCCCAAGAA AATCTCCTCA GAGGCCTGGC CTCCAGTTGG GACTCCTCCA TCATCAGAGT CTGAGCCTGT GAGAACCAGC AGGGAACACC CAGTGCCCTT GCTGCCCATT AGGCAGACTC TCCCGGAGGA CAATGAGGAG CCCCCAGCTC TGCCCCCTAG GACTCTGGAA GGCCTCCAGG TGGAGGAAGA GCCAGTGTAC GAAGCAGAGC CTGAGCCTGA GCCCGAGCCT GAGCCCGAGC CTGAGAATGA CTATGAGGAC GTTGAGGAGA TGGACAGGCA TGAGCAGGAG GATGAACCAG AGGGGGACTA TGAGGAGGTG CTCGAGCCTG AAGATTCTTC TTTTTCTTCT GCTCTGGCTG GATCATCAGG CTGCCCGGCT GGGGCTGGGG CTGGGGCTGT GGCTCTGGGG ATCTCAGCTG TGGCTGTATA TGATTACCAA GGAGAGGGAA GTGATGAGCT TTCCTTTGAT CCGGACGACG TAATCACTGA CATTGAGATG GTGGACGAGG GCTGGTGGCG GGGACGTTGC CATGGCCACT TTGGACTCTT CCCTGCAAAT TATGTCAAGC TTCTGGAGTG A
The stop codons will be deleted if pcDNA3.1+ /C-(K)DYK vector is selected.
CloneID
OHu108219
Clone ID Related Accession (Same CDS sequence)
NM_001292041.2
Accession Version
NM_001292041.2 Latest version!
Documents for ORF clone product in default vector
Sequence Information
ORF Nucleotide Sequence (Length: 1350bp)
Protein sequence
SNP
Vector
pcDNA3.1+ /C-(K)DYK or customized vector
User Manual
Clone information
Clone Map
MSDS
Tag on pcDNA3.1+ /C-(K)DYK
C terminal DYKDDDDK tags
ORF Insert Method
CloneEZ™ Seamless cloning technology
Insert Structure
linear
Update Date
2019-09-27
Organism
Homo sapiens(human)
Product
hematopoietic lineage cell-specific protein isoform 2
Comment
Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC133750.2. On May 31, 2019 this sequence version replaced NM_001292041.1.
Transcript Variant: This variant (2) lacks an exon in the coding region compared to variant 1. The resulting protein (isoform 2) is shorter but has the same N- and C-termini compared to isoform 1.
Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: AK298696.1, SRR1163657.191831.1 [ECO:0000332]
RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
1 61 121 181 241 301 361 421 481 541 601 661 721 781 841 901 961 1021 1081 1141 1201 1261 1321 ATGTGGAAGT CTGTAGTGGG CCATGATGTG TCTGTTTCCG TGGAGACCCA GGGTGATGAT TGGGACACAG ATCCTGACTT TGTGAATGAC ATCTCTGAAA AGGAGCAACG ATGGGGAGCC AAGACCATCG AGGGGTCTGG ACGCACAGAA CACATCAACA TCCACCAGCT GAGGAACAAA GTATCAGAGG AGCATGATGT TCTCAGGAAG AAAGAGATGG AGTCAGGGCC CAAAGCATCC CATGGCTATG GAGGTCGGTT TGGAGTAGAA AGAGACCGAA TGGACAAGAG TGCAGTGGGC CATGAGTATG TTGCCGAGGT GGAGAAGCAC TCTTCTCAGA CGGATGCTGC CAAAGGCTTT GGGGGCAAGT ACGGAGTTGA GAGGGACAGG GCAGACAAGT CAGCAGTCGG CTTTGATTAT AAAGGAGAAG TGGAGAAGCA CACATCTCAG AAAGATTATG CCAAGGGCTT TGGTGGCCAG TATGGAATCC AGAAGGACCG AGTGGATAAG AGCGCTGTCG GCTTCAATGA AATGGAGGCC CCGACCACAG CTTATAAGAA GACGACGCCC ATAGAAGCCG CTTCTAGTGG TACCCGTGGG CTGAAGGCGA AATTTGAGTC CATGGCTGAG GAGAAGAGGA AGCGAGAGGA AGAGGAGAAG GCACAGCAGG TGGCCAGGAG GCAACAGGAG CGAAAGGCTG TGACAAAGAG GAGCCCTGAG GCTCCACAGC CAGTGATAGC TATGGAAGAG CCAGCAGTAC CGGCCCCACT GCCCAAGAAA ATCTCCTCAG AGGCCTGGCC TCCAGTTGGG ACTCCTCCAT CATCAGAGTC TGAGCCTGTG AGAACCAGCA GGGAACACCC AGTGCCCTTG CTGCCCATTA GGCAGACTCT CCCGGAGGAC AATGAGGAGC CCCCAGCTCT GCCCCCTAGG ACTCTGGAAG GCCTCCAGGT GGAGGAAGAG CCAGTGTACG AAGCAGAGCC TGAGCCTGAG CCCGAGCCTG AGCCCGAGCC TGAGAATGAC TATGAGGACG TTGAGGAGAT GGACAGGCAT GAGCAGGAGG ATGAACCAGA GGGGGACTAT GAGGAGGTGC TCGAGCCTGA AGATTCTTCT TTTTCTTCTG CTCTGGCTGG ATCATCAGGC TGCCCGGCTG GGGCTGGGGC TGGGGCTGTG GCTCTGGGGA TCTCAGCTGT GGCTGTATAT GATTACCAAG GAGAGGGAAG TGATGAGCTT TCCTTTGATC CGGACGACGT AATCACTGAC ATTGAGATGG TGGACGAGGG CTGGTGGCGG GGACGTTGCC ATGGCCACTT TGGACTCTTC CCTGCAAATT ATGTCAAGCT TCTGGAGTGA
The stop codons will be deleted if pcDNA3.1+ /C-(K)DYK vector is selected.
RefSeq
NP_001278970.2
CDS 85..1434
Translation
Target ORF information:
RefSeq Version NM_001292041.2
Organism Homo sapiens(human)
Definition Homo sapiens hematopoietic cell-specific Lyn substrate 1 (HCLS1), transcript variant 2, mRNA.
Target ORF information:
Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+ /C-(K)DYK
NM_001292041.2
ORF Insert Sequence:
1 61 121 181 241 301 361 421 481 541 601 661 721 781 841 901 961 1021 1081 1141 1201 1261 1321 ATGTGGAAGT CTGTAGTGGG CCATGATGTG TCTGTTTCCG TGGAGACCCA GGGTGATGAT TGGGACACAG ATCCTGACTT TGTGAATGAC ATCTCTGAAA AGGAGCAACG ATGGGGAGCC AAGACCATCG AGGGGTCTGG ACGCACAGAA CACATCAACA TCCACCAGCT GAGGAACAAA GTATCAGAGG AGCATGATGT TCTCAGGAAG AAAGAGATGG AGTCAGGGCC CAAAGCATCC CATGGCTATG GAGGTCGGTT TGGAGTAGAA AGAGACCGAA TGGACAAGAG TGCAGTGGGC CATGAGTATG TTGCCGAGGT GGAGAAGCAC TCTTCTCAGA CGGATGCTGC CAAAGGCTTT GGGGGCAAGT ACGGAGTTGA GAGGGACAGG GCAGACAAGT CAGCAGTCGG CTTTGATTAT AAAGGAGAAG TGGAGAAGCA CACATCTCAG AAAGATTATG CCAAGGGCTT TGGTGGCCAG TATGGAATCC AGAAGGACCG AGTGGATAAG AGCGCTGTCG GCTTCAATGA AATGGAGGCC CCGACCACAG CTTATAAGAA GACGACGCCC ATAGAAGCCG CTTCTAGTGG TACCCGTGGG CTGAAGGCGA AATTTGAGTC CATGGCTGAG GAGAAGAGGA AGCGAGAGGA AGAGGAGAAG GCACAGCAGG TGGCCAGGAG GCAACAGGAG CGAAAGGCTG TGACAAAGAG GAGCCCTGAG GCTCCACAGC CAGTGATAGC TATGGAAGAG CCAGCAGTAC CGGCCCCACT GCCCAAGAAA ATCTCCTCAG AGGCCTGGCC TCCAGTTGGG ACTCCTCCAT CATCAGAGTC TGAGCCTGTG AGAACCAGCA GGGAACACCC AGTGCCCTTG CTGCCCATTA GGCAGACTCT CCCGGAGGAC AATGAGGAGC CCCCAGCTCT GCCCCCTAGG ACTCTGGAAG GCCTCCAGGT GGAGGAAGAG CCAGTGTACG AAGCAGAGCC TGAGCCTGAG CCCGAGCCTG AGCCCGAGCC TGAGAATGAC TATGAGGACG TTGAGGAGAT GGACAGGCAT GAGCAGGAGG ATGAACCAGA GGGGGACTAT GAGGAGGTGC TCGAGCCTGA AGATTCTTCT TTTTCTTCTG CTCTGGCTGG ATCATCAGGC TGCCCGGCTG GGGCTGGGGC TGGGGCTGTG GCTCTGGGGA TCTCAGCTGT GGCTGTATAT GATTACCAAG GAGAGGGAAG TGATGAGCTT TCCTTTGATC CGGACGACGT AATCACTGAC ATTGAGATGG TGGACGAGGG CTGGTGGCGG GGACGTTGCC ATGGCCACTT TGGACTCTTC CCTGCAAATT ATGTCAAGCT TCTGGAGTGA
The stop codons will be deleted if pcDNA3.1+ /C-(K)DYK vector is selected.
CloneID
OHu24656
Clone ID Related Accession (Same CDS sequence)
NM_001292041.1
Accession Version
NM_001292041.1 Latest version!
Documents for ORF clone product in default vector
Sequence Information
ORF Nucleotide Sequence (Length: 1350bp)
Protein sequence
SNP
Vector
pcDNA3.1+ /C-(K)DYK or customized vector
User Manual
Clone information
Clone Map
MSDS
Tag on pcDNA3.1+ /C-(K)DYK
C terminal DYKDDDDK tags
ORF Insert Method
CloneEZ™ Seamless cloning technology
Insert Structure
linear
Update Date
2018-06-29
Organism
Homo sapiens(human)
Product
hematopoietic lineage cell-specific protein isoform 2
Comment
Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from DC427610.1, BY994733.1, BP338037.1, BC016758.2, AI091876.1 and BQ002360.1.
Transcript Variant: This variant (2) lacks an exon in the coding region compared to variant 1. The resulting protein (isoform 2) is shorter but has the same N- and C-termini compared to isoform 1.
Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: SRR1163657.191831.1, AK298696.1 [ECO:0000332]
RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
1 61 121 181 241 301 361 421 481 541 601 661 721 781 841 901 961 1021 1081 1141 1201 1261 1321 ATGTGGAAGT CTGTAGTGGG CCATGATGTG TCTGTTTCCG TGGAGACCCA GGGTGATGAT TGGGACACAG ATCCTGACTT TGTGAATGAC ATCTCTGAAA AGGAGCAACG ATGGGGAGCC AAGACCATCG AGGGGTCTGG ACGCACAGAA CACATCAACA TCCACCAGCT GAGGAACAAA GTATCAGAGG AGCATGATGT TCTCAGGAAG AAAGAGATGG AGTCAGGGCC CAAAGCATCC CATGGCTATG GAGGTCGGTT TGGAGTAGAA AGAGACCGAA TGGACAAGAG TGCAGTGGGC CATGAGTATG TTGCCGAGGT GGAGAAGCAC TCTTCTCAGA CGGATGCTGC CAAAGGCTTT GGGGGCAAGT ACGGAGTTGA GAGGGACAGG GCAGACAAGT CAGCAGTCGG CTTTGATTAT AAAGGAGAAG TGGAGAAGCA CACATCTCAG AAAGATTATG CCAAGGGCTT TGGTGGCCAG TATGGAATCC AGAAGGACCG AGTGGATAAG AGCGCTGTCG GCTTCAATGA AATGGAGGCC CCGACCACAG CTTATAAGAA GACGACGCCC ATAGAAGCCG CTTCTAGTGG TACCCGTGGG CTGAAGGCGA AATTTGAGTC CATGGCTGAG GAGAAGAGGA AGCGAGAGGA AGAGGAGAAG GCACAGCAGG TGGCCAGGAG GCAACAGGAG CGAAAGGCTG TGACAAAGAG GAGCCCTGAG GCTCCACAGC CAGTGATAGC TATGGAAGAG CCAGCAGTAC CGGCCCCACT GCCCAAGAAA ATCTCCTCAG AGGCCTGGCC TCCAGTTGGG ACTCCTCCAT CATCAGAGTC TGAGCCTGTG AGAACCAGCA GGGAACACCC AGTGCCCTTG CTGCCCATTA GGCAGACTCT CCCGGAGGAC AATGAGGAGC CCCCAGCTCT GCCCCCTAGG ACTCTGGAAG GCCTCCAGGT GGAGGAAGAG CCAGTGTACG AAGCAGAGCC TGAGCCTGAG CCCGAGCCTG AGCCCGAGCC TGAGAATGAC TATGAGGACG TTGAGGAGAT GGACAGGCAT GAGCAGGAGG ATGAACCAGA GGGGGACTAT GAGGAGGTGC TCGAGCCTGA AGATTCTTCT TTTTCTTCTG CTCTGGCTGG ATCATCAGGC TGCCCGGCTG GGGCTGGGGC TGGGGCTGTG GCTCTGGGGA TCTCAGCTGT GGCTCTATAT GATTACCAAG GAGAGGGAAG TGATGAGCTT TCCTTTGATC CGGACGACGT AATCACTGAC ATTGAGATGG TGGACGAGGG CTGGTGGCGG GGACGTTGCC ATGGCCACTT TGGACTCTTC CCTGCAAATT ATGTCAAGCT TCTGGAGTGA
The stop codons will be deleted if pcDNA3.1+ /C-(K)DYK vector is selected.
RefSeq
NP_001278970.1
CDS 130..1479
Translation
Target ORF information:
RefSeq Version NM_001292041.1
Organism Homo sapiens(human)
Definition Homo sapiens hematopoietic cell-specific Lyn substrate 1 (HCLS1), transcript variant 2, mRNA.
Target ORF information:
Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+ /C-(K)DYK
NM_001292041.1
ORF Insert Sequence:
1 61 121 181 241 301 361 421 481 541 601 661 721 781 841 901 961 1021 1081 1141 1201 1261 1321 ATGTGGAAGT CTGTAGTGGG CCATGATGTG TCTGTTTCCG TGGAGACCCA GGGTGATGAT TGGGACACAG ATCCTGACTT TGTGAATGAC ATCTCTGAAA AGGAGCAACG ATGGGGAGCC AAGACCATCG AGGGGTCTGG ACGCACAGAA CACATCAACA TCCACCAGCT GAGGAACAAA GTATCAGAGG AGCATGATGT TCTCAGGAAG AAAGAGATGG AGTCAGGGCC CAAAGCATCC CATGGCTATG GAGGTCGGTT TGGAGTAGAA AGAGACCGAA TGGACAAGAG TGCAGTGGGC CATGAGTATG TTGCCGAGGT GGAGAAGCAC TCTTCTCAGA CGGATGCTGC CAAAGGCTTT GGGGGCAAGT ACGGAGTTGA GAGGGACAGG GCAGACAAGT CAGCAGTCGG CTTTGATTAT AAAGGAGAAG TGGAGAAGCA CACATCTCAG AAAGATTATG CCAAGGGCTT TGGTGGCCAG TATGGAATCC AGAAGGACCG AGTGGATAAG AGCGCTGTCG GCTTCAATGA AATGGAGGCC CCGACCACAG CTTATAAGAA GACGACGCCC ATAGAAGCCG CTTCTAGTGG TACCCGTGGG CTGAAGGCGA AATTTGAGTC CATGGCTGAG GAGAAGAGGA AGCGAGAGGA AGAGGAGAAG GCACAGCAGG TGGCCAGGAG GCAACAGGAG CGAAAGGCTG TGACAAAGAG GAGCCCTGAG GCTCCACAGC CAGTGATAGC TATGGAAGAG CCAGCAGTAC CGGCCCCACT GCCCAAGAAA ATCTCCTCAG AGGCCTGGCC TCCAGTTGGG ACTCCTCCAT CATCAGAGTC TGAGCCTGTG AGAACCAGCA GGGAACACCC AGTGCCCTTG CTGCCCATTA GGCAGACTCT CCCGGAGGAC AATGAGGAGC CCCCAGCTCT GCCCCCTAGG ACTCTGGAAG GCCTCCAGGT GGAGGAAGAG CCAGTGTACG AAGCAGAGCC TGAGCCTGAG CCCGAGCCTG AGCCCGAGCC TGAGAATGAC TATGAGGACG TTGAGGAGAT GGACAGGCAT GAGCAGGAGG ATGAACCAGA GGGGGACTAT GAGGAGGTGC TCGAGCCTGA AGATTCTTCT TTTTCTTCTG CTCTGGCTGG ATCATCAGGC TGCCCGGCTG GGGCTGGGGC TGGGGCTGTG GCTCTGGGGA TCTCAGCTGT GGCTCTATAT GATTACCAAG GAGAGGGAAG TGATGAGCTT TCCTTTGATC CGGACGACGT AATCACTGAC ATTGAGATGG TGGACGAGGG CTGGTGGCGG GGACGTTGCC ATGGCCACTT TGGACTCTTC CCTGCAAATT ATGTCAAGCT TCTGGAGTGA
The stop codons will be deleted if pcDNA3.1+ /C-(K)DYK vector is selected.
Exome sequencing reveals recurrent germ line variants in patients with familial Waldenstr?m macroglobulinemia.
Blood127(21)2598-606(2016 05)
Roccaro AM,Sacco A,Shi J,Chiarini M,Perilla-Glen A,Manier S,Glavey S,Aljawai Y,Mishima Y,Kawano Y,Moschetta M,Correll M,Improgo MR,Brown JR,Imberti L,Rossi G,Castillo JJ,Treon SP,Freedman ML,Van Allen EM,Hide W,Hiller E,Rainville I,Ghobrial IM
Interactions among HCLS1, HAX1 and LEF-1 proteins are essential for G-CSF-triggered granulopoiesis.
Nature medicine18(10)1550-9(2012 Oct)
Skokowa J,Klimiankou M,Klimenkova O,Lan D,Gupta K,Hussein K,Carrizosa E,Kusnetsova I,Li Z,Sustmann C,Ganser A,Zeidler C,Kreipe HH,Burkhardt J,Grosschedl R,Welte K